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Gene: Pals1 (protein associated with LIN7 1, MAGUK p55 family member) Rattus norvegicus

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Symbol:

Pals1

Name:

protein associated with LIN7 1, MAGUK p55 family member

RGD ID:

1308071

Description:

Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in myelin assembly and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC314259; MAGUK p55 subfamily member 5; membrane palmitoylated protein 5; membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Mpp5; protein associated with LIN7 1, MAGUK family member

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	103,327,965 - 103,384,543 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	103,281,154 - 103,387,209 (+)	Ensembl				GRCr8
mRatBN7.2	6	97,548,133 - 97,654,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	97,548,630 - 97,653,305 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	98,031,311 - 98,081,039 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	98,330,473 - 98,380,201 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	97,710,535 - 97,767,135 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	101,923,675 - 102,029,705 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	101,923,785 - 102,028,592 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	111,299,821 - 111,404,519 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	101,414,657 - 101,471,504 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	95,983,793 - 96,039,503 (+)	NCBI		Celera
RGSC_v3.1	6	101,370,971 - 101,477,629 (+)	NCBI
Cytogenetic Map	6	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Leber congenital amaurosis (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

Evodiamine (ISO)

fluvastatin (ISO)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen cyanide (ISO)

indole-3-methanol (EXP)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (ISO)

phenobarbital (ISO)

potassium cyanide (ISO)

propiconazole (EXP)

quercetin (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system neuron development (IEA,ISO,ISS)

cerebral cortex development (IEA,ISO,ISS)

establishment or maintenance of epithelial cell apical/basal polarity (IBA)

establishment or maintenance of polarity of embryonic epithelium (IBA)

gene expression (ISO)

generation of neurons (IBA)

intracellular protein localization (ISO)

morphogenesis of an epithelial sheet (IBA,IEA,ISO)

myelin assembly (IMP)

myelination (IEA)

peripheral nervous system myelin maintenance (IEA,ISO)

plasma membrane organization (ISO)

protein localization to myelin sheath abaxonal region (IEA,ISO)

protein localization to plasma membrane (IBA,IMP)

regulation of transforming growth factor beta receptor signaling pathway (IEA,ISO,ISS)

Cellular Component

adherens junction (IBA,IEA,ISO,ISS)

apical part of cell (IEA,ISO)

apical plasma membrane (IEA)

axon (IEA)

bicellular tight junction (IEA)

cell junction (IEA,ISO)

cytoplasm (IEA,ISO)

endomembrane system (IEA)

Golgi apparatus (IEA)

lateral loop (IEA,ISO)

myelin sheath adaxonal region (IEA,ISO)

perikaryon (IEA)

plasma membrane (IBA,IEA,ISO)

protein-containing complex (IDA,IEA,ISO)

Schmidt-Lanterman incisure (IEA,ISO)

Molecular Function

ATP binding (IEA)

identical protein binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.	Ozcelik M, etal., J Neurosci. 2010 Mar 17;30(11):4120-31. doi: 10.1523/JNEUROSCI.5185-09.2010.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis.	Wong EW, etal., Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62. Epub 2008 Jul 10.

Additional References at PubMed

PMID:10753959	PMID:12477932	PMID:15914641	PMID:16885194	PMID:17332497	PMID:19056867	PMID:19506035	PMID:23201090	PMID:23376485	PMID:23533145	PMID:25636444

Genomics

Comparative Map Data

Pals1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	103,327,965 - 103,384,543 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	103,281,154 - 103,387,209 (+)	Ensembl				GRCr8
mRatBN7.2	6	97,548,133 - 97,654,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	97,548,630 - 97,653,305 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	98,031,311 - 98,081,039 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	98,330,473 - 98,380,201 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	97,710,535 - 97,767,135 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	101,923,675 - 102,029,705 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	101,923,785 - 102,028,592 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	111,299,821 - 111,404,519 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	101,414,657 - 101,471,504 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	95,983,793 - 96,039,503 (+)	NCBI		Celera
RGSC_v3.1	6	101,370,971 - 101,477,629 (+)	NCBI
Cytogenetic Map	6	q24	NCBI

PALS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	67,241,435 - 67,336,061 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	67,240,713 - 67,336,061 (+)	Ensembl			hg38	GRCh38
GRCh37	14	67,708,152 - 67,802,778 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	66,777,774 - 66,872,289 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	66,777,773 - 66,872,288	NCBI
Celera	14	47,767,078 - 47,861,589 (+)	NCBI		Celera
Cytogenetic Map	14	q23.3	NCBI
HuRef	14	47,877,875 - 47,972,701 (+)	NCBI		HuRef
CHM1_1	14	67,646,631 - 67,741,468 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	61,448,560 - 61,543,185 (+)	NCBI		T2T-CHM13v2.0

Pals1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	78,795,606 - 78,887,488 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	78,795,681 - 78,887,488 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	78,748,882 - 78,840,714 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	78,748,907 - 78,840,714 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	79,849,934 - 79,941,701 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	79,667,864 - 79,756,927 (+)	NCBI		MGSCv36	mm8
Celera	12	80,213,557 - 80,305,293 (+)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	35.51	NCBI

Pals1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	2,874,058 - 2,918,122 (-)	Ensembl
ChiLan1.0	NW_004955466	2,871,445 - 2,937,296 (-)	NCBI	ChiLan1.0	ChiLan1.0

PALS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	68,332,567 - 68,441,611 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	67,549,079 - 67,658,119 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	47,814,896 - 47,911,206 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	66,693,863 - 66,790,122 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	66,693,863 - 66,790,122 (+)	Ensembl			panPan2	panpan1.1

PALS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	41,230,230 - 41,330,017 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	41,275,947 - 41,327,348 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	40,921,970 - 41,021,764 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	41,456,949 - 41,557,356 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	41,482,039 - 41,557,348 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	41,075,824 - 41,176,237 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	41,149,990 - 41,249,790 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	41,508,622 - 41,608,769 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pals1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	63,464,311 - 63,554,909 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	10,636,670 - 10,725,647 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	10,636,762 - 10,729,060 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PALS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	90,984,394 - 91,055,620 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	90,955,524 - 91,055,923 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	97,264,802 - 97,365,354 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PALS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	44,483,005 - 44,576,017 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	44,483,199 - 44,573,172 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	32,712,858 - 32,805,769 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pals1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	33,658,975 - 33,721,548 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	33,659,625 - 33,758,680 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pals1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	92,863,288 - 92,952,250 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pals1
214 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	292
Count of miRNA genes:	171
Interacting mature miRNAs:	222
Transcripts:	ENSRNOT00000012005
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	64367996	109367996	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat

Markers in Region

AW535964

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	97,652,671 - 97,652,841 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	102,028,218 - 102,028,387	NCBI	Rnor6.0
Rnor_5.0	6	111,403,032 - 111,403,201	UniSTS	Rnor5.0
RGSC_v3.4	6	101,472,686 - 101,472,855	UniSTS	RGSC3.4
Celera	6	96,040,685 - 96,040,854	UniSTS
RH 3.4 Map	6	689.6	UniSTS
Cytogenetic Map	6	q24	UniSTS

BE121443

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	97,652,537 - 97,652,690 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	102,028,084 - 102,028,236	NCBI	Rnor6.0
Rnor_5.0	6	111,402,898 - 111,403,050	UniSTS	Rnor5.0
RGSC_v3.4	6	101,472,552 - 101,472,704	UniSTS	RGSC3.4
Celera	6	96,040,551 - 96,040,703	UniSTS
RH 3.4 Map	6	690.19	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC139976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012005 ⟹ ENSRNOP00000012005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	101,923,785 - 102,028,592 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092157 ⟹ ENSRNOP00000070368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	103,281,154 - 103,387,209 (+)	Ensembl
mRatBN7.2 Ensembl	6	97,548,630 - 97,653,305 (+)	Ensembl
Rnor_6.0 Ensembl	6	101,924,000 - 102,026,810 (+)	Ensembl

RefSeq Acc Id:

NM_001108034 ⟹ NP_001101504

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	103,327,965 - 103,384,543 (+)	NCBI
mRatBN7.2	6	97,594,908 - 97,651,490 (+)	NCBI
Rnor_6.0	6	101,970,458 - 102,027,036 (+)	NCBI
Rnor_5.0	6	111,299,821 - 111,404,519 (+)	NCBI
RGSC_v3.4	6	101,414,657 - 101,471,504 (+)	RGD
Celera	6	95,983,793 - 96,039,503 (+)	RGD

Sequence:

show sequence

AGTTTTGCAGAATAAGAAAGCTAACCTGAATATTGGGGGGAAAGACAGAGAAGAGAAACAAGGA
TTGAAGACGAGGTTTTCCAGTTTGCATAATATTTGCCTCATGGATACATTTCATAGCATTATTA
TGTGATATGAGAAGTTATTTTTCTTTTTTGAAGTAACATGGATTTTATACTACAGAATCAAGAG
AATTGGCTTTATAGGAAATTTTGATATATAAAAAGTGATAGAGGTTTTTATAGATAACCATGAC
AACATCGTATATGAATGGGCATGTGACAGAGGAATCAGACAGCGGAATAAAAAATCTTGGTCTT
GCATCACCAGAGGAACATCCGAAACACAGAGAGATGGCTGTTGACTGCCCTGGAGATTTGGGCA
CCAGATTGATGCCAGTGCGAAGAAGTGCACAGTTAGAGCGCATTCGACAGCAACAGGAGGATAT
GAGACGTAGGCGTGAAGAAGAAGGGAAAAAGCAAGAACTTGACCTAAATTCTTCCATGAGACTT
AAGAAACTAGCTCAAATTCCTCCGAAGACTGGAATAGATAACCCTATATTTGACACAGAAGAAG
GAATTGTTTTAGAAAGTCCTCACTATGCTGTGAAAATATTAGAAGTTGAAGACTTGTTCTCTTC
ACTTAAACATATCCAGCACACTTTGGTTGATTCTCAGAGCCAGGAGGATATTTCACTGCTTTTA
CAGCTTGTACAAAATAGAGATTTTCAGAATGCATTCAAGATACACAATGCTGTCACAGTGCACA
TGAACAAGGCCAGCCCTCCGTTTCCTCTTATCGCCAATGTACAAGACCTTGTACAAGAGGTACA
AACTGTCTTAAAGCCAGTCCATCAGAAGGAAGGACAAGAATTAACTGCTTTGTTAAATGCTCCA
CATATTCAGGCACTTTTACTGGCCCATGATAAGGTTGCTGAGCAGGAAATGCAGCTAGAGCCCA
TAACAGATGAGAGAGTCTATGAAAGTATCGGCCATTATGGGGGAGAAACTGTAAAAATAGTTCG
TATAGAAAAGGCTCGGGATATTCCATTGGGTGCCACGGTTCGTAATGAGATGGATTCTGTCATC
ATAAGTCGGATAGTGAAAGGAGGCGCGGCAGAGAAGAGCGGGCTTCTGCACGAAGGAGACGAAG
TCCTAGAGATCAATGGCATCGAAATCCGGGGCAAGGACGTCAATGAGGTTTTTGACTTGTTGTC
TGATATGCACGGTACGTTGACATTTGTTCTGATTCCTAGTCAACAGATCAAGCCTCCTCCCGCC
AAAGAAACTGTAATCCACGTGAAAGCTCATTTTGACTATGACCCCTCAGATGACCCTTATGTTC
CCTGTCGAGAGTTAGGACTGTCTTTTCAAAAAGGAGATATACTTCATGTGATTAGTCAAGAAGA
TCCGAATTGGTGGCAGGCCTATAGAGAAGGAGACGAAGACAATCAGCCTCTAGCTGGACTTGTT
CCAGGGAAAAGTTTTCAGCAGCAAAGGGAAGCCATGAAGCAAACTATAGAAGAAGATAAGGAGC
CAGAAAAATCAGGAAAACTATGGTGTGCAAAGAAGAATAAAAAGAAGAGGAAAAAGGTTTTATA
TAATGCCAATAAAAATGATGATTATGACAATGAAGAGATCCTAACGTATGAAGAAATGTCACTT
TACCATCAGCCAGCAAATAGGAAAAGACCTATCATCTTGATTGGTCCCCAGAACTGTGGCCAGA
ATGAACTGCGCCAGAGACTCATGAACAAAGAAAAAGACCGCTTTGCATCTGCAGTTCCTCATAC
AACTCGGAATAGGCGAGACCACGAAGTAGCTGGGAGAGATTACCACTTTGTTTCACGGCAAGCA
TTTGAAGCAGATATAGCAGCTGGCAAGTTCATTGAACATGGTGAATTTGAGAAAAACCTGTATG
GAACCAGCATAGATTCTGTACGACAAGTAATCAACTCTGGCAAAATATGTCTTTTAAGTCTTCG
AGCACAGTCCTTGAAGACCCTCCGGAATTCAGATTTGAAACCATACATCATCTTCATTGCACCA
CCTTCACAAGAGAGACTTCGGGCGTTGTTAGCCAAGGAAGGCAAGAACCCAAAGCCGGAAGAAT
TAAGGGAGATTATTGAGAAGACGAGAGAGATGGAACAGAACAACGGCCACTACTTCGACACTGC
GATTGTGAATTCAGATCTTGATAAAGCCTATCAGGAACTGCTTAGGCTTATTAACAAACTGGAC
ACCGAGCCTCAGTGGGTGCCATCCACCTGGCTAAGGTGAAGGAAATGGCTGTTCTGTGTCATCA
TGATGAGCTTTATTTGATAAACCGCCAACAGGAAGATGGCCTTAACGCTGAGAGTTAATCTCCT
ACACTAGTGAGAAAGGCCCGTTAGGCAATTTGTACACAACACTTCCTGCACATTGCTTTAGGGG
GCCTTGACTTGTTTGGAGATTTAAAATGGAAACTTTCTTCAGAGCATTTCTGATTTATGTTTTC
ACCTTTCTTGCCTCTTGGTCAGATGTCTATAAAAAAAAATGTATATATATACGTAATATACCAT
TGTCTCACTTAGGTATGAATACTAACATTATTTAACATTTAACTTAAATGACTTCATGGGATTA
TTGAGAGAAGGGGCTGTGCTTCTGTGCACTGAGAATAACAGTATTTTCTTAAACTGATTTAGTC
ATCAGAAATATTTCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101504	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68247	(Get FASTA)	NCBI Sequence Viewer
	B4F7E7	(Get FASTA)	NCBI Sequence Viewer
	EDM03700	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070368
	ENSRNOP00000070368.1

RefSeq Acc Id:

NP_001101504 ⟸ NM_001108034

- UniProtKB:

B4F7E7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTTSYMNGHVTEESDSGIKNLGLASPEEHPKHREMAVDCPGDLGTRLMPVRRSAQLERIRQQQE
DMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVKILEVEDLF
SSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMNKASPPFPLIANVQDLVQE
VQTVLKPVHQKEGQELTALLNAPHIQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKI
VRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDL
LSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQ
EDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKV
LYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVP
HTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLS
LRAQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFD
TAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR

hide sequence

Ensembl Acc Id:

ENSRNOP00000070368 ⟸ ENSRNOT00000092157

Ensembl Acc Id:

ENSRNOP00000012005 ⟸ ENSRNOT00000012005

Protein Domains

Guanylate kinase-like L27 PDZ SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B4F7E7-F1-model_v2	AlphaFold	B4F7E7	1-675	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694694

Promoter ID:

EPDNEW_R5211

Type:

initiation region

Name:

Mpp5_1

Description:

membrane palmitoylated protein 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	101,923,740 - 101,923,800	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308071	AgrOrtholog
BioCyc Gene	G2FUF-36988	BioCyc
Ensembl Genes	ENSRNOG00000008788	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000092157	ENTREZGENE
	ENSRNOT00000092157.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
	L27 domain	UniProtKB/Swiss-Prot
	SH3 Domains	UniProtKB/Swiss-Prot
InterPro	GK/Ca_channel_bsu	UniProtKB/Swiss-Prot
	Guanylate_kin-like_dom	UniProtKB/Swiss-Prot
	Guanylate_kinase_CS	UniProtKB/Swiss-Prot
	L27_C	UniProtKB/Swiss-Prot
	L27_dom	UniProtKB/Swiss-Prot
	L27_dom_sf	UniProtKB/Swiss-Prot
	L27_N	UniProtKB/Swiss-Prot
	MAGUK	UniProtKB/Swiss-Prot
	MPP5_SH3	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	SH3-like_dom_sf	UniProtKB/Swiss-Prot
	SH3_domain	UniProtKB/Swiss-Prot
KEGG Report	rno:314259	UniProtKB/Swiss-Prot
NCBI Gene	314259	ENTREZGENE
PANTHER	MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK	UniProtKB/Swiss-Prot
Pfam	Guanylate_kin	UniProtKB/Swiss-Prot
	L27	UniProtKB/Swiss-Prot
	L27_N	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SH3_2	UniProtKB/Swiss-Prot
PhenoGen	Pals1	PhenoGen
PROSITE	GUANYLATE_KINASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_KINASE_2	UniProtKB/Swiss-Prot
	L27	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008788	RatGTEx
SMART	GuKc	UniProtKB/Swiss-Prot
	L27	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF101288	UniProtKB/Swiss-Prot
	SSF50044	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	B4F7E7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-09-23	Pals1	protein associated with LIN7 1, MAGUK p55 family member	Pals1	protein associated with LIN7 1, MAGUK family member	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2021-03-09	Pals1	protein associated with LIN7 1, MAGUK family member	Mpp5	membrane palmitoylated protein 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-04-14	Mpp5	membrane palmitoylated protein 5	Mpp5	membrane protein, palmitoylated 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-20	Mpp5	membrane protein, palmitoylated 5	Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	Mpp5_predicted	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mpp5_predicted	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI