Tnfrsf10b (TNF receptor superfamily member 10b) - Rat Genome Database

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Gene: Tnfrsf10b (TNF receptor superfamily member 10b) Rattus norvegicus
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Symbol: Tnfrsf10b (Ensembl: AABR07018323.1)
Name: TNF receptor superfamily member 10b
RGD ID: 1308041
Description: Predicted to enable identical protein binding activity and protease binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and male gonad development. Predicted to be located in Golgi apparatus; cytosol; and membrane raft. Predicted to be active in cell surface and plasma membrane raft. Biomarker of colon cancer and osteoarthritis. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC364420; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,249,883 - 51,278,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1551,250,112 - 51,278,082 (+)EnsemblGRCr8
mRatBN7.21544,840,386 - 44,868,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,840,386 - 44,867,467 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1548,958,259 - 48,986,200 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,069,754 - 50,097,693 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,929,101 - 46,957,032 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,433,853 - 51,464,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,161,595 - 55,192,095 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41550,138,439 - 50,163,254 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1544,522,716 - 44,548,374 (+)NCBICelera
RGSC_v3.11550,155,031 - 50,177,989 (+)NCBI
Cytogenetic Map15p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-tert-butylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
Azoxymethane  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bupropion  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobicistat  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (ISO)
DDE  (EXP)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DuP 697  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
Fusarenone X  (ISO)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (EXP)
helenalin  (ISO)
hemin  (ISO)
hydroxyl  (ISO)
hydroxyurea  (ISO)
Ilimaquinone  (ISO)
Isoangustone A  (ISO)
isoflurane  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipoic acid  (EXP,ISO)
lupulone  (ISO)
LY294002  (ISO)
Maduramicin  (ISO)
magnesium oxide  (ISO)
melittin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
Myrtucommulone A  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
Nonidet P-40  (ISO)
NS-398  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
Pendulone  (ISO)
pentobarbital  (EXP)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
selenium atom  (ISO)
sesquiterpene  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vismodegib  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Bousserouel S, etal., Int J Oncol. 2010 Jun;36(6):1485-90.
2. Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma. Diegmann J, etal., Int J Mol Med. 2006 Sep;18(3):395-403.
3. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Estes JM, etal., Gynecol Oncol. 2007 May;105(2):291-8. Epub 2007 Feb 15.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms. Fernandez V, etal., Haematologica. 2004 Nov;89(11):1322-31.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Death receptor response in rodent testis after mono-(2-ethylhexyl) phthalate exposure. Giammona CJ, etal., Toxicol Appl Pharmacol. 2002 Dec 1;185(2):119-27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development. Grataroli R, etal., Biol Reprod 2002 Jun;66(6):1707-15.
10. Stimulation of erythropoiesis by thalidomide in multiple myeloma patients: its influence on FasL, TRAIL and their receptors on erythroblasts. Grzasko N, etal., Haematologica. 2006 Mar;91(3):386-9.
11. Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Lamy V, etal., Carcinogenesis. 2007 Jul;28(7):1575-81. Epub 2007 Apr 13.
12. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
13. [Expression of tumor necrosis factor related apoptosis inducing ligand and its receptor in thymus during early post-burn stage in rat with severe burns] Leng XF, etal., Zhonghua Shao Shang Za Zhi. 2007 Jun;23(3):184-7.
14. Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells apoptosis. Li W, etal., Exp Biol Med (Maywood). 2009 Dec;234(12):1468-76.
15. Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. McCarthy MM, etal., Clin Cancer Res. 2005 Jul 15;11(14):5188-94.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Straughn JM Jr, etal., Gynecol Oncol. 2006 Apr;101(1):46-54. Epub 2005 Nov 4.
26. Differential apoptosis gene expression in pediatric tumors of the kidney. Takamizawa S, etal., J Pediatr Surg. 2000 Feb;35(2):390-5.
27. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Teng MW, etal., Cancer Res. 2007 Aug 1;67(15):7495-504.
28. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
29. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. Wolf S, etal., Int J Cancer. 2006 Apr 1;118(7):1831-5.
30. Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model. Zhang L, etal., Cancer Lett. 2007 Jun 18;251(1):146-57. Epub 2006 Dec 20.
Additional References at PubMed
PMID:18165900   PMID:19090789   PMID:19593445   PMID:21785459   PMID:22240897   PMID:22286051   PMID:22952982   PMID:31473246  


Genomics

Comparative Map Data
Tnfrsf10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,249,883 - 51,278,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1551,250,112 - 51,278,082 (+)EnsemblGRCr8
mRatBN7.21544,840,386 - 44,868,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,840,386 - 44,867,467 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1548,958,259 - 48,986,200 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,069,754 - 50,097,693 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,929,101 - 46,957,032 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,433,853 - 51,464,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,161,595 - 55,192,095 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41550,138,439 - 50,163,254 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1544,522,716 - 44,548,374 (+)NCBICelera
RGSC_v3.11550,155,031 - 50,177,989 (+)NCBI
Cytogenetic Map15p11NCBI
TNFRSF10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,190,452 - 23,225,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,190,452 - 23,225,121 (-)Ensemblhg38GRCh38
GRCh37823,047,965 - 23,082,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,104,915 - 23,138,584 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34823,104,915 - 23,138,584NCBI
Celera822,011,569 - 22,045,255 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,594,946 - 21,628,637 (-)NCBIHuRef
CHM1_1823,251,086 - 23,284,807 (-)NCBICHM1_1
T2T-CHM13v2.0823,465,337 - 23,499,970 (-)NCBIT2T-CHM13v2.0
Tnfrsf10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,004,921 - 70,021,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,004,921 - 70,021,860 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381469,767,472 - 69,784,411 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,767,472 - 69,784,411 (+)Ensemblmm10GRCm38
MGSCv371470,167,279 - 70,184,218 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361468,502,609 - 68,519,491 (+)NCBIMGSCv36mm8
Celera1467,301,078 - 67,318,034 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
TNFRSF10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,692,326 - 41,732,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,422,892 - 17,459,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,440,502 - 22,476,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,378,547 - 19,414,724 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,378,547 - 19,414,724 (-)EnsemblpanPan2panpan1.1
LOC100737977
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1147,344,788 - 7,371,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,869,520 - 7,886,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFRSF10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,318,987 - 21,351,641 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,315,149 - 21,351,673 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605220,871,352 - 20,907,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tnfrsf10b
189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:104
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000066128
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 30 31 101 59 11 29 35 32 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000066128   ⟹   ENSRNOP00000063335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1551,250,112 - 51,278,082 (+)Ensembl
mRatBN7.2 Ensembl1544,840,386 - 44,867,467 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077758   ⟹   ENSRNOP00000071012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,840,591 - 44,866,421 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093234   ⟹   ENSRNOP00000076261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,842,732 - 44,866,421 (+)Ensembl
RefSeq Acc Id: NM_001395720   ⟹   NP_001382649
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,250,161 - 51,278,091 (+)NCBI
mRatBN7.21544,840,386 - 44,868,318 (+)NCBI
RefSeq Acc Id: XM_063274494   ⟹   XP_063130564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,249,883 - 51,274,227 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382649 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACL51000 (Get FASTA)   NCBI Sequence Viewer  
  EDM02194 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063335
  ENSRNOP00000063335.6
Ensembl Acc Id: ENSRNOP00000063335   ⟸   ENSRNOT00000066128
Ensembl Acc Id: ENSRNOP00000071012   ⟸   ENSRNOT00000077758
Ensembl Acc Id: ENSRNOP00000076261   ⟸   ENSRNOT00000093234
RefSeq Acc Id: NP_001382649   ⟸   NM_001395720
- Peptide Label: precursor
- UniProtKB: A0A0G2JZE1 (UniProtKB/TrEMBL),   B8YBG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130564   ⟸   XM_063274494
- Peptide Label: isoform X1
Protein Domains
Death   TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZE1-F1-model_v2 AlphaFold A0A0G2JZE1 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308041 AgrOrtholog
BioCyc Gene G2FUF-13252 BioCyc
Ensembl Genes ENSRNOG00000038483 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066128 ENTREZGENE
  ENSRNOT00000066128.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFR_10 UniProtKB/TrEMBL
  TNFRSF10 UniProtKB/TrEMBL
  TNFRSF10_N UniProtKB/TrEMBL
  TNFRSF10A/B_death UniProtKB/TrEMBL
NCBI Gene 364420 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/TrEMBL
PhenoGen Tnfrsf10b PhenoGen
PRINTS TNFACTORR10 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038483 RatGTEx
SMART DEATH UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/TrEMBL
UniProt A0A0G2JZE1 ENTREZGENE
  B8YBG7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYZ1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Tnfrsf10b  TNF receptor superfamily member 10b  Tnfrsf10b  tumor necrosis factor receptor superfamily, member 10b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tnfrsf10b  tumor necrosis factor receptor superfamily, member 10b   Tnfrsf10b_predicted  tumor necrosis factor receptor superfamily, member 10b (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tnfrsf10b_predicted  tumor necrosis factor receptor superfamily, member 10b (predicted)      Symbol and Name status set to approved 70820 APPROVED