Sppl2b (signal peptide peptidase-like 2B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Sppl2b (signal peptide peptidase-like 2B) Rattus norvegicus
Analyze
Symbol: Sppl2b
Name: signal peptide peptidase-like 2B
RGD ID: 1308556
Description: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362828; presenilin-like protein 1; RGD1308556; similar to SPPL2b; SPP-like 2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,494,593 - 9,507,317 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,494,593 - 9,507,278 (-)EnsemblGRCr8
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,028,038 - 7,040,694 (-)NCBICelera
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2313285   PMID:15385547   PMID:15489334   PMID:15998642   PMID:16829951   PMID:16829952   PMID:16873890   PMID:17965014   PMID:19114711   PMID:21896273   PMID:22194595  


Genomics

Comparative Map Data
Sppl2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,494,593 - 9,507,317 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,494,593 - 9,507,278 (-)EnsemblGRCr8
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,028,038 - 7,040,694 (-)NCBICelera
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Cytogenetic Map7q11NCBI
SPPL2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,328,684 - 2,355,095 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,328,613 - 2,355,095 (+)Ensemblhg38GRCh38
GRCh37192,328,683 - 2,355,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,279,629 - 2,306,100 (+)NCBIBuild 36Build 36hg18NCBI36
Celera192,262,722 - 2,289,416 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,099,320 - 2,126,087 (+)NCBIHuRef
CHM1_1192,328,242 - 2,354,745 (+)NCBICHM1_1
T2T-CHM13v2.0192,302,357 - 2,328,755 (+)NCBIT2T-CHM13v2.0
Sppl2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,691,067 - 80,704,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,691,109 - 80,704,542 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,855,242 - 80,868,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,855,275 - 80,868,708 (+)Ensemblmm10GRCm38
MGSCv371080,318,020 - 80,331,453 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,258,386 - 80,271,834 (+)NCBIMGSCv36mm8
Celera1081,874,073 - 81,887,506 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sppl2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)Ensembl
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBIChiLan1.0ChiLan1.0
SPPL2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,711,728 - 6,736,722 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,941,082 - 5,968,189 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,337,570 - 1,355,755 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,309,360 - 2,331,951 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,309,360 - 2,331,951 (+)EnsemblpanPan2panpan1.1
SPPL2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,714,306 - 56,730,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,712,390 - 56,757,938 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2056,509,908 - 56,525,995 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,447,711 - 57,463,802 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,447,720 - 57,463,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,499,796 - 56,515,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,985,051 - 57,001,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,185,354 - 57,201,441 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sppl2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,426,113 - 216,435,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,399,085 - 1,408,783 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,399,125 - 1,408,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,230,061 - 76,247,051 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,230,060 - 76,247,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,781,961 - 76,798,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,121,568 - 2,142,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,121,634 - 2,144,682 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660816,566,507 - 6,588,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sppl2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sppl2b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,017,770 - 154,030,592 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sppl2b
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:150
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000043162
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH134584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,844,009 - 8,844,191 (+)MAPPERmRatBN7.2
Rnor_6.0711,712,279 - 11,712,460NCBIRnor6.0
Rnor_5.0711,879,799 - 11,879,980UniSTSRnor5.0
RGSC_v3.4710,354,646 - 10,354,827UniSTSRGSC3.4
Celera77,028,130 - 7,028,311UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC103000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000084144   ⟹   ENSRNOP00000074120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,494,593 - 9,507,278 (-)Ensembl
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)Ensembl
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097476   ⟹   ENSRNOP00000089491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,494,593 - 9,507,278 (-)Ensembl
mRatBN7.2 Ensembl78,843,920 - 8,856,586 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100592   ⟹   ENSRNOP00000087622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,844,616 - 8,856,591 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109298   ⟹   ENSRNOP00000081849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,494,593 - 9,502,272 (-)Ensembl
mRatBN7.2 Ensembl78,843,918 - 8,851,660 (-)Ensembl
RefSeq Acc Id: NM_001014200   ⟹   NP_001014222
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,278 (-)NCBI
mRatBN7.278,843,918 - 8,856,603 (-)NCBI
Rnor_6.0711,712,187 - 11,724,843 (-)NCBI
Rnor_5.0711,879,707 - 11,892,620 (-)NCBI
RGSC_v3.4710,354,554 - 10,367,210 (-)RGD
Celera77,028,038 - 7,040,694 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401073   ⟹   NP_001388002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,278 (-)NCBI
mRatBN7.278,843,918 - 8,856,603 (-)NCBI
RefSeq Acc Id: NM_001401074   ⟹   NP_001388003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,278 (-)NCBI
mRatBN7.278,843,918 - 8,856,603 (-)NCBI
RefSeq Acc Id: XM_006240948   ⟹   XP_006241010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,911 (-)NCBI
Rnor_5.0711,879,707 - 11,892,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765110   ⟹   XP_008763332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765111   ⟹   XP_008763333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765112   ⟹   XP_008763334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079385   ⟹   XP_038935313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,495,767 - 9,507,317 (-)NCBI
mRatBN7.278,845,093 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_039079386   ⟹   XP_038935314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_039079389   ⟹   XP_038935317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,498,462 - 9,507,317 (-)NCBI
mRatBN7.278,847,791 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_063263721   ⟹   XP_063119791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263723   ⟹   XP_063119793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263724   ⟹   XP_063119794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263725   ⟹   XP_063119795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263726   ⟹   XP_063119796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263727   ⟹   XP_063119797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263728   ⟹   XP_063119798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263730   ⟹   XP_063119800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,506,701 (-)NCBI
RefSeq Acc Id: XM_063263731   ⟹   XP_063119801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,279 (-)NCBI
RefSeq Acc Id: XM_063263732   ⟹   XP_063119802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263733   ⟹   XP_063119803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263734   ⟹   XP_063119804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263735   ⟹   XP_063119805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263736   ⟹   XP_063119806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,507,317 (-)NCBI
RefSeq Acc Id: XM_063263737   ⟹   XP_063119807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,498,640 (-)NCBI
RefSeq Acc Id: XM_063263739   ⟹   XP_063119809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,498,462 (-)NCBI
RefSeq Acc Id: XM_063263740   ⟹   XP_063119810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,494,593 - 9,498,640 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014222 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388002 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388003 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241010 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763332 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763333 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763334 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935313 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935314 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935317 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119791 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119793 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119794 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119795 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119796 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119797 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119798 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119800 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119801 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119802 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119803 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119804 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119805 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119806 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119807 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119809 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119810 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87132 (Get FASTA)   NCBI Sequence Viewer  
  EDL89213 (Get FASTA)   NCBI Sequence Viewer  
  EDL89214 (Get FASTA)   NCBI Sequence Viewer  
  EDL89215 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074120
  ENSRNOP00000081849
GenBank Protein Q5PQL3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014222   ⟸   NM_001014200
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5PQL3 (UniProtKB/Swiss-Prot),   A0A8I5ZVS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241010   ⟸   XM_006240948
- Peptide Label: isoform X11
- UniProtKB: A0A8L2R960 (UniProtKB/TrEMBL),   A0A8I5ZVS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763334   ⟸   XM_008765112
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763333   ⟸   XM_008765111
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763332   ⟸   XM_008765110
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074120   ⟸   ENSRNOT00000084144
RefSeq Acc Id: XP_038935314   ⟸   XM_039079386
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935313   ⟸   XM_039079385
- Peptide Label: isoform X14
- UniProtKB: A0A8I6GG67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935317   ⟸   XM_039079389
- Peptide Label: isoform X23
Ensembl Acc Id: ENSRNOP00000089491   ⟸   ENSRNOT00000097476
Ensembl Acc Id: ENSRNOP00000081849   ⟸   ENSRNOT00000109298
Ensembl Acc Id: ENSRNOP00000087622   ⟸   ENSRNOT00000100592
RefSeq Acc Id: NP_001388003   ⟸   NM_001401074
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388002   ⟸   NM_001401073
- Peptide Label: isoform 1 precursor
- UniProtKB: A6K8E3 (UniProtKB/TrEMBL),   A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119806   ⟸   XM_063263736
- Peptide Label: isoform X19
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119804   ⟸   XM_063263734
- Peptide Label: isoform X17
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119805   ⟸   XM_063263735
- Peptide Label: isoform X18
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119802   ⟸   XM_063263732
- Peptide Label: isoform X13
- UniProtKB: A0A8I6GG67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119796   ⟸   XM_063263726
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119793   ⟸   XM_063263723
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119797   ⟸   XM_063263727
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119803   ⟸   XM_063263733
- Peptide Label: isoform X16
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119795   ⟸   XM_063263725
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119794   ⟸   XM_063263724
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119798   ⟸   XM_063263728
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GG67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119791   ⟸   XM_063263721
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119801   ⟸   XM_063263731
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063119800   ⟸   XM_063263730
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063119810   ⟸   XM_063263740
- Peptide Label: isoform X22
RefSeq Acc Id: XP_063119807   ⟸   XM_063263737
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063119809   ⟸   XM_063263739
- Peptide Label: isoform X21
Protein Domains
PA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQL3-F1-model_v2 AlphaFold Q5PQL3 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694999
Promoter ID:EPDNEW_R5523
Type:multiple initiation site
Name:Sppl2b_1
Description:signal peptide peptidase-like 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,724,860 - 11,724,920EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308556 AgrOrtholog
BioCyc Gene G2FUF-34974 BioCyc
Ensembl Genes ENSRNOG00000057881 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084144 ENTREZGENE
  ENSRNOT00000109298 ENTREZGENE
Gene3D-CATH 3.50.30.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121303 IMAGE-MGC_LOAD
InterPro PA_dom_sf UniProtKB/Swiss-Prot
  PA_domain UniProtKB/Swiss-Prot
  Peptidase_A22B_SPP UniProtKB/Swiss-Prot
  Preselin/SPP UniProtKB/Swiss-Prot
KEGG Report rno:362828 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95005 IMAGE-MGC_LOAD
NCBI Gene 362828 ENTREZGENE
PANTHER PTHR12174 UniProtKB/Swiss-Prot
  PTHR12174:SF39 UniProtKB/Swiss-Prot
Pfam Peptidase_A22B UniProtKB/Swiss-Prot
  PF02225 UniProtKB/Swiss-Prot
PhenoGen Sppl2b PhenoGen
RatGTEx ENSRNOG00000057881 RatGTEx
SMART PSN UniProtKB/Swiss-Prot
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot
UniProt A0A8I5ZVS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7E0_RAT UniProtKB/TrEMBL
  A0A8I6GG67 ENTREZGENE
  A0A8L2R960 ENTREZGENE, UniProtKB/TrEMBL
  A6K8E3 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQL3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Sppl2b  signal peptide peptidase-like 2B  RGD1308556  similar to SPPL2b; presenilin-like protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308556  similar to SPPL2b; presenilin-like protein 1  RGD1308556_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308556_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)  LOC362828_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362828_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL