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Gene: Dmrta2 (DMRT-like family A2) Rattus norvegicus

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Symbol:

Dmrta2

Name:

DMRT-like family A2

RGD ID:

1308173

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of neuroblast proliferation; and stem cell fate specification. Predicted to be active in nucleus. Orthologous to human DMRTA2 (DMRT like family A2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

doublesex and mab-3 related transcription factor like family A2; doublesex- and mab-3-related transcription factor A2; LOC313471

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DMRTA2 (DMRT like family A2)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Dmrta2 (doublesex and mab-3 related transcription factor like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dmrta2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DMRTA2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DMRTA2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dmrta2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DMRTA2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DMRTA2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dmrta2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dmrta2 (DMRT like family A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Dmrta2 (doublesex and mab-3 related transcription factor like family A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DMRTA2 (DMRT like family A2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dmrta2 (DMRT-like family A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dmrta2 (DMRT-like family A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dmd-5	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	dmd-5	Alliance	DIOPT (OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	dmrt99B	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dmrta2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dmrta2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Candidate Gene For:

Bp156

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	130,034,473 - 130,040,283 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	130,034,473 - 130,040,222 (+)	Ensembl				GRCr8
mRatBN7.2	5	124,805,883 - 124,811,694 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	124,805,883 - 124,811,630 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	127,419,929 - 127,425,663 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	129,142,998 - 129,148,731 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	129,194,273 - 129,200,006 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	129,754,295 - 129,760,045 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	129,756,149 - 129,758,986 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	133,586,293 - 133,592,043 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	131,410,451 - 131,416,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	123,544,868 - 123,550,615 (+)	NCBI		Celera
RGSC_v3.1	5	131,417,530 - 131,420,383 (+)	NCBI
Cytogenetic Map	5	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

C60 fullerene (EXP)

CGP 52608 (ISO)

choline (ISO)

Cuprizon (EXP)

dorsomorphin (ISO)

ethylparaben (ISO)

folic acid (ISO)

iron dichloride (ISO)

L-methionine (ISO)

maneb (ISO)

ozone (ISO)

panobinostat (ISO)

paraquat (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

pyridaben (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cerebral cortex regionalization (ISO)

dopaminergic neuron differentiation (ISO)

neuron fate specification (ISO)

positive regulation of neuroblast proliferation (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

sex differentiation (IBA)

skeletal muscle cell differentiation (ISO)

Cellular Component

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:17605809	PMID:21576465	PMID:22147266	PMID:22923088	PMID:23056351

Genomics

Comparative Map Data

Dmrta2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	130,034,473 - 130,040,283 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	130,034,473 - 130,040,222 (+)	Ensembl				GRCr8
mRatBN7.2	5	124,805,883 - 124,811,694 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	124,805,883 - 124,811,630 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	127,419,929 - 127,425,663 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	129,142,998 - 129,148,731 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	129,194,273 - 129,200,006 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	129,754,295 - 129,760,045 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	129,756,149 - 129,758,986 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	133,586,293 - 133,592,043 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	131,410,451 - 131,416,198 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	123,544,868 - 123,550,615 (+)	NCBI		Celera
RGSC_v3.1	5	131,417,530 - 131,420,383 (+)	NCBI
Cytogenetic Map	5	q35	NCBI

DMRTA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	50,417,550 - 50,423,443 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	50,417,550 - 50,423,468 (-)	Ensembl			hg38	GRCh38
GRCh37	1	50,883,222 - 50,889,115 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	50,655,812 - 50,661,729 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	50,596,127 - 50,599,063	NCBI
Celera	1	49,169,119 - 49,175,035 (-)	NCBI		Celera
Cytogenetic Map	1	p32.3	NCBI
HuRef	1	49,001,308 - 49,007,204 (-)	NCBI		HuRef
CHM1_1	1	51,000,873 - 51,006,767 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	50,297,157 - 50,303,048 (-)	NCBI		T2T-CHM13v2.0

Dmrta2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	109,835,222 - 109,840,896 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	109,835,250 - 109,840,884 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	109,977,989 - 109,983,691 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	109,978,053 - 109,983,687 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	109,650,630 - 109,656,289 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	109,475,985 - 109,481,616 (+)	NCBI		MGSCv36	mm8
Celera	4	108,318,012 - 108,323,671 (+)	NCBI		Celera
Cytogenetic Map	4	C7	NCBI
cM Map	4	51.37	NCBI

Dmrta2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	8,495,055 - 8,497,909 (+)	Ensembl
ChiLan1.0	NW_004955464	8,493,392 - 8,498,007 (+)	NCBI	ChiLan1.0	ChiLan1.0

DMRTA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	176,446,108 - 176,452,108 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	175,586,744 - 175,592,761 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	49,659,379 - 49,665,262 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	51,166,161 - 51,170,399 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

DMRTA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	10,706,096 - 10,710,506 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	10,856,530 - 10,860,875 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	10,842,633 - 10,846,982 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	10,844,098 - 10,846,907 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	10,642,900 - 10,647,244 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	10,731,267 - 10,735,476 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	10,748,208 - 10,752,562 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dmrta2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	65,233,995 - 65,240,604 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	10,175,686 - 10,182,301 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	10,175,742 - 10,181,596 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DMRTA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	161,616,646 - 161,621,904 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	161,616,646 - 161,622,591 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	149,319,448 - 149,324,965 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DMRTA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	82,489,938 - 82,496,302 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	82,492,299 - 82,495,173 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	34,697,589 - 34,703,671 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dmrta2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624859	2,645,733 - 2,648,559 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624859	2,644,569 - 2,649,581 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dmrta2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	42,677,040 - 42,682,810 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dmrta2
53 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	311
Count of miRNA genes:	185
Interacting mature miRNAs:	221
Transcripts:	ENSRNOT00000067277
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1582230	Bw78	Body weight QTL 78	3.2	0.0016	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	124314582	133270832	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
11528624	Bss114	Bone structure and strength QTL 114	6.54	3e-07	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	129627938	131996704	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	95062526	133270832	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	89369373	134369373	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	97492524	133270832	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	95062526	133270832	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

RH142714

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	124,800,896 - 124,801,071 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	129,749,306 - 129,749,480	NCBI	Rnor6.0
Rnor_5.0	5	133,581,304 - 133,581,478	UniSTS	Rnor5.0
RGSC_v3.4	5	131,405,462 - 131,405,636	UniSTS	RGSC3.4
Celera	5	123,539,879 - 123,540,053	UniSTS
RH 3.4 Map	5	822.9	UniSTS
Cytogenetic Map	5	q35	UniSTS

RH140568

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	124,804,647 - 124,804,833 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	129,753,060 - 129,753,245	NCBI	Rnor6.0
Rnor_5.0	5	133,585,058 - 133,585,243	UniSTS	Rnor5.0
RGSC_v3.4	5	131,409,216 - 131,409,401	UniSTS	RGSC3.4
Celera	5	123,543,633 - 123,543,818	UniSTS
RH 3.4 Map	5	822.5	UniSTS
Cytogenetic Map	5	q35	UniSTS

Dmrta2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	124,808,216 - 124,809,825 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	129,756,629 - 129,758,237	NCBI	Rnor6.0
Rnor_5.0	5	133,588,627 - 133,590,235	UniSTS	Rnor5.0
Celera	5	123,547,202 - 123,548,809	UniSTS
Cytogenetic Map	5	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	2	62	141	78	77	51	71	51	6	295	159	7	120	72	86	26	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006238589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067277 ⟹ ENSRNOP00000059247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	129,756,149 - 129,758,986 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099147 ⟹ ENSRNOP00000094808

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	130,034,473 - 130,040,222 (+)	Ensembl
mRatBN7.2 Ensembl	5	124,805,883 - 124,811,630 (+)	Ensembl

RefSeq Acc Id:

NM_001107951 ⟹ NP_001101421

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	130,034,473 - 130,040,222 (+)	NCBI
mRatBN7.2	5	124,805,883 - 124,811,633 (+)	NCBI
Rnor_6.0	5	129,754,295 - 129,760,042 (+)	NCBI
Rnor_5.0	5	133,586,293 - 133,592,043 (+)	NCBI
RGSC_v3.4	5	131,410,451 - 131,416,198 (+)	RGD
Celera	5	123,544,868 - 123,550,615 (+)	RGD

Sequence:

show sequence

GGACTACCCGGCCCGGGGCGAGCGCAGCGTCCGGAGCGCACCGAGGGGACGCGGGTTGCAACCA
GAGGGCCCCCGACCAGACCCCCGGCCCCGAGGCCCTCCGTGGTGTTGGACTGCTGTGTTCCCAG
AGGGGTCCGGAAGTTCGGACATGGTGGCTGAAGGAGGGTGACGTGGTCAGAGAAGGGGCCCAGG
GCAAAGGGACGAGGCTGAGAAAGCCGCTGAGCGAGCGGGGCTGGGCAACGCGTGCTGCGCCATC
GGAGGAGGAGCCAGGAGCTGGAGACAGGTCCAGCCATGGAGCTGCGCTCGGAGCTGCCCAGCGT
GCCCGGCGCGGCGACAGCAGCAGCGACAGCGACGGGACCACCCGTGGCATCCGTGGCGTCCGTG
GCTGCGGCGGCAGCTGCCGCAGCATCGCTACCAGTGAGCGTGGCCGGAGGCTTGCTGCGGGCGC
CGCCGCTGCTGTTGAGGGCAGCGGAGAAGTACCCGCGGACCCCCAAGTGCGCGCGCTGCCGCAA
CCACGGAGTGGTGTCCGCGCTCAAGGGCCACAAGCGCTACTGCCGCTGGAAGGACTGCCTGTGC
GCCAAGTGCACGCTCATCGCCGAGCGCCAGCGCGTCATGGCGGCCCAGGTGGCGTTGCGCAGGC
AGCAGGCGCAGGAGGAAAACGAGGCACGCGAGTTGCAACTGCTGTACGGCACTGCCGAGGGCCT
GGCGCTGGCCGCCGCCAACGGCATCATCCCACCGCGGCCAGCTTACGAAGTCTTTGGCTCGGTT
TGCGCCACCGACGGCGGGGGGCCGGGAGCTGGAGCGCCCGCGGGGAGTGCAGGGGGCGCTGGGG
GCGCAGGGGGCGCAGAGGCCAAGTTGCAGAAGTTTGATCTGTTTCCCAAGACGCTACTTCAGGC
CGGCCGCCCAGACAGTCCGCAGCCGCCGCCAGGGAAGCCCTTGTCGCCCGACGGCGCGGACTCA
GGTCCCGGGACCTCGTCCCCGGAGGTGCGGCCCGGTTCAGGCTCGGAGAACGGAGATGGCGAGT
CCTTTTCCGGGTCGCCTCTGGCCCGTGCCTCCAAGGAGGCGGGTGGCAGCTGTCCTGGGAGCGC
GGGCGCCAGCGGTGGCGGCGAGGAGGACAGCCCCGGCTCCTCCAGCCCCCTGGGTTCGGAATCG
GGCTCGGAAGCTGACAAAGAAGAAGCCGAGGCCGCACCGACTCCAGGGCTGGGCGGCGGGCCGG
GGCCGCGGCAGCGGACGCCGCTGGACATCTTGACGCGTGTCTTCCCGGGCCACCGGAGAGGCGT
CCTGGAGCTGGTGCTTCAGGGCTGTGGCGGCGACGTGGTGCAGGCCATTGAGCAGGTGCTCAAC
CACCACCGCGGAGGCCTGGCGGCCGGCCTGGGCCCCGCCGCGCCGCTGGAGAAAGCCGCGGTGA
GCGCGGCCGCGGCGGTGGAGGACGCGTGGCCCGGACGCGTGGAGGCAGCTAGGGGCACGGGGAG
CCGGGCTGCCCTCTCCGCTGCAGACCGGGCCCGCAGCGCCCCCGCACCACAGACCCTTGCTGGC
CGGGGCCATGACGCCCGGCGCGCTGGGCTCGCTCAGCAGCCGGTCCGCCTTCTCGCCTCTGCAG
CCCAACGCCAGCCACTTCGGCGCCGACGCGGGCGCCTACCCTCTGGGCGCGCCGCTCGGCCTGA
GCCCGCTGCGCCTGGCCTACTCCGCAGCAGCGGCCCACAGCCGCGGTCTGGCCTTCATGGCGCC
CTACTCCACGGCCGGCCTGGTGCCCACGCTCGGCTTCCGGCCGCCCATGGACTACGCCTTCAGC
GACCTCATGCGCGACCGCTCGGCCGCCGCCGCCGCCGCGGTGCACAAGGAGCCCGGTTACGGGG
GCGGGCTGTACGGGCCCATGGTCAACGGCACCCCTGAGAAGCAGTAGGGTACGGGGACCGACAG
CCCGAACACCCCGAAACATCGACCCAGCCTGCTTCCCCAGTCGCGGACCCCTCCTCGCTCTGCC
CTGCGCCCTCCGCTCACAATTGGCTTTAGGGGCTTCTTTGGGAGGGTGGGTGAGTGGGTGGGAG
CATCTCGGCTGACCCTGCAGGTGTCCTCAGAGGAGCCTTGTGGTCTGGGTGCTCTTCCCACCTC
CGGCCACCTTCCCCTAGGCCTGCTCGCCCTGTTGTCAAGAGGCTGGGGATCCCTAAGAACCCCG
AGGGCGACTGCGGCCTCGCTCGCCTCTGCTGCTCCCTCTGCTCCGCTCGCCTTTCCAGCCCTCG
CTCAGGTGGATGGCAGGATGGATCAGCCCCTTGTGTGTCCTCCAATACCCATTCCCCTTTCGTT
TAAAAAAAAATCCGCTCTAACAAATATAAATTTAGGATGTATACATCTCTTGGCACTGAGTCGA
GTCTTTGGGACACATATATATCGATATCAATTGTAAAAAAAAAAAAAAAAGGAAACGTTCTAAG
GTGCACTTTCCTCGTTGCGGTATTTGTCGCTCTCTTTGTTGCTTATGCGGATAAGCATGGGTTT
CCTTGGTGCAGTGTGAGTTTTTATATATGTATAAATCTATATATAATCTATACATATATATATA
CAAGCCAGTGTATAATGTTATAAAATGGAATTCTAAGTTATTAATTGTAATCTGTAGGTGACCT
CGGTATTAACGTGAAAAACACTCAAAAATCAAAGCAAAAAAAAAAAGGACAAAATGGAAAAAAT
TAGACTATTCGCGCATTGTACGTATCGGGTTTCATAGCTGAAATCTACTGTTCGCTGGGGAGGA
ACCCTGCCGATCCCTGGCCCCCGGCCTGCGGCTGTTCTCCAAAGCTGTCCAGGCTGCGCTGGAG
CACGAATAAAGCGTCGGGTGAGCGAGCCAGAAGCTCCGGGACTCGCCAGCAAGCGACGCTGCGC
AGAACTGCTCACTTTGTGCTTTCCTTTGCATAGGTATGAGCTAGAAATAAATGTTATTTTCTAA
AT

hide sequence

RefSeq Acc Id:

XM_039109960 ⟹ XP_038965888

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	130,034,765 - 130,040,283 (+)	NCBI
mRatBN7.2	5	124,806,320 - 124,811,694 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101421	(Get FASTA)	NCBI Sequence Viewer
	XP_038965888	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90352	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000094808
	ENSRNOP00000094808.1

RefSeq Acc Id:

NP_001101421 ⟸ NM_001107951

- UniProtKB:

A0A8I6ANN9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELRSELPSVPGAATAAATATGPPVASVASVAAAAAAAASLPVSVAGGLLRAPPLLLRAAEKYP
RTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIAERQRVMAAQVALRRQQAQEENEAREL
QLLYGTAEGLALAAANGIIPPRPAYEVFGSVCATDGGGPGAGAPAGSAGGAGGAGGAEAKLQKF
DLFPKTLLQAGRPDSPQPPPGKPLSPDGADSGPGTSSPEVRPGSGSENGDGESFSGSPLARASK
EAGGSCPGSAGASGGGEEDSPGSSSPLGSESGSEADKEEAEAAPTPGLGGGPGPRQRTPLDILT
RVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPLEKAAVSAAAAVEDAWPG
RVEAARGTGSRAALSAADRARSAPAPQTLAGRGHDARRAGLAQQPVRLLASAAQRQPLRRRRGR
LPSGRAARPEPAAPGLLRSSGPQPRSGLHGALLHGRPGAHARLPAAHGLRLQRPHARPLGRRRR
RGAQGARLRGRAVRAHGQRHP

hide sequence

Ensembl Acc Id:

ENSRNOP00000059247 ⟸ ENSRNOT00000067277

RefSeq Acc Id:	XP_038965888 ⟸ XM_039109960
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ANN9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000094808 ⟸ ENSRNOT00000099147

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A0L2-F1-model_v2	AlphaFold	D4A0L2	1-532	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308173	AgrOrtholog
BioCyc Gene	G2FUF-40342	BioCyc
Ensembl Genes	ENSRNOG00000008105	Ensembl
	ENSRNOG00000068045	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000099147	ENTREZGENE
	ENSRNOT00000099147.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.1040.10	UniProtKB/TrEMBL
InterPro	DM_DNA-bd	UniProtKB/TrEMBL
	DM_DNA-bd_sf	UniProtKB/TrEMBL
	DMA	UniProtKB/TrEMBL
	DMRT	UniProtKB/TrEMBL
	DMRT5_1_DMB_dom	UniProtKB/TrEMBL
	UBA-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:313471	UniProtKB/TrEMBL
NCBI Gene	313471	ENTREZGENE
PANTHER	DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A2	UniProtKB/TrEMBL
	PTHR12322	UniProtKB/TrEMBL
Pfam	DMA	UniProtKB/TrEMBL
	DMRT5_DMB	UniProtKB/TrEMBL
	PF00751	UniProtKB/TrEMBL
PhenoGen	Dmrta2	PhenoGen
PROSITE	DM_1	UniProtKB/TrEMBL
	DM_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008105	RatGTEx
	ENSRNOG00000068045	RatGTEx
SMART	SM00301	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46934	UniProtKB/TrEMBL
	SSF82927	UniProtKB/TrEMBL
UniProt	A0A8I6ANN9	ENTREZGENE, UniProtKB/TrEMBL
	A6JZ01_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-17	Dmrta2	DMRT-like family A2	Dmrta2	doublesex and mab-3 related transcription factor like family A2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Dmrta2	doublesex and mab-3 related transcription factor like family A2	Dmrta2_predicted	doublesex and mab-3 related transcription factor like family A2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dmrta2_predicted	doublesex and mab-3 related transcription factor like family A2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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