Mzt2 (mitotic spindle organizing protein 2) - Rat Genome Database

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Gene: Mzt2 (mitotic spindle organizing protein 2) Rattus norvegicus
Analyze
Symbol: Mzt2 (Ensembl: Mzt2b)
Name: mitotic spindle organizing protein 2 (Ensembl:mitotic spindle organizing protein 2B)
RGD ID: 1308126
Description: Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome and spindle. Orthologous to human MZT2A (mitotic spindle organizing protein 2A) and MZT2B (mitotic spindle organizing protein 2B); INTERACTS WITH 1,2-dichloroethane (ortholog); 1,2-dimethylhydrazine (ortholog); 2,3',4,4',5-Pentachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fam128b; family with sequence similarity 128, member B; hypothetical protein LOC287929; LOC287929; mitotic spindle organizing protein 2B; mitotic-spindle organizing protein 2B; Mzt2b; RGD1308126; similar to RIKEN cDNA 2610001E06
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,528,236 - 98,535,340 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,511,832 - 98,550,487 (+)EnsemblGRCr8
mRatBN7.21185,024,120 - 85,031,960 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,024,315 - 85,031,167 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,751,403 - 93,757,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,412,568 - 86,418,491 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,466,164 - 85,472,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,276,869 - 89,283,939 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,277,039 - 89,282,929 (+)Ensemblrn6Rnor6.0
Rnor_5.01192,330,531 - 92,337,567 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,934,910 - 86,940,800 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,765,027 - 83,770,917 (+)NCBICelera
RGSC_v3.11186,975,458 - 86,981,573 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,IEA,ISO)
spindle  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21399614  


Genomics

Comparative Map Data
Mzt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,528,236 - 98,535,340 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1198,511,832 - 98,550,487 (+)EnsemblGRCr8
mRatBN7.21185,024,120 - 85,031,960 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,024,315 - 85,031,167 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1193,751,403 - 93,757,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,412,568 - 86,418,491 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,466,164 - 85,472,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,276,869 - 89,283,939 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,277,039 - 89,282,929 (+)Ensemblrn6Rnor6.0
Rnor_5.01192,330,531 - 92,337,567 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,934,910 - 86,940,800 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1183,765,027 - 83,770,917 (+)NCBICelera
RGSC_v3.11186,975,458 - 86,981,573 (+)NCBI
Cytogenetic Map11q23NCBI
MZT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,469,728 - 131,493,754 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,464,900 - 131,492,743 (-)Ensemblhg38GRCh38
GRCh372132,241,533 - 132,249,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,958,003 - 131,966,534 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2125,967,515 - 125,974,405 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2124,234,987 - 124,243,516 (-)NCBIHuRef
CHM1_12132,245,154 - 132,253,685 (-)NCBICHM1_1
T2T-CHM13v2.02131,904,493 - 131,928,522 (-)NCBIT2T-CHM13v2.0
Mzt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,666,305 - 15,681,233 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1615,666,305 - 15,681,233 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381615,848,441 - 15,863,369 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,848,441 - 15,863,369 (-)Ensemblmm10GRCm38
MGSCv371615,848,534 - 15,863,415 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361615,762,019 - 15,776,900 (-)NCBIMGSCv36mm8
Celera1616,419,723 - 16,434,603 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
LOC100153925
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11450,658,328 - 50,664,549 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,221,751 - 54,227,974 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:124
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000002511
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002511   ⟹   ENSRNOP00000002511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1189,277,039 - 89,282,929 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115744   ⟹   ENSRNOP00000082783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1198,511,832 - 98,536,120 (+)Ensembl
mRatBN7.2 Ensembl1185,024,315 - 85,031,167 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167814   ⟹   ENSRNOP00000110599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1198,511,832 - 98,550,487 (+)Ensembl
RefSeq Acc Id: NM_001105860   ⟹   NP_001099330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,440 - 98,534,330 (+)NCBI
mRatBN7.21185,024,276 - 85,030,166 (+)NCBI
Rnor_6.01189,277,039 - 89,282,929 (+)NCBI
Rnor_5.01192,330,531 - 92,337,567 (+)NCBI
RGSC_v3.41186,934,910 - 86,940,800 (+)RGD
Celera1183,765,027 - 83,770,917 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248729   ⟹   XP_006248791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,446 - 98,535,340 (+)NCBI
mRatBN7.21185,024,298 - 85,031,960 (+)NCBI
Rnor_6.01189,277,068 - 89,283,939 (+)NCBI
Rnor_5.01192,330,531 - 92,337,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248730   ⟹   XP_006248792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,279 - 98,535,340 (+)NCBI
mRatBN7.21185,024,126 - 85,031,960 (+)NCBI
Rnor_6.01189,276,869 - 89,283,939 (+)NCBI
Rnor_5.01192,330,531 - 92,337,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248731   ⟹   XP_006248793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,236 - 98,535,340 (+)NCBI
mRatBN7.21185,024,120 - 85,031,960 (+)NCBI
Rnor_6.01189,276,869 - 89,283,939 (+)NCBI
Rnor_5.01192,330,531 - 92,337,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088058   ⟹   XP_038943986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,471 - 98,535,340 (+)NCBI
mRatBN7.21185,024,318 - 85,031,960 (+)NCBI
RefSeq Acc Id: XM_039088059   ⟹   XP_038943987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81198,528,308 - 98,535,340 (+)NCBI
mRatBN7.21185,024,139 - 85,031,960 (+)NCBI
RefSeq Acc Id: NP_001099330   ⟸   NM_001105860
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248792   ⟸   XM_006248730
- Peptide Label: isoform X1
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248793   ⟸   XM_006248731
- Peptide Label: isoform X1
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248791   ⟸   XM_006248729
- Peptide Label: isoform X1
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002511   ⟸   ENSRNOT00000002511
RefSeq Acc Id: XP_038943987   ⟸   XM_039088059
- Peptide Label: isoform X1
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943986   ⟸   XM_039088058
- Peptide Label: isoform X1
- UniProtKB: A6JSR4 (UniProtKB/TrEMBL),   A0A8I5ZVW0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082783   ⟸   ENSRNOT00000115744
Ensembl Acc Id: ENSRNOP00000110599   ⟸   ENSRNOT00000167814

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA02-F1-model_v2 AlphaFold D4AA02 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698348
Promoter ID:EPDNEW_R8873
Type:initiation region
Name:Mzt2b_1
Description:mitotic spindle organizing protein 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8874  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01189,276,980 - 89,277,040EPDNEW
RGD ID:13698349
Promoter ID:EPDNEW_R8874
Type:multiple initiation site
Name:Mzt2b_2
Description:mitotic spindle organizing protein 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8873  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01189,277,503 - 89,277,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308126 AgrOrtholog
BioCyc Gene G2FUF-20543 BioCyc
Ensembl Genes ENSRNOG00000001834 Ensembl
  ENSRNOG00000066842 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115744 ENTREZGENE
  ENSRNOT00000115744.2 UniProtKB/TrEMBL
  ENSRNOT00000167814.1 UniProtKB/TrEMBL
InterPro MOZART2 UniProtKB/TrEMBL
KEGG Report rno:287929 UniProtKB/TrEMBL
NCBI Gene 287929 ENTREZGENE
PANTHER MITOTIC-SPINDLE ORGANIZING PROTEIN 2 UniProtKB/TrEMBL
  PTHR28578 UniProtKB/TrEMBL
Pfam MOZART2 UniProtKB/TrEMBL
PhenoGen Mzt2 PhenoGen
RatGTEx ENSRNOG00000001834 RatGTEx
  ENSRNOG00000066842 RatGTEx
UniProt A0A8I5ZVW0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M5Y9_RAT UniProtKB/TrEMBL
  A6JSR4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Mzt2  mitotic spindle organizing protein 2  Mzt2b  mitotic spindle organizing protein 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Mzt2b  mitotic spindle organizing protein 2B  Fam128b  family with sequence similarity 128, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam128b  family with sequence similarity 128, member B  RGD1308126_predicted  similar to RIKEN cDNA 2610001E06 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308126_predicted  similar to RIKEN cDNA 2610001E06 (predicted)  LOC287929_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287929_predicted  similar to RIKEN cDNA 2610001E06 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL