Arhgap5 (Rho GTPase activating protein 5) - Rat Genome Database

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Gene: Arhgap5 (Rho GTPase activating protein 5) Rattus norvegicus
Analyze
Symbol: Arhgap5
Name: Rho GTPase activating protein 5
RGD ID: 1308507
Description: Predicted to enable GTPase activator activity and SH2 domain binding activity. Involved in mammary gland development. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytosol. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC299012; LRRGT00098; rho GTPase-activating protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,711,199 - 75,774,636 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl675,711,515 - 75,774,636 (+)EnsemblGRCr8
mRatBN7.2669,975,904 - 70,039,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,976,214 - 70,037,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx670,400,553 - 70,463,444 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,707,197 - 70,770,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0670,146,761 - 70,209,656 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0673,345,129 - 73,408,304 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl673,345,392 - 73,405,880 (+)Ensemblrn6Rnor6.0
Rnor_5.0682,905,983 - 82,970,518 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4672,685,231 - 72,693,052 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera668,851,685 - 68,859,506 (+)NCBICelera
RGSC_v3.1672,688,353 - 72,735,913 (+)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
hydralazine  (ISO)
irinotecan  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
plasma membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Chakravarty G, etal., Cell Growth Differ. 2000 Jul;11(7):343-54.
2. MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. Fang Y, etal., Oncotarget. 2015 May 30;6(15):13164-75.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Heckman-Stoddard BM, etal., Breast Cancer Res. 2009;11(4):R61. doi: 10.1186/bcr2352. Epub 2009 Aug 24.
6. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. McHenry PR, etal., Breast Cancer Res. 2010;12(5):R73. doi: 10.1186/bcr2643. Epub 2010 Sep 22.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:1689011   PMID:12015964   PMID:17662267   PMID:36790698  


Genomics

Comparative Map Data
Arhgap5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8675,711,199 - 75,774,636 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl675,711,515 - 75,774,636 (+)EnsemblGRCr8
mRatBN7.2669,975,904 - 70,039,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,976,214 - 70,037,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx670,400,553 - 70,463,444 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0670,707,197 - 70,770,089 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0670,146,761 - 70,209,656 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0673,345,129 - 73,408,304 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl673,345,392 - 73,405,880 (+)Ensemblrn6Rnor6.0
Rnor_5.0682,905,983 - 82,970,518 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4672,685,231 - 72,693,052 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera668,851,685 - 68,859,506 (+)NCBICelera
RGSC_v3.1672,688,353 - 72,735,913 (+)NCBI
Cytogenetic Map6q23NCBI
ARHGAP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381432,077,304 - 32,159,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1432,075,794 - 32,159,728 (+)Ensemblhg38GRCh38
GRCh371432,546,510 - 32,628,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361431,616,246 - 31,698,685 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341431,616,247 - 31,694,095NCBI
Celera1412,412,908 - 12,495,351 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1412,663,810 - 12,746,250 (+)NCBIHuRef
CHM1_11432,546,410 - 32,628,781 (+)NCBICHM1_1
T2T-CHM13v2.01426,274,927 - 26,357,362 (+)NCBIT2T-CHM13v2.0
Arhgap5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391252,550,555 - 52,618,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1252,550,755 - 52,618,758 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381252,503,763 - 52,571,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1252,503,972 - 52,571,975 (+)Ensemblmm10GRCm38
MGSCv371253,617,064 - 53,668,839 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361253,437,697 - 53,489,472 (+)NCBIMGSCv36mm8
Celera1253,816,020 - 53,871,323 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.16NCBI
Arhgap5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540928,627,176 - 28,705,893 (-)Ensembl
ChiLan1.0NW_00495540928,627,176 - 28,682,302 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21533,393,901 - 33,487,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11432,610,399 - 32,702,106 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01412,844,042 - 12,934,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11431,036,491 - 31,125,349 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1431,036,511 - 31,125,349 (+)EnsemblpanPan2panpan1.1
ARHGAP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1811,190,663 - 11,269,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl811,204,696 - 11,267,086 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha811,052,457 - 11,131,162 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0811,292,865 - 11,371,626 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl811,293,336 - 11,370,667 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,977,322 - 11,056,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0811,057,909 - 11,136,737 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0811,336,405 - 11,415,092 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864043,056,223 - 43,122,569 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364946,562,069 - 6,623,175 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364946,562,092 - 6,624,015 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl767,494,941 - 67,594,197 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1767,494,237 - 67,631,461 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2772,356,323 - 72,370,515 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1248,914,485 - 8,986,498 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl248,928,252 - 8,988,302 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606218,559,918 - 18,566,253 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624820305,475 - 381,058 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624820302,000 - 381,043 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgap5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1765,931,541 - 65,991,217 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgap5
522 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000041373
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
BE101321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,039,120 - 70,039,276 (+)MAPPERmRatBN7.2
Rnor_6.0673,408,128 - 73,408,283NCBIRnor6.0
Rnor_5.0682,969,325 - 82,969,480UniSTSRnor5.0
RGSC_v3.4672,736,817 - 72,736,972UniSTSRGSC3.4
Celera668,903,215 - 68,903,370UniSTS
RH 3.4 Map6516.19UniSTS
Cytogenetic Map6q23UniSTS
BE108339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2670,022,168 - 70,022,320 (+)MAPPERmRatBN7.2
Rnor_6.0673,391,177 - 73,391,328NCBIRnor6.0
Rnor_5.0682,952,374 - 82,952,525UniSTSRnor5.0
RGSC_v3.4672,718,282 - 72,718,433UniSTSRGSC3.4
Celera668,886,264 - 68,886,415UniSTS
RH 3.4 Map6517.98UniSTS
Cytogenetic Map6q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 86 59 6 350 186 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041373   ⟹   ENSRNOP00000047384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl673,358,112 - 73,365,933 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088378   ⟹   ENSRNOP00000074284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl675,711,515 - 75,774,636 (+)Ensembl
mRatBN7.2 Ensembl669,976,214 - 70,037,660 (+)Ensembl
Rnor_6.0 Ensembl673,345,392 - 73,405,880 (+)Ensembl
RefSeq Acc Id: NM_001399400   ⟹   NP_001386329
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8675,711,718 - 75,774,636 (+)NCBI
mRatBN7.2669,976,375 - 70,039,297 (+)NCBI
RefSeq Acc Id: XM_017594084   ⟹   XP_017449573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8675,711,357 - 75,774,636 (+)NCBI
mRatBN7.2669,976,024 - 70,039,299 (+)NCBI
Rnor_6.0673,345,129 - 73,408,304 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111971   ⟹   XP_038967899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8675,711,199 - 75,774,636 (+)NCBI
mRatBN7.2669,975,904 - 70,039,299 (+)NCBI
RefSeq Acc Id: XM_039111972   ⟹   XP_038967900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8675,711,479 - 75,774,636 (+)NCBI
mRatBN7.2669,976,233 - 70,039,299 (+)NCBI
RefSeq Acc Id: XM_063261673   ⟹   XP_063117743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8675,711,367 - 75,774,636 (+)NCBI
RefSeq Acc Id: XP_017449573   ⟸   XM_017594084
- Peptide Label: isoform X1
- UniProtKB: A6HBI5 (UniProtKB/TrEMBL),   E9PTJ5 (UniProtKB/TrEMBL),   Q6TUE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047384   ⟸   ENSRNOT00000041373
Ensembl Acc Id: ENSRNOP00000074284   ⟸   ENSRNOT00000088378
RefSeq Acc Id: XP_038967899   ⟸   XM_039111971
- Peptide Label: isoform X1
- UniProtKB: A6HBI5 (UniProtKB/TrEMBL),   E9PTJ5 (UniProtKB/TrEMBL),   Q6TUE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967900   ⟸   XM_039111972
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K7N9 (UniProtKB/TrEMBL),   E9PTJ5 (UniProtKB/TrEMBL),   Q6TUE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386329   ⟸   NM_001399400
- UniProtKB: A6HBI5 (UniProtKB/TrEMBL),   E9PTJ5 (UniProtKB/TrEMBL),   Q6TUE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117743   ⟸   XM_063261673
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K7N9 (UniProtKB/TrEMBL),   E9PTJ5 (UniProtKB/TrEMBL),   Q6TUE6 (UniProtKB/TrEMBL)
Protein Domains
FF   pG1 pseudoGTPase   pG2 pseudoGTPase   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7N9-F1-model_v2 AlphaFold A0A0G2K7N9 1-1503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694596
Promoter ID:EPDNEW_R5117
Type:multiple initiation site
Name:Arhgap5_1
Description:Rho GTPase activating protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0673,345,387 - 73,345,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308507 AgrOrtholog
BioCyc Gene G2FUF-37574 BioCyc
Ensembl Genes ENSRNOG00000004696 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088378 ENTREZGENE
  ENSRNOT00000088378.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.440 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro FF_domain UniProtKB/TrEMBL
  FF_domain_sf UniProtKB/TrEMBL
  FF_RHG35_4th UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  pG1 UniProtKB/TrEMBL
  Rho-GAP_domain UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP-FF1 UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  RhoGAP_pG1_pG2 UniProtKB/TrEMBL
  RhoGAP_pG2 UniProtKB/TrEMBL
NCBI Gene 299012 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 190 UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 5 UniProtKB/TrEMBL
Pfam FF_RHG35_4th UniProtKB/TrEMBL
  PF01846 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  RhoGAP-FF1 UniProtKB/TrEMBL
  RhoGAP_pG1_pG2 UniProtKB/TrEMBL
PharmGKB ARHGAP5 RGD
PhenoGen Arhgap5 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE PG1 UniProtKB/TrEMBL
  PG2 UniProtKB/TrEMBL
  PS51676 UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004696 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  SM00441 UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF81698 UniProtKB/TrEMBL
UniProt A0A0G2K7N9 ENTREZGENE, UniProtKB/TrEMBL
  A6HBI5 ENTREZGENE, UniProtKB/TrEMBL
  E9PTJ5 ENTREZGENE
  Q6TUE6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PTJ5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Arhgap5  Rho GTPase activating protein 5  Arhgap5_predicted  Rho GTPase activating protein 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Arhgap5_predicted  Rho GTPase activating protein 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED