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Gene: Trim31 (tripartite motif-containing 31) Rattus norvegicus

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Symbol:

Trim31

Name:

tripartite motif-containing 31

RGD ID:

1308607

Description:

Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including innate immune response; negative regulation of NLRP3 inflammasome complex assembly; and protein polyubiquitination. Predicted to act upstream of or within NLRP3 inflammasome complex assembly. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human TRIM31 (tripartite motif containing 31); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

E3 ubiquitin-protein ligase TRIM31; LOC294208; Trim31l; tripartite motif protein 31; tripartite motif protein 31-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIM31 (tripartite motif containing 31)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL
Mus musculus (house mouse):	Trim31 (tripartite motif-containing 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIM31 (tripartite motif containing 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trim31 (tripartite motif containing 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIM31 (tripartite motif containing 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Trim31 (tripartite motif containing 31)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TRIM15 (tripartite motif containing 15)	HGNC	Treefam
Homo sapiens (human):	TRIM26 (tripartite motif containing 26)	HGNC	Treefam
Homo sapiens (human):	TRIM10 (tripartite motif containing 10)	HGNC	Treefam
Alliance orthologs ³
Homo sapiens (human):	TRIM31 (tripartite motif containing 31)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Trim31 (tripartite motif-containing 31)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:194990	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-219e21.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-18p12.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-114c12.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	btr29 (bloodthirsty-related gene family, member 29)	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	si:ch211-120g10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	F43C11.7	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	Y47G6A.14	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nhl-3	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C28G1.6	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	XB5796700	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	XB5960628	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408243	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100490328	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100493468	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408231	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408245	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408247	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100493962	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC108644876	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408362	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC101731211	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100494464	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100489535	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408358	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408232	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC105945670	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100489639	Alliance	DIOPT (Ensembl Compara\|OMA)
Xenopus tropicalis (tropical clawed frog):	LOC116412608	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408361	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408231	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC116408362	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	LOC100494464	Alliance	DIOPT (Ensembl Compara\|Hieranoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	1,658,386 - 1,671,711 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	1,658,386 - 1,671,711 (-)	Ensembl				GRCr8
mRatBN7.2	20	1,653,165 - 1,666,494 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	1,653,165 - 1,666,494 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	1,706,020 - 1,719,826 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	1,709,513 - 1,723,321 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	1,650,953 - 1,663,946 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	2,146,245 - 2,159,875 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	2,146,257 - 2,159,631 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	4,183,577 - 4,196,772 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	1,745,437 - 1,758,194 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	2,361,720 - 2,375,040 (-)	NCBI		Celera
RGSC_v3.1	20	1,746,131 - 1,757,962 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

irritant dermatitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

camptothecin (ISO)

capecitabine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper(II) chloride (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

gentamycin (EXP)

glycidol (EXP)

glyphosate (ISO)

isotretinoin (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

N-Nitrosopyrrolidine (ISO)

Nutlin-3 (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

propanal (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium hydroxide (ISO)

Theaflavin 3,3'-digallate (ISO)

trichloroethene (EXP)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (IEA,ISO)

defense response to virus (IEA,ISO)

host-mediated suppression of symbiont invasion (IEA,ISO)

innate immune response (IBA,IEA,ISO)

negative regulation of NLRP3 inflammasome complex assembly (IEA,ISO)

negative regulation of viral transcription (ISO)

positive regulation of DNA-templated transcription (IEA)

protein K48-linked ubiquitination (IEA,ISO)

protein K63-linked ubiquitination (ISO)

ubiquitin-dependent protein catabolic process (IEA,ISO)

viral release from host cell (ISO)

Cellular Component

cytoplasm (IBA,IEA)

mitochondrion (ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transcription coactivator activity (ISO)

ubiquitin protein ligase activity (IBA,IEA,ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15060004	PMID:18248090	PMID:23077300

Genomics

Comparative Map Data

Trim31
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	1,658,386 - 1,671,711 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	1,658,386 - 1,671,711 (-)	Ensembl				GRCr8
mRatBN7.2	20	1,653,165 - 1,666,494 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	1,653,165 - 1,666,494 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	1,706,020 - 1,719,826 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	1,709,513 - 1,723,321 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	1,650,953 - 1,663,946 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	2,146,245 - 2,159,875 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	2,146,257 - 2,159,631 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	4,183,577 - 4,196,772 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	1,745,437 - 1,758,194 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	2,361,720 - 2,375,040 (-)	NCBI		Celera
RGSC_v3.1	20	1,746,131 - 1,757,962 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

TRIM31
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	30,102,897 - 30,113,090 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	30,102,886 - 30,113,090 (-)	Ensembl			hg38	GRCh38
GRCh37	6	30,070,674 - 30,080,867 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	30,178,653 - 30,188,846 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	30,178,654 - 30,188,833	NCBI
Celera	6	31,668,926 - 31,679,124 (-)	NCBI		Celera
Cytogenetic Map	6	p22.1	NCBI
HuRef	6	29,868,836 - 29,879,034 (-)	NCBI		HuRef
CHM1_1	6	30,072,756 - 30,082,946 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	29,967,171 - 29,977,357 (-)	NCBI		T2T-CHM13v2.0

Trim31
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	37,209,022 - 37,221,109 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	37,209,010 - 37,221,106 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	36,898,130 - 36,910,217 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	36,898,118 - 36,910,214 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	37,035,075 - 37,047,162 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	36,506,183 - 36,518,270 (+)	NCBI		MGSCv36	mm8
Celera	17	40,317,255 - 40,329,416 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	19.16	NCBI

TRIM31
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	44,693,821 - 44,720,839 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	40,656,853 - 40,683,843 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	29,880,668 - 29,890,905 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	30,550,802 - 30,560,993 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	30,550,802 - 30,560,977 (-)	Ensembl			panPan2	panpan1.1

Trim31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	32,646,388 - 32,657,283 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936723	934,808 - 945,279 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM31
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	22,665,150 - 22,681,616 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	24,946,635 - 24,960,048 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Trim31
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	9,871,281 - 9,881,870 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trim31
240 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	208
Count of miRNA genes:	152
Interacting mature miRNAs:	167
Transcripts:	ENSRNOT00000061558
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1533200	5306452	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	1	6693431	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	6693431	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
724519	Bp144	Blood pressure QTL 144		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	20	1	3629303	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

D20Rat1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	20	1,664,124 - 1,664,359 (+)	Marker Load Pipeline
mRatBN7.2	20	1,658,903 - 1,659,140 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	2,151,984 - 2,152,218	NCBI	Rnor6.0
Rnor_5.0	20	4,189,287 - 4,189,521	UniSTS	Rnor5.0
Celera	20	2,367,455 - 2,367,687	UniSTS
RH 3.4 Map	20	11.4	RGD
RH 3.4 Map	20	11.4	UniSTS
RH 2.0 Map	20	0.0	RGD
SHRSP x BN Map	20	0.04	RGD
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	30	62	80	79	48	55	48	6	236	118	11	33	46	46	31	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC108572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000061558 ⟹ ENSRNOP00000058275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	1,658,386 - 1,671,711 (-)	Ensembl
mRatBN7.2 Ensembl	20	1,653,165 - 1,666,494 (-)	Ensembl
Rnor_6.0 Ensembl	20	2,146,257 - 2,159,631 (-)	Ensembl

RefSeq Acc Id:

NM_001106376 ⟹ NP_001099846

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	1,658,386 - 1,671,711 (-)	NCBI
mRatBN7.2	20	1,653,165 - 1,666,494 (-)	NCBI
Rnor_6.0	20	2,146,245 - 2,159,631 (-)	NCBI
Rnor_5.0	20	4,183,577 - 4,196,772 (-)	NCBI
RGSC_v3.4	20	1,745,437 - 1,758,194 (-)	RGD
Celera	20	2,361,720 - 2,375,040 (-)	RGD

Sequence:

show sequence

CAGTGAGGGAGGGCTTACCGTCTGTTTTCTTCTCTTTAGAATATTCCCCATTTAGGTCTGACTC
TTTTCTGTCATTATTGACTTAACCCCCTCTCTTCCCGTGTCCTCCTCTAATCCTCCCATTGAGA
GACTCTTCAACCTCCGTCTCCTGTTTTCCGTCTCCCTTCCCAGCACCAGTGTCTGCCTTGGATT
TCTGGGCTTTCACATCTCAGATTAGCCCTGCTGCTCTGTCATGGCAGACCCAAAGATGGCCAGC
CAACTGCAGGAGGATGTGACCTGCCCCATCTGCTTGGAAATTCTACAAGATCCTGTCACCATTG
ACTGTGGGCACAACTTCTGCCTGAAGTGTATCAATCAGATTGGGAAAACGTCAGAAAATATCCT
ATGTCCTCTCTGCAAGTGCTCTGTGAGTAAGAATACTTTCAGGCCCAATAAGCTGCTGGCTAGT
CTTGCAGAGAAGATCCAGACTATGGATCCTGCTGACATCCAACAAGAAAAGGAAGAGGCAAGAT
GTCAGAAGCACAAGAAAAAGCTATATTACTTCTGCGAGCAGGATGGGGCGCTCCTCTGCGTAGT
GTGTCGTGACTCCAAGGACCACAAATTCCACGATGTCACCTTGATAGATGAGGCTGTCCAGAAC
TACAAGGTGCAGATTGAGTCACAGGCCCAGGATTTGGGGCGAAAGGACAAGGAAATAATTGAAG
AGAAAAAACGAGGCGAAGGGGCAATCTGGACATTCAGGGCCCAGGTGGAACTAGAGAAACTAAA
GGTCATTGAGGAATTCAAGCACCTGCGCCAGAGACTGGACGAGGAAGAAAGTTTCCTCCTGTCC
AGGATGGACTGGCTGGAGAAGCAGGGAGCCAAGCAGTTGGGACAATATGTCACTGTGACAGAGA
AGCAGCTGAACTCTCTTAGGACGCTCACTAAATCCTTGAAAATTAGACTGCAATCTTCATCCAT
AGAGTTACTAAAGGACATTAAAGACACCCTGAGCAGGAATAAGGAATTTCAGTTTCTCAGCCCA
ATTCCAGTTCCTGTGGACCTGGAGAAAAAACGCAGTGAAGCAAAAGCAAGACTTGAGTCCGTCC
TAAAATCCCTGACAGAATTCAAAGACAACCTGAAGGCCAAAGGGAAGAAAGATAAAAGCGAGTT
CGTGAGCAGCCTGAATAAAGAAGAAAGGGAGAGCTGGAGCCTATTACAGAAGAATAACTCGATG
TCGCCCACCCCAGTCCCCATGACCCTGGACAAGGACTCAGCTGACCCAGACCTCACCATTTCTC
ATGATGGAAAGAAAGTGACCTTGTATTATATAGCTGGAAAAGCTTCCAATAAGCAGGCAAAGCC
TCGACCATTCTACCCATTCCACTGTGTGAGGGGTTCCCCAGGCCTCTCCTCAGGCCGCCGGGTG
TGGGAGGCAGAAATCTGGGAGCCCTCAGGTGGGGCATGCATCATTGGCGTGGCTACAGAGTTGG
CTCAAGGGTCCCAGAGTCAAAACATCAGGATGCAGAACTGCATATGGGCACTGCGGATCTCACC
CACTGGATGCCAGCCATTCACCAATTGTAAAACGCAGGAGCATCTCCAGGTCTGTCTCAAGAAA
GTGGGTGTCTACGTGAATCATGACTGCGGGGAGGTCATCTTCTATGATGCCATCACTAGCAAAC
ACATCTATACTTTCCAAACTTCTTTTAACGGGAGGGTCTTCCCCCTTTTCGGGCTCCAAGTTAC
CTGCAGCCATATCACCCTGACCCCTTAGGGCTGCTCGCTTGTGGGTGCCTAGGTCTCTTCCCTA
CCTATCCCTCAGCATGGGATGAGACAAAGTGGTAGGAGTGAAGCATGGCCCTACTCCAGCACTC
TACACACCTATGCACACCTGATGTATCCTCTCCCCTCCACCCCTGAGTAGAGAAGACAGTGGAA
TACTCCCAAAGGCTAGACACAAGATTTTTCACCACTGCACTTGGTAGCAGGAACTCTGGCCATG
CTCTGCTGAGACACGGGTGCAAGGCGCTGTCCAGCACCCTGGCTGCTTTCTCCACTTTACTACT
CAAAGCTCCCATGACTCTAAATTTGAGCACTTGACTCTCATCCTTTCCTGAGATCGGAGAACCA
GAGGCTGTGTAGAGTCAGTCAGTTCTGTGCCAATTCCCAGTTTGTAGACGGGGATAGTCTACAA
TCAGGGATGCAACCTTTTGATATTTCAAAGCAACATTGTCATTCTCAGCAGCTCTGTCTTCCAA
TTGAAAACAAAATTGTGGGGGCTGGAGGGATGGCTCAGTGGTTAAGGGCACTGACTGCTCTTCC
AGAGGTCCTGAGTTCAATTCCCAGCAACCACATGGTGGCTCACGACCATCTGTACTGAGATCTG
ATGCCCTCTTCTGGTGTGTCTGAAGATAGCTATAGTGTACTTATATTAATAAAAGTTAAAAAAA
AACAAAATTGTAAATCACC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099846	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84606	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000058275
	ENSRNOP00000058275.3

RefSeq Acc Id:

NP_001099846 ⟸ NM_001106376

- UniProtKB:

D3ZN56 (UniProtKB/TrEMBL), A6KR83 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADPKMASQLQEDVTCPICLEILQDPVTIDCGHNFCLKCINQIGKTSENILCPLCKCSVSKNTF
RPNKLLASLAEKIQTMDPADIQQEKEEARCQKHKKKLYYFCEQDGALLCVVCRDSKDHKFHDVT
LIDEAVQNYKVQIESQAQDLGRKDKEIIEEKKRGEGAIWTFRAQVELEKLKVIEEFKHLRQRLD
EEESFLLSRMDWLEKQGAKQLGQYVTVTEKQLNSLRTLTKSLKIRLQSSSIELLKDIKDTLSRN
KEFQFLSPIPVPVDLEKKRSEAKARLESVLKSLTEFKDNLKAKGKKDKSEFVSSLNKEERESWS
LLQKNNSMSPTPVPMTLDKDSADPDLTISHDGKKVTLYYIAGKASNKQAKPRPFYPFHCVRGSP
GLSSGRRVWEAEIWEPSGGACIIGVATELAQGSQSQNIRMQNCIWALRISPTGCQPFTNCKTQE
HLQVCLKKVGVYVNHDCGEVIFYDAITSKHIYTFQTSFNGRVFPLFGLQVTCSHITLTP

hide sequence

Ensembl Acc Id:

ENSRNOP00000058275 ⟸ ENSRNOT00000061558

Protein Domains

B box-type B30.2/SPRY RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZN56-F1-model_v2	AlphaFold	D3ZN56	1-507	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701275

Promoter ID:

EPDNEW_R11799

Type:

initiation region

Name:

Trim31_1

Description:

tripartite motif-containing 31

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	2,159,643 - 2,159,703	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308607	AgrOrtholog
BioCyc Gene	G2FUF-4974	BioCyc
Ensembl Genes	ENSRNOG00000021518	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000061558	ENTREZGENE
	ENSRNOT00000061558.7	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.920	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	B30.2/SPRY_sf	UniProtKB/TrEMBL
	B302	UniProtKB/TrEMBL
	Butyrophylin	UniProtKB/TrEMBL
	ConA-like_dom	UniProtKB/TrEMBL
	PRY	UniProtKB/TrEMBL
	SPRY_rcpt	UniProtKB/TrEMBL
	TRIM/RBCC	UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:294208	UniProtKB/TrEMBL
NCBI Gene	294208	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
Pfam	SPRY	UniProtKB/TrEMBL
	zf-B_box	UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/TrEMBL
PhenoGen	Trim31	PhenoGen
PRINTS	BUTYPHLNCDUF	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021518	RatGTEx
SMART	BBOX	UniProtKB/TrEMBL
	PRY	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	ConA_like_lec_gl	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
UniProt	A6KR83	ENTREZGENE, UniProtKB/TrEMBL
	D3ZN56	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-31	Trim31	tripartite motif-containing 31	Trim31_predicted	tripartite motif protein 31 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Trim31_predicted	tripartite motif protein 31 (predicted)		tripartite motif-containing 31 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Trim31_predicted	tripartite motif-containing 31 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD