Hsdl1 (hydroxysteroid dehydrogenase like 1) - Rat Genome Database

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Pathways
Gene: Hsdl1 (hydroxysteroid dehydrogenase like 1) Rattus norvegicus
Analyze
Symbol: Hsdl1
Name: hydroxysteroid dehydrogenase like 1
RGD ID: 1308433
Description: Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in mitochondrion. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inactive hydroxysteroid dehydrogenase-like protein 1; LOC361418; MGC114519; RGD1308433; similar to steroid dehydrogenase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,524,435 - 64,540,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,525,891 - 64,540,762 (-)EnsemblGRCr8
mRatBN7.21947,615,794 - 47,631,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,615,796 - 47,631,846 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,411,623 - 54,418,476 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,092,500 - 55,099,330 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,306,144 - 57,313,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,209,403 - 52,225,486 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,210,859 - 52,217,728 (-)Ensemblrn6Rnor6.0
Rnor_5.01962,957,885 - 62,973,686 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,807,247 - 49,814,030 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,876,394 - 46,883,153 (-)NCBICelera
RGSC_v3.11949,812,129 - 49,818,911 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:19026618  


Genomics

Comparative Map Data
Hsdl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,524,435 - 64,540,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,525,891 - 64,540,762 (-)EnsemblGRCr8
mRatBN7.21947,615,794 - 47,631,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,615,796 - 47,631,846 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,411,623 - 54,418,476 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,092,500 - 55,099,330 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,306,144 - 57,313,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,209,403 - 52,225,486 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,210,859 - 52,217,728 (-)Ensemblrn6Rnor6.0
Rnor_5.01962,957,885 - 62,973,686 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,807,247 - 49,814,030 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,876,394 - 46,883,153 (-)NCBICelera
RGSC_v3.11949,812,129 - 49,818,911 (-)NCBI
Cytogenetic Map19q12NCBI
HSDL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,122,141 - 84,145,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,122,141 - 84,145,212 (-)Ensemblhg38GRCh38
GRCh371684,155,746 - 84,178,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,713,389 - 82,736,265 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341682,713,388 - 82,736,265NCBI
Celera1668,457,660 - 68,480,593 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1669,909,727 - 69,932,582 (-)NCBIHuRef
CHM1_11685,567,127 - 85,590,179 (-)NCBICHM1_1
T2T-CHM13v2.01690,188,232 - 90,211,260 (-)NCBIT2T-CHM13v2.0
Hsdl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,288,717 - 120,301,930 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,288,728 - 120,301,922 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388119,561,978 - 119,575,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,561,989 - 119,575,183 (-)Ensemblmm10GRCm38
MGSCv378122,085,878 - 122,099,100 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368122,447,966 - 122,461,160 (-)NCBIMGSCv36mm8
Celera8123,779,426 - 123,792,652 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map867.95NCBI
Hsdl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955564162,318 - 175,266 (+)Ensembl
ChiLan1.0NW_004955564155,080 - 172,712 (+)NCBIChiLan1.0ChiLan1.0
HSDL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21893,869,346 - 93,892,069 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,786,516 - 99,809,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,788,471 - 64,810,423 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,131,341 - 84,153,503 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,131,341 - 84,153,503 (-)EnsemblpanPan2panpan1.1
HSDL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,206,392 - 68,226,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,213,188 - 68,225,448 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha568,219,828 - 68,240,676 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0568,503,734 - 68,524,631 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,503,682 - 68,524,613 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,451,511 - 68,472,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,287,988 - 68,308,942 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,703,767 - 68,724,668 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hsdl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,928,311 - 27,938,638 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,681,960 - 3,693,063 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,674,575 - 3,692,175 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSDL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,479,933 - 4,501,236 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.164,479,916 - 4,501,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.265,061,592 - 5,083,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSDL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,532,858 - 69,554,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,532,223 - 69,554,299 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660476,201,569 - 6,226,409 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsdl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,441,907 - 3,462,857 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247463,441,751 - 3,462,859 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hsdl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11739,206,759 - 39,222,598 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:142
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000020859
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH140606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,616,802 - 47,616,989 (+)MAPPERmRatBN7.2
Rnor_6.01952,210,410 - 52,210,596NCBIRnor6.0
Rnor_5.01962,958,892 - 62,959,078UniSTSRnor5.0
RGSC_v3.41949,806,800 - 49,806,986UniSTSRGSC3.4
Celera1946,875,947 - 46,876,133UniSTS
RH 3.4 Map19654.0UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020859   ⟹   ENSRNOP00000020860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,525,891 - 64,540,108 (-)Ensembl
mRatBN7.2 Ensembl1947,615,796 - 47,631,503 (-)Ensembl
Rnor_6.0 Ensembl1952,210,859 - 52,217,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114729   ⟹   ENSRNOP00000088924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,525,891 - 64,540,762 (-)Ensembl
mRatBN7.2 Ensembl1947,615,796 - 47,631,846 (-)Ensembl
RefSeq Acc Id: NM_001024896   ⟹   NP_001020067
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,525,889 - 64,532,740 (-)NCBI
mRatBN7.21947,617,250 - 47,624,105 (-)NCBI
Rnor_6.01952,210,857 - 52,217,728 (-)NCBI
Rnor_5.01962,957,885 - 62,973,686 (-)NCBI
RGSC_v3.41949,807,247 - 49,814,030 (-)RGD
Celera1946,876,394 - 46,883,153 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255713   ⟹   XP_006255775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,524,435 - 64,540,527 (-)NCBI
mRatBN7.21947,615,794 - 47,631,892 (-)NCBI
Rnor_6.01952,209,403 - 52,225,486 (-)NCBI
Rnor_5.01962,957,885 - 62,973,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097871   ⟹   XP_038953799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,524,435 - 64,540,476 (-)NCBI
mRatBN7.21947,615,794 - 47,631,887 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001020067 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255775 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953799 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97457 (Get FASTA)   NCBI Sequence Viewer  
  EDL92671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020860
  ENSRNOP00000088924.1
GenBank Protein Q4V8B7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020067   ⟸   NM_001024896
- UniProtKB: Q4V8B7 (UniProtKB/Swiss-Prot),   A6IZJ3 (UniProtKB/TrEMBL),   A0A8L2UJL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255775   ⟸   XM_006255713
- Peptide Label: isoform X1
- UniProtKB: Q4V8B7 (UniProtKB/Swiss-Prot),   A6IZJ3 (UniProtKB/TrEMBL),   A0A8L2UJL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020860   ⟸   ENSRNOT00000020859
RefSeq Acc Id: XP_038953799   ⟸   XM_039097871
- Peptide Label: isoform X1
- UniProtKB: Q4V8B7 (UniProtKB/Swiss-Prot),   A6IZJ3 (UniProtKB/TrEMBL),   A0A8L2UJL9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088924   ⟸   ENSRNOT00000114729

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8B7-F1-model_v2 AlphaFold Q4V8B7 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308433 AgrOrtholog
BioCyc Gene G2FUF-5514 BioCyc
Ensembl Genes ENSRNOG00000015576 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020859 ENTREZGENE
  ENSRNOT00000114729.1 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7457192 IMAGE-MGC_LOAD
InterPro 17-beta-HSD3-like UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:361418 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114519 IMAGE-MGC_LOAD
NCBI Gene 361418 ENTREZGENE
PANTHER INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Hsdl1 PhenoGen
PIRSF 11-beta-HSD1 UniProtKB/Swiss-Prot
PRINTS GDHRDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015576 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A8L2UJL9 ENTREZGENE, UniProtKB/TrEMBL
  A6IZJ3 ENTREZGENE, UniProtKB/TrEMBL
  HSDL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hsdl1  hydroxysteroid dehydrogenase like 1  RGD1308433  similar to steroid dehydrogenase-like  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1308433  similar to steroid dehydrogenase-like  RGD1308433_predicted  similar to steroid dehydrogenase-like (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308433_predicted  similar to steroid dehydrogenase-like (predicted)  LOC361418_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361418_predicted  similar to steroid dehydrogenase-like (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL