Zfp647 (zinc finger protein 647) - Rat Genome Database

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Gene: Zfp647 (zinc finger protein 647) Rattus norvegicus
Analyze
Symbol: Zfp647
Name: zinc finger protein 647
RGD ID: 1308203
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF250 (zinc finger protein 250); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102555083; LOC362948; zinc finger protein 250; zinc finger protein 250-like; Znf250; Znf647
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,512,866 - 110,527,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7110,512,866 - 110,527,778 (-)EnsemblGRCr8
mRatBN7.27108,632,248 - 108,649,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,632,250 - 108,637,433 (-)EnsemblmRatBN7.2
Rnor_6.07117,973,657 - 117,989,094 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,513,684 - 118,518,193 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl7117,974,278 - 117,978,787 (-)Ensemblrn6Rnor6.0
Rnor_5.07118,505,725 - 118,521,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47114,960,731 - 114,965,240 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7104,981,102 - 104,996,288 (-)NCBICelera
RGSC_v3.17114,994,943 - 114,999,471 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25416956  


Genomics

Comparative Map Data
Zfp647
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,512,866 - 110,527,680 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7110,512,866 - 110,527,778 (-)EnsemblGRCr8
mRatBN7.27108,632,248 - 108,649,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,632,250 - 108,637,433 (-)EnsemblmRatBN7.2
Rnor_6.07117,973,657 - 117,989,094 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,513,684 - 118,518,193 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl7117,974,278 - 117,978,787 (-)Ensemblrn6Rnor6.0
Rnor_5.07118,505,725 - 118,521,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47114,960,731 - 114,965,240 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7104,981,102 - 104,996,288 (-)NCBICelera
RGSC_v3.17114,994,943 - 114,999,471 (-)NCBI
Cytogenetic Map7q34NCBI
ZNF250
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,876,955 - 144,902,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,876,497 - 144,902,217 (-)Ensemblhg38GRCh38
GRCh378146,102,340 - 146,127,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368146,075,775 - 146,097,616 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348146,077,336 - 146,097,632NCBI
Celera8142,278,872 - 142,303,378 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8141,218,182 - 141,242,687 (-)NCBIHuRef
CHM1_18146,140,622 - 146,165,124 (-)NCBICHM1_1
T2T-CHM13v2.08146,050,748 - 146,075,971 (-)NCBIT2T-CHM13v2.0
Zfp647
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,794,570 - 76,809,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,794,571 - 76,809,648 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381576,910,370 - 76,925,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,910,371 - 76,925,448 (-)Ensemblmm10GRCm38
MGSCv371576,740,800 - 76,755,878 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361576,737,626 - 76,752,703 (-)NCBIMGSCv36mm8
Celera1578,405,400 - 78,420,478 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.28NCBI
ZNF250
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27162,349,677 - 162,410,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,919,997 - 137,941,088 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08141,628,421 - 141,683,924 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18144,643,023 - 144,663,226 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8144,643,662 - 144,652,461 (-)EnsemblpanPan2panpan1.1
ZNF250
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,130,240 - 38,149,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,131,000 - 38,145,563 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1338,090,962 - 38,111,064 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01338,604,057 - 38,624,155 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,604,065 - 38,624,651 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,295,497 - 38,315,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,404,364 - 38,424,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,879,711 - 38,899,832 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Znf250
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530386,659 - 107,102 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364707,517,581 - 7,532,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100621388
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl466,932 - 84,170 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl487,577 - 109,180 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1462,884 - 108,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,330 - 138,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF250
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18139,080,027 - 139,106,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8139,080,043 - 139,106,262 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666039734,705 - 761,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf250
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,047,092 - 12,060,276 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473512,040,515 - 12,060,959 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Znf250
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11249,237,859 - 249,252,126 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp647
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:38
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000074262, ENSRNOT00000075636
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 50 55 126 83 11 49 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074262   ⟹   ENSRNOP00000067546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7117,974,278 - 117,978,787 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075636   ⟹   ENSRNOP00000067685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7110,512,866 - 110,527,778 (-)Ensembl
mRatBN7.2 Ensembl7108,632,250 - 108,637,433 (-)Ensembl
Rnor_6.0 Ensembl7118,513,684 - 118,518,193 (-)Ensembl
RefSeq Acc Id: NM_001427380   ⟹   NP_001414309
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,512,866 - 110,527,680 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067685
  ENSRNOP00000067685.1
Ensembl Acc Id: ENSRNOP00000067685   ⟸   ENSRNOT00000075636
Ensembl Acc Id: ENSRNOP00000067546   ⟸   ENSRNOT00000074262
RefSeq Acc Id: NP_001414309   ⟸   NM_001427380
- UniProtKB: M0RDI4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDI4-F1-model_v2 AlphaFold M0RDI4 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308203 AgrOrtholog
Ensembl Genes ENSRNOG00000050651 Ensembl
  ENSRNOG00000050661 Ensembl
  ENSRNOG00000068661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075636 ENTREZGENE
  ENSRNOT00000075636.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro C2H2-ZF_domain UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene Zfp647 ENTREZGENE
PANTHER FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 628 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp647 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050651 RatGTEx
  ENSRNOG00000050661 RatGTEx
  ENSRNOG00000068661 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt M0RDI4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zfp647  zinc finger protein 647  LOC102555083  zinc finger protein 250-like  Data merged from RGD:7691715 737654 PROVISIONAL
2013-12-18 LOC102555083  zinc finger protein 250-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-19 Zfp647  zinc finger protein 647  Znf250  zinc finger protein 250  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf250  zinc finger protein 250  Zfp647  zinc finger protein 647   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zfp647  zinc finger protein 647   Zfp647_predicted  zinc finger protein 647 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp647_predicted  zinc finger protein 647 (predicted)  Znf647_predicted    Symbol updated 1299863 APPROVED
2005-01-12 Znf647_predicted  zinc finger protein 647 (predicted)      Symbol and Name status set to approved 70820 APPROVED