Klb (klotho beta) - Rat Genome Database

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Gene: Klb (klotho beta) Rattus norvegicus
Analyze
Symbol: Klb
Name: klotho beta
RGD ID: 1308227
Description: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in carbohydrate metabolic process and response to fibroblast growth factor. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Orthologous to human KLB (klotho beta); PARTICIPATES IN fibroblast growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; aflatoxin B1; diallyl trisulfide.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: AABR07015003.1; beta-klotho; Klb-ps1; klotho beta, pseudogene 1; LOC289625; RGD1308227; similar to betaKlotho protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,253,963 - 43,304,532 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,253,255 - 43,304,515 (-)EnsemblGRCr8
mRatBN7.21442,899,050 - 42,950,788 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,899,510 - 42,950,799 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd1443,525,006 - 43,575,472 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1443,658,540 - 43,709,006 (-)NCBILyon_Normotensive
Lyon_Hypertensive1443,680,550 - 43,731,016 (-)NCBILyon_Hypertensive
F344_StmMcwi1443,700,805 - 43,751,269 (-)NCBIF344_StmMcwi
Rnor_6.01444,529,523 - 44,614,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,548,287 - 44,613,904 (-)NCBIrn6Rnor6.0
Rnor_5.01444,362,418 - 44,428,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41445,598,875 - 45,650,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1442,059,574 - 42,094,328 (-)NCBICelera
RGSC_v3.11445,601,737 - 45,652,823 (-)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors. Farinelli P, etal., J Neurochem. 2013 Dec;127(6):868-79. doi: 10.1111/jnc.12353. Epub 2013 Jul 22.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17627937   PMID:18187602   PMID:18829467   PMID:19117008   PMID:21873635  


Genomics

Comparative Map Data
Klb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81443,253,963 - 43,304,532 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1443,253,255 - 43,304,515 (-)EnsemblGRCr8
mRatBN7.21442,899,050 - 42,950,788 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,899,510 - 42,950,799 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd1443,525,006 - 43,575,472 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1443,658,540 - 43,709,006 (-)NCBILyon_Normotensive
Lyon_Hypertensive1443,680,550 - 43,731,016 (-)NCBILyon_Hypertensive
F344_StmMcwi1443,700,805 - 43,751,269 (-)NCBIF344_StmMcwi
Rnor_6.01444,529,523 - 44,614,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,548,287 - 44,613,904 (-)NCBIrn6Rnor6.0
Rnor_5.01444,362,418 - 44,428,134 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41445,598,875 - 45,650,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1442,059,574 - 42,094,328 (-)NCBICelera
RGSC_v3.11445,601,737 - 45,652,823 (-)NCBI
Cytogenetic Map14p11NCBI
KLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38439,406,930 - 39,451,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl439,406,930 - 39,451,533 (+)Ensemblhg38GRCh38
GRCh37439,408,550 - 39,453,153 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36439,084,868 - 39,126,748 (+)NCBIBuild 36Build 36hg18NCBI36
Celera439,846,293 - 39,890,979 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef438,733,659 - 38,778,142 (+)NCBIHuRef
CHM1_1439,407,982 - 39,452,605 (+)NCBICHM1_1
T2T-CHM13v2.0439,376,567 - 39,421,181 (+)NCBIT2T-CHM13v2.0
Klb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,505,754 - 65,544,300 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,505,657 - 65,541,350 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38565,348,411 - 65,386,957 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl565,348,314 - 65,384,007 (+)Ensemblmm10GRCm38
MGSCv37565,739,650 - 65,775,242 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36565,627,546 - 65,663,138 (+)NCBIMGSCv36mm8
Celera562,625,529 - 62,660,680 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.64NCBI
Klb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554437,917,585 - 7,954,322 (-)Ensembl
ChiLan1.0NW_0049554437,917,047 - 7,954,390 (-)NCBIChiLan1.0ChiLan1.0
KLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2339,596,718 - 39,640,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1439,789,092 - 39,832,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0433,736,350 - 33,780,309 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1439,588,702 - 39,632,480 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl439,588,702 - 39,632,480 (+)EnsemblpanPan2panpan1.1
KLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,996,725 - 73,033,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,998,816 - 73,033,651 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha375,543,588 - 75,580,413 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0373,770,160 - 73,807,259 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl373,770,190 - 73,807,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1373,036,749 - 73,073,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0373,183,012 - 73,219,858 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0373,569,554 - 73,606,370 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528539,238,635 - 39,271,423 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364827,026,871 - 7,059,848 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364827,026,871 - 7,060,495 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl830,653,572 - 30,691,349 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1830,653,434 - 30,696,123 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2832,268,411 - 32,303,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12710,860,301 - 10,933,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2710,861,760 - 10,903,400 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604757,252,417 - 57,296,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,836,473 - 4,885,950 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248704,835,943 - 4,901,965 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Klb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11122,366,923 - 22,405,935 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klb
502 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
exocrine system
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
10 7 1 97 130 6 97 16 238 213 11 127 28 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003811   ⟹   ENSRNOP00000003811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1443,253,255 - 43,304,515 (-)Ensembl
mRatBN7.2 Ensembl1442,899,510 - 42,950,799 (-)Ensembl
RefSeq Acc Id: NM_001432739   ⟹   NP_001419668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd1443,525,006 - 43,575,472 (-)NCBI
Lyon_Normotensive1443,658,540 - 43,709,006 (-)NCBI
Lyon_Hypertensive1443,680,550 - 43,731,016 (-)NCBI
F344_StmMcwi1443,700,805 - 43,751,269 (-)NCBI
RefSeq Acc Id: XM_039092743   ⟹   XP_038948671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81443,253,963 - 43,304,532 (-)NCBI
mRatBN7.21442,899,050 - 42,950,788 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001419668 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003811
  ENSRNOP00000003811.7
RefSeq Acc Id: XP_038948671   ⟸   XM_039092743
Ensembl Acc Id: ENSRNOP00000003811   ⟸   ENSRNOT00000003811
RefSeq Acc Id: NP_001419668   ⟸   NM_001432739

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8T6-F1-model_v2 AlphaFold D3Z8T6 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308227 AgrOrtholog
BioCyc Gene G2FUF-15743 BioCyc
Ensembl Genes ENSRNOG00000002834 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003811 ENTREZGENE
  ENSRNOT00000003811.8 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro Glyco_hydro_1 UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
NCBI Gene 289625 ENTREZGENE
PANTHER BETA-KLOTHO UniProtKB/TrEMBL
  PTHR10353 UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/TrEMBL
PhenoGen Klb PhenoGen
PRINTS GLHYDRLASE1 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002834 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt D3Z8T6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Klb  klotho beta  AABR07015003.1    Data merged from RGD:15003246 737654 PROVISIONAL
2021-09-02 AABR07015003.1    Klb  klotho beta  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Klb  klotho beta  AABR07015003.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AABR07015003.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-03-05 Klb  klotho beta  Klb-ps1  klotho beta, pseudogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-08 Klb-ps1  klotho beta, pseudogene 1  Klb  klotho beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klb  klotho beta   Klb_predicted  klotho beta (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Klb_predicted  klotho beta (predicted)  RGD1308227_predicted  similar to betaKlotho protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308227_predicted  similar to betaKlotho protein (predicted)  LOC289625_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289625_predicted  similar to betaKlotho protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL