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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308488 Species: Rattus norvegicus RGD Object: Gene Symbol: Atp8b1 Name: ATPase, aminophospholipid transporter, class I, type 8B, member 1

Acc ID: CHEBI:29865 Term: benzo[a]pyrene Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. CasRN: 50-32-8 Chemical ID: MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1318284	6480464	CTD	Benzo(a)pyrene results in decreased expression of ATP8B1 mRNA	PMID:20106945
multiple interactions	ISO	RGD:1551010	6480464	CTD	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ATP8B1 mRNA	PMID:21715664
increases expression	ISO	RGD:1551010	6480464	CTD	Benzo(a)pyrene results in increased expression of ATP8B1 mRNA	PMID:20127859
increases expression	ISO	RGD:1551010	6480464	CTD	Benzo(a)pyrene results in increased expression of ATP8B1 mRNA	PMID:20127859 PMID:22228805
decreases expression	ISO	RGD:1318284	6480464	CTD	Benzo(a)pyrene results in decreased expression of ATP8B1 mRNA	PMID:20106945 PMID:21632981