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Gene: Orc3 (origin recognition complex, subunit 3) Rattus norvegicus

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Symbol:

Orc3

Name:

origin recognition complex, subunit 3

RGD ID:

1308457

Description:

Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within glial cell proliferation and neural precursor cell proliferation. Predicted to be located in chromatin. Predicted to be part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC313138; Orc3l; origin recognition complex subunit 3; origin recognition complex, subunit 3-like; origin recognition complex, subunit 3-like (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ORC3 (origin recognition complex subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Orc3 (origin recognition complex, subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Orc3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ORC3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ORC3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Orc3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ORC3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ORC3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Orc3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Orc3 (origin recognition complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ORC3 (origin recognition complex subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Orc3 (origin recognition complex, subunit 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	orc3 (origin recognition complex, subunit 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ORC3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Orc3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	orc3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	orc3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Orc3^{Tn(sb-T2/Bart3)2.275Mcwi}

Genetic Models:

F344-Orc3^{Tn(sb-T2/Bart3)2.275Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	53,923,264 - 53,977,869 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	53,923,393 - 53,978,115 (-)	Ensembl				GRCr8
mRatBN7.2	5	49,123,758 - 49,181,552 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	49,126,955 - 49,181,633 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	51,320,134 - 51,374,803 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	52,920,367 - 52,975,034 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	52,826,274 - 52,880,639 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	50,019,159 - 50,075,533 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	50,020,815 - 50,075,454 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	54,588,113 - 54,644,440 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	51,172,243 - 51,226,644 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	47,877,684 - 47,931,950 (-)	NCBI		Celera
RGSC_v3.1	5	51,172,422 - 51,226,823 (-)	NCBI
Cytogenetic Map	5	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-nitrophenol (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

azoxystrobin (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

fenthion (ISO)

fipronil (EXP)

folic acid (ISO)

indole-3-methanol (EXP)

ivermectin (ISO)

methapyrilene (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

topotecan (EXP)

Triptolide (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA replication (IEA)

DNA replication initiation (IBA,IEA,ISO)

neural precursor cell proliferation (ISO)

regulation of DNA replication (IEA,ISO,ISS)

Cellular Component

chromatin (IEA,ISO,ISS)

chromosome (IEA)

DNA replication preinitiation complex (IBA)

nuclear origin of replication recognition complex (IBA,IEA,ISO,ISS)

nuclear pre-replicative complex (IBA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

origin recognition complex (IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA replication origin binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:17716973	PMID:19135898	PMID:20674557	PMID:20932478	PMID:21029866	PMID:21185282	PMID:23349620	PMID:31160578

Genomics

Comparative Map Data

Orc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	53,923,264 - 53,977,869 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	53,923,393 - 53,978,115 (-)	Ensembl				GRCr8
mRatBN7.2	5	49,123,758 - 49,181,552 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	49,126,955 - 49,181,633 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	51,320,134 - 51,374,803 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	52,920,367 - 52,975,034 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	52,826,274 - 52,880,639 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	50,019,159 - 50,075,533 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	50,020,815 - 50,075,454 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	54,588,113 - 54,644,440 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	51,172,243 - 51,226,644 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	47,877,684 - 47,931,950 (-)	NCBI		Celera
RGSC_v3.1	5	51,172,422 - 51,226,823 (-)	NCBI
Cytogenetic Map	5	q21	NCBI

ORC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	87,590,135 - 87,677,823 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	87,590,067 - 87,677,823 (+)	Ensembl			hg38	GRCh38
GRCh37	6	88,299,853 - 88,377,169 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	88,356,562 - 88,433,888 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	88,356,561 - 88,433,885	NCBI
Celera	6	88,718,203 - 88,795,190 (+)	NCBI		Celera
Cytogenetic Map	6	q15	NCBI
HuRef	6	85,515,390 - 85,592,365 (+)	NCBI		HuRef
CHM1_1	6	88,397,143 - 88,474,506 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	88,798,431 - 88,886,160 (+)	NCBI		T2T-CHM13v2.0

Orc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	34,566,781 - 34,614,942 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	34,570,796 - 34,614,944 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	34,566,781 - 34,614,963 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	34,570,796 - 34,614,944 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	34,514,030 - 34,562,191 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	34,758,190 - 34,803,831 (-)	NCBI		MGSCv36	mm8
Celera	4	34,296,360 - 34,344,495 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	16.81	NCBI

Orc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	14,528,043 - 14,595,616 (+)	Ensembl
ChiLan1.0	NW_004955411	14,527,987 - 14,595,216 (+)	NCBI	ChiLan1.0	ChiLan1.0

ORC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	107,671,472 - 107,757,550 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	105,565,286 - 105,651,326 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	85,466,928 - 85,552,619 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	88,741,362 - 88,816,434 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	88,741,362 - 88,829,801 (+)	Ensembl			panPan2	panpan1.1

ORC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	47,047,341 - 47,108,126 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	47,047,195 - 47,108,117 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	46,855,302 - 46,915,592 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	47,853,551 - 47,913,880 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	47,853,396 - 47,913,878 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	47,145,146 - 47,206,401 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	47,072,621 - 47,133,465 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	47,261,944 - 47,323,195 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Orc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	82,189,035 - 82,256,122 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936510	4,225,697 - 4,282,190 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936510	4,222,036 - 4,281,800 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	55,954,159 - 56,042,853 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	55,982,132 - 56,044,244 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	62,784,200 - 62,787,566 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	12,068,167 - 12,159,079 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	12,068,235 - 12,159,401 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	188,322,311 - 188,395,205 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Orc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624799	6,649,634 - 6,729,604 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624799	6,649,034 - 6,728,933 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Orc3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	108,134,662 - 108,189,595 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Orc3
377 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	77
Count of miRNA genes:	65
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000011085
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1578774	Tcas8	Tongue tumor susceptibility QTL 8	3.47		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	15707451	60707451	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	14606078	59606078	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2303577	Gluco47	Glucose level QTL 47	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	16520019	61520019	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Markers in Region

BE118179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	49,127,063 - 49,127,216 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	50,021,034 - 50,021,186	NCBI	Rnor6.0
Rnor_5.0	5	54,589,988 - 54,590,140	UniSTS	Rnor5.0
RGSC_v3.4	5	51,172,217 - 51,172,369	UniSTS	RGSC3.4
Celera	5	47,877,658 - 47,877,810	UniSTS
RH 3.4 Map	5	267.5	UniSTS
Cytogenetic Map	5	q21	UniSTS

Genetic Models

This gene Orc3 is modified in the following models/strains:

F344-Orc3^{Tn(sb-T2/Bart3)2.275Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB219142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011085 ⟹ ENSRNOP00000011085

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	53,923,393 - 53,978,115 (-)	Ensembl
mRatBN7.2 Ensembl	5	49,126,955 - 49,181,633 (-)	Ensembl
Rnor_6.0 Ensembl	5	50,021,060 - 50,075,454 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084643 ⟹ ENSRNOP00000071439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	53,923,393 - 53,971,755 (-)	Ensembl
mRatBN7.2 Ensembl	5	49,126,955 - 49,175,456 (-)	Ensembl
Rnor_6.0 Ensembl	5	50,020,815 - 50,068,706 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000170791 ⟹ ENSRNOP00000100536

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	53,923,393 - 53,977,961 (-)	Ensembl

RefSeq Acc Id:

NM_001025282 ⟹ NP_001020453

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	53,923,393 - 53,977,794 (-)	NCBI
mRatBN7.2	5	49,127,090 - 49,181,495 (-)	NCBI
Rnor_6.0	5	50,021,060 - 50,075,454 (-)	NCBI
Rnor_5.0	5	54,588,113 - 54,644,440 (-)	NCBI
RGSC_v3.4	5	51,172,243 - 51,226,644 (-)	RGD
Celera	5	47,877,684 - 47,931,950 (-)	RGD

Sequence:

show sequence

ATGGCCACCTCCTCCGTGTCCAAGGGCTGTTTTGTGTTTAAACCAGACTTCAAAAAAAGAAAGA
TCTCTGTGCCAATAGAGGACTATTTTAATAATGAGGAACTTGACTCAGAAGACAGTAAACTTCG
ATTTGAAACATATCGCTTGCTATGGCAACGGATAAAATCTGAAACAGAGCAATTACAGGAGGGA
TTAAATGAAAATCTGTTTGATAACCTAGTTGACTTTCTGCAGAAGTCCCATTCTGAATTTCAGA
AAAATTCAGGAAACTGGGGCTCTCAGATGAGACTCAGAGAAATTCCAACAGCTGCTCTTATTCT
TGGCGTGAACGTCACAGATCATGACGTGATATTCAGGAGTCTAACAGAGACCCTTCACAATAAT
GTCACACCGTATGTCGTCTCCCTGCAAGCTAAGGATTGTCCAGATGTGAAACATTTTTTACAGA
AGTTGACCTCTGAGTTGATAGACTGCTGTGTAGATAGAAATTCCAAGGAGGAGAAAAATGACAA
AGCCCTGAGGAGGACCAGTTATTCCATGGATTCGCTTTCTAGTTGGTATTCGACGGTTGCACAG
AAGACAGGCCCCAAAATGACAAGCAAAAAGAGAGCGACTTGTAGCCAATGGCAGTCCCCTCCTG
TGGTGCTTATCTTAAAGAACATGGAGAGTTTCAGCACAAAAGTACTGCAGGACTTCATAATTAT
CAGCAGTCAGCATCTGCATGAGTTTCCTCTAATTCTCATTTTTGGGATCGCCACATCTCCTGTT
ATTATCCACCGACTGCTTCCTCATTCAGTGTCATCTCTGTTGTGTATAGAACTGTTCCAGTCTC
TGTCTTGCAAGGAACACCTGACAGTAGTTCTTGATAAGCTGCTTCTTACCCCTCAGTTTCCCTT
TAAATTGAGTAAAAAGGCATTACAAGTTCTGACCAACATCTTTTTGTATCATGATTTCTCAATT
CAAAACTTCATCAAAGGACTTAAGCTTTCTCTACTAGAACATTTTTATTCTCAGCCCCTAAGTG
TTCTGTGCTGTGATCTCTCAGAAGCCAAAAAAAGAATAAATGTTTTCTCAGTCAATCAATGTGA
AAAAATCCGGCGCCTTCCTTCATTTAGGAGGTACGTGGAAAATCAACCTTTGGAAAAGCAAGTT
GCACTGTTGACCAATGAGACCTTTTTAAAGGAGGAAACGCAATCATTGTTGGAAGACCTGCATG
TTTACCATATCAATTACTTCCTTGTTTTGAGATGTCTTCATAATTTTACCTCTTCTCTTCCCAA
GTACCCACTGGGTCGACAGATTAGGGAGCTGTATTGTACATGTTTGGAAAAGAAGATATGGGAT
TCGGAGGAGTACGAATCAGCCTTGCAGTTGCTGAGAATGCTGGCAAAGGACGAACTGATGGGCA
TACTTGAGCAGTGTGTTAAGGTTTTGAATTCCTCTACTGAAAAGCAGCTTAGCAACACAGCACA
GAAAATAAAGGGCTTCCTGACCCAGTTTCAGAACCTTGATGATAGCAAAGAGGAAGAGGATGCT
TGTGGTTCACAGCCAAAGGGGCTGCAGAAGACGGACCTGTACCACCTTCAGAAGTCCTTACTGG
AAATGAAAGAGCTAAGGAGAACAACTAAGAAGCCAACCAAGTTTGAAATGCTCAGAGAAAATGT
TATAAACTTCATCGACAACCTGGTGAGAGACTACCTTCTGCCTCCCGAGGGCCAGCCTCTGCAT
GAGGTAGTGTACTTCAGTGCTGCCAACACACTCCGAGAGCACTTAAATGCTGCTCCAAGAATCG
CCCTCCACACTGCACTCAACAACCCTTACTATTACCTAAAGAATGAAGCATTGAAAAGTGAGGA
AGGCTGCATTCCAAGTGTTGCCCCTGACATCTGCATAGCATATAAACTGCACCTGGAGTGTAGT
CGGCTGATTAACCTTGTCGACTGGTCAGAGGCTTTTGCAACAGTTGTGACAGCTGCTGAGAAAA
TGGATACAAATTCTACAGTCTCCGAAGAAATGAGTGAAATCATCCATGCTCGATTTATTAGAGC
TGTTTCTGAATTAGAACTTTTAGGCTTTATAAAACCTACGAAACAGAAGACTGACCATGTTGCA
AGGCTCACATGGGGAGGCTGCTAAAAAGCAAATGTGTGAAGA

hide sequence

RefSeq Acc Id:

XM_006237995 ⟹ XP_006238057

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	53,923,264 - 53,977,869 (-)	NCBI
mRatBN7.2	5	49,123,758 - 49,181,552 (-)	NCBI
Rnor_6.0	5	50,019,159 - 50,075,533 (-)	NCBI
Rnor_5.0	5	54,588,113 - 54,644,440 (-)	NCBI

Sequence:

show sequence

CCTCCGCGCCGGAAGTCGCCTCTGCTTCCGCCAGGGTGCGCGGAAGTGTATAGTGCGCAGGCAC
ACGGGGCCGCGGACTATGGCCACCTCCTCCGTGTCCAAGGGCTGTTTTGTGTTTAAACCAGACT
TCAAAAAAAGAAAGATCTCTGTGCCAATAGAGGACTATTTTAATAATGAGGAACTTGACTCAGA
AGACAGTAAACTTCGATTTGAAACATATCGCTTGCTATGGCAACGGATAAAATCTGAAACAGAG
CAATTACAGGAGGGATTAAATGAAAATCTGTTTGATAACCTAGTTGACTTTCTGCAGAAGTCCC
ATTCTGAACTTCAGAAAAATTCAGGAAACTGGGGCTCTCAGATGAGACTCAGAGAAATTCCAAC
AGCTGCTCTTATTCTTGGCGTGAACGTCACAGATCATGACGTGATATTCAGGAGTCTAACAGAG
ACCCTTCACAATAATGTCACACCGTATGTTGTCTCCCTGCAAGCTAAGGATTGTCCAGATGTGA
AACATTTTTTACAGAAGTTGACCTCTGAGTTGATAGACTGCTGTGTAGATAGAAATTCCAAGGA
GGAGAAAAATGACAAAGCCCTGAGGAGGACCAGTTATTCCATGGATTCGCTTTCTAGTTGGTAT
TCGACGGTTGCACAGAAGACAGGCCCCAAAATGACAAGCAAAAAGAGAGCGACTTGTAGCCAAT
GGCAGTCCCCTCCTGTGGTGCTTATCTTAAAGAACATGGAGAGTTTCAGCACAAAAGTACTGCA
GGACTTCATAATTATCAGCAGTCAGCATCTGCATGAGTTTCCTCTAATTCTCATTTTTGGGATC
GCCACATCTCCTGTTATTATCCACCGACTGCTTCCTCATTCAGTGTCATCTCTGTTGTGTATAG
AACTGTTCCAGTCTCTGTCTTGCAAGGAACACCTGACAGTAGTTCTTGATAAGCTGCTTCTTAC
CCCTCAGTTTCCCTTTAAATTGAGTAAAAAGGCATTACAAGTTCTGACCAACATCTTTTTGTAT
CATGATTTCTCAATTCAAAACTTCATCAAAGGACTTAAGCTTTCTCTACTAGAACATTTTTATT
CTCAGCCCCTAAGTGTTCTGTGCTGTGATCTCTCAGAAGCCAAAAAAAGAATAAATGTTTTCTC
AGTCAATCAATGTGAAAAAATCCGGCGCCTTCCTTCATTTAGGAGGTACGTGGAAAATCAACCT
TTGGAAAAGCAAGTTGCACTGTTGACCAATGAGACCTTTTTAAAGGAGGAAACGCAATCATTGT
TGGAAGACCTGCATGTTTACCATATCAATTACTTCCTTGTTTTGAGATGTCTTCATAATTTTAC
CTCTTCTCTTCCCAAGTACCCACTGGGTCGACAGATTAGGGAGCTGTATTGTACATGTTTGGAA
AAGAAGATATGGGATTCGGAGGAGTACGAATCAGCCTTGCAGTTGCTGAGAATGCTGGCAAAGG
ACGAACTGATGGGCATACTTGAGCAGTGTGTTAAGGTTTTGAATTCCTCTACTGAAAAGCAGCT
TAGCAACACAGCACAGAAAATAAAGGGCTTCCTGACCCAGTTTCAGAACCTTGATGCAGATAGC
AAAGAGGAAGAGGATGCTTGTGGTTCACAGCCAAAGGGGCTGCAGAAGACGGACCTGTACCACC
TTCAGAAGTCCTTACTGGAAATGAAAGAGCTAAGGAGAACAACTAAGAAGCCAACCAAGTTTGA
AATGCTCAGAGAAAATGTTATAAACTTCATCGACAACCTGGTGAGAGACTACCTTCTGCCTCCC
GAGGGCCAGCCTCTGCATGAGGTAGTGTACTTCAGTGCTGCCAACACACTCCGAGAGCACTTAA
ATGCTGCTCCAAGAATCGCCCTCCACACTGCACTCAACAACCCTTACTATTACCTAAAGAATGA
AGCATTGAAAAGTGAGGAAGGCTGCATTCCAAGTGTTGCCCCTGACATCTGCATAGCATATAAA
CTGCACCTGGAGTGTAGTCGGCTGATTAACCTTGTCGACTGGTCAGAGGCTTTTGCAACAGTTG
TGACAGCTGCTGAGAAAATGGATACAAATTCTACAGTCTCCGAAGAAATGAGTGAAATCATCCA
TGCTCGATTTATTAGAGCTGTTTCTGAATTAGAACTTTTAGGCTTTATAAAACCTACGAAACAG
AAGACTGACCATGTTGCAAGGCTCACATGGGGAGGCTGCTAAAAAGCAAATGTGTGAAGACAAG
AGTTCTGCATCTAACTTAAGGCTAAAAGCAATCTGGAATATTTATATAGTTGTATCAAAATGTT
TTTGGAGTACTTCAAAATCTAAGAAATGCATAAAGCCTTTATACATTGTCAGTATACATTACTA
AGTTTAAACAAGCCGTTCTTGCTTGTCCAGTGTGTAAATGTTAGACCTTCCACATAGTTACTCC
TCAGCAGCACTCATTCCTTTCCCTGGATAACTTGCGGCACGCCGCACACCGTAAGTACACTGTG
TAAAAATCACTCTTACCTAACTAATAGGTGTTTTCCTTGCTAGAGAGGTTCTAAAATTGCCTCT
GCCTCCCCATTTCTTATAGTCTTGGCAACCTACCAGGCCCAAAGCTATTTGGCTTTATACTTTA
AATATTCACATGAACAGTCACTGAGACTTACAACCAGTAAGGGCCTTCACAAACTGCTCCCCTA
ACTTACAAAACGGAAATGTAAAGGTCTAGTAAAATAATATCTTCATCTCTTTCATGATAAGAAC
TTAAGAATCATACACCTAGAACTCATTATTTAATGTTCAACCCTCAAGAGAATTATACCAAAAT
TGTTCACAAATGATTCAAAGAGCCCATGTCCAGGAAAAGCCTTTTTACTTTGACTTGTAATGCA
GGATATGTGCAAGAGTATGATCCCTACCCCATGCTCCCATCCCCAAGTGCTAAGATTATAAGGA
ATTTCAGTATGCCCAGATGAGAAGACAGTCTTTAAACAACACGTTATGCATACAGAGGAACTAG
TTTTAATACTGGCATAATTTTGTCTTGTCTGAGGCATGTGTTCTTGTTGTTTTTCTTTTCCTAG
GCATTTACCTCCATTTGTGCACGTACACACGTTGGCCGTTCTCTTTACCACTTAAGATTAACAC
AATGGAAGTGCTGTCATACTATCAAAAGGACCTGTAAGACTGATTTGTGTCCTTACTTGATATC
CTATAGAATTCAGTCCTTAGTTGAGATGCCTGGCACTTCTTACTTATTTTAGAAAACAAAATCA
GTGTTTTCCTTGTACTTTATTTAGCAAAGCAGAACAACACATGCGTGCAAACACACACAGAAAC
ACACACAACAGCAAGGTAAGAAGTAGGATTGTCATTGTGGTTTTAAAGAATGGTGAAACTAGAC
CTCACTTGAGCAAAAGTACAAGGATTGGGGGAAAAAAAACTACCCAGGAAGATTTATGGGTTCA
CCCATTAGGCAGGGAACAGCAGTAACCAATGTCCTAAGGTGGGAGTACCCCAAGTATATCAAAG
GAAGAGAGATAGCTAGAATGGATAAGGTGGTTCAAACAATAGAAATTGAATGAGTAGGGCAAGA
GTGCAGGTAATGAAGCTTGTTTTCCTTGGTCAGAAGCAGAAGAGGTAAGCAAGCCTTTCAATTC
AATGATCAACATGTGTTGTGAGAGCACAGTGAAAGGACTGATGTAGCAAATCCATAACCAGTTA
GTTGACCACTGAGATAATCCGGGCAAGGCCAATCTTAGATGGGGTAACAGCAACAGGGATGTGA
CACTGTAGATAAACTACAATTAGATGCACATTTAGAGCCTTAAGGGCCTTTCTGCTTATGAACT
AGAAGCATTGCTGTCAGTGGGCTTGCTATGACCCCTAGGGTGGCACTGCTGCTTGGTTGTGGAA
CCTCTAGGAACTAAAGTCTAAAGGGAGTTTCTCCAGTCACTGGGAGTGTGGCCCAAGGGAAATG
GTGGGGTCTTTATTCTTCTGCCTCCTGGCTGATGAGCTGACGGTTTGGCTTTACACTGGACCCC
AGCTATGTCTGCTGCCCATTACAGACCAAAGCAATGAGGACAACTGATCACATAATGAAGTCTT
CAAAATGGAATTAAAGTAAACTTTCTGACTTTGTAGATCAA

hide sequence

RefSeq Acc Id:

XM_063287589 ⟹ XP_063143659

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	53,923,264 - 53,977,869 (-)	NCBI

RefSeq Acc Id:

XM_063287590 ⟹ XP_063143660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	53,923,264 - 53,977,869 (-)	NCBI

RefSeq Acc Id:

XR_010066380

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	53,930,223 - 53,977,869 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020453	(Get FASTA)	NCBI Sequence Viewer
	XP_006238057	(Get FASTA)	NCBI Sequence Viewer
	XP_063143659	(Get FASTA)	NCBI Sequence Viewer
	XP_063143660	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAE02662	(Get FASTA)	NCBI Sequence Viewer
	EDL98594	(Get FASTA)	NCBI Sequence Viewer
	EDL98595	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011085
GenBank Protein	Q4R180	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020453 ⟸ NM_001025282

- UniProtKB:

Q4R180 (UniProtKB/Swiss-Prot), A6IIM4 (UniProtKB/TrEMBL), F1LSH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATSSVSKGCFVFKPDFKKRKISVPIEDYFNNEELDSEDSKLRFETYRLLWQRIKSETEQLQEG
LNENLFDNLVDFLQKSHSEFQKNSGNWGSQMRLREIPTAALILGVNVTDHDVIFRSLTETLHNN
VTPYVVSLQAKDCPDVKHFLQKLTSELIDCCVDRNSKEEKNDKALRRTSYSMDSLSSWYSTVAQ
KTGPKMTSKKRATCSQWQSPPVVLILKNMESFSTKVLQDFIIISSQHLHEFPLILIFGIATSPV
IIHRLLPHSVSSLLCIELFQSLSCKEHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSI
QNFIKGLKLSLLEHFYSQPLSVLCCDLSEAKKRINVFSVNQCEKIRRLPSFRRYVENQPLEKQV
ALLTNETFLKEETQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWD
SEEYESALQLLRMLAKDELMGILEQCVKVLNSSTEKQLSNTAQKIKGFLTQFQNLDDSKEEEDA
CGSQPKGLQKTDLYHLQKSLLEMKELRRTTKKPTKFEMLRENVINFIDNLVRDYLLPPEGQPLH
EVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPSVAPDICIAYKLHLECS
RLINLVDWSEAFATVVTAAEKMDTNSTVSEEMSEIIHARFIRAVSELELLGFIKPTKQKTDHVA
RLTWGGC

hide sequence

RefSeq Acc Id:	XP_006238057 ⟸ XM_006237995
- Peptide Label:	isoform X1
- UniProtKB:	F1LSH3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATSSVSKGCFVFKPDFKKRKISVPIEDYFNNEELDSEDSKLRFETYRLLWQRIKSETEQLQEG LNENLFDNLVDFLQKSHSELQKNSGNWGSQMRLREIPTAALILGVNVTDHDVIFRSLTETLHNN VTPYVVSLQAKDCPDVKHFLQKLTSELIDCCVDRNSKEEKNDKALRRTSYSMDSLSSWYSTVAQ KTGPKMTSKKRATCSQWQSPPVVLILKNMESFSTKVLQDFIIISSQHLHEFPLILIFGIATSPV IIHRLLPHSVSSLLCIELFQSLSCKEHLTVVLDKLLLTPQFPFKLSKKALQVLTNIFLYHDFSI QNFIKGLKLSLLEHFYSQPLSVLCCDLSEAKKRINVFSVNQCEKIRRLPSFRRYVENQPLEKQV ALLTNETFLKEETQSLLEDLHVYHINYFLVLRCLHNFTSSLPKYPLGRQIRELYCTCLEKKIWD SEEYESALQLLRMLAKDELMGILEQCVKVLNSSTEKQLSNTAQKIKGFLTQFQNLDADSKEEED ACGSQPKGLQKTDLYHLQKSLLEMKELRRTTKKPTKFEMLRENVINFIDNLVRDYLLPPEGQPL HEVVYFSAANTLREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPSVAPDICIAYKLHLEC SRLINLVDWSEAFATVVTAAEKMDTNSTVSEEMSEIIHARFIRAVSELELLGFIKPTKQKTDHV ARLTWGGC hide sequence

Ensembl Acc Id:

ENSRNOP00000071439 ⟸ ENSRNOT00000084643

Ensembl Acc Id:

ENSRNOP00000011085 ⟸ ENSRNOT00000011085

RefSeq Acc Id:	XP_063143660 ⟸ XM_063287590
- Peptide Label:	isoform X3
- UniProtKB:	F1LSH3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143659 ⟸ XM_063287589
- Peptide Label:	isoform X2
- UniProtKB:	F1LSH3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000100536 ⟸ ENSRNOT00000170791

Protein Domains

Origin recognition complex subunit 3 insertion Origin recognition complex subunit 3 N-terminal Origin recognition complex subunit 3 winged helix C-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4R180-F1-model_v2	AlphaFold	Q4R180	1-711	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693619

Promoter ID:

EPDNEW_R4142

Type:

initiation region

Name:

Orc3_1

Description:

origin recognition complex, subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	50,075,459 - 50,075,519	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308457	AgrOrtholog
BioCyc Gene	G2FUF-41656	BioCyc
Ensembl Genes	ENSRNOG00000008314	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000011085	ENTREZGENE
InterPro	ORC3	UniProtKB/Swiss-Prot
	ORC3_ins	UniProtKB/Swiss-Prot
	ORC3_N	UniProtKB/Swiss-Prot
	ORC_WH_C	UniProtKB/Swiss-Prot
KEGG Report	rno:313138	UniProtKB/Swiss-Prot
NCBI Gene	313138	ENTREZGENE
PANTHER	ORIGIN RECOGNITION COMPLEX SUBUNIT 3	UniProtKB/Swiss-Prot
	PTHR12748	UniProtKB/Swiss-Prot
Pfam	ORC3_ins	UniProtKB/Swiss-Prot
	ORC3_N	UniProtKB/Swiss-Prot
	ORC_WH_C	UniProtKB/Swiss-Prot
PhenoGen	Orc3	PhenoGen
RatGTEx	ENSRNOG00000008314	RatGTEx
UniProt	A0A0G2K0G7_RAT	UniProtKB/TrEMBL
	A0ABK0KZ33_RAT	UniProtKB/TrEMBL
	A6IIM4	ENTREZGENE, UniProtKB/TrEMBL
	F1LSH3	ENTREZGENE, UniProtKB/TrEMBL
	ORC3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-24	Orc3l	origin recognition complex, subunit 3-like (yeast)	Orc3l	origin recognition complex, subunit 3-like (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Orc3l	origin recognition complex, subunit 3-like (S. cerevisiae)	Orc3l_predicted	origin recognition complex, subunit 3-like (S. cerevisiae) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Orc3l_predicted	origin recognition complex, subunit 3-like (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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