Atp8b1 (ATPase phospholipid transporting 8B1) - Rat Genome Database

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Gene: Atp8b1 (ATPase phospholipid transporting 8B1) Rattus norvegicus
Analyze
Symbol: Atp8b1
Name: ATPase phospholipid transporting 8B1
RGD ID: 1308488
Description: Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; nervous system development; and phospholipid transport. Predicted to act upstream of or within bile acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, Class I, type 8B, member 1; LOC291555; P4-ATPase flippase complex alpha subunit ATP8B1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,286,605 - 60,427,862 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1860,288,464 - 60,427,027 (-)EnsemblGRCr8
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)Ensemblrn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1856,155,326 - 56,236,232 (-)NCBICelera
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
atazanavir sulfate  (ISO)
ATP  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gadodiamide hydrate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
heptachlor  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium azide  (EXP)
tartrazine  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Bull LN, etal., Nat Genet. 1998 Mar;18(3):219-24.
2. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
3. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. Eppens EF, etal., J Hepatol. 2001 Oct;35(4):436-43.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Recurrent familial intrahepatic cholestasis in the Faeroe Islands. Phenotypic heterogeneity but genetic homogeneity. Tygstrup N, etal., Hepatology. 1999 Feb;29(2):506-8. doi: 10.1002/hep.510290214.
12. Familial intrahepatic cholestasis 1: studies of localization and function. Ujhazy P, etal., Hepatology. 2001 Oct;34(4 Pt 1):768-75.
Additional References at PubMed
PMID:14976163   PMID:16628629   PMID:19478059   PMID:19731236   PMID:20510206   PMID:20512993   PMID:20852622   PMID:20947505   PMID:21914794   PMID:24643366   PMID:26240149  


Genomics

Comparative Map Data
Atp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,286,605 - 60,427,862 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1860,288,464 - 60,427,027 (-)EnsemblGRCr8
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)Ensemblrn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1856,155,326 - 56,236,232 (-)NCBICelera
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Cytogenetic Map18q12.1NCBI
ATP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381857,646,426 - 57,803,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1857,646,426 - 57,803,560 (-)Ensemblhg38GRCh38
GRCh371855,313,658 - 55,470,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,464,656 - 53,550,037 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341853,466,585 - 53,550,037NCBI
Celera1852,031,466 - 52,187,934 (-)NCBICelera
Cytogenetic Map18q21.31ENTREZGENE
HuRef1852,024,999 - 52,180,652 (-)NCBIHuRef
CHM1_11855,309,031 - 55,466,164 (-)NCBICHM1_1
T2T-CHM13v2.01857,847,030 - 58,003,571 (-)NCBIT2T-CHM13v2.0
Atp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391864,662,050 - 64,794,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1864,662,038 - 64,794,338 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381864,528,979 - 64,661,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,528,967 - 64,661,267 (-)Ensemblmm10GRCm38
MGSCv371864,688,633 - 64,820,654 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361864,654,348 - 64,786,369 (-)NCBIMGSCv36mm8
Celera1865,795,381 - 65,929,579 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.49NCBI
Atp8b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540241,996,001 - 42,113,895 (-)Ensembl
ChiLan1.0NW_00495540241,994,993 - 42,113,380 (-)NCBIChiLan1.0ChiLan1.0
ATP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,183,233 - 75,337,189 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11860,875,498 - 61,029,604 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,035,483 - 51,187,461 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,370,844 - 54,522,158 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,370,447 - 54,522,196 (-)EnsemblpanPan2panpan1.1
ATP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,156,664 - 18,279,131 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,156,410 - 18,277,904 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha119,140,072 - 19,262,621 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0118,037,713 - 18,160,586 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,037,170 - 18,160,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,094,570 - 18,217,205 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,992,383 - 18,114,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,261,266 - 18,383,909 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494431,413,185 - 31,471,774 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,652,185 - 6,713,034 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,652,240 - 6,712,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,936,581 - 163,061,612 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11162,936,209 - 163,063,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATP8B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,930,150 - 22,086,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,930,837 - 22,088,480 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660603,481,874 - 3,637,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp8b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,156,367 - 3,287,751 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247923,154,512 - 3,287,681 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp8b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11566,608,902 - 66,744,446 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp8b1
1218 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:51
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000038652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Chm97  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,085,512 - 58,085,730 (+)MAPPERmRatBN7.2
Rnor_6.01860,081,657 - 60,081,874NCBIRnor6.0
Rnor_5.01859,291,816 - 59,292,033UniSTSRnor5.0
RGSC_v3.41860,815,969 - 60,816,186UniSTSRGSC3.4
Celera1856,222,551 - 56,222,768UniSTS
Cytogenetic Map18q12.1UniSTS
RH140076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,018,069 - 58,018,280 (+)MAPPERmRatBN7.2
Rnor_6.01860,015,049 - 60,015,259NCBIRnor6.0
Rnor_5.01859,225,208 - 59,225,418UniSTSRnor5.0
RGSC_v3.41860,748,540 - 60,748,750UniSTSRGSC3.4
Celera1856,155,128 - 56,155,338UniSTS
RH 3.4 Map18569.2UniSTS
Cytogenetic Map18q12.1UniSTS
AU049633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,046,279 - 58,046,462 (+)MAPPERmRatBN7.2
Rnor_6.01860,042,430 - 60,042,612NCBIRnor6.0
Rnor_5.01859,252,589 - 59,252,771UniSTSRnor5.0
RGSC_v3.41860,776,742 - 60,776,924UniSTSRGSC3.4
Celera1856,183,329 - 56,183,513UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 140 91 90 59 30 59 6 294 130 11 119 81 92 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000038652   ⟹   ENSRNOP00000038207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1860,288,464 - 60,427,027 (-)Ensembl
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)Ensembl
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)Ensembl
RefSeq Acc Id: NM_001106140   ⟹   NP_001099610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,288,464 - 60,369,384 (-)NCBI
mRatBN7.21858,018,268 - 58,099,197 (-)NCBI
Rnor_6.01860,015,247 - 60,095,334 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
RGSC_v3.41860,748,738 - 60,829,650 (-)RGD
Celera1856,155,326 - 56,236,232 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254842   ⟹   XP_006254904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,286,605 - 60,427,862 (-)NCBI
mRatBN7.21858,016,382 - 58,157,213 (-)NCBI
Rnor_6.01860,013,388 - 60,152,920 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099610 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424194 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AA47 (Get FASTA)   NCBI Sequence Viewer  
  EDM14675 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099610   ⟸   NM_001106140
- Sequence:
RefSeq Acc Id: XP_006254904   ⟸   XM_006254842
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000038207   ⟸   ENSRNOT00000038652
Protein Domains
P-type ATPase C-terminal   P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA47-F1-model_v2 AlphaFold D4AA47 1-1251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308488 AgrOrtholog
BioCyc Gene G2FUF-7253 BioCyc
Ensembl Genes ENSRNOG00000024952 Ensembl, ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IV UniProtKB/Swiss-Prot
  P-type_ATPase_N UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_c UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
NCBI Gene 291555 ENTREZGENE
PANTHER PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
  PTHR24092:SF48 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
  PhoLip_ATPase_C UniProtKB/Swiss-Prot
  PhoLip_ATPase_N UniProtKB/Swiss-Prot
PhenoGen Atp8b1 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024952 RatGTEx
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt A0A8L2QJ69 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP4 ENTREZGENE, UniProtKB/TrEMBL
  AT8B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp8b1  ATPase phospholipid transporting 8B1  Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-30 Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Atp8b1  ATPase, Class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Atp8b1  ATPase, Class I, type 8B, member 1   Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED