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Gene: Cul1 (cullin 1) Rattus norvegicus

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Symbol:

Cul1

Name:

cullin 1

RGD ID:

1308157

Description:

Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within several processes, including protein ubiquitination; regulation of autophagy; and regulation of intracellular signal transduction. Predicted to be located in plasma membrane. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human CUL1 (cullin 1); PARTICIPATES IN neddylation pathway; Notch signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH aconitine; bisphenol A; Brodifacoum.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cullin-1; LOC362356

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CUL1 (cullin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cul1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cul1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CUL1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CUL1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cul1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CUL1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CUL1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cul1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cul1 (cullin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CARMIL2 (capping protein regulator and myosin 1 linker 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CUL1 (cullin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cul1 (cullin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cul1a (cullin 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cul1b (cullin 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cul1b (cullin 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	CDC53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cul1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cul1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cul-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cul-6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cul-6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cul1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cul1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	77,551,781 - 77,634,210 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	77,551,787 - 77,621,760 (+)	Ensembl				GRCr8
mRatBN7.2	4	76,551,952 - 76,625,830 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	76,551,983 - 76,627,980 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	81,518,199 - 81,586,396 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	77,431,538 - 77,499,741 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	75,811,714 - 75,879,914 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	77,211,814 - 77,283,369 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	77,211,692 - 77,280,250 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	141,883,675 - 141,954,829 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	75,636,914 - 75,705,724 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	71,356,492 - 71,424,907 (+)	NCBI		Celera
RGSC_v3.1	4	75,913,432 - 75,981,935 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Stevens-Johnson syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

aconitine (EXP)

acrolein (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bortezomib (ISO)

Brodifacoum (EXP)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

copper(II) sulfate (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dieldrin (EXP)

endosulfan (EXP)

ethanol (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glyphosate (ISO)

hydralazine (ISO)

isobutanol (ISO)

isoprenaline (EXP)

ivermectin (ISO)

L-methionine (ISO)

methidathion (ISO)

methylseleninic acid (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel dichloride (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

pevonedistat (ISO)

phlorizin (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

rimonabant (ISO)

sertraline (ISO)

tamibarotene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

apoptotic process (IEA,ISO)

biological_process (ND)

cell population proliferation (ISO)

cellular response to oxidative stress (IEA,ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA,ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA,ISO)

protein K48-linked ubiquitination (IEA,ISO)

protein monoubiquitination (ISO)

protein ubiquitination (IBA,IEA,ISO)

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

cullin-RING ubiquitin ligase complex (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Parkin-FBXW7-Cul1 ubiquitin ligase complex (IEA,ISO)

plasma membrane (IEA,ISO)

protein-containing complex (ISO)

SCF ubiquitin ligase complex (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

ubiquitin ligase complex scaffold activity (IBA,IEA,ISO)

ubiquitin protein ligase binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

Endoplasmic Reticulum-associated degradation pathway (IEA)

neddylation pathway (ISS)

Notch signaling pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

nuclear factor, erythroid 2 like 2 signaling pathway (ISO)

proteasome degradation pathway involving cullin-dependent ubiquitin ligases (ISS)

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

Wnt signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.	Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
4.	Expanding role of ubiquitination in NF-kappaB signaling.	Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).	Morimoto M, etal., Biochem Biophys Res Commun. 2000 Apr 21;270(3):1093-6.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.	Zheng N, etal., Nature. 2002 Apr 18;416(6882):703-9.

Additional References at PubMed

PMID:10508527	PMID:11158290	PMID:11956208	PMID:12140560	PMID:12477932	PMID:12628165	PMID:12665572	PMID:14673179	PMID:15103331	PMID:15145941	PMID:16880511	PMID:17062563
PMID:19028597	PMID:20596027	PMID:21343341	PMID:21572392	PMID:21725316	PMID:22405651	PMID:22871113	PMID:23263282	PMID:23452856	PMID:25585578	PMID:28007894	PMID:29593216
PMID:31505169

Genomics

Comparative Map Data

Cul1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	77,551,781 - 77,634,210 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	77,551,787 - 77,621,760 (+)	Ensembl				GRCr8
mRatBN7.2	4	76,551,952 - 76,625,830 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	76,551,983 - 76,627,980 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	81,518,199 - 81,586,396 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	77,431,538 - 77,499,741 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	75,811,714 - 75,879,914 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	77,211,814 - 77,283,369 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	77,211,692 - 77,280,250 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	141,883,675 - 141,954,829 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	75,636,914 - 75,705,724 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	71,356,492 - 71,424,907 (+)	NCBI		Celera
RGSC_v3.1	4	75,913,432 - 75,981,935 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

CUL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	148,697,756 - 148,801,110 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	148,697,914 - 148,801,110 (+)	Ensembl			hg38	GRCh38
GRCh37	7	148,394,848 - 148,498,202 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	148,026,866 - 148,129,135 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	147,833,580 - 147,935,849	NCBI
Celera	7	143,066,358 - 143,168,625 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	142,474,925 - 142,577,198 (+)	NCBI		HuRef
CHM1_1	7	148,404,339 - 148,506,599 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	149,879,652 - 149,982,884 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	147,733,888 - 147,836,155 (+)	NCBI

Cul1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	47,430,516 - 47,503,078 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	47,430,332 - 47,503,073 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	47,453,732 - 47,526,144 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	47,453,398 - 47,526,139 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	47,404,323 - 47,476,138 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	47,383,910 - 47,455,725 (+)	NCBI		MGSCv36	mm8
Celera	6	47,309,280 - 47,381,243 (+)	NCBI		Celera
Cytogenetic Map	6	B2.3	NCBI
cM Map	6	22.9	NCBI

Cul1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	4,165,561 - 4,212,054 (+)	Ensembl
ChiLan1.0	NW_004955491	4,165,400 - 4,212,483 (+)	NCBI	ChiLan1.0	ChiLan1.0

CUL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	185,284,645 - 185,386,756 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	37,293,911 - 37,397,018 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	140,428,442 - 140,531,136 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	152,907,803 - 153,011,254 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	152,908,303 - 153,011,254 (+)	Ensembl			panPan2	panpan1.1

CUL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	1,995,637 - 2,086,853 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	1,995,960 - 2,052,864 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	3,094,500 - 3,190,996 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	1,800,318 - 1,893,359 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	1,800,261 - 1,893,706 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	1,786,922 - 1,879,856 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	1,646,255 - 1,739,205 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	1,650,453 - 1,743,455 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cul1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	7,883,967 - 7,967,988 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	4,971,000 - 5,019,562 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	4,971,002 - 5,019,465 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CUL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	109,454,534 - 109,557,649 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	109,454,523 - 109,559,114 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	120,392,339 - 120,495,724 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CUL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	117,271,477 - 117,373,983 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	117,271,548 - 117,374,379 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	13,218,021 - 13,323,070 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cul1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624800	6,877,986 - 6,978,587 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cul1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	93,226,734 - 93,295,038 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cul1
638 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	158
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000007620
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	59753119	104753119	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58817672	103817672	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58080146	80212111	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	71647492	116647492	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	51085655	113588029	Rat
2317588	Eae27	Experimental allergic encephalomyelitis QTL 27			nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	4	69036742	114036742	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	57613242	102613242	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	57613242	102613242	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	57613242	102613242	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58079875	82597589	Rat
2306547	Iddm38	Insulin dependent diabetes mellitus QTL 38			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	68353567	113353567	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	59836842	104836842	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	61041057	94638356	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	64209744	109209744	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58079875	92690793	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63224393	108224393	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	63900458	88813920	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	59603319	80216952	Rat

Markers in Region

AW532086

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	76,551,468 - 76,551,632 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	77,211,290 - 77,211,453	NCBI	Rnor6.0
Rnor_5.0	4	141,883,151 - 141,883,314	UniSTS	Rnor5.0
RGSC_v3.4	4	75,636,390 - 75,636,553	UniSTS	RGSC3.4
Celera	4	71,355,968 - 71,356,131	UniSTS
RH 3.4 Map	4	463.0	UniSTS
Cytogenetic Map	4	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007620 ⟹ ENSRNOP00000007620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,552,285 - 77,619,994 (+)	Ensembl
mRatBN7.2 Ensembl	4	76,552,463 - 76,620,235 (+)	Ensembl
Rnor_6.0 Ensembl	4	77,211,692 - 77,280,169 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085805 ⟹ ENSRNOP00000074678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,552,285 - 77,620,002 (+)	Ensembl
mRatBN7.2 Ensembl	4	76,552,444 - 76,620,160 (+)	Ensembl
Rnor_6.0 Ensembl	4	77,212,203 - 77,280,250 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094075 ⟹ ENSRNOP00000076905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,552,285 - 77,621,760 (+)	Ensembl
mRatBN7.2 Ensembl	4	76,551,983 - 76,627,980 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117165 ⟹ ENSRNOP00000081597

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,552,393 - 77,619,967 (+)	Ensembl
mRatBN7.2 Ensembl	4	76,552,730 - 76,620,165 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118452 ⟹ ENSRNOP00000094688

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,551,787 - 77,620,004 (+)	Ensembl
mRatBN7.2 Ensembl	4	76,551,983 - 76,620,248 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000154546 ⟹ ENSRNOP00000106643

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	77,552,393 - 77,619,967 (+)	Ensembl

RefSeq Acc Id:

NM_001108627 ⟹ NP_001102097

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,551,825 - 77,619,988 (+)	NCBI
mRatBN7.2	4	76,551,993 - 76,620,164 (+)	NCBI
Rnor_6.0	4	77,211,814 - 77,280,169 (+)	NCBI
Rnor_5.0	4	141,883,675 - 141,954,829 (+)	NCBI
RGSC_v3.4	4	75,636,914 - 75,705,724 (+)	RGD
Celera	4	71,356,492 - 71,424,907 (+)	RGD

Sequence:

show sequence

CGACGCGAGGGCGGCGGGAAAACCTGGCGGAGGATTCCGCACGTCCGGCGGGACCTAGTTCGGC
GTTTGGGAAGCAGAGGCCATGGCTCCCAGGTTTGCCTGCAATGAGACTTTAATCTCTACACTTA
AAGAACATTCTTTCTGAGCTGCTGTGAATAAATTTGGAATGATATTGTCTATTTTCAACTAATG
GAGAACTAGCTGCATCTTGAACAAGGATTGCTGTATTGGACAACTTCAGAACATTGATCAAAAT
GTCATCAAACAGGAGTCAGAATCCTCATGGACTGAAGCAGATCGGTCTTGACCAGATCTGGGAT
GACCTCAGAGCTGGAATTCAGCAAGTGTACACCAGACAAAGCATGGCAAAGTCCAGATACATGG
AGCTCTACACTCATGTTTATAACTACTGTACTAGTGTGCATCAGTCCAACCAAGCCCGGGGTGC
TGGAGTCCCTCCTTCCAAGTCAAAAAAGGGGCAGACTCCTGGGGGAGCTCAGTTTGTCGGCTTG
GAGTTATACAAGCGATTGAAGGAGTTTTTGAAGAATTACTTGACAAATCTTCTTAAGGATGGAG
AAGATTTAATGGATGAGAGTGTGCTGAAGTTCTACACTCAGCAGTGGGAAGATTACCGATTCTC
CAGCAAAGTGCTGAATGGAATCTGTGCCTACCTCAATAGACATTGGGTTCGTCGCGAATGTGAT
GAAGGACGAAAAGGAATATATGAAATCTATTCGCTTGCGTTGGTGACATGGAGAGATTGTTTGT
TCAGGCCATTGAATAAACAGGTAACAAATGCTGTTTTAAAACTGATTGAGAAGGAAAGAAATGG
CGAAACCATCAATACAAGACTGATTAGTGGAGTTGTACAATCTTATGTGGAATTGGGACTGAAT
GAAGATGATGCATTTGCAAAGGGCCCTACGTTAACAGTGTATAAAGAATCCTTTGAATCTCAAT
TTTTGGCTGACACAGAGAGATTTTATACCAGAGAAAGTACTGAATTCTTACAGCAGAACCCAGT
TACTGAATATATGAAAAAGGCTGAAGCTCGTCTGCTTGAGGAACAGCGGAGAGTTCAGGTTTAT
CTCCATGAGAGCACACAAGATGAGCTAGCACGGAAATGTGAGCAGGTCCTCATTGAAAAACACT
TGGAAATTTTTCACACAGAGTTTCAGAATTTGTTGGATGCTGACAAGAATGAAGATTTGGGCCG
CATGTATAATCTTGTATCTAGAATTCAGGATGGCCTAGGAGAATTGAAAAAACTACTAGAGACA
CATATTCATAATCAGGGTCTTGCGGCAATTGAGAAGTGTGGAGAAGCTGCTCTGAATGACCCCA
AGATGTATGTGCAGACAGTGCTGGATGTTCATAAAAAATACAATGCCCTGGTGATGTCAGCATT
CAACAACGATGCTGGCTTCGTGGCTGCACTTGATAAGGCTTGTGGTCGCTTCATAAACAACAAT
GCAGTTACCAAAATGGCCCAGTCATCCAGTAAATCCCCTGAGCTTCTTGCTCGGTACTGTGACT
CCTTGTTGAAGAAAAGTTCTAAGAACCCAGAAGAGGCAGAACTAGAAGATACCCTCAATCAAGT
GATGGTGGTCTTCAAGTACATCGAGGACAAAGATGTATTTCAGAAGTTCTATGCAAAGATGCTT
GCCAAGAGACTGGTACATCAGAACAGTGCGAGTGACGATGCTGAAGCAAGCATGATCTCTAAAT
TAAAGCAAGCTTGTGGTTTTGAGTACACTTCCAAACTCCAGCGAATGTTTCAAGACATTGGTGT
AAGCAAAGATCTAAATGAACAGTTCAAAAAGCACCTGACGAATTCAGAACCACTGGACTTGGAC
TTCAGTATTCAGGTCCTGAGTTCCGGATCATGGCCCTTTCAGCAGTCTTGCACGTTTGCCTTGC
CGTCAGAGTTGGAGCGCAGTTACCAACGGTTTACAGCTTTCTACGCCAGCCGTCACAGTGGCAG
AAAATTGACATGGTTGTATCAACTGTCCAAAGGGGAACTAGTCACTAACTGCTTCAAAAACAGA
TACACTTTGCAGGCGTCCACATTCCAGATGGCCATCCTGCTTCAGTACAACACAGAAGACGCCT
ATACTGTGCAGCAGCTGACCGACAGCACTCAGATTAAAATGGACATTTTGGCACAAGTCCTACA
GATTTTACTGAAGTCAAAATTGCTGGTCTTAGAAGATGAAAATGCCAATGTTGATGAGGTGGAA
TTGAAGCCAGACACCTTAATAAAGTTATATCTTGGTTATAAAAATAAGAAATTGAGGGTTAATA
TCAATGTACCAATGAAAACTGAACAGAAGCAGGAACAAGAAACCACACACAAAAATATAGAGGA
AGACCGCAAACTACTGATTCAGGCGGCCATCGTAAGAATCATGAAAATGAGGAAGGTTCTGAAA
CACCAGCAGTTACTTGGTGAAGTCCTCACTCAGCTGTCCTCCAGGTTCAAACCTCGGGTCCCAG
TGATCAAGAAATGCATTGATATTCTCATCGAAAAAGAATATTTGGAGCGAGTCGATGGTGAGAA
GGACACCTACAGTTACTTGGCTTAACCCATCTAGCAGGGTCTCCGTGACCCACGAGCAGATAGT
TCCAGTGAATAAAGTGGAAACAACTCGAGTTCATAGCAGCCAGCCTGCCACCATTTGGACCTTC
CTTTTTAAAGCTGAGACCACAGTTTCCACCAGCTGGTCTCAAGCTACAGCAGGACTGCTCAGGA
CTGACACATTTCAGTCTGTAAACAGACGCCAATGCCATTTACCCTAACTCACAGACAGAGGGGA
ACCGAACCTTCCATGCTGAGGCTGCATGCTACCGCACTTAAATCAATACATTGGCTCCCTGGTT
AACAGCTGTCGTCTGAGGCAGCACACGAGAGCGAGTCTGAATGGACCCACGTGTAATCTGCTAT
GAAAACCATTTGTATAGTGTGTTTCATTTTTTTAATGTGTGAAAATAAAGAAAATTAAAGGAAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236411 ⟹ XP_006236473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,234 - 77,620,074 (+)	NCBI
mRatBN7.2	4	76,552,407 - 76,620,240 (+)	NCBI
Rnor_6.0	4	77,212,277 - 77,280,255 (+)	NCBI
Rnor_5.0	4	141,883,675 - 141,954,829 (+)	NCBI

Sequence:

show sequence

GCGCTGAGGGACGCGGCCAGACCTCGGCGGGCCCCGCGAGCACTACACGCCGCCCGAGCGTCGG
GGGGCGCCCGGAGATGCGGGTTTGCCTGCAATGAGACTTTAATCTCTACACTTAAAGAACATTC
TTTCTGAGCTGCTGTGAATAAATTTGGAATGATATTGTCTATTTTCAACTAATGGAGAACTAGC
TGCATCTTGAACAAGGATTGCTGTATTGGACAACTTCAGAACATTGATCAAAATGTCATCAAAC
AGGAGTCAGAATCCTCATGGACTGAAGCAGATCGGTCTTGACCAGATCTGGGATGACCTCAGAG
CTGGAATTCAGCAAGTGTACACCAGACAAAGCATGGCAAAGTCCAGATACATGGAGCTCTACAC
TCATGTTTATAACTACTGTACTAGTGTGCATCAGTCCAACCAAGCCCGGGGTGCTGGAGTCCCT
CCTTCCAAGTCAAAAAAGGGGCAGACTCCTGGGGGAGCTCAGTTTGTCGGCTTGGAGTTATACA
AGCGATTGAAGGAGTTTTTGAAGAATTACTTGACAAATCTTCTTAAGGATGGAGAAGATTTAAT
GGATGAGAGTGTGCTGAAGTTCTACACTCAGCAGTGGGAAGATTACCGATTCTCCAGCAAAGTG
CTGAATGGAATCTGTGCCTACCTCAATAGACATTGGGTTCGTCGCGAATGTGATGAAGGACGAA
AAGGAATATATGAAATCTATTCGCTTGCGTTGGTGACATGGAGAGATTGTTTGTTCAGGCCATT
GAATAAACAGGTAACAAATGCTGTTTTAAAACTGATTGAGAAGGAAAGAAATGGCGAAACCATC
AATACAAGACTGATTAGTGGAGTTGTACAATCTTATGTGGAATTGGGACTGAATGAAGATGATG
CATTTGCAAAGGGCCCTACGTTAACAGTGTATAAAGAATCCTTTGAATCTCAATTTTTGGCTGA
CACAGAGAGATTTTATACCAGAGAAAGTACTGAATTCTTACAGCAGAACCCAGTTACTGAATAT
ATGAAAAAGGCTGAAGCTCGTCTGCTTGAGGAACAGCGGAGAGTTCAGGTTTATCTCCATGAGA
GCACACAAGATGAGCTAGCACGGAAATGTGAGCAGGTCCTCATTGAAAAACACTTGGAAATTTT
TCACACAGAGTTTCAGAATTTGTTGGATGCTGACAAGAATGAAGATTTGGGCCGCATGTATAAT
CTTGTATCTAGAATTCAGGATGGCCTAGGAGAATTGAAAAAACTACTAGAGACACATATTCATA
ATCAGGGTCTTGCGGCAATTGAGAAGTGTGGAGAAGCTGCTCTGAATGACCCCAAGATGTATGT
GCAGACAGTGCTGGATGTTCATAAAAAATACAATGCCCTGGTGATGTCAGCATTCAACAACGAT
GCTGGCTTCGTGGCTGCACTTGATAAGGCTTGTGGTCGCTTCATAAACAACAATGCAGTTACCA
AAATGGCCCAGTCATCCAGTAAATCCCCTGAGCTTCTTGCTCGGTACTGTGACTCCTTGTTGAA
GAAAAGTTCTAAGAACCCAGAAGAGGCAGAACTAGAAGATACCCTCAATCAAGTGATGGTGGTC
TTCAAGTACATCGAGGACAAAGATGTATTTCAGAAGTTCTATGCAAAGATGCTTGCCAAGAGAC
TGGTACATCAGAACAGTGCGAGTGACGATGCTGAAGCAAGCATGATCTCTAAATTAAAGCAAGC
TTGTGGTTTTGAGTACACTTCCAAACTCCAGCGAATGTTTCAAGACATTGGTGTAAGCAAAGAT
CTAAATGAACAGTTCAAAAAGCACCTGACGAATTCAGAACCACTGGACTTGGACTTCAGTATTC
AGGTCCTGAGTTCCGGATCATGGCCCTTTCAGCAGTCTTGCACGTTTGCCTTGCCGTCAGAGTT
GGAGCGCAGTTACCAACGGTTTACAGCTTTCTACGCCAGCCGTCACAGTGGCAGAAAATTGACA
TGGTTGTATCAACTGTCCAAAGGGGAACTAGTCACTAACTGCTTCAAAAACAGATACACTTTGC
AGGCGTCCACATTCCAGATGGCCATCCTGCTTCAGTACAACACAGAAGACGCCTATACTGTGCA
GCAGCTGACCGACAGCACTCAGATTAAAATGGACATTTTGGCACAAGTCCTACAGATTTTACTG
AAGTCAAAATTGCTGGTCTTAGAAGATGAAAATGCCAATGTTGATGAGGTGGAATTGAAGCCAG
ACACCTTAATAAAGTTATATCTTGGTTATAAAAATAAGAAATTGAGGGTTAATATCAATGTACC
AATGAAAACTGAACAGAAGCAGGAACAAGAAACCACACACAAAAATATAGAGGAAGACCGCAAA
CTACTGATTCAGGCGGCCATCGTAAGAATCATGAAAATGAGGAAGGTTCTGAAACACCAGCAGT
TACTTGGTGAAGTCCTCACTCAGCTGTCCTCCAGGTTCAAACCTCGGGTCCCAGTGATCAAGAA
ATGCATTGATATTCTCATCGAAAAAGAATATTTGGAGCGAGTCGATGGTGAGAAGGACACCTAC
AGTTACTTGGCTTAACCCATCTAGCAGGGTCTCCGTGACCCACGAGCAGATAGTTCCAGTGAAT
AAAGTGGAAACAACTCGAGTTCATAGCAGCCAGCCTGCCACCATTTGGACCTTCCTTTTTAAAG
CTGAGACCACAGTTTCCACCAGCTGGTCTCAAGCTACAGCAGGACTGCTCAGGACTGACACATT
TCAGTCTGTAAACAGACGCCAATGCCATTTACCCTAACTCACAGACAGAGGGGAACCGAACCTT
CCATGCTGAGGCTGCATGCTACCGCACTTAAATCAATACATTGGCTCCCTGGTTAACAGCTGTC
GTCTGAGGCAGCACACGAGAGCGAGTCTGAATGGACCCACGTGTAATCTGCTATGAAAACCATT
TGTATAGTGTGTTTCATTTTTTTAATGTGTGAAAATAAAGAAAATTAAAGGATTTCTGTACAAG
TTGCATTTGGTTTTGTTTTAAGTTTTACTAATTTCTATTATGTAAATAAAAGATTTAATGATTG
TGCAAGTGTA

hide sequence

RefSeq Acc Id:

XM_063286252 ⟹ XP_063142322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,766 - 77,620,074 (+)	NCBI

RefSeq Acc Id:

XM_063286253 ⟹ XP_063142323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,766 - 77,620,074 (+)	NCBI

RefSeq Acc Id:

XR_010065657

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,234 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065658

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,551,781 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065659

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,766 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065660

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,559,626 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065661

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,234 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065662

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,234 - 77,634,210 (+)	NCBI

RefSeq Acc Id:

XR_010065663

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	77,552,234 - 77,634,210 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102097	(Get FASTA)	NCBI Sequence Viewer
	XP_006236473	(Get FASTA)	NCBI Sequence Viewer
	XP_063142322	(Get FASTA)	NCBI Sequence Viewer
	XP_063142323	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61932	(Get FASTA)	NCBI Sequence Viewer
	EDM15554	(Get FASTA)	NCBI Sequence Viewer
	EDM15555	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007620.6
	ENSRNOP00000074678
	ENSRNOP00000074678.3
	ENSRNOP00000076905.1
	ENSRNOP00000081597
	ENSRNOP00000081597.2
	ENSRNOP00000094688
	ENSRNOP00000094688.2
	ENSRNOP00000106643.1

RefSeq Acc Id:

NP_001102097 ⟸ NM_001108627

- UniProtKB:

B1WBY1 (UniProtKB/TrEMBL), A0A8I5ZSD2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARG
AGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRF
SSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERN
GETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNP
VTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLG
RMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSA
FNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQ
VMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIG
VSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSG
RKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVL
QILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE
EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGE
KDTYSYLA

hide sequence

RefSeq Acc Id:	XP_006236473 ⟸ XM_006236411
- Peptide Label:	isoform X1
- UniProtKB:	B1WBY1 (UniProtKB/TrEMBL), A0A8I5ZSD2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSNRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARG AGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRF SSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERN GETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNP VTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLG RMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSA FNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQ VMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIG VSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSG RKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVL QILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE EDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGE KDTYSYLA hide sequence

Ensembl Acc Id:

ENSRNOP00000007620 ⟸ ENSRNOT00000007620

Ensembl Acc Id:

ENSRNOP00000074678 ⟸ ENSRNOT00000085805

Ensembl Acc Id:

ENSRNOP00000081597 ⟸ ENSRNOT00000117165

Ensembl Acc Id:

ENSRNOP00000076905 ⟸ ENSRNOT00000094075

Ensembl Acc Id:

ENSRNOP00000094688 ⟸ ENSRNOT00000118452

RefSeq Acc Id:	XP_063142322 ⟸ XM_063286252
- Peptide Label:	isoform X1
- UniProtKB:	B1WBY1 (UniProtKB/TrEMBL), A0A8I5ZSD2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142323 ⟸ XM_063286253
- Peptide Label:	isoform X1
- UniProtKB:	B1WBY1 (UniProtKB/TrEMBL), A0A8I5ZSD2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000106643 ⟸ ENSRNOT00000154546

Protein Domains

Cullin family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WBY1-F1-model_v2	AlphaFold	B1WBY1	1-776	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693018

Promoter ID:

EPDNEW_R3541

Type:

initiation region

Name:

Cul1_1

Description:

cullin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	77,212,295 - 77,212,355	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308157	AgrOrtholog
BioCyc Gene	G2FUF-45012	BioCyc
Ensembl Genes	ENSRNOG00000005310	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007620.8	UniProtKB/TrEMBL
	ENSRNOT00000085805	ENTREZGENE
	ENSRNOT00000085805.3	UniProtKB/TrEMBL
	ENSRNOT00000094075.2	UniProtKB/TrEMBL
	ENSRNOT00000117165	ENTREZGENE
	ENSRNOT00000117165.2	UniProtKB/TrEMBL
	ENSRNOT00000118452	ENTREZGENE
	ENSRNOT00000118452.2	UniProtKB/TrEMBL
	ENSRNOT00000154546.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	Cullin Repeats	UniProtKB/TrEMBL
	Ring Box Chain A, domain 5	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9021933	IMAGE-MGC_LOAD
InterPro	Cullin	UniProtKB/TrEMBL
	Cullin_CS	UniProtKB/TrEMBL
	Cullin_homology	UniProtKB/TrEMBL
	Cullin_homology_sf	UniProtKB/TrEMBL
	Cullin_N	UniProtKB/TrEMBL
	Cullin_neddylation_domain	UniProtKB/TrEMBL
	Cullin_repeat-like_dom	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:362356	UniProtKB/TrEMBL
MGC_CLONE	MGC:187713	IMAGE-MGC_LOAD
NCBI Gene	362356	ENTREZGENE
PANTHER	PTHR11932	UniProtKB/TrEMBL
Pfam	Cullin	UniProtKB/TrEMBL
	Cullin_Nedd8	UniProtKB/TrEMBL
PhenoGen	Cul1	PhenoGen
PROSITE	CULLIN_1	UniProtKB/TrEMBL
	CULLIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005310	RatGTEx
SMART	CULLIN	UniProtKB/TrEMBL
	Cullin_Nedd8	UniProtKB/TrEMBL
Superfamily-SCOP	Cullin_homology	UniProtKB/TrEMBL
	Cullin_repeat-like	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	A0A0G2K8N8_RAT	UniProtKB/TrEMBL
	A0A8I5Y0H0_RAT	UniProtKB/TrEMBL
	A0A8I5ZSD2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GLA1_RAT	UniProtKB/TrEMBL
	A0ABK0LWU9_RAT	UniProtKB/TrEMBL
	B1WBY1	ENTREZGENE, UniProtKB/TrEMBL
	F7FMJ3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Cul1	cullin 1	Cul1_predicted	cullin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Cul1_predicted	cullin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)