Spast (spastin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Spast (spastin) Rattus norvegicus
Analyze
Symbol: Spast
Name: spastin
RGD ID: 1308494
Description: Predicted to enable ATP hydrolysis activity; microtubule severing ATPase activity; and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including endoplasmic reticulum tubular network; microtubule cytoskeleton; and nuclear membrane. Predicted to be active in cytoplasm and spindle. Predicted to colocalize with several cellular components, including endoplasmic reticulum; endosome; and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362700; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant); spastic paraplegia 4 (autosomal dominant, spastin); Spg4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8626,807,220 - 26,858,456 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl626,807,220 - 26,858,446 (-)EnsemblGRCr8
mRatBN7.2621,055,349 - 21,106,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx621,386,251 - 21,436,870 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0621,702,093 - 21,752,711 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,182,545 - 21,233,162 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,230,067 - 22,282,166 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)Ensemblrn6Rnor6.0
Rnor_5.0632,118,321 - 32,168,698 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4620,990,083 - 21,048,692 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera620,614,184 - 20,664,224 (-)NCBICelera
RGSC_v3.1620,995,867 - 21,051,815 (-)NCBI
Cytogenetic Map6q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
axon cytoplasm  (IEA)
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endoplasmic reticulum tubular network  (ISO)
endosome  (IEA,ISO,ISS)
membrane  (IEA)
microtubule  (IEA)
microtubule cytoskeleton  (IEA,ISO,ISS)
midbody  (IEA,ISO,ISS)
nuclear membrane  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
spindle  (IBA,IEA)
spindle pole  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. Mead SH, etal., J Neurol Neurosurg Psychiatry 2001 Dec;71(6):788-91.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12490534   PMID:15716377   PMID:16026783   PMID:16219033   PMID:17389232   PMID:18997780   PMID:19000169   PMID:19056867   PMID:19453301   PMID:20530212   PMID:21310966  
PMID:21545838   PMID:23745751   PMID:23969831   PMID:25390646   PMID:26040712   PMID:26875866   PMID:31963385   PMID:36587525  


Genomics

Comparative Map Data
Spast
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8626,807,220 - 26,858,456 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl626,807,220 - 26,858,446 (-)EnsemblGRCr8
mRatBN7.2621,055,349 - 21,106,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx621,386,251 - 21,436,870 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0621,702,093 - 21,752,711 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,182,545 - 21,233,162 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,230,067 - 22,282,166 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)Ensemblrn6Rnor6.0
Rnor_5.0632,118,321 - 32,168,698 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4620,990,083 - 21,048,692 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera620,614,184 - 20,664,224 (-)NCBICelera
RGSC_v3.1620,995,867 - 21,051,815 (-)NCBI
Cytogenetic Map6q13NCBI
SPAST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38232,063,556 - 32,157,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl232,063,530 - 32,157,637 (+)Ensemblhg38GRCh38
GRCh37232,288,625 - 32,382,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36232,142,184 - 32,236,210 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34232,200,330 - 32,294,356NCBI
Celera232,133,566 - 32,227,549 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef232,027,230 - 32,121,818 (+)NCBIHuRef
CHM1_1232,218,851 - 32,312,626 (+)NCBICHM1_1
T2T-CHM13v2.0232,111,981 - 32,206,198 (+)NCBIT2T-CHM13v2.0
Spast
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,643,805 - 74,698,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,645,982 - 74,698,110 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381774,337,923 - 74,391,115 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1774,338,987 - 74,391,115 (+)Ensemblmm10GRCm38
MGSCv371774,738,327 - 74,790,453 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361774,243,969 - 74,293,468 (+)NCBIMGSCv36mm8
Celera1778,633,795 - 78,686,156 (+)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.64NCBI
Spast
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955441485,815 - 520,452 (+)Ensembl
ChiLan1.0NW_004955441471,609 - 521,920 (+)NCBIChiLan1.0ChiLan1.0
SPAST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21294,335,723 - 94,425,719 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A94,339,698 - 94,429,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A32,085,245 - 32,175,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A32,150,514 - 32,888,168 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A32,150,792 - 32,885,029 (+)EnsemblpanPan2panpan1.1
SPAST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11725,393,169 - 25,447,686 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1725,393,422 - 25,446,539 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1725,185,513 - 25,240,078 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01725,955,733 - 26,010,638 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,955,693 - 26,011,753 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11725,255,491 - 25,310,582 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01725,327,446 - 25,381,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01725,426,764 - 25,481,606 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spast
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,496,954 - 69,555,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,283,729 - 1,343,390 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,283,754 - 1,342,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPAST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,439,813 - 107,508,926 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13107,439,810 - 107,508,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,454,182 - 114,524,375 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q21-q27NCBI
SPAST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11475,343,437 - 75,429,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1475,343,327 - 75,429,139 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604536,643,431 - 36,733,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spast
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473813,721,136 - 13,780,530 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spast
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1718,860,333 - 18,911,276 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spast
231 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:703
Count of miRNA genes:294
Interacting mature miRNAs:377
Transcripts:ENSRNOT00000039375
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)62328466429732046Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)62228825727729050Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
RH132989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,054,936 - 21,055,134 (+)MAPPERmRatBN7.2
Rnor_6.0622,230,516 - 22,230,713NCBIRnor6.0
Rnor_5.0632,117,909 - 32,118,106UniSTSRnor5.0
RGSC_v3.4620,989,764 - 20,989,961UniSTSRGSC3.4
Celera620,613,772 - 20,613,969UniSTS
Cytogenetic Map6q12UniSTS
RH139397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,055,653 - 21,055,746 (+)MAPPERmRatBN7.2
Rnor_6.0622,231,233 - 22,231,325NCBIRnor6.0
Rnor_5.0632,118,626 - 32,118,718UniSTSRnor5.0
RGSC_v3.4620,990,481 - 20,990,573UniSTSRGSC3.4
Celera620,614,489 - 20,614,581UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039375   ⟹   ENSRNOP00000033763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,807,220 - 26,858,446 (-)Ensembl
mRatBN7.2 Ensembl621,055,349 - 21,106,312 (-)Ensembl
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079137   ⟹   ENSRNOP00000073338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,807,220 - 26,858,446 (-)Ensembl
mRatBN7.2 Ensembl621,055,349 - 21,106,312 (-)Ensembl
Rnor_6.0 Ensembl622,231,455 - 22,281,724 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105595   ⟹   ENSRNOP00000085299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,807,220 - 26,858,446 (-)Ensembl
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159739   ⟹   ENSRNOP00000099795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,807,220 - 26,858,374 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173450   ⟹   ENSRNOP00000110215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,807,220 - 26,858,446 (-)Ensembl
RefSeq Acc Id: NM_001108702   ⟹   NP_001102172
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,446 (-)NCBI
mRatBN7.2621,055,349 - 21,106,579 (-)NCBI
Rnor_6.0622,230,928 - 22,281,886 (-)NCBI
Rnor_5.0632,118,321 - 32,168,698 (-)NCBI
RGSC_v3.4620,990,083 - 21,048,692 (-)RGD
Celera620,614,184 - 20,664,224 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001414954   ⟹   NP_001401883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,446 (-)NCBI
mRatBN7.2621,055,349 - 21,106,579 (-)NCBI
RefSeq Acc Id: XM_008764486   ⟹   XP_008762708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,456 (-)NCBI
mRatBN7.2621,055,349 - 21,106,585 (-)NCBI
Rnor_6.0622,230,067 - 22,282,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764488   ⟹   XP_008762710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,416 (-)NCBI
mRatBN7.2621,055,349 - 21,106,586 (-)NCBI
Rnor_6.0622,230,067 - 22,282,166 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001102172   ⟸   NM_001108702
- Peptide Label: isoform 2
- UniProtKB: B2RYN7 (UniProtKB/Swiss-Prot),   A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762710   ⟸   XM_008764488
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3R4 (UniProtKB/TrEMBL),   A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762708   ⟸   XM_008764486
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073338   ⟸   ENSRNOT00000079137
Ensembl Acc Id: ENSRNOP00000033763   ⟸   ENSRNOT00000039375
Ensembl Acc Id: ENSRNOP00000085299   ⟸   ENSRNOT00000105595
RefSeq Acc Id: NP_001401883   ⟸   NM_001414954
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K590 (UniProtKB/TrEMBL),   A0A8L2QK18 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099795   ⟸   ENSRNOT00000159739
Ensembl Acc Id: ENSRNOP00000110215   ⟸   ENSRNOT00000173450
Protein Domains
AAA+ ATPase   MIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYN7-F1-model_v2 AlphaFold B2RYN7 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694422
Promoter ID:EPDNEW_R4938
Type:initiation region
Name:Spast_1
Description:spastin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0622,281,725 - 22,281,785EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308494 AgrOrtholog
BioCyc Gene G2FUF-38441 BioCyc
Ensembl Genes ENSRNOG00000027136 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079137 ENTREZGENE
  ENSRNOT00000105595 ENTREZGENE
  ENSRNOT00000159739 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Phosphotransferase system, lactose/cellobiose-type IIA subunit UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9030077 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  MIT UniProtKB/Swiss-Prot
  MT-severing_AAA_ATPase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Spastin UniProtKB/Swiss-Prot
  Spastin_chordate UniProtKB/Swiss-Prot
  Vps4_C UniProtKB/Swiss-Prot
KEGG Report rno:362700 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188738 IMAGE-MGC_LOAD
NCBI Gene 362700 ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  SPASTIN UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Vps4_C UniProtKB/Swiss-Prot
PhenoGen Spast PhenoGen
PIRSF Spastin UniProtKB/Swiss-Prot
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027136 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
  MIT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K590 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QK18 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KYD6_RAT UniProtKB/TrEMBL
  A0ABK0LXP1_RAT UniProtKB/TrEMBL
  B2RYN7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Spast  spastin   Spast_predicted  spastin (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Spast_predicted  spastin (predicted)  Spg4_predicted  spastic paraplegia 4 (autosomal dominant; spastin) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Spg4_predicted  spastic paraplegia 4 (autosomal dominant; spastin) (predicted)      Symbol and Name status set to approved 70820 APPROVED