Mttp (microsomal triglyceride transfer protein) - Rat Genome Database

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Gene: Mttp (microsomal triglyceride transfer protein) Rattus norvegicus
Analyze
Symbol: Mttp
Name: microsomal triglyceride transfer protein
RGD ID: 1308388
Description: Enables apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in basolateral plasma membrane; cell projection membrane; and vesicle. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein); INTERACTS WITH (R)-carnitine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: microsomal triglyceride transfer protein large subunit; MTP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,286,501 - 229,327,650 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,286,501 - 229,327,650 (-)EnsemblGRCr8
mRatBN7.22226,613,090 - 226,654,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,613,090 - 226,654,239 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,352,193 - 234,393,386 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,251,937 - 232,293,127 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,116,603 - 227,157,800 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,366,181 - 243,407,608 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,366,181 - 243,407,608 (-)Ensemblrn6Rnor6.0
Rnor_5.02261,907,825 - 261,948,693 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42235,613,710 - 235,654,848 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2218,769,332 - 218,810,411 (-)NCBICelera
RGSC_v3.12235,600,461 - 235,641,567 (-)NCBI
Cytogenetic Map2q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-carnitine  (EXP)
1,1-dichloroethene  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
allopurinol  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CDN1163  (ISO)
chenodeoxycholic acid  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorotoluron  (ISO)
choline  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
indinavir  (ISO)
indometacin  (ISO)
isosilybin  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
Muraglitazar  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
procymidone  (ISO)
propiconazole  (ISO)
PX-866  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
stavudine  (EXP)
sulfluramid  (ISO)
sulindac  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
taurine  (EXP)
teniposide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (ISO)
triazines  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triolein  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tuberostemonine  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
voriconazole  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Triglyceride-lowering effect of pitavastatin in a rat model of postprandial lipemia. Aoki T, etal., Eur J Pharmacol. 2002 May 24;444(1-2):107-13.
2. Molecular screening of the microsomal triglyceride transfer protein: association between polymorphisms and both abdominal obesity and plasma apolipoprotein B concentration. Berthier MT, etal., J Hum Genet. 2004;49(12):684-90. Epub 2004 Nov 10.
3. The c.419-420insA in the MTP gene is associated with abetalipoproteinemia among French-Canadians. Berthier MT, etal., Mol Genet Metab. 2004 Feb;81(2):140-3.
4. Augmentation of Ca2+-induced microsomal triglyceride transfer protein activity by glucose supply enhances hypertriglyceridemia in vivo. Cho HJ, etal., Biol Pharm Bull. 2006 May;29(5):889-95.
5. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. Cuchel M, etal., N Engl J Med. 2007 Jan 11;356(2):148-56.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Ledmyr H, etal., Circulation. 2004 May 18;109(19):2279-84. Epub 2004 May 10.
9. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. Levy E, etal., J Biol Chem. 2002 May 10;277(19):16470-7. Epub 2002 Feb 5.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Mirandola S, etal., Gastroenterology. 2006 May;130(6):1661-9. Epub 2006 Mar 6.
12. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. Namikawa C, etal., J Hepatol. 2004 May;40(5):781-6.
13. Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia. Narcisi TM, etal., Am J Hum Genet. 1995 Dec;57(6):1298-310.
14. Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia. Ohashi K, etal., J Lipid Res. 2000 Aug;41(8):1199-204.
15. Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins. Rava P, etal., J Biol Chem. 2006 Apr 21;281(16):11019-27. doi: 10.1074/jbc.M512823200. Epub 2006 Feb 13.
16. Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein. Rava P, etal., J Lipid Res. 2005 Aug;46(8):1779-85. doi: 10.1194/jlr.D400043-JLR200. Epub 2005 May 16.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats. Ringseis R and Eder K, J Nutr Biochem. 2004 Feb;15(2):103-11.
20. Identification of microsomal triglyceride transfer protein in intestinal brush-border membrane. Slight I, etal., Exp Cell Res. 2004 Oct 15;300(1):11-22.
21. Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. St-Pierre J, etal., Atherosclerosis. 2002 Feb;160(2):317-24.
22. Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women. Yamada Y, etal., Int J Mol Med. 2006 Jan;17(1):83-8.
Additional References at PubMed
PMID:10713055   PMID:11971950   PMID:12072432   PMID:15537571   PMID:16950764   PMID:17378158   PMID:17575276   PMID:17635917   PMID:17690102   PMID:19874708   PMID:20181985   PMID:20567026  
PMID:20938890   PMID:22236406   PMID:23382219   PMID:23475612   PMID:23749231   PMID:23911221   PMID:24333444   PMID:24353284   PMID:25108285   PMID:26092479   PMID:26184122   PMID:26224785  
PMID:28270444  


Genomics

Comparative Map Data
Mttp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,286,501 - 229,327,650 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2229,286,501 - 229,327,650 (-)EnsemblGRCr8
mRatBN7.22226,613,090 - 226,654,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,613,090 - 226,654,239 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2234,352,193 - 234,393,386 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,251,937 - 232,293,127 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,116,603 - 227,157,800 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,366,181 - 243,407,608 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,366,181 - 243,407,608 (-)Ensemblrn6Rnor6.0
Rnor_5.02261,907,825 - 261,948,693 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42235,613,710 - 235,654,848 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2218,769,332 - 218,810,411 (-)NCBICelera
RGSC_v3.12235,600,461 - 235,641,567 (-)NCBI
Cytogenetic Map2q43NCBI
MTTP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,564,130 - 99,623,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,564,081 - 99,623,997 (+)Ensemblhg38GRCh38
GRCh374100,485,287 - 100,545,154 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,704,263 - 100,764,177 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344100,853,158 - 100,901,804NCBI
Celera497,782,659 - 97,842,577 (+)NCBICelera
Cytogenetic Map4q23NCBI
HuRef496,223,283 - 96,283,485 (+)NCBIHuRef
CHM1_14100,461,713 - 100,521,565 (+)NCBICHM1_1
T2T-CHM13v2.04102,878,899 - 102,939,426 (+)NCBIT2T-CHM13v2.0
Mttp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393137,795,616 - 137,849,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3137,795,615 - 137,850,729 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383138,089,855 - 138,143,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,089,854 - 138,144,968 (-)Ensemblmm10GRCm38
MGSCv373137,752,819 - 137,806,352 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363138,028,273 - 138,068,711 (-)NCBIMGSCv36mm8
Celera3144,502,913 - 144,554,347 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.06NCBI
Mttp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554967,963,262 - 8,009,838 (-)Ensembl
ChiLan1.0NW_0049554967,963,323 - 8,022,393 (-)NCBIChiLan1.0ChiLan1.0
MTTP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,646,193 - 97,705,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,929,920 - 97,989,327 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,987,756 - 92,047,127 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,648,793 - 102,708,107 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,648,793 - 102,708,107 (+)EnsemblpanPan2panpan1.1
MTTP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,582,368 - 21,626,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,570,801 - 21,628,624 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3220,269,932 - 20,326,464 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03221,791,316 - 21,847,942 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,803,303 - 21,847,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,768,037 - 21,824,593 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,555,521 - 21,612,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,256,944 - 18,313,535 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mttp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530119,994,708 - 20,057,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,338,881 - 3,381,627 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,337,726 - 3,417,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTTP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8120,820,656 - 120,879,388 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18120,820,660 - 120,871,468 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,036,478 - 130,087,445 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTTP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,706,591 - 47,765,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,717,089 - 47,765,149 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603726,182,236 - 26,230,115 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mttp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248307,464,686 - 7,506,129 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248307,463,671 - 7,505,607 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mttp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1321,031,510 - 21,072,723 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mttp
329 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:450
Count of miRNA genes:235
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000014631
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 56 129 88 90 59 43 59 6 286 128 11 111 77 83 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000014631   ⟹   ENSRNOP00000014630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2229,286,501 - 229,327,650 (-)Ensembl
mRatBN7.2 Ensembl2226,613,090 - 226,654,239 (-)Ensembl
Rnor_6.0 Ensembl2243,366,181 - 243,407,608 (-)Ensembl
RefSeq Acc Id: NM_001107727   ⟹   NP_001101197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,286,501 - 229,327,650 (-)NCBI
mRatBN7.22226,613,090 - 226,654,239 (-)NCBI
Rnor_6.02243,366,181 - 243,407,608 (-)NCBI
Rnor_5.02261,907,825 - 261,948,693 (-)NCBI
RGSC_v3.42235,613,710 - 235,654,848 (-)RGD
Celera2218,769,332 - 218,810,411 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A1W8 (Get FASTA)   NCBI Sequence Viewer  
  EDL82305 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014630
  ENSRNOP00000014630.4
RefSeq Acc Id: NP_001101197   ⟸   NM_001107727
- Peptide Label: precursor
- UniProtKB: D4A1W8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014630   ⟸   ENSRNOT00000014631
Protein Domains
Vitellogenin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1W8-F1-model_v2 AlphaFold D4A1W8 1-896 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691781
Promoter ID:EPDNEW_R2306
Type:multiple initiation site
Name:Mttp_1
Description:microsomal triglyceride transfer protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,407,591 - 243,407,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308388 AgrOrtholog
BioCyc Gene G2FUF-51082 BioCyc
Ensembl Genes ENSRNOG00000010655 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014631 ENTREZGENE
  ENSRNOT00000014631.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.20 UniProtKB/Swiss-Prot
  Lipovitellin, beta-sheet shell regions, chain A UniProtKB/Swiss-Prot
InterPro Lipid_transp_b-sht_shell UniProtKB/Swiss-Prot
  Lipid_transpt_N UniProtKB/Swiss-Prot
  Lipovitellin_superhlx_dom UniProtKB/Swiss-Prot
  MTP_lip_bd UniProtKB/Swiss-Prot
  MTTP UniProtKB/Swiss-Prot
  Vitellinogen_b-sht_N UniProtKB/Swiss-Prot
KEGG Report rno:310900 UniProtKB/Swiss-Prot
NCBI Gene 310900 ENTREZGENE
PANTHER MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN LARGE SUBUNIT UniProtKB/Swiss-Prot
  PTHR13024 UniProtKB/Swiss-Prot
Pfam MTP_lip_bd UniProtKB/Swiss-Prot
  Vitellogenin_N UniProtKB/Swiss-Prot
PhenoGen Mttp PhenoGen
PROSITE VITELLOGENIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010655 RatGTEx
SMART LPD_N UniProtKB/Swiss-Prot
Superfamily-SCOP Lipovitellin-phosvitin complex, beta-sheet shell regions UniProtKB/Swiss-Prot
  SSF48431 UniProtKB/Swiss-Prot
UniProt D4A1W8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mttp  microsomal triglyceride transfer protein  Mttp_predicted  microsomal triglyceride transfer protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mttp_predicted  microsomal triglyceride transfer protein (predicted)      Symbol and Name status set to approved 70820 APPROVED