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Gene: Meltf (melanotransferrin) Rattus norvegicus

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Symbol:

Meltf

Name:

melanotransferrin

RGD ID:

1308155

Description:

Predicted to enable iron ion binding activity. Predicted to be involved in several processes, including negative regulation of substrate adhesion-dependent cell spreading; positive regulation of extracellular matrix disassembly; and positive regulation of plasminogen activation. Predicted to be located in cell surface. Predicted to be active in endosome; extracellular space; and plasma membrane. Orthologous to human MELTF (melanotransferrin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; LOC288038; Magea1; melanoma antigen, family A, 1; Mfi2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MELTF (melanotransferrin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Meltf (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Meltf (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MELTF (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MELTF (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Meltf (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MELTF (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MELTF (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Meltf (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Meltf (melanotransferrin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MELTF (melanotransferrin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Meltf (melanotransferrin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tsf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tsf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	meltf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	meltf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	82,389,420 - 82,411,270 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	82,389,420 - 82,411,270 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,884,446 - 68,906,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,884,446 - 68,906,300 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,721,502 - 77,743,348 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	70,378,082 - 70,399,924 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,410,595 - 69,432,442 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	72,135,311 - 72,158,106 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	72,135,668 - 72,157,522 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	75,210,907 - 75,232,739 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,706,384 - 70,728,239 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	68,306,411 - 68,328,215 (-)	NCBI		Celera
RGSC_v3.1	11	70,763,761 - 70,789,919 (-)	NCBI
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

curcumin (ISO)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

folic acid (ISO)

formaldehyde (ISO)

L-methionine (ISO)

mercury dibromide (ISO)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

ochratoxin A (EXP)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paricalcitol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

phosphorus atom (ISO)

phosphorus(.) (ISO)

progesterone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

iron ion transport (IBA,IEA,ISO)

monoatomic ion transport (IEA)

negative regulation of substrate adhesion-dependent cell spreading (IEA,ISO)

positive regulation of extracellular matrix disassembly (IEA,ISO)

positive regulation of plasminogen activation (IEA,ISO)

regulation of cell growth (ISO)

regulation of cell population proliferation (ISO)

Cellular Component

cell surface (IEA,ISO)

early endosome (IBA)

extracellular region (IEA)

extracellular space (IBA,IEA)

plasma membrane (IBA,IEA,ISO)

recycling endosome (IBA)

side of membrane (IEA)

Molecular Function

iron ion binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7556058	PMID:15469901	PMID:16291590	PMID:16713448	PMID:19056867	PMID:19199708	PMID:20458337	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Meltf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	82,389,420 - 82,411,270 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	82,389,420 - 82,411,270 (-)	Ensembl				GRCr8
mRatBN7.2	11	68,884,446 - 68,906,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	68,884,446 - 68,906,300 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	77,721,502 - 77,743,348 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	70,378,082 - 70,399,924 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	69,410,595 - 69,432,442 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	72,135,311 - 72,158,106 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	72,135,668 - 72,157,522 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	75,210,907 - 75,232,739 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	70,706,384 - 70,728,239 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	68,306,411 - 68,328,215 (-)	NCBI		Celera
RGSC_v3.1	11	70,763,761 - 70,789,919 (-)	NCBI
Cytogenetic Map	11	q22	NCBI

MELTF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	197,001,740 - 197,029,817 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	196,980,590 - 197,029,874 (-)	Ensembl			hg38	GRCh38
GRCh37	3	196,728,611 - 196,756,688 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	198,214,553 - 198,241,083 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	198,234,134 - 198,244,952	NCBI
Celera	3	195,315,485 - 195,343,561 (-)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	194,028,926 - 194,056,861 (-)	NCBI		HuRef
CHM1_1	3	196,699,891 - 196,727,973 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	199,727,923 - 199,756,006 (-)	NCBI		T2T-CHM13v2.0

Meltf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	31,697,449 - 31,717,838 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	31,697,628 - 31,717,838 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	31,878,629 - 31,899,020 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	31,878,810 - 31,899,020 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	31,878,896 - 31,899,106 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	31,798,557 - 31,818,767 (+)	NCBI		MGSCv36	mm8
Celera	16	32,372,678 - 32,392,986 (+)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	22.4	NCBI

Meltf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	13,035,309 - 13,055,548 (-)	Ensembl
ChiLan1.0	NW_004955420	13,036,767 - 13,055,477 (-)	NCBI	ChiLan1.0	ChiLan1.0

MELTF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	194,871,162 - 194,899,434 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	194,877,388 - 194,904,154 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	194,345,474 - 194,373,690 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	204,283,094 - 204,310,867 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	204,262,182 - 204,310,710 (-)	Ensembl			panPan2	panpan1.1

MELTF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	29,985,007 - 30,006,437 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	29,985,206 - 30,003,742 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	30,009,799 - 30,029,326 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	30,234,505 - 30,254,139 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	30,234,535 - 30,254,104 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	30,028,940 - 30,048,487 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	30,065,764 - 30,085,678 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	30,687,031 - 30,706,694 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Meltf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	143,060,677 - 143,084,817 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936833	853,007 - 875,547 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936833	853,925 - 875,069 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MELTF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	133,094,863 - 133,122,065 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	133,094,869 - 133,122,092 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	142,726,198 - 142,753,704 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MELTF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	90,225,699 - 90,254,893 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	90,225,780 - 90,255,263 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	64,002,116 - 64,030,310 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Meltf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	61,971,877 - 61,988,902 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	61,967,868 - 61,990,576 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Meltf
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	16,719,084 - 16,737,642 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Meltf
85 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	269
Count of miRNA genes:	163
Interacting mature miRNAs:	204
Transcripts:	ENSRNOT00000002373
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	73308487	96070872	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	58928336	99753367	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
1549848	Bvd6	Brain ventricular dilatation QTL 6	3.1	0.0001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	79618519	99753367	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	73850894	99753367	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	54415391	96071021	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	58931822	92356038	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	57754837	96071021	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	67962184	99753367	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	68599321	96497754	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	69855943	99753367	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	73308315	99753367	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	51071021	96071021	Rat

Markers in Region

BQ190983

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	68,885,411 - 68,885,603 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	72,136,634 - 72,136,825	NCBI	Rnor6.0
Rnor_5.0	11	75,211,873 - 75,212,064	UniSTS	Rnor5.0
RGSC_v3.4	11	70,707,350 - 70,707,541	UniSTS	RGSC3.4
Celera	11	68,307,377 - 68,307,568	UniSTS
RH 3.4 Map	11	405.2	UniSTS
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	7	47	140	67	67	36	66	36	6	273	142	11	114	74	92	31	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002373 ⟹ ENSRNOP00000002373

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	82,389,420 - 82,411,270 (-)	Ensembl
mRatBN7.2 Ensembl	11	68,884,446 - 68,906,300 (-)	Ensembl
Rnor_6.0 Ensembl	11	72,135,668 - 72,157,522 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116374 ⟹ ENSRNOP00000093219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	68,884,446 - 68,901,990 (-)	Ensembl

RefSeq Acc Id:

NM_001105872 ⟹ NP_001099342

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	82,389,420 - 82,411,270 (-)	NCBI
mRatBN7.2	11	68,884,446 - 68,906,300 (-)	NCBI
Rnor_6.0	11	72,135,668 - 72,157,522 (-)	NCBI
Rnor_5.0	11	75,210,907 - 75,232,739 (-)	NCBI
RGSC_v3.4	11	70,706,384 - 70,728,239 (-)	RGD
Celera	11	68,306,411 - 68,328,215 (-)	RGD

Sequence:

show sequence

GGTGTGTTGAGGGGCGTGGACTCTTCCAGGACTGCGCTTAAATAGTGAAGGGCCAAAGAGACCA
GGGAGGAGGAAGCCAGGACGGACCCGCCAGCACCCCAGCCAACCCAACGTTGCCATGAGGCTCC
TGAGCGTGACTTTTTGGCTACTCCTGTCCCTGCGCACTGTCCTCTGTGTGATGGAGATGCAGTG
GTGTACCATCTCAGACCCGGAACAGCAGAAATGCAAGGACATGAGCAAGGCTTTCCAGGGAGCT
GGAATTCAGCCCTCCCTCCTCTGCGTCCAGGGCACCTCCACTGACCACTGCGTCCAGCTCATCA
AGGACCAAAAAGCGGATGCCATCACCCTGGATGGAGGAGCCATCTATCAGGCTGGCAAGGAGTA
TGGCCTGAAGCCAGTGGTGGGTGAAGTCTATGACCAAGACATTGGGACTTCCTATTATGCGGTG
GCTGTGGTCAGGAGGAATTCCAATGTGACCATCAACACCCTGAAGGGCGTCAAGTCCTGCCACA
CTGGCATTAACCGGACTGTGGGCTGGAATGTGCCTGTCGGCTACCTCGTAGAGACTGGCCATCT
GTCAGTGATGGGCTGCGATGTGCTCAAAGCCGTTGGCGATTATTTTGGGGGCAGCTGTGTCCCT
GGAGCGGGAGAAACCAGCCATTCCGAGTCCCTCTGTCGCCTCTGCCGTGGTGACTCTTCTGGGC
ACAATGTGTGTGACAAGAGTCCCCTAGAGAGATACTATGACTACAGCGGAGCCTTCCGGTGCCT
GGCGGAAGGAGCCGGTGATGTGGCCTTCGTGAAGCACAGCACAGTGTTGGAGAACACTGATGGG
AAAACCCTGCCTTCCTGGGGCAAGGCCCTGATGTCACAGGACTTCCAGCTACTCTGCAGGGACG
GCAGCCGGGCTGACATTACTGAGTGGAGACGATGCCACTTGGCCAAGGTGCCTGCTCATGCTGT
GGTGGTCAGGGATGACATGGACGGAGGCCTCATATTCCGGCTGCTCAACGAAGGCCAGCTTCTG
TTCAGCCATGAAGACAGCAGCTTCCAGATGTTCAGCTCCAAAGCCTACGGCCAGAAGAACTTGC
TGTTCAAAGACTCCACCCTAGAGCTCGTGCCCATTGCCACACAGAACTATGAGTCCTGGCTGGG
CCAGGAATACCTGCATGCCATGAAGGGGCTGCTCTGTGATCCCAACCGGCTGCCCCACTACCTG
CGCTGGTGTGTGTTGTCGGTGCCCGAGATCCAGAAGTGTGGCGATATGGCTGTGGCCTTCAGCC
GCCAGAGTCTGAAGCCAGAGATCCAGTGTGTGTCAGCCGAGTCCCCTGAGCACTGCATGCAGCA
GATCCAGGCTGGGCACATCGATGCTGTGACTCTGAGGGGCGAAGACATTTACAGGGCAGGAAAG
GCATATGGCCTGGTTCCGGCGGCTGGGGAGCTGTATGCTGAGGAGGACAGGAGTAATTCCTACT
TTGTGGTGGCTGTGGTGAGGCGGGACAGCTCCTACTCCTTCACCCTGGATGAGCTTCGCAGCAA
GCGTTCCTGCCACCCAGGCTTGGGCAGCCCTGCGGGCTGGGAGGTGCCCATAGGCTCCCTCATC
CAGCGGGGCTTCATCCGGCCCAAGGACTGTGATGTGCTCACAGCGGTGAGCGAGTTCTTCAATG
CCAGCTGTGTGCCTGTAAACAACCCTAAGAACTACCCCTCCTCACTGTGCGCGCTCTGCGTGGG
AGATGAGAAGGGCCGCAACAAGTGTGTGGGCAGCAGCCAGGAGAGATACTACGGCTACAGTGGG
GCCTTCAGGTGCCTTGTGGAGAATGCAGGGGACGTTGCCTTCCTCAAGCACACAACTGTCTTTG
AGAACACAAATGGTCACAATCCTGAGCCCTGGGCTTCTCACCTCAGGTGGCAAGACTATGAACT
ACTGTGCCCCAATGGGGCACGGGCTGAGGTAGACCAGTTCCAAGCTTGCAACCTGGCACAAATG
CCATCCCATGCTGTCATGGTTCATCCAGACACCAACATCTTCACTGTGTACGGACTTCTGGACA
AGGCCCAGGACCTATTTGGAGACGACCACAACAAGAACGGTTTCCAAATGTTTGACTCCTCCAA
ATACCACAGCCAAGATCTGCTTTTCAAAGATGCTACGGTCCGAGCAGTGCCCGTCCGGGAGAAA
ACCACGTATCTGGACTGGCTGGGTCCTGACTACGTGGTTGCTCTGGAGGGGATGCTATCTCAGC
AGTGCTCGGGTGCAGGGGCCGCGGTGCACCGAGTCCCCCCACCGGCCCTGCTCCTGCTGGCCCT
GGCTGCAGGCCTCCTCCCGCGAGTTCTCTGAAGGTGGCTGCTTCAGGCCACGCCCTGCCCAGGA
AAAGCTACAGAATCCAACCCAAGAAACCAGGAAATCAGCTAACCCTGCAGGAGAGCGCGAGATG
CGATGCGAGAGGCAAGGTGAGAATTCACACGCACAACCCTCCGATGTGCGATTCTAACCCAAAG
AGAAATTTCTAGAATCAGGATGATTGTTAACGCCAAGTCTTCCCACCTGCCGGAGCCCTCAGTA
CCTGAGGCGACTGGCGAGCAGCCCAGTCACTCCTCCCACACTGGTGGCGCCTGCAGCGAACCTG
TGCCTCCCTCCCACCTGGAACCTCCCGGCTGGCTGGGGGATTGGGGGAGGGGAGAGAGAGAGAG
AGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAGG
CTGGTTGCCATGGCAACCGTGGAGCTGCTTCCAGCCTCTGAACTGGTCACGTGGTTGGGGGAGT
GCCAAGGAAGGAGCGCAACACCAACCTCCTTGACCAGCCAGCAGCCCCTGCTCTTGCTGCCCCA
CCCCACGCACTCTCCTGTGGACACTTGCTCACCAAGGCTCGGGCCACGCCCTCGGAAGAGCAGG
GTTGCCGAGCACATCAGCTTTTGTCATTGTCTTCTGTGACACTAACCAAGGACCCCAGCCCACT
GGACAACAGATTTTGCCAGACTGGGATGGGAGGAAAGCCAGAGCTGTACTGAGGGGGTGAAGTC
TCCAAAAATCCTCAGAGGACGGAAGTGCCCCTCCTAGTAAGAATGTTAATGGGTGAGGAACTTG
ATGCAGGGAGAGAACTATCCTGCTTAACAGCTCCTGCCTCAAACAGGACTTGCCCTGCCCTGCC
TGGACCTCACTGCACAATGAAACTGTCGCCTAGAATCTACCGTTCGCTCTCCTGATCTCAATCT
CAACATTACCTTTCTCTCTGCTTCATATACCCCTTCCCACAATCAACACACATGCACAGGCACA
TGCACGCGCGCACGCGCACATGCACGCACACATGCACGCACATGGACACACGTCCCTTATCTCT
GTGTGAGCATATCTGCTTGTCTGAAGAAGCATGAGTTAACCCAAAATAAGAGCCTTTCATGAAC
TGGGCTTTAGGACACACCACGGAGCCAAGGGATTGGGAAGAACCCTGTCTTCCCCTGACCTTGC
GTGTTGACCGGTTGTATCTTTGGAGAGGGTCCCTGGTTCCCAAGAGCTGTAAGAGCCAAGGCCT
AGGGAAGAGCCTCTTCTCCACCATTTTGCCATTGTTCTCTCGAGAACCAGAAAAAGTTTTCCAA
AGCTACCAACTCTTACTCCAAATCGTGTTCCTTTAAAACTAATAAATAAAACGGGGAGGAAATA
GGATCAAGCAGCCCTCGTCAGCACACTGGAAGCAGCGTGGGCCTGGAGTTATTTTCGTCTTGGT
CTGTGTGGGGGGCCTCAGGATGCTGATGACAGGCCAGGTTCCCAGTGGCTCGCCCCCACCTGTG
GGTGCCGGGACAGATCCGTACATGGCTCACCAGTGTCCCAGCCAGAGTCACACAGTCCTGAGGA
ATCTCCGGTCACCATGCTGCTTCGGAGAGCAAGCCCCTCCTCTCAGTACACAGCCATCCATTCT
TCCCTGAGCTGAGGGCTTTCACAGTGAGAAGTGTACTGTGTGTGGGCGACCGTGCTGCCCAAAG
TGTGATGTCTGCACCGTGTGCTTTCCAGGTGTGATTTTTCCAGAGCGCTCTGTAAATGACGTCT
GATTGCCATGGGCCACTGCCGTGTTAGTGCTAAAGAAAGACATTGGTTTCTTTTTAAATAAAGC
CAAATATCCCTGCATACGCAGAGGCTTGGATCCTGGTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099342	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM11456	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002373
	ENSRNOP00000002373.5

RefSeq Acc Id:	NP_001099342 ⟸ NM_001105872
- Peptide Label:	precursor
- UniProtKB:	D4ADK7 (UniProtKB/TrEMBL), A6IRV3 (UniProtKB/TrEMBL), A0A8I6AJB3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLLSVTFWLLLSLRTVLCVMEMQWCTISDPEQQKCKDMSKAFQGAGIQPSLLCVQGTSTDHCV QLIKDQKADAITLDGGAIYQAGKEYGLKPVVGEVYDQDIGTSYYAVAVVRRNSNVTINTLKGVK SCHTGINRTVGWNVPVGYLVETGHLSVMGCDVLKAVGDYFGGSCVPGAGETSHSESLCRLCRGD SSGHNVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGKALMSQDFQLL CRDGSRADITEWRRCHLAKVPAHAVVVRDDMDGGLIFRLLNEGQLLFSHEDSSFQMFSSKAYGQ KNLLFKDSTLELVPIATQNYESWLGQEYLHAMKGLLCDPNRLPHYLRWCVLSVPEIQKCGDMAV AFSRQSLKPEIQCVSAESPEHCMQQIQAGHIDAVTLRGEDIYRAGKAYGLVPAAGELYAEEDRS NSYFVVAVVRRDSSYSFTLDELRSKRSCHPGLGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSE FFNASCVPVNNPKNYPSSLCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVENAGDVAFLKHT TVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPSHAVMVHPDTNIFTVYG LLDKAQDLFGDDHNKNGFQMFDSSKYHSQDLLFKDATVRAVPVREKTTYLDWLGPDYVVALEGM LSQQCSGAGAAVHRVPPPALLLLALAAGLLPRVL hide sequence

Ensembl Acc Id:

ENSRNOP00000002373 ⟸ ENSRNOT00000002373

Ensembl Acc Id:

ENSRNOP00000093219 ⟸ ENSRNOT00000116374

Protein Domains

Transferrin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADK7-F1-model_v2	AlphaFold	D4ADK7	1-738	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308155	AgrOrtholog
BioCyc Gene	G2FUF-21067	BioCyc
Ensembl Genes	ENSRNOG00000001739	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002373	ENTREZGENE
	ENSRNOT00000002373.7	UniProtKB/TrEMBL
Gene3D-CATH	Periplasmic binding protein-like II	UniProtKB/TrEMBL
InterPro	Peptidase_S60	UniProtKB/TrEMBL
	Transferrin	UniProtKB/TrEMBL
	Transferrin_Fe_BS	UniProtKB/TrEMBL
KEGG Report	rno:288038	UniProtKB/TrEMBL
NCBI Gene	288038	ENTREZGENE
PANTHER	PTHR11485:SF21	UniProtKB/TrEMBL
	TRANSFERRIN	UniProtKB/TrEMBL
Pfam	Transferrin	UniProtKB/TrEMBL
PhenoGen	Meltf	PhenoGen
PIRSF	Transferrin	UniProtKB/TrEMBL
PRINTS	TRANSFERRIN	UniProtKB/TrEMBL
PROSITE	TRANSFERRIN_LIKE_1	UniProtKB/TrEMBL
	TRANSFERRIN_LIKE_2	UniProtKB/TrEMBL
	TRANSFERRIN_LIKE_3	UniProtKB/TrEMBL
	TRANSFERRIN_LIKE_4	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001739	RatGTEx
SMART	TR_FER	UniProtKB/TrEMBL
Superfamily-SCOP	Periplasmic binding protein-like II	UniProtKB/TrEMBL
UniProt	A0A8I6AJB3	ENTREZGENE
	A6IRV3	ENTREZGENE, UniProtKB/TrEMBL
	D4ADK7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Meltf	melanotransferrin	Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mfi2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	Mfi2_predicted	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mfi2_predicted	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD