SPAST (spastin) - Rat Genome Database

Name: SPAST
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: SPAST (spastin) Sus scrofa

Analyze

Symbol:

SPAST

Name:

spastin

RGD ID:

14177342

Description:

ENCODES a protein that exhibits alpha-tubulin binding (ortholog); beta-tubulin binding (ortholog); microtubule binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); axonal transport of mitochondrion (ortholog); cytokinetic process (ortholog); ASSOCIATED WITH Autoinflammation with Infantile Enterocolitis (ortholog); cerebral palsy (ortholog); epilepsy (ortholog); FOUND IN axon (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum tubular network (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

SPG4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPAST (spastin)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Spast (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Spast (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spast (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPAST (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPAST (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spast (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPAST (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spast (spastin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	107,439,813 - 107,508,926 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	107,439,810 - 107,508,915 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	114,454,182 - 114,524,375 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	3	q21-q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autoinflammation with Infantile Enterocolitis (ISO)

cerebral palsy (ISO)

epilepsy (ISO)

familial cold autoinflammatory syndrome 4 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 10 (ISO)

hereditary spastic paraplegia 2 (ISO)

hereditary spastic paraplegia 4 (ISO)

Muscle Spasticity (ISO)

Neurodevelopmental Disorders (ISO)

paraplegia (ISO)

spastic ataxia (ISO)

Spastic Paraparesis (ISO)

Tics (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde axonal transport (IEA,ISS)

axonal transport of mitochondrion (IEA,ISS)

axonogenesis (IEA)

cell differentiation (IEA)

cell division (IEA)

cytokinetic process (IEA,ISS)

endoplasmic reticulum to Golgi vesicle-mediated transport (IEA,ISS)

exit from mitosis (IEA,ISS)

membrane fission (IEA,ISS)

microtubule bundle formation (IEA,ISS)

microtubule cytoskeleton organization (IEA)

microtubule severing (IEA,ISO,ISS)

mitotic cytokinesis (IEA,ISS)

mitotic spindle disassembly (IEA,ISS)

nervous system development (IEA)

nuclear membrane reassembly (IEA,ISS)

positive regulation of cytokinesis (IEA)

positive regulation of microtubule depolymerization (IEA)

protein hexamerization (IEA,ISS)

protein homooligomerization (IEA,ISS)

Cellular Component

axon (IEA,ISS)

axon cytoplasm (IEA)

cell projection (IEA)

centrosome (IEA)

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

cytoskeleton (IEA)

cytosol (IEA)

endoplasmic reticulum (IEA,ISS)

endoplasmic reticulum tubular network (ISO)

endosome (IEA,ISS)

membrane (IEA)

microtubule (IEA)

microtubule cytoskeleton (IBA,IEA,ISS)

midbody (IEA,ISS)

nuclear membrane (IEA,ISS)

nucleoplasm (IEA)

nucleus (IEA,ISS)

perinuclear region of cytoplasm (IEA)

spindle (IEA)

spindle pole (IEA,ISS)

Molecular Function

alpha-tubulin binding (IEA,ISS)

ATP binding (IEA)

ATP hydrolysis activity (IBA,IEA)

beta-tubulin binding (IEA,ISS)

isomerase activity (IEA)

microtubule binding (IEA,ISS)

microtubule severing ATPase activity (IEA,ISS)

protein binding (ISO)

References

Additional References at PubMed

PMID:17868079	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SPAST
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	107,439,813 - 107,508,926 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	107,439,810 - 107,508,915 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	114,454,182 - 114,524,375 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	3	q21-q27	NCBI

SPAST
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	32,063,556 - 32,157,637 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	32,063,556 - 32,157,637 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	32,288,625 - 32,382,706 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	32,142,184 - 32,236,210 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	32,200,330 - 32,294,356	NCBI
Celera	2	32,133,566 - 32,227,549 (+)	NCBI		Celera
Cytogenetic Map	2	p22.3	NCBI
HuRef	2	32,027,230 - 32,121,818 (+)	NCBI		HuRef
CHM1_1	2	32,218,851 - 32,312,626 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	32,111,981 - 32,206,198 (+)	NCBI		T2T-CHM13v2.0

Spast
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	74,643,805 - 74,698,110 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	74,645,982 - 74,698,110 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	74,337,923 - 74,391,115 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	74,338,987 - 74,391,115 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	74,738,327 - 74,790,453 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	74,243,969 - 74,293,468 (+)	NCBI		MGSCv36	mm8
Celera	17	78,633,795 - 78,686,156 (+)	NCBI		Celera
Cytogenetic Map	17	E2	NCBI
cM Map	17	45.64	NCBI

Spast
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	26,807,220 - 26,858,456 (-)	NCBI		GRCr8
mRatBN7.2	6	21,055,349 - 21,106,586 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	21,055,349 - 21,107,954 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	21,386,251 - 21,436,870 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	21,702,093 - 21,752,711 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	21,182,545 - 21,233,162 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	22,230,067 - 22,282,166 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	22,230,928 - 22,281,886 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	32,118,321 - 32,168,698 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	20,990,083 - 21,048,692 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	20,995,867 - 21,051,815 (-)	NCBI
Celera	6	20,614,184 - 20,664,224 (-)	NCBI		Celera
Cytogenetic Map	6	q13	NCBI

Spast
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	485,815 - 520,452 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	471,609 - 521,920 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPAST
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	94,335,723 - 94,425,719 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	94,339,698 - 94,429,694 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	32,085,245 - 32,175,137 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	32,150,514 - 32,888,168 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	32,150,792 - 32,885,029 (+)	Ensembl	panpan1.1		panPan2

SPAST
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	25,393,169 - 25,447,686 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	25,393,422 - 25,446,539 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	25,185,513 - 25,240,078 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	25,955,733 - 26,010,638 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	25,955,693 - 26,011,753 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	25,255,491 - 25,310,582 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	25,327,446 - 25,381,966 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	25,426,764 - 25,481,606 (+)	NCBI		UU_Cfam_GSD_1.0

Spast
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	69,496,954 - 69,555,811 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	1,283,729 - 1,343,390 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	1,283,754 - 1,342,592 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPAST
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	75,343,437 - 75,429,196 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	75,343,327 - 75,429,139 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	36,643,431 - 36,733,159 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spast
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624738	13,721,136 - 13,780,530 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SPAST
1683 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	9	2	3	5	2	23		3	3
Low	1	2					2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_213749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021085819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF540879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY184291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU469148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01016972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000009321 ⟹ ENSSSCP00000009083

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	107,442,593 - 107,508,619 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000071605 ⟹ ENSSSCP00000068761

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	107,440,857 - 107,508,774 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000077952 ⟹ ENSSSCP00000065102

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	107,439,813 - 107,508,926 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000084054 ⟹ ENSSSCP00000064530

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	107,439,813 - 107,508,926 (-)	Ensembl

RefSeq Acc Id:

NM_213749 ⟹ NP_998914

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	107,442,206 - 107,508,612 (-)	NCBI

Sequence:

show sequence

CTCCGGGTGGACGAGGGAAGAAGAAAGGCTCCGGCGGCCCCAGCAGCCCGGTGCCTCCCAGGCC
TCCGCCCCCCTGCCTGGCCTCCTCCCGCCCCGCCCCCAGGCCAGCCCCTCCGCCCCAATCGCCG
CATAAGCGGAACCTGTACTACTTCTCCTACCCGCTGTTCTTAGGCTTCGCGCTGCTGCGTTTGG
TCGCTTTCCACTTGGGGCTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGC
CGCCAAGAGGAGCTCCCGGGCTGCGCCGGCCCCGGCCTCGGCCTCGCCCCCGGCGCCGGTGCCA
GGCGGGGAGGTCGAACGAGTACGAGCCTTCCACAAACAGGCCTTCGAGTACATCTCCGTTGCCC
TGCGCATCGACGAGGACGAGAAAGTAGGACAAAAGGAGCAAGCTGTGGAATGGTATAAGAAAGG
TATTGAAGAACTAGAAAAAGGAATTGCCGTTGTAGTTACAGGACAAGGTGAACAGTGTGAAAGA
GCCAGACGCCTTCAAGCTAAAATGATGACTAATTTGGTTATGGCAAAGGACCGTTTACAGCTAT
TAGAGAAGCTGCAACCAGTTTTGCAATTTTCCAAGTCACAGATGGACGTCTATAATGATAGTAC
TAACTTGACATGCCGCAACGGACATCTCCAGTCAGAAAGTGGAGCTGTTCCTAAAAGAAAAGAC
CCCTTAACACACCCTAGTAATTCACTGCCTCGTTCAAAAGCGATTATGAAAACTGGATCCACAG
GTCTTTCAGGCCACCACAGAGCACCTAGCTGCAGCGGTTTATCCATTGTTTCTGGAATGAGACA
GGGGCCTGGTCCTACAACTGCCACTCATAAGAGTACACCAAAAACAAATAGAACAAATAAACCT
TCCACTCCTACAACTGCTCCCCGTAAAAAGAAAGACTTGAAGAATTTTAGGAATGTGGACAGCA
ACCTTGCTAACTTTATAATGAACGAAATTGTGGACAATGGAACAGCTGTTAAATTTGATGATAT
AGCTGGTCAAGAATTGGCAAAACAAGCATTGCAAGAAATTGTCATTCTTCCTTCTCTGAGGCCT
GAGTTGTTCACAGGTCTTAGAGCTCCTGCCAGAGGATTGTTACTCTTTGGTCCACCTGGAAATG
GGAAAACAATGCTGGCTAAAGCAGTAGCTGCAGAATCTAATGCAACCTTCTTTAATATAAGTGC
TGCAAGTCTAACTTCAAAATATGTAGGAGAAGGAGAAAAATTGGTGAGAGCTCTTTTTGCTGTG
GCTCGAGAACTTCAGCCTTCTATAATTTTTATAGATGAAGTTGATAGCCTTTTGCGTGAAAGAA
GAGAAGGAGAACATGATGCCAGTAGACGTCTAAAAACTGAATTTTTAATAGAATTTGATGGTGT
ACAATCTGCTGGAGATGACAGAGTGCTTGTAATGGGTGCAACTAACAGGCCACAAGAGCTTGAT
GAGGCTGTTCTCAGGCGTTTCATCAAACGGGTATATGTGTCTTTGCCAAATGAGGAGACACGAC
TACTTTTATTAAAAAATCTATTATGTAAACAAGGAAGCCCACTGACCCAAAAGGAACTGGCACA
ACTTGCTAGATTGACCGACGGATACTCAGGAAGTGATCTAACAGCTTTGGCAAAAGATGCAGCC
CTGGGTCCTATCCGAGAACTGAAACCAGAACAAGTGAAGAATATGTCTGCCAGTGAGATGAGAA
ATATTCGATTATCTGACTTCACTGAATCCTTAAAAAAGATAAAACGCAGCGTGAGCCCTCAGAC
CTTAGAAGCATACATACGTTGGAACAAGGACTTTGGAGACACCACTGTTTAAGCCTGCAGAATG
TCGTACTTTCCAAGAGAGAAACTCACCATCTTCAATGAATAGTTAGCAGCTACAGAAACTCAAC
CCAAGTTTACAGGACTTTTCAGAGTCCTAAAATTATTTGTGCACCCCAGAAGATGAACCATAAA
ATAAATAAAGTATACAGTACAAATGGAATATTTTGTTTAAGGCCTTCTTGCCTTGATGGTTATT
GTTACCCCAATGGGCACTGTAAGAGCACAACTAAAACTGATTCTGGTCTTTACCAATATAATCA
TAATGTAAATAATACTTTGTACGTTATGTTGCAGATGAAAGTATTCCAGAGACAGCAAAGAGTA
GAAGACATTAGAGCCTTTGGTGGTTTGTCTTCTGACATCTTTTCTTAAAAGAGTA

hide sequence

RefSeq Acc Id:

XM_021085819 ⟹ XP_020941478

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	107,439,810 - 107,508,915 (-)	NCBI

Sequence:

show sequence

GGAGGGCGTGCGCGTGCACGCGCGGCCGCCGCTCGGAGTTACCAAGCCGCAGAGAGGACGGAGA
AAGGGAGGGGCAGGAGCTACCGACCAAAGGAGGAGGAGAAGGGGTTGTGCTCCTGACCTAGCGA
GGAGAAAGGGGCGGGGCCGTCCAGCTGCGCGCGGAGGTGCAGAGCTCCTGGGACCGGCGGGCGC
GCGGGGGTCTGTGGCCCTTGCCCTCCCAGTAGCCGCCGCCGTCGCTTGACCGCCGTCGGTCTGC
GGAAGGCGGGTTATGGCGGCGGCGGCAGTGGGAGCTGTGAATGAATTCTCCGGGTGGACGAGGG
AAGAAGAAAGGCTCCGGCGGCCCCAGCAGCCCGGTGCCTCCCAGGCCTCCGCCCCCCTGCCTGG
CCTCCTCCCGCCCCGCCCCCAGGCCAGCCCCTCCGCCCCAATCGCCGCATAAGCGGAACCTGTA
CTACTTCTCCTACCCGCTGTTCTTAGGCTTCGCGCTGCTGCGTTTGGTCGCTTTCCACTTGGGG
CTCCTCTTCGTGTGGCTCTGCCAGCGCTTCTCCCGCGCCCTCATGGCCGCCAAGAGGAGCTCCC
GGGCTGCGCCGGCCCCGGCCTCGGCCTCGCCCCCGGCGCCGGTGCCAGGCGGGGAGGTCGAACG
AGTACGAGCCTTCCACAAACAGGCCTTCGAGTACATCTCCGTTGCCCTGCGCATCGACGAGGAC
GAGAAAGTAGGACAAAAGGAGCAAGCTGTGGAATGGTATAAGAAAGGTATTGAAGAACTAGAAA
AAGGAATTGCCGTTGTAGTTACAGGACAAGGTGAACAGTGTGAAAGAGCCAGACGCCTTCAAGC
TAAAATGATGACTAATTTGGTTATGGCAAAGGACCGTTTACAGCTATTAGAGAAGCTGCAACCA
GTTTTGCAATTTTCCAAGTCACAGATGGACGTCTATAATGATAGTACTAACTTGACATGCCGCA
ACGGACATCTCCAGTCAGAAAGTGGAGCTGTTCCTAAAAGAAAAGACCCCTTAACACACCCTAG
TAATTCACTGCCTCGTTCAAAAGCGATTATGAAAACTGGATCCACAGGTCTTTCAGGCCACCAC
AGAGCACCTAGCTGCAGCGGTTTATCCATTGTTTCTGGAATGAGACAGGGGCCTGGTCCTACAA
CTGCCACTCATAAGAGTACACCAAAAACAAATAGAACAAATAAACCTTCCACTCCTACAACTGC
TCCCCGTAAAAAGAAAGACTTGAAGAATTTTAGGAATGTGGACAGCAACCTTGCTAACTTTATA
ATGAACGAAATTGTGGACAATGGAACAGCTGTTAAATTTGATGATATAGCTGGTCAAGAATTGG
CAAAACAAGCATTGCAAGAAATTGTCATTCTTCCTTCTCTGAGGCCTGAGTTTGTCATTCTTTA
CTACTGTCATTGCATTTATAGCTCGCTTAGAGCTCCTGCCAGAGGATTGTTACTCTTTGGTCCA
CCTGGAAATGGGAAAACAATGCTGGCTAAAGCAGTAGCTGCAGAATCTAATGCAACCTTCTTTA
ATATAAGTGCTGCAAGTCTAACTTCAAAATATGTAGGAGAAGGAGAAAAATTGGTGAGAGCTCT
TTTTGCTGTGGCTCGAGAACTTCAGCCTTCTATAATTTTTATAGATGAAGTTGATAGCCTTTTG
CGTGAAAGAAGAGAAGGAGAACATGATGCCAGTAGACGTCTAAAAACTGAATTTTTAATAGAAT
TTGATGGTGTACAATCTGCTGGAGATGACAGAGTGCTTGTAATGGGTGCAACTAACAGGCCACA
AGAGCTTGATGAGGCTGTTCTCAGGCGTTTCATCAAACGGGTATATGTGTCTTTGCCAAATGAG
GAGACACGACTACTTTTATTAAAAAATCTATTATGTAAACAAGGAAGCCCACTGACCCAAAAGG
AACTGGCACAACTTGCTAGATTGACCGACGGATACTCAGGAAGTGATCTAACAGCTTTGGCAAA
AGATGCAGCCCTGGGTCCTATCCGAGAACTGAAACCAGAACAAGTGAAGAATATGTCTGCCAGT
GAGATGAGAAATATTCGATTATCTGACTTCACTGAATCCTTAAAAAAGATAAAACGCAGCGTGA
GCCCTCAGACCTTAGAAGCATACATACGTTGGAACAAGGACTTTGGAGACACCACTGTTTAAGC
CTGCAGAATGTCGTACTTTCCAAGAGAGAAACTCACCATCTTCAATGAATAGTTAGCAGCTACA
GAAACTCAACCCAAGTTTACAGGACTTTTCAGAGTCCTAAAATTATTTGTGCACCCCAGAAGAT
GAACCATAAAATAAATAAAGTATACAGTACAAATGGAATATTTTGTTTAAGGCCTTCTTGCCTT
GATGGTTATTGTTACCCCAATGGGCACTGTAAGAGCACAACTAAAACTGATTCTGGTCTTTACC
AATATAATCATAATGTAAATAATACTTTGTACGTTATGTTGCAGATGAAAGTATTCCAGAGACA
GCAAAGAGTAGAAGACATTAGAGCCTTTGGTGGTTTGTCTTCTGACATCTTTTCTTAAAAGAGT
AATTTTTCCTATTTTCCTTTCTTGCTGTTGTCATTACTATGGGTTATCGAAATGCCAAACACTT
TCTTTTTTTTTTCTTTCGTTTTACAAATTGTGTGCCAAATGAAACTTTTTCCTGTGTAACAGTA
GTAGGAAAAAGTATTTTGAAGGTTTTTTTCTTCTTCATAAATCTACAGAGATTAAATAATGTGT
TTTTTTCACTTTTTATTTTTCTATTAACTTTCTACCAAACAATTTAGAAAGCAATATATCACAA
AAGAAATCTAGTGAAATGGAGAAGTTTTGAGATTTCGAGACACTCTGTCATACAACATGTAGAT
CAATCCTCCTGTGACCTGCAGTATTTTTTTTCTAATATATTTGTCAAAAATCTATTGTCGACTG
TTAACTTATTCCTAATGGAATTTATTTTCTGCTAGAATTAGTCTAATACTTAAGAAGGCCAATT
TTAACTGCTTTAAAGGTGGTTCCTTTGCAAGAGAAGGGAAGTACCAGGAGCTAAGACATTTCTA
ATTTATTGCTTATTACTTTCTTACTGTTTACAGGATAATTACAAACCAGTGGATCTACCGTCTT
TTATTCTTAATAATTATTAATCCCACTAATGAAACTTTAAAAAATTACTGACTTTTTATATATT
GCGTACATTTTATAGGCTTCTTGTGCTCACTTTGTTAACTAAAAAGGTTTAGTCTGTTAATCTC
CCTTTTGTTCCCCAAAAATGTACAGTAATTCCATTTCTTGTTTGTATGCCTGGGTTTTTATTAT
AAAAATGTCATTGTAGGAAGTAGAGACTCATATCATGGCCTTTTAAATATTGTAATAAAGGCAA
ATGGATATTTGCCCTTAGTTTACTGGTTAAAAGTTTGTTTACAGAAATTTTCTTTGGTGCTTTT
ATGTGAAATGTCATGGGTGGAAAGAATAATTTTATAAGTAGTAAGAAATATTTTTCATTTAGGA
AAAGTATCTTTGGTTTTGAGAGAATATATTTAAGTTAAAAACTTGCCCCACTAGATAAGAATTT
TATAATGAAGACACATTCTTCTTAATTTTACTTTCTCATCTTAAAGATTTATCTCAACACAGAT
GTATGATCTCTTACGGTCATATGCTATTTGTAGCCATAACTTAATCATGTCTCTTCTAATCCTA
GAACTCCTTGAATAATAAAAGTGAAGGTTGAGATAAATAGAAGAAAAAATTTAAGCCAGAGCCA
TGTGTATTTTAGATCATGAGGAATACTTTTTGAGGTCTCAAACATTAAAGCATCAATTATAAAA
TATTGATGATTAAAGATGAAATATGATGAAAAAGATTAGGAACATCCCAAATTAAAACATTTTC
AATAAAACTCATAATGTTTCATTTTTTATTTTCATTTAGAAAAGAATTAACTTTACTGAAGCTT
GGATAACTGGTCAATTGTATTAAAAGTCTGTGTGCTTCAAGCTCAACTCTAAAAATAGAAACTT
CCAAATTATTGAAATGTAATCTGTAACAATTGAATGTAGCTCACTTTTATGGGGAAATATTTTA
GGTAACAAAGATTTCAAAAGATATAAAAGTCAAAATTAATATTGTCATAAACATTGAGAATTTT
ATTACTCTGAGTATCCATCCATGTATAGAAGTTACTTTAATTTCCTGGTCAAGTCTGAAGTTGA
GCTTAGTGCTAGAGGACTAGTTTCTATGACTGACTATGACAGACTTTTATTTTAAACTGTGTTT
CTTTCATAGAAGGGCCATAAAAATAGAATAATTATATAGTAGGAGGTTTAAGGGTTGGTTTGGT
CTTGTTCGATAAAGATAGAGGTTGCTGAGGTTTTCTGAATTAATATTAGACTTAGACTGTGACC
TTGTAGATTTTGCACTGAGCTCTGTGTCATATTCTTTCGTAAAAGGTAATGTTTAAACATTAAA
CGTTAGTGTGCTCTTCATGTTAATATGGCAGAGTTTTGTAAACTAAATTAAAGCTTATTGATGC
ACTGGACTTTGAGCCAACAGAAAAAATCAACACCGTCTTTTCAGATATCTTGAGGGTAAAAGGT
TATTCCAAGACAGTCTGCCAATGAAGTTATTAGGTTTCGGGCATGCAGGTATGCTTTGTGCTTG
AGAATTGCAGGAAAAGCAGATACTAGAATTCTAATTTAAGTAAATATACAGCAGTCTTTGTTTA
TAGTGTAAAATTCATTATATTTTGTACAAAAACTAATTCTTTGGTAGAATGAACCATTTACAGT
TTGTTTTTTGGACTCTGAGTCAAAGGATTTCCCTTTAAATGCTTGTCTCAATTTTACTCTGGTC
TTTTGTACTTTTCTTCGGAAGAAATGAATTAAAAGGTTCAGCTGCATAAGTGGGTTTTTATCCT
AATGGACTGGAAATAAATTATAAACTTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_998914	(Get FASTA)	NCBI Sequence Viewer
	XP_020941478	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO60067	(Get FASTA)	NCBI Sequence Viewer
	AAQ11216	(Get FASTA)	NCBI Sequence Viewer
	AAQ11224	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000009083.4
	ENSSSCP00000064530.2
	ENSSSCP00000065102
	ENSSSCP00000065102.1
	ENSSSCP00000068761.1
	ENSSSCP00005041907.1
	ENSSSCP00015030143.1
	ENSSSCP00015030222.1
	ENSSSCP00015030272.1
	ENSSSCP00015030377.1
	ENSSSCP00025024060.1
	ENSSSCP00025024141.1
	ENSSSCP00030020409.1
	ENSSSCP00030020461.1
	ENSSSCP00030020483.1
	ENSSSCP00030020527.1
	ENSSSCP00035027620.1
	ENSSSCP00040004041.1
	ENSSSCP00040004055.1
	ENSSSCP00040004060.1
	ENSSSCP00040004072.1
	ENSSSCP00045018309.1
	ENSSSCP00045018406.1
	ENSSSCP00045018469.1
	ENSSSCP00045018550.1
	ENSSSCP00050028220.1
	ENSSSCP00050028226.1
	ENSSSCP00050028228.1
	ENSSSCP00050028233.1
	ENSSSCP00055018661.1
	ENSSSCP00055018754.1
	ENSSSCP00055018826.1
	ENSSSCP00060028018.1
	ENSSSCP00060028021.1
	ENSSSCP00060028026.1
	ENSSSCP00060028032.1
	ENSSSCP00065004059.1
	ENSSSCP00065004061.1
	ENSSSCP00070012635.1
	ENSSSCP00070012675.1
GenBank Protein	Q719N1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_020941478 ⟸ XM_021085819
- Peptide Label:	isoform X1
- UniProtKB:	A0A5G2QUW8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNSPGGRGKKKGSGGPSSPVPPRPPPPCLASSRPAPRPAPPPQSPHKRNLYYFSYPLFLGFALL RLVAFHLGLLFVWLCQRFSRALMAAKRSSRAAPAPASASPPAPVPGGEVERVRAFHKQAFEYIS VALRIDEDEKVGQKEQAVEWYKKGIEELEKGIAVVVTGQGEQCERARRLQAKMMTNLVMAKDRL QLLEKLQPVLQFSKSQMDVYNDSTNLTCRNGHLQSESGAVPKRKDPLTHPSNSLPRSKAIMKTG STGLSGHHRAPSCSGLSIVSGMRQGPGPTTATHKSTPKTNRTNKPSTPTTAPRKKKDLKNFRNV DSNLANFIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPEFVILYYCHCIYSSLRAPA RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIF IDEVDSLLRERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKR VYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARLTDGYSGSDLTALAKDAALGPIRELKPE QVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV hide sequence

RefSeq Acc Id:

NP_998914 ⟸ NM_213749

- UniProtKB:

A0A8D1HKC9 (UniProtKB/TrEMBL), A0A8D1A3N9 (UniProtKB/TrEMBL), A0A8D0LXS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAKRSSRAAPAPASASPPAPVPGGEVERVRAFHKQAFEYISVALRIDEDEKVGQKEQAVEWYK
KGIEELEKGIAVVVTGQGEQCERARRLQAKMMTNLVMAKDRLQLLEKLQPVLQFSKSQMDVYND
STNLTCRNGHLQSESGAVPKRKDPLTHPSNSLPRSKAIMKTGSTGLSGHHRAPSCSGLSIVSGM
RQGPGPTTATHKSTPKTNRTNKPSTPTTAPRKKKDLKNFRNVDSNLANFIMNEIVDNGTAVKFD
DIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNI
SAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLRERREGEHDASRRLKTEFLIEFD
GVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKEL
AQLARLTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSP
QTLEAYIRWNKDFGDTTV

hide sequence

RefSeq Acc Id:

ENSSSCP00000064530 ⟸ ENSSSCT00000084054

RefSeq Acc Id:

ENSSSCP00000009083 ⟸ ENSSSCT00000009321

RefSeq Acc Id:

ENSSSCP00000068761 ⟸ ENSSSCT00000071605

RefSeq Acc Id:

ENSSSCP00000065102 ⟸ ENSSSCT00000077952

Protein Domains

AAA+ ATPase MIT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000008517	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005041921	UniProtKB/TrEMBL
	ENSSSCG00015056092	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00025041768	UniProtKB/TrEMBL
	ENSSSCG00030032740	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00035051190	UniProtKB/TrEMBL
	ENSSSCG00040007869	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00045015548	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00050048078	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00055011862	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00060048175	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00065007284	UniProtKB/TrEMBL
	ENSSSCG00070007858	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000009321.4	UniProtKB/TrEMBL
	ENSSSCT00000071605.1	UniProtKB/TrEMBL
	ENSSSCT00000077952	ENTREZGENE
	ENSSSCT00000077952.2	UniProtKB/TrEMBL
	ENSSSCT00000084054.2	UniProtKB/TrEMBL
	ENSSSCT00005067474.1	UniProtKB/TrEMBL
	ENSSSCT00015075155.1	UniProtKB/TrEMBL
	ENSSSCT00015075354.1	UniProtKB/TrEMBL
	ENSSSCT00015075466.1	UniProtKB/Swiss-Prot
	ENSSSCT00015075681.1	UniProtKB/TrEMBL
	ENSSSCT00025056892.1	UniProtKB/TrEMBL
	ENSSSCT00025057102.1	UniProtKB/TrEMBL
	ENSSSCT00030045379.1	UniProtKB/TrEMBL
	ENSSSCT00030045474.1	UniProtKB/TrEMBL
	ENSSSCT00030045517.1	UniProtKB/Swiss-Prot
	ENSSSCT00030045609.1	UniProtKB/TrEMBL
	ENSSSCT00035068187.1	UniProtKB/TrEMBL
	ENSSSCT00040010397.1	UniProtKB/TrEMBL
	ENSSSCT00040010425.1	UniProtKB/TrEMBL
	ENSSSCT00040010438.1	UniProtKB/Swiss-Prot
	ENSSSCT00040010460.1	UniProtKB/TrEMBL
	ENSSSCT00045026529.1	UniProtKB/Swiss-Prot
	ENSSSCT00045026664.1	UniProtKB/TrEMBL
	ENSSSCT00045026754.1	UniProtKB/TrEMBL
	ENSSSCT00045026857.1	UniProtKB/TrEMBL
	ENSSSCT00050065525.1	UniProtKB/TrEMBL
	ENSSSCT00050065536.1	UniProtKB/TrEMBL
	ENSSSCT00050065540.1	UniProtKB/Swiss-Prot
	ENSSSCT00050065548.1	UniProtKB/TrEMBL
	ENSSSCT00055023599.1	UniProtKB/Swiss-Prot
	ENSSSCT00055023713.1	UniProtKB/TrEMBL
	ENSSSCT00055023802.1	UniProtKB/TrEMBL
	ENSSSCT00060065443.1	UniProtKB/TrEMBL
	ENSSSCT00060065453.1	UniProtKB/TrEMBL
	ENSSSCT00060065463.1	UniProtKB/Swiss-Prot
	ENSSSCT00060065477.1	UniProtKB/TrEMBL
	ENSSSCT00065009763.1	UniProtKB/TrEMBL
	ENSSSCT00065009775.1	UniProtKB/TrEMBL
	ENSSSCT00070015288.1	UniProtKB/TrEMBL
	ENSSSCT00070015345.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Phosphotransferase system, lactose/cellobiose-type IIA subunit	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MIT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Spastin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Spastin_chordate	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Vps4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:396584	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	SPAST	ENTREZGENE
PANTHER	AAA DOMAIN-CONTAINING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPASTIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Vps4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF	Spastin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MIT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1P0REP6_PIG	UniProtKB/TrEMBL
	A0A480RPZ2_PIG	UniProtKB/TrEMBL
	A0A4X1TB59_PIG	UniProtKB/TrEMBL
	A0A4X1TB88_PIG	UniProtKB/TrEMBL
	A0A5G2QIA6_PIG	UniProtKB/TrEMBL
	A0A5G2QSY7_PIG	UniProtKB/TrEMBL
	A0A5G2QUW8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0LXS3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0RYX3_PIG	UniProtKB/TrEMBL
	A0A8D0S0J2_PIG	UniProtKB/TrEMBL
	A0A8D1A3N9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1DAL1_PIG	UniProtKB/TrEMBL
	A0A8D1HKC9	ENTREZGENE, UniProtKB/TrEMBL
	Q719N1	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1S3Z2	UniProtKB/Swiss-Prot
VGNC ID	VGNC:98333	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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