SPPL2C (signal peptide peptidase like 2C)

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Keyword

Gene: SPPL2C (signal peptide peptidase like 2C) Homo sapiens

Symbol:

SPPL2C

Name:

signal peptide peptidase like 2C

Description:

ENCODES a protein that exhibits protein homodimerization activity; FOUND IN endoplasmic reticulum membrane; integral to cytosolic side of endoplasmic reticulum membrane; integral to lumenal side of endoplasmic reticulum membrane; INTERACTS WITH diarsenic trioxide

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

IMP-5; IMP5; intramembrane protease 5; signal peptide peptidase-like 2C; SPP-like 2C

Orthologs:

Mus musculus : Sppl2c (signal peptide peptidase 2C) MGI
Rattus norvegicus : Imp5 (intramembrane protease 5)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	17	45,119,269 - 45,121,451	+	NCBI
Human Genome Assembly HuRef	17	39,586,040 - 39,588,222	+	NCBI
Human Genome Assembly GRCh37	17	43,922,256 - 43,924,438	+	NCBI
Human Celera Assembly	17	40,569,532 - 40,571,714	+	NCBI
Human Genome Assembly Build 36	17	41,278,053 - 41,280,107	+	NCBI
Human Cytogenetic Map	17	q21.31		NCBI

Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - curated

References - uncurated

Genomics

Comparative Map Data

QTLs in Region (Human Genome Assembly GRCh37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298468	BP34_H	Blood pressure QTL 34 (human)	2.16		Blood pressure	systolic	17	623167	66547903	Human
1331651	COPD12_H	Chronic obstructive pulmonary disease QTL 12 (human)	2.44		Chronic airflow obstruction	post-bronchodilator FEV1/FVC	17	10859378	66547903	Human
1559242	FBRL6_H	Fibrinogen level QTL 6 (human)	1.5		Fibrinogen level		17	10859378	80253028	Human
1559256	SCL59_H	Serum cholesterol level QTL 59 (human)	2.48		Lipid level	total cholesterol	17	16064515	80253028	Human
2289574	BW499_H	Body weight QTL 499 (human)	1.96		Body weight	BMI	17	18290029	44290029	Human
1357357	BW56_H	Body weight QTL 56 (human)	2.33		Body weight	body mass index	17	19560307	45560307	Human
2314737	GLUCO88_H	Glucose level QTL 88 (human)	.62	.01	Glucose level	non-insulin dependent	17	22006539	48006539	Human
1331649	COPD22_H	Chronic obstructive pulmonary disease QTL 22 (human)	2.68		Chronic airflow obstruction	FEV1/FVC ratio	17	28382175	46673227	Human
2289219	BW363_H	Body weight QTL 363 (human)		.023	Body fat amount	percent fat	17	29807083	55807083	Human
1298510	RA28_H	Rheumatoid arthritis QTL 28 (human)		.0054	Joint/bone inflammation	rheumatoid arthritis	17	33673168	59673168	Human
1643409	BW271_H	Body Weight QTL 271 (human)	2.09	.001	Body weight		17	33673168	59673168	Human
2292948	PRSTS109_H	Prostate tumor susceptibility QTL 109 (human)	2.99		Prostate tumor susceptibility		17	36784990	62784990	Human
2292966	PRSTS114_H	Prostate tumor susceptibility QTL 114 (human)	3.85		Prostate tumor susceptibility		17	36784990	62784990	Human
2292975	PRSTS112_H	Prostate tumor susceptibility QTL 112 (human)	2.55		Prostate tumor susceptibility		17	36784990	62784990	Human
2292980	PRSTS115_H	Prostate tumor susceptibility QTL 115 (human)	1.7		Prostate tumor susceptibility		17	36784990	62784990	Human
2292987	PRSTS116_H	Prostate tumor susceptibility QTL 116 (human)	5.49		Prostate tumor susceptibility		17	36784990	62784990	Human
2292996	PRSTS108_H	Prostate tumor susceptibility QTL 108 (human)	2.52		Prostate tumor susceptibility		17	36784990	62784990	Human
2292997	PRSTS113_H	Prostate tumor susceptibility QTL 113 (human)	3.24		Prostate tumor susceptibility		17	36784990	62784990	Human
2293010	PRSTS111_H	Prostate tumor susceptibility QTL 111 (human)	3.99		Prostate tumor susceptibility		17	36784990	62784990	Human
2292925	PRSTS110_H	Prostate tumor susceptibility QTL 110 (human)	3.15		Prostate tumor susceptibility		17	36784990	62784990	Human
2292887	PRSTS90_H	Prostate tumor susceptibility QTL 90 (human)			Prostate tumor susceptibility		17	36784990	62784990	Human
2292890	PRSTS84_H	Prostate tumor susceptibility QTL 84 (human)			Prostate tumor susceptibility		17	36784990	62784990	Human
1298421	BP35_H	Blood pressure QTL 35 (human)		.0001	Blood pressure	hypertension susceptibility	17	36852911	68465676	Human
2302768	MAMTS25_H	Mammary tumor susceptibility QTL 25 (human)		.01	Mammary tumor susceptibility		17	36917829	62917829	Human
1643075	BP89_H	Blood pressure QTL 89 (human)	3.22	.000059	Blood pressure		17	38994411	72681088	Human
2292952	PRSTS193_H	Prostate tumor susceptibility QTL 193 (human)	4.51	.0045	Prostate tumor susceptibility		17	40282159	66282159	Human
2292953	PRSTS184_H	Prostate tumor susceptibility QTL 184 (human)	5.82	.0053	Prostate tumor susceptibility		17	40282159	66282159	Human
2292963	PRSTS178_H	Prostate tumor susceptibility QTL 178 (human)	6.18	.0033	Prostate tumor susceptibility		17	40282159	66282159	Human
2292979	PRSTS186_H	Prostate tumor susceptibility QTL 186 (human)	5.75	.0079	Prostate tumor susceptibility		17	40282159	66282159	Human
2292991	PRSTS133_H	Prostate tumor susceptibility QTL 133 (human)	2.56	.01	Prostate tumor susceptibility		17	40282159	66282159	Human
2292999	PRSTS179_H	Prostate tumor susceptibility QTL 179 (human)	6.18	.0033	Prostate tumor susceptibility		17	40282159	66282159	Human
2293008	PRSTS188_H	Prostate tumor susceptibility QTL 188 (human)	6.06	.0029	Prostate tumor susceptibility		17	40282159	66282159	Human
2292927	PRSTS191_H	Prostate tumor susceptibility QTL 191 (human)	4.13	.0018	Prostate tumor susceptibility		17	40282159	66282159	Human
2292933	PRSTS182_H	Prostate tumor susceptibility QTL 182 (human)	5.44	.0026	Prostate tumor susceptibility		17	40282159	66282159	Human
2292944	PRSTS180_H	Prostate tumor susceptibility QTL 180 (human)	6.18	.0065	Prostate tumor susceptibility		17	40282159	66282159	Human
2289501	BW444_H	Body weight QTL 444 (human)	2.83		Body weight	BMI	17	43331542	69331542	Human
2289511	BW453_H	Body weight QTL 453 (human)	2.15		Body fat amount	abdominal	17	43331542	69331542	Human

Sequence

Nucleotide Sequences

Protein Sequences

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	SPPL2C	COSMIC
Ensembl Genes	ENSG00000185294	ENTREZGENE
Ensembl Protein	ENSP00000332488	ENTREZGENE
Ensembl Transcript	ENST00000329196	ENTREZGENE
Entrez Gene	162540	ENTREZGENE
HGNC ID	28902	ENTREZGENE
HomoloGene Group ID	18491	ENTREZGENE
HPRD ID	07085	ENTREZGENE
InterPro	Peptidase_A22	UniProtKB/Swiss-Prot
	Peptidase_A22B_SPP	UniProtKB/Swiss-Prot
	Protease-assoc_domain	UniProtKB/Swiss-Prot
IPI	IPI00103286	UniProtKB/Swiss-Prot
KEGG Report	hsa:162540	ENTREZGENE, UniProtKB/Swiss-Prot
OMIM	608284	OMIM
PANTHER	Peptidase_A22B	UniProtKB/Swiss-Prot
Pfam	Peptidase_A22B	UniProtKB/Swiss-Prot
	PF02225	UniProtKB/Swiss-Prot
SMART	PSN	UniProtKB/Swiss-Prot
UniGene	Hs.144491	ENTREZGENE
UniProt	IMP5_HUMAN	UniProtKB/Swiss-Prot

Nomenclature History

More on SPPL2C

Entrez Gene

Ensembl Gene

Genome Browser:

(hg18) (hg19)

RGD Object Information
RGD ID:	1606947
Created:	2007-04-29
Species:	Homo sapiens
Last Modified:	2013-03-06
Status:	ACTIVE