Dhx9 (DExH-box helicase 9) - Rat Genome Database

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Gene: Dhx9 (DExH-box helicase 9) Rattus norvegicus
Analyze
Symbol: Dhx9
Name: DExH-box helicase 9
RGD ID: 1308548
Description: Predicted to enable several functions, including DNA binding activity; RNA binding activity; and helicase activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; regulation of defense response; and regulatory ncRNA-mediated gene silencing. Predicted to act upstream of or within cellular response to heat and circadian rhythm. Predicted to be located in several cellular components, including cytoskeleton; perichromatin fibrils; and ribonucleoprotein granule. Predicted to be part of CRD-mediated mRNA stability complex; RISC complex; and RISC-loading complex. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 75. Orthologous to human DHX9 (DExH-box helicase 9); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent RNA helicase A; DEAH (Asp-Glu-Ala-His) box helicase 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH-box helicase 9; LOC304859
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,152,813 - 68,189,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1368,152,813 - 68,189,546 (-)EnsemblGRCr8
mRatBN7.21365,602,322 - 65,639,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,602,323 - 65,639,069 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1368,205,589 - 68,242,212 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,494,069 - 69,530,666 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,745,395 - 66,781,953 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,885,503 - 70,922,278 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,885,504 - 70,922,245 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,851,156 - 75,887,898 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,471,256 - 68,507,999 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,505,727 - 65,542,475 (-)NCBICelera
RGSC_v3.11368,485,388 - 68,522,077 (-)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-azacytidine  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chloromethylisothiazolinone  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
succimer  (ISO)
tert-butyl hydroperoxide  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alternative mRNA splicing, via spliceosome  (IEA,ISO)
biological_process  (ND)
cellular response to exogenous dsRNA  (IEA,ISO)
cellular response to heat  (ISO)
chromatin organization  (IEA,ISO)
circadian rhythm  (ISO)
CRD-mediated mRNA stabilization  (IEA,ISO)
DNA-templated transcription termination  (IEA)
DNA-templated viral transcription  (IEA,ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA,ISO)
mRNA processing  (IEA)
mRNA transport  (IEA)
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
positive regulation of cytoplasmic translation  (IEA,ISO)
positive regulation of DNA repair  (IEA,ISO)
positive regulation of DNA replication  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of response to cytokine stimulus  (IEA,ISO)
positive regulation of RNA export from nucleus  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of viral transcription  (IEA,ISO)
protein localization to cytoplasmic stress granule  (IEA,ISO)
protein-containing complex assembly  (IEA,ISO)
pyroptotic inflammatory response  (ISO)
regulation of cytoplasmic translation  (IEA,ISO)
regulation of defense response to virus by host  (ISO)
regulation of mRNA processing  (IBA,IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of translation  (IEA)
regulatory ncRNA-mediated gene silencing  (IEA)
RISC complex assembly  (IEA,ISO)
RNA splicing  (IEA)

Cellular Component

Molecular Function
3'-5' DNA helicase activity  (IBA,IEA,ISO)
3'-5' DNA/RNA helicase activity  (IEA,ISO)
3'-5' RNA helicase activity  (IEA,ISO)
ATP binding  (IEA,ISO)
ATP hydrolysis activity  (IBA,IEA,ISO)
chromatin DNA binding  (IEA,ISO)
DNA binding  (IEA)
DNA helicase activity  (IEA,ISO)
DNA replication origin binding  (IEA,ISO)
double-stranded DNA binding  (IEA,ISO)
double-stranded RNA binding  (IEA,ISO)
G-quadruplex unwinding activity  (IEA,ISO)
helicase activity  (IEA)
hydrolase activity  (IEA)
importin-alpha family protein binding  (IEA,ISO)
metal ion binding  (IEA)
mRNA binding  (IEA,ISO)
nucleic acid binding  (IEA)
nucleoside triphosphate diphosphatase activity  (IEA,ISO)
nucleotide binding  (IEA)
promoter-specific chromatin binding  (IEA,ISO)
protein binding  (ISO)
regulatory region RNA binding  (IEA,ISO)
ribosome binding  (IEA,ISO)
RISC complex binding  (IEA,ISO)
RNA binding  (IBA,IEA,ISO)
RNA helicase activity  (IBA,IEA,ISO)
RNA polymerase binding  (IEA,ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IEA,ISO)
RNA polymerase II complex binding  (IEA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IEA,ISO)
RNA stem-loop binding  (IEA,ISO)
sequence-specific mRNA binding  (IEA,ISO)
single-stranded 3'-5' DNA helicase activity  (IEA,ISO)
single-stranded DNA binding  (IEA,ISO)
single-stranded RNA binding  (IEA,ISO)
siRNA binding  (IEA,ISO)
transcription coactivator activity  (IEA,ISO)
transcription coregulator activity  (IEA,ISO)
triplex DNA binding  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:1537828   PMID:9111062   PMID:9162007   PMID:9323138   PMID:9662397   PMID:10198287   PMID:10207077   PMID:11038348   PMID:11096080   PMID:11402034   PMID:11416126   PMID:11687588  
PMID:12711669   PMID:14704337   PMID:14729462   PMID:15121898   PMID:15355351   PMID:16210410   PMID:16375861   PMID:16680162   PMID:17289661   PMID:17303075   PMID:17498979   PMID:17531811  
PMID:18755693   PMID:18809582   PMID:19029303   PMID:19946888   PMID:20669935   PMID:20696886   PMID:21247876   PMID:21561811   PMID:21957149   PMID:22082260   PMID:22190748   PMID:22658674  
PMID:22681889   PMID:22767893   PMID:23361462   PMID:24049074   PMID:24625528   PMID:24965446   PMID:24990949   PMID:27107641   PMID:28221134   PMID:28355180   PMID:28636595  


Genomics

Comparative Map Data
Dhx9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,152,813 - 68,189,580 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1368,152,813 - 68,189,546 (-)EnsemblGRCr8
mRatBN7.21365,602,322 - 65,639,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,602,323 - 65,639,069 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1368,205,589 - 68,242,212 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,494,069 - 69,530,666 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,745,395 - 66,781,953 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,885,503 - 70,922,278 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,885,504 - 70,922,245 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,851,156 - 75,887,898 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,471,256 - 68,507,999 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,505,727 - 65,542,475 (-)NCBICelera
RGSC_v3.11368,485,388 - 68,522,077 (-)NCBI
Cytogenetic Map13q21NCBI
DHX9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,839,347 - 182,887,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,839,302 - 182,887,982 (+)Ensemblhg38GRCh38
GRCh371182,808,482 - 182,857,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,075,074 - 181,123,507 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341179,582,076 - 179,588,539NCBI
Celera1155,919,588 - 155,968,267 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,044,114 - 154,092,793 (+)NCBIHuRef
CHM1_11184,231,696 - 184,280,375 (+)NCBICHM1_1
T2T-CHM13v2.01182,198,510 - 182,247,148 (+)NCBIT2T-CHM13v2.0
Dhx9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,331,506 - 153,363,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,331,504 - 153,363,406 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,455,756 - 153,487,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,455,758 - 153,487,660 (-)Ensemblmm10GRCm38
MGSCv371155,302,888 - 155,334,790 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361155,218,031 - 155,249,826 (-)NCBIMGSCv36mm8
Celera1155,879,742 - 155,911,641 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.37NCBI
Dhx9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,697,813 - 21,745,011 (+)Ensembl
ChiLan1.0NW_00495540621,697,813 - 21,743,551 (+)NCBIChiLan1.0ChiLan1.0
DHX9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,843,815 - 66,892,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,527,338 - 66,576,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,355,472 - 158,404,178 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,006,822 - 162,055,833 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,006,822 - 162,055,833 (+)EnsemblpanPan2panpan1.1
DHX9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,233,763 - 16,292,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,233,814 - 16,292,618 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha715,819,539 - 15,878,326 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0715,962,809 - 16,021,792 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,962,805 - 16,022,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,874,239 - 15,933,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,983,090 - 16,042,030 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,112,798 - 16,171,750 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dhx9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,049,741 - 89,088,183 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,896,359 - 6,935,623 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,896,487 - 6,934,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,141,967 - 124,185,349 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19124,141,929 - 124,183,838 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DHX9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,485,602 - 46,534,046 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,485,427 - 46,518,406 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605547,703,717 - 47,751,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhx9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,863,337 - 10,921,075 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462481410,863,079 - 10,923,842 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dhx9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11032,909,365 - 32,944,570 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dhx9
299 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:53
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000064860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
AA875461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,602,542 - 65,602,633 (+)MAPPERmRatBN7.2
Rnor_6.01370,885,724 - 70,885,814NCBIRnor6.0
Rnor_5.01375,851,377 - 75,851,467UniSTSRnor5.0
RGSC_v3.41368,471,476 - 68,471,566UniSTSRGSC3.4
Celera1365,505,947 - 65,506,037UniSTS
RH 3.4 Map13340.3UniSTS
Cytogenetic Map13q21UniSTS
RH143807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,609,221 - 65,609,374 (+)MAPPERmRatBN7.2
Rnor_6.01370,892,403 - 70,892,555NCBIRnor6.0
Rnor_5.01375,858,056 - 75,858,208UniSTSRnor5.0
RGSC_v3.41368,478,155 - 68,478,307UniSTSRGSC3.4
Celera1365,512,629 - 65,512,781UniSTS
RH 3.4 Map13340.7UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064860   ⟹   ENSRNOP00000061368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1368,152,813 - 68,189,546 (-)Ensembl
mRatBN7.2 Ensembl1365,602,323 - 65,639,069 (-)Ensembl
Rnor_6.0 Ensembl1370,885,504 - 70,922,245 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116976   ⟹   ENSRNOP00000090956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1368,152,813 - 68,189,546 (-)Ensembl
mRatBN7.2 Ensembl1365,602,620 - 65,639,069 (-)Ensembl
RefSeq Acc Id: NM_001395556   ⟹   NP_001382485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,152,813 - 68,189,546 (-)NCBI
mRatBN7.21365,602,322 - 65,639,058 (-)NCBI
RefSeq Acc Id: XM_006249996   ⟹   XP_006250058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,152,813 - 68,189,580 (-)NCBI
mRatBN7.21365,602,322 - 65,639,098 (-)NCBI
Rnor_6.01370,885,503 - 70,922,278 (-)NCBI
Rnor_5.01375,851,156 - 75,887,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769633   ⟹   XP_008767855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,152,813 - 68,176,768 (-)NCBI
mRatBN7.21365,602,322 - 65,626,277 (-)NCBI
Rnor_6.01370,885,503 - 70,909,410 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001382485 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250058 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767855 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061368
  ENSRNOP00000061368.2
  ENSRNOP00000090956
  ENSRNOP00000090956.1
RefSeq Acc Id: XP_006250058   ⟸   XM_006249996
- Peptide Label: isoform X1
- UniProtKB: A6ICV0 (UniProtKB/TrEMBL),   D4A9D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767855   ⟸   XM_008769633
- Peptide Label: isoform X2
- UniProtKB: A6ICV0 (UniProtKB/TrEMBL),   D4A9D6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061368   ⟸   ENSRNOT00000064860
Ensembl Acc Id: ENSRNOP00000090956   ⟸   ENSRNOT00000116976
RefSeq Acc Id: NP_001382485   ⟸   NM_001395556
- UniProtKB: A0A8I6ABZ7 (UniProtKB/TrEMBL),   A6ICV0 (UniProtKB/TrEMBL),   D4A9D6 (UniProtKB/TrEMBL)
Protein Domains
DRBM   Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9D6-F1-model_v2 AlphaFold D4A9D6 1-1174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698897
Promoter ID:EPDNEW_R9422
Type:initiation region
Name:Dhx9_1
Description:DExH-box helicase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01370,922,234 - 70,922,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308548 AgrOrtholog
BioCyc Gene G2FUF-17884 BioCyc
Ensembl Genes ENSRNOG00000002735 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064860 ENTREZGENE
  ENSRNOT00000064860.3 UniProtKB/TrEMBL
  ENSRNOT00000116976 ENTREZGENE
  ENSRNOT00000116976.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1080 UniProtKB/TrEMBL
  3.30.160.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD-like_N UniProtKB/TrEMBL
  DHX9_DEXHc UniProtKB/TrEMBL
  DHX9_DSRM_1 UniProtKB/TrEMBL
  DHX9_DSRM_2 UniProtKB/TrEMBL
  DNA/RNA_helicase_C UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAD/DEAH_N UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/TrEMBL
  dsRNA-bd-like UniProtKB/TrEMBL
  DUF1605 UniProtKB/TrEMBL
  HA2_WH UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 304859 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE A UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  dsrm UniProtKB/TrEMBL
  DUF1605 UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HA2_C UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PhenoGen Dhx9 PhenoGen
PROSITE DEAH_ATP_HELICASE UniProtKB/TrEMBL
  DS_RBD UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002735 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  DSRM UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ABZ7 ENTREZGENE, UniProtKB/TrEMBL
  A6ICV0 ENTREZGENE, UniProtKB/TrEMBL
  D4A9D6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-05 Dhx9  DExH-box helicase 9  Dhx9  DEAH-box helicase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-13 Dhx9  DEAH-box helicase 9  Dhx9  DEAH (Asp-Glu-Ala-His) box helicase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-22 Dhx9  DEAH (Asp-Glu-Ala-His) box helicase 9  Dhx9  DEAH (Asp-Glu-Ala-His) box polypeptide 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dhx9  DEAH (Asp-Glu-Ala-His) box polypeptide 9   Dhx9_predicted  DEAH (Asp-Glu-Ala-His) box polypeptide 9 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dhx9_predicted  DEAH (Asp-Glu-Ala-His) box polypeptide 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED