Mlx (MAX dimerization protein MLX)

Gene: Mlx (MAX dimerization protein MLX) Rattus norvegicus

Analyze

Symbol:

Mlx

Name:

MAX dimerization protein MLX

RGD ID:

1308590

Description:

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of lipid biosynthetic process and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amiodarone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC360631; max-like factor protein; MAX-like protein X; MLX, MAX dimerization protein; Tcfl4; transcription factor-like 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MLX (MAX dimerization protein MLX)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mlx (MAX-like protein X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mlx (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MLX (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MLX (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mlx (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MLX (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MLX (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mlx (MAX dimerization protein MLX)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RUNX1 (RUNX family transcription factor 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MLX (MAX dimerization protein MLX)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mlx (MAX-like protein X)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mlx (MAX dimerization protein MLX)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mxl-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	bigmax	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mlx	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,519,517 - 86,524,607 (+)	NCBI		GRCr8
mRatBN7.2	10	86,019,216 - 86,024,326 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,019,588 - 86,032,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	91,056,115 - 91,060,833 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,534,894 - 90,539,610 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,928,061 - 85,932,777 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,997,011 - 89,002,154 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,997,399 - 89,002,152 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,795,855 - 88,800,662 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	90,104,233 - 90,108,952 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	90,118,592 - 90,123,270 (+)	NCBI
Celera	10	84,737,300 - 84,742,019 (+)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

mucopolysaccharidosis type IIIB (ISO)

oligoasthenoteratozoospermia (ISS)

ovarian dysgenesis 3 (ISO)

Takayasu's arteritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,4-dichlorobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

amiodarone (EXP)

amitriptyline (EXP)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

clomipramine (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cyproconazole (EXP)

D-glucose (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

epoxiconazole (EXP)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fructose (EXP)

glucose (ISO)

imipramine (EXP)

ketoconazole (EXP)

leflunomide (EXP)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-methyl-N-nitrosourea (ISO)

nefazodone (EXP)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

prochloraz (EXP)

rac-lactic acid (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

thapsigargin (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

nucleocytoplasmic transport (ISO)

positive regulation of glycolytic process (ISO)

positive regulation of lipid biosynthetic process (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription from RNA polymerase II promoter by glucose (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

nuclear membrane (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

DNA binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.	Tamura N, etal., Circ Genom Precis Med. 2018 Oct;11(10):e002296. doi: 10.1161/CIRCGEN.118.002296.
7.	Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.	Terao C, etal., Am J Hum Genet. 2013 Aug 8;93(2):289-97. doi: 10.1016/j.ajhg.2013.05.024. Epub 2013 Jul 3.

Additional References at PubMed

PMID:8889548	PMID:10918583	PMID:11073985	PMID:11230181	PMID:12446771	PMID:12477932	PMID:16644726	PMID:16778019	PMID:16885160

Genomics

Comparative Map Data

Mlx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,519,517 - 86,524,607 (+)	NCBI		GRCr8
mRatBN7.2	10	86,019,216 - 86,024,326 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,019,588 - 86,032,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	91,056,115 - 91,060,833 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,534,894 - 90,539,610 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,928,061 - 85,932,777 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,997,011 - 89,002,154 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,997,399 - 89,002,152 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,795,855 - 88,800,662 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	90,104,233 - 90,108,952 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	90,118,592 - 90,123,270 (+)	NCBI
Celera	10	84,737,300 - 84,742,019 (+)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

MLX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,567,100 - 42,573,203 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,567,072 - 42,573,239 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,719,118 - 40,725,221 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	37,972,604 - 37,978,747 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	37,375,011 - 37,381,154 (+)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,483,747 - 36,489,890 (+)	NCBI		HuRef
CHM1_1	17	40,954,910 - 40,961,053 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	43,424,288 - 43,430,391 (+)	NCBI		T2T-CHM13v2.0

Mlx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,978,116 - 100,983,033 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	100,978,103 - 100,983,033 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	101,086,707 - 101,092,207 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	101,087,277 - 101,092,207 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,948,604 - 100,953,521 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,903,400 - 100,908,297 (+)	NCBI		MGSCv36	mm8
Celera	11	112,383,392 - 112,388,309 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	64.18	NCBI

Mlx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,459,879 - 16,464,529 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,460,737 - 16,464,529 (+)	NCBI	ChiLan1.0	ChiLan1.0

MLX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,411,883 - 22,417,767 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	24,301,879 - 24,307,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	14,743,314 - 14,749,484 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	14,967,236 - 14,972,887 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	14,967,236 - 14,972,875 (-)	Ensembl	panpan1.1		panPan2

MLX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,391,762 - 20,395,792 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,391,762 - 20,395,735 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	19,853,081 - 19,857,639 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,110,183 - 21,114,741 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	9	19,896,017 - 19,900,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,160,949 - 20,165,810 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,265,296 - 20,269,857 (-)	NCBI		UU_Cfam_GSD_1.0

Mlx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	19,746,563 - 19,751,620 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	17,323,919 - 17,328,485 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	17,323,137 - 17,327,774 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MLX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,249,761 - 20,257,526 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,249,760 - 20,257,543 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,462,461 - 20,470,244 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MLX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	63,714,934 - 63,720,466 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	63,716,012 - 63,720,408 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,510,298 - 34,516,165 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mlx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,539,935 - 1,543,115 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	1,539,935 - 1,543,600 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mlx
25 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	131
Count of miRNA genes:	93
Interacting mature miRNAs:	114
Transcripts:	ENSRNOT00000027116
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	72552416	93995749	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	74372084	94965338	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	75631887	87055282	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	94965338	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	78775516	98279596	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	78899655	87307728	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	80515287	91230079	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	80515287	101325465	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	82564856	92369470	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84007272	95933025	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84007272	95933025	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	84022321	93995963	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	85565469	103884409	Rat

Markers in Region

RH127869

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	86,023,884 - 86,024,094 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	89,001,713 - 89,001,922	NCBI	Rnor6.0
Rnor_5.0	10	88,800,209 - 88,800,418	UniSTS	Rnor5.0
RGSC_v3.4	10	90,108,513 - 90,108,722	UniSTS	RGSC3.4
Celera	10	84,741,580 - 84,741,789	UniSTS
RH 3.4 Map	10	875.3	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

AI176866

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	86,018,672 - 86,018,782 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	88,996,502 - 88,996,611	NCBI	Rnor6.0
Rnor_5.0	10	88,794,998 - 88,795,107	UniSTS	Rnor5.0
RGSC_v3.4	10	90,103,302 - 90,103,411	UniSTS	RGSC3.4
Celera	10	84,736,369 - 84,736,478	UniSTS
RH 3.4 Map	10	875.3	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

RH136418

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	86,024,432 - 86,024,704 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	89,002,261 - 89,002,532	NCBI	Rnor6.0
Rnor_5.0	10	88,800,757 - 88,801,028	UniSTS	Rnor5.0
RGSC_v3.4	10	90,109,061 - 90,109,332	UniSTS	RGSC3.4
Celera	10	84,742,128 - 84,742,399	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

MLX

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	86,020,577 - 86,021,199 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	88,998,406 - 88,999,027	NCBI	Rnor6.0
Rnor_5.0	10	88,796,902 - 88,797,523	UniSTS	Rnor5.0
RGSC_v3.4	10	90,105,206 - 90,105,827	UniSTS	RGSC3.4
Celera	10	84,738,273 - 84,738,894	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

SHGC-53165

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	86,020,571 - 86,021,201 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	88,998,400 - 88,999,029	NCBI	Rnor6.0
Rnor_5.0	10	88,796,896 - 88,797,525	UniSTS	Rnor5.0
RGSC_v3.4	10	90,105,200 - 90,105,829	UniSTS	RGSC3.4
Celera	10	84,738,267 - 84,738,896	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	7	10	74	35	41	11	7
Low							1	1					1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC128702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI286092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ194554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO560831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO574572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ350891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ350892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ350893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ756753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027116 ⟹ ENSRNOP00000027116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	86,019,611 - 86,032,350 (+)	Ensembl
Rnor_6.0 Ensembl	10	88,997,399 - 89,002,152 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099833 ⟹ ENSRNOP00000095005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	86,019,886 - 86,032,350 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106512 ⟹ ENSRNOP00000083006

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	86,019,588 - 86,024,323 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119770 ⟹ ENSRNOP00000091763

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	86,019,592 - 86,032,350 (+)	Ensembl

RefSeq Acc Id:

NM_001034112 ⟹ NP_001029284

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,886 - 86,524,605 (+)	NCBI
mRatBN7.2	10	86,019,605 - 86,024,324 (+)	NCBI
Rnor_6.0	10	88,997,433 - 89,002,152 (+)	NCBI
Rnor_5.0	10	88,795,855 - 88,800,662 (+)	NCBI
RGSC_v3.4	10	90,104,233 - 90,108,952 (+)	RGD
Celera	10	84,737,300 - 84,742,019 (+)	RGD

Sequence:

show sequence

TCCACGATGACGGAGCCGGGCGCCTCTCCGGAGGACCCTTGGGTCAAGGCAAGCTCCGCGGATG
CGCACGCCGGCGAGGGGAGGGCGGGTCGGGCTCGTGCACGTAGGGGGTCCGGAAGACGTGGGGC
TCCCCAACTATCCCCAGAGTCTCCCCTGCTGTCCAGGCCCCGGGGCTGCAGAGAAGACAGCTCT
CACCCGGCCTGTGCCAAGGTCGAGTATGCCTACAGTGACAACAGCCTGGACCCTGGGCTTTTTG
TAGAAAGCACCCACAAGGGGAGTGTAGTGTCCAGAGCTAATAGCATCGGTTCCACCAGTGCCTC
TTCTGTCCCCAACACAGATGATGAGGACAGCGATTATCAGCAGGAATCCTACAAGGAGTCCTAT
AAAGACCGGAGGCGGCGTGCGCACACTCAGGCTGAACAGAAGAGGAGGGATGCTATTAAGAGAG
GCTATGATGACCTTCAGACCATTGTCCCTACTTGCCAGCAGCAGGATTTCTCCATTGGCTCCCA
AAAACTCAGCAAAGCCATCGTTCTACAGAAGACCATTGACTACATCCAGTTTTTACACAAGGAG
AAGAAAAAACAGGAGGAGGAGGTGTCCACCCTGCGCAAGGACGTCACAGCCTTGAAGATAATGA
AAGTGAACTATGAGCAGATCGTGAAGGCACATCAGGACAACCCTCATGAGGGAGAGGACCAGGT
CTCTGACCAGGTCAAGTTCAACGTCTTTCAAGGCATCATGGACTCCCTGTTCCAGTCTTTCAAC
GCCTCCATCTCTGTGGCCAGCTTCCAGGAGCTCTCAGCCTGTGTCTTCAGCTGGATTGAAGAAC
ACTGTGAACCGCAGACTCTACGGGAGATTGTGATCGGTGTCCTTCATCAGTTGAAAAACCAACT
CTACTGACGGTTCCCAGAAACCCGAAGAGCAGCCAACAAGTGGCCTTGAGTGTTTGGTCACGGA
ACTGCTGGGCCTGAGATTGGACTGCAACACCTCACACCAGTCAGCTGGTTTCTACTTGGTGTTT
GGTTTTCCCAGCCCCACTTGAGCTTCTGATTAATTTATTATATTGCCTACAATGTTGAGCCTAT
CCAACCTTCCCCTTCCCAGGAATAGCATCTAGGGCAAGTCTGTGCAGGGAACCTCAGAATCCCG
AGCCTCTCAGCCCCTTCTCTACCCATTGGGTTCCTGCTCACAATCTATATATACAATTTGGAAA
CTGTTTGCCTCTGCTTGGTCTCTTGGGCAACACTTGGCTCAAGTTTGGGTATTTTGGCAGTTCT
TAAGTTAGAGGAAAAAGAAATAGCCCCATGGGCATGAAGGGTAAAAGGCCACCTTGTGTATAAG
CTAAGGCTGTGTGGTCAATACTAAGTTAAGGCTAGAGTATTCTAGCCAGCTCAGGGTAGAGCTG
CCAGGTTCCTGCTGCCCCTCACATTCTGCCACCCACTTCTTCAGCTACTGTGGGTGCTACAGGA
AACAGTGTCCCATCAGCTCTTGCCCTGTCTTTCCCCAAAGGCAGCATTACATATTTGAATTTAT
TTTCTAAATACCAACAGTGCATTTTTGTTACGTGCAGTTTTCCGAGATTCTTAGCAGACCTGCA
AAGCACCCCAGCCTCTTCTGCATAATGTGTGTTTCCGCCCCACGCGTGTGTTGCCTACATTTCT
CCTAGGATCTGGGGAGAGAGTAAGTGGTACAGAAGATACCCAAATCTTCTGGGGGCAGGCAAGG
GTGATACCTTGGGATTCTCAAAATGTTGGTGTGTGACACCCTTTCTGTACTTTTATCCCGTGTT
CCCTACTGCCTTCCCCAGGTTTGATATCTGGGAGGTTTGATCATCCAGAGGAAATTAAGTATTT
TTATATCAAATTATATTACAATAAATATTACAAATACTTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006247362 ⟹ XP_006247424

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,526 - 86,524,607 (+)	NCBI
mRatBN7.2	10	86,019,505 - 86,024,326 (+)	NCBI
Rnor_6.0	10	88,997,020 - 89,002,154 (+)	NCBI
Rnor_5.0	10	88,795,855 - 88,800,662 (+)	NCBI

Sequence:

show sequence

TTACAGGGCAGATCAGCTGTGCGCGTGCGTACACAGTGTCACACTGTTCAGATTTTTTTTTTTT
TCTGAGATGCTAGGGCACTCTCGCCAGTTCTATCACTGAACTAATTACACTTTTAGTCCCTCTG
ACAATCTTTTTGGAGGTGCTCCATTGCACAGAAAATCGCCCCCATTGAAGATTCTCATTCGGAG
GCGGGTAGGAACCCTCAGGGGCTGACACTACCTATATTAATGAGAATTGGGCAAATTTAGCCAC
CACCAATATTCGTTTAACAACTGGAGCTGCGCAAGCGCAGCGCTTTCGCACCGCTCAAGACTGC
GGTTGTGGATTGGTGGCTTGGATCACGTGACTGAGCCTCGCCTCTTCCTGGAGGTTGGGGGCCA
GTCCGCTGGCTTGTTTCCGGTTCGGTAGGTCCACGATGACGGAGCCGGGCGCCTCTCCGGAGGA
CCCTTGGGTCAAGGTCGAGTATGCCTACAGTGACAACAGCCTGGACCCTGGGCTTTTTGTAGAA
AGCACCCACAAGGGGAGTGTAGTGTCCAGAGCTAATAGCATCGGTTCCACCAGTGCCTCTTCTG
TCCCCAACACAGATGATGAGGACAGCGATTATCAGCAGGAATCCTACAAGGAGTCCTATAAAGA
CCGGAGGCGGCGTGCGCACACTCAGGCTGAACAGAAGAGGAGGGATGCTATTAAGAGAGGCTAT
GATGACCTTCAGACCATTGTCCCTACTTGCCAGCAGCAGGATTTCTCCATTGGCTCCCAAAAAC
TCAGCAAAGCCATCGTTCTACAGAAGACCATTGACTACATCCAGTTTTTACACAAGGAGAAGAA
AAAACAGGAGGAGGAGGTGTCCACCCTGCGCAAGGACGTCACAGCCTTGAAGATAATGAAAGTG
AACTATGAGCAGATCGTGAAGGCACATCAGGACAACCCTCATGAGGGAGAGGACCAGGTCTCTG
ACCAGGTCAAGTTCAACGTCTTTCAAGGCATCATGGACTCCCTGTTCCAGTCTTTCAACGCCTC
CATCTCTGTGGCCAGCTTCCAGGAGCTCTCAGCCTGTGTCTTCAGCTGGATTGAAGAACACTGT
GAACCGCAGACTCTACGGGAGATTGTGATCGGTGTCCTTCATCAGTTGAAAAACCAACTCTACT
GACGGTTCCCAGAAACCCGAAGAGCAGCCAACAAGTGGCCTTGAGTGTTTGGTCACGGAACTGC
TGGGCCTGAGATTGGACTGCAACACCTCACACCAGTCAGCTGGTTTCTACTTGGTGTTTGGTTT
TCCCAGCCCCACTTGAGCTTCTGATTAATTTATTATATTGCCTACAATGTTGAGCCTATCCAAC
CTTCCCCTTCCCAGGAATAGCATCTAGGGCAAGTCTGTGCAGGGAACCTCAGAATCCCGAGCCT
CTCAGCCCCTTCTCTACCCATTGGGTTCCTGCTCACAATCTATATATACAATTTGGAAACTGTT
TGCCTCTGCTTGGTCTCTTGGGCAACACTTGGCTCAAGTTTGGGTATTTTGGCAGTTCTTAAGT
TAGAGGAAAAAGAAATAGCCCCATGGGCATGAAGGGTAAAAGGCCACCTTGTGTATAAGCTAAG
GCTGTGTGGTCAATACTAAGTTAAGGCTAGAGTATTCTAGCCAGCTCAGGGTAGAGCTGCCAGG
TTCCTGCTGCCCCTCACATTCTGCCACCCACTTCTTCAGCTACTGTGGGTGCTACAGGAAACAG
TGTCCCATCAGCTCTTGCCCTGTCTTTCCCCAAAGGCAGCATTACATATTTGAATTTATTTTCT
AAATACCAACAGTGCATTTTTGTTACGTGCAGTTTTCCGAGATTCTTAGCAGACCTGCAAAGCA
CCCCAGCCTCTTCTGCATAATGTGTGTTTCCGCCCCACGCGTGTGTTGCCTACATTTCTCCTAG
GATCTGGGGAGAGAGTAAGTGGTACAGAAGATACCCAAATCTTCTGGGGGCAGGCAAGGGTGAT
ACCTTGGGATTCTCAAAATGTTGGTGTGTGACACCCTTTCTGTACTTTTATCCCGTGTTCCCTA
CTGCCTTCCCCAGGTTTGATATCTGGGAGGTTTGATCATCCAGAGGAAATTAAGTATTTTTATA
TCAAATTATATTACAATAAATATTACAAATACTTTA

hide sequence

RefSeq Acc Id:

XM_017597398 ⟹ XP_017452887

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,869 - 86,524,607 (+)	NCBI
mRatBN7.2	10	86,019,221 - 86,024,324 (+)	NCBI
Rnor_6.0	10	88,997,011 - 89,000,697 (+)	NCBI

Sequence:

show sequence

CAGCCGCAATTACAGGGCAGATCAGCTGTGCGCGTGCGTACACAGTGTCACACTGTTCAGATTT
TTTTTTTTTTCTGAGATGCTAGGGCACTCTCGCCAGTTCTATCACTGAACTAATTACACTTTTA
GTCCCTCTGACAATCTTTTTGGAGGTGCTCCATTGCACAGAAAATCGCCCCCATTGAAGATTCT
CATTCGGAGGCGGGTAGGAACCCTCAGGGGCTGACACTACCTATATTAATGAGAATTGGGCAAA
TTTAGCCACCACCAATATTCGTTTAACAACTGGAGCTGCGCAAGCGCAGCGCTTTCGCACCGCT
CAAGACTGCGGTTGTGGATTGGTGGCTTGGATCACGTGACTGAGCCTCGCCTCTTCCTGGAGGT
TGGGGGCCAGTCCGCTGGCTTGTTTCCGGTTCGGTAGGTCCACGATGACGGAGCCGGGCGCCTC
TCCGGAGGACCCTTGGGTCAAGGCAAGCTCCGCGGATGCGCACGCCGGCGAGGGGAGGGCGGGT
CGGGCTCGTGCACGTAGGGGGTCCGGAAGACGTGGGGCTCCCCAACTATCCCCAGAGTCTCCCC
TGCTGTCCAGGCCCCGGGGCTGCAGAGAAGACAGCTCTCACCCGGCCTGTGCCAAGGTCGAGTA
TGCCTACAGTGACAACAGCCTGGACCCTGGGCTTTTTGTAGAAAGCACCCACAAGGGGAGTGTA
GTGTCCAGAGCTAATAGCATCGGTTCCACCAGTGCCTCTTCTGTCCCCAACACAGATGATGAGG
ACAGCGATTATCAGCAGGAATCCTACAAGGAGTCCTATAAAGACCGGAGGCGGCGTGCGCACAC
TCAGGCTGAACAGAAGAGGAGGGATGCTATTAAGAGAGGCTATGATGACCTTCAGACCATTGTC
CCTACTTGCCAGCAGCAGGATTTCTCCATTGGCTCCCAAAAACTCAGCAAAGCCATCGTTCTAC
AGAAGACCATTGACTACATCCAGTTTTTACACAAGGAGAAGAAAAAACAGGAGGAGGAGGTGTC
CACCCTGCGCAAGGACGTCACAGCCTTGAAGATAATGAAAGTGAACTATGAGCAGATCGTGAAG
GCACATCAGGACAACCCTCATGAGGGAGAGGACCAGGTCTCTGACCAGGTCAAGTTCAACGTCT
TTCAAGGCATCATGGACTCCCTGTTCCAGTCTTTCAACGCCTCCATCTCTGTGGCCAGCTTCCA
GGAGCTCTCAGCCTGTGTCTTCAGCTGGATTGAAGAACACTGTGAACCGCAGGGATCTTGAAAT
TAAAAGGAGGCCACACTCCATTTCAGGGACTTTATGTACATGGGTATTTTGTCTGCATATAATC
TGTGTACTACATGTGTGTGCCTGATGCCTGAGGC

hide sequence

RefSeq Acc Id:

XM_039086404 ⟹ XP_038942332

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,869 - 86,524,607 (+)	NCBI
mRatBN7.2	10	86,019,216 - 86,024,324 (+)	NCBI

RefSeq Acc Id:

XM_039086405 ⟹ XP_038942333

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,526 - 86,524,607 (+)	NCBI
mRatBN7.2	10	86,019,237 - 86,024,326 (+)	NCBI

RefSeq Acc Id:

XM_063269439 ⟹ XP_063125509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,517 - 86,524,607 (+)	NCBI

RefSeq Acc Id:

XM_063269440 ⟹ XP_063125510

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	86,519,526 - 86,524,607 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001029284	(Get FASTA)	NCBI Sequence Viewer
	XP_006247424	(Get FASTA)	NCBI Sequence Viewer
	XP_017452887	(Get FASTA)	NCBI Sequence Viewer
	XP_038942332	(Get FASTA)	NCBI Sequence Viewer
	XP_038942333	(Get FASTA)	NCBI Sequence Viewer
	XP_063125509	(Get FASTA)	NCBI Sequence Viewer
	XP_063125510	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI28703	(Get FASTA)	NCBI Sequence Viewer
	ABC70884	(Get FASTA)	NCBI Sequence Viewer
	ABC70885	(Get FASTA)	NCBI Sequence Viewer
	ABC70886	(Get FASTA)	NCBI Sequence Viewer
	EDM06085	(Get FASTA)	NCBI Sequence Viewer
	EDM06086	(Get FASTA)	NCBI Sequence Viewer
	EDM06087	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027116.5
	ENSRNOP00000083006
	ENSRNOP00000083006.1
	ENSRNOP00000091763
	ENSRNOP00000091763.1
	ENSRNOP00000095005
	ENSRNOP00000095005.1

RefSeq Acc Id:

NP_001029284 ⟸ NM_001034112

- UniProtKB:

A2VCV8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHP
ACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKD
RRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKK
KQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNAS
ISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY

hide sequence

RefSeq Acc Id:	XP_006247424 ⟸ XM_006247362
- Peptide Label:	isoform X4
- UniProtKB:	Q2I1Z0 (UniProtKB/TrEMBL), A6HJ81 (UniProtKB/TrEMBL), F7F8B8 (UniProtKB/TrEMBL), Q2I1Y9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTEPGASPEDPWVKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQ QESYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTID YIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIM DSLFQSFNASISVASFQELSACVFSWIEEHCEPQTLREIVIGVLHQLKNQLY hide sequence

RefSeq Acc Id:

XP_017452887 ⟸ XM_017597398

- Peptide Label:

isoform X1

- Sequence:

show sequence

MTEPGASPEDPWVKASSADAHAGEGRAGRARARRGSGRRGAPQLSPESPLLSRPRGCREDSSHP
ACAKVEYAYSDNSLDPGLFVESTHKGSVVSRANSIGSTSASSVPNTDDEDSDYQQESYKESYKD
RRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKK
KQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNAS
ISVASFQELSACVFSWIEEHCEPQGS

hide sequence

RefSeq Acc Id:

ENSRNOP00000027116 ⟸ ENSRNOT00000027116

RefSeq Acc Id:	XP_038942332 ⟸ XM_039086404
- Peptide Label:	isoform X2
- UniProtKB:	F7F8B8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038942333 ⟸ XM_039086405
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6GJW1 (UniProtKB/TrEMBL), A6HJ82 (UniProtKB/TrEMBL), F7F8B8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000095005 ⟸ ENSRNOT00000099833

RefSeq Acc Id:

ENSRNOP00000091763 ⟸ ENSRNOT00000119770

RefSeq Acc Id:

ENSRNOP00000083006 ⟸ ENSRNOT00000106512

RefSeq Acc Id:	XP_063125509 ⟸ XM_063269439
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063125510 ⟸ XM_063269440
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZVP0 (UniProtKB/TrEMBL)

Protein Domains

bHLH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A2VCV8-F1-model_v2	AlphaFold	A2VCV8	1-298	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697740

Promoter ID:

EPDNEW_R8265

Type:

multiple initiation site

Name:

Mlx_1

Description:

MLX, MAX dimerization protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	88,997,416 - 88,997,476	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308590	AgrOrtholog
BioCyc Gene	G2FUF-23201	BioCyc
Ensembl Genes	ENSRNOG00000019983	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027116.6	UniProtKB/TrEMBL
	ENSRNOT00000099833.1	UniProtKB/TrEMBL
	ENSRNOT00000106512.1	UniProtKB/TrEMBL
	ENSRNOT00000119770.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7323425	IMAGE-MGC_LOAD
InterPro	HLH_DNA-bd	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:360631	UniProtKB/TrEMBL
MGC_CLONE	MGC:156499	IMAGE-MGC_LOAD
NCBI Gene	360631	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
	PTHR15741:SF25	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PhenoGen	Mlx	PhenoGen
PROSITE	HLH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019983	RatGTEx
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	HLH_basic	UniProtKB/TrEMBL
UniProt	A0A8I5ZVP0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AN49_RAT	UniProtKB/TrEMBL
	A0A8I6GJW1	ENTREZGENE, UniProtKB/TrEMBL
	A2VCV8	ENTREZGENE, UniProtKB/TrEMBL
	A6HJ81	ENTREZGENE
	A6HJ82	ENTREZGENE, UniProtKB/TrEMBL
	F7F8B8	ENTREZGENE, UniProtKB/TrEMBL
	Q2I1Y9	ENTREZGENE, UniProtKB/TrEMBL
	Q2I1Z0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A6HJ81	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-28	Mlx	MAX dimerization protein MLX	Mlx	MAX dimerization protein MLX	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-05-06	Mlx	MAX dimerization protein MLX	Mlx	MAX dimerization protein MLX	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-04	Mlx	MAX dimerization protein MLX	Mlx	MLX, MAX dimerization protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-11-21	Mlx	MLX, MAX dimerization protein	Mlx	MAX-like protein X	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Mlx	MAX-like protein X	Tcfl4	transcription factor-like 4	Symbol and Name updated	1299863	APPROVED
2006-03-07	Tcfl4	transcription factor-like 4	Tcfl4_predicted	transcription factor-like 4 (predicted)	Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Tcfl4_predicted	transcription factor-like 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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