Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ppp2r5a | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPP2R5A mRNA] | CTD | PMID:31150632 | Ppp2r5a | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPP2R5A mRNA | CTD | PMID:36331819 | Ppp2r5a | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of PPP2R5A mRNA | CTD | PMID:22206623 | Ppp2r5a | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of PPP2R5A mRNA] | CTD | PMID:22206623 | Ppp2r5a | Rat | 17beta-estradiol | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Estradiol results in increased expression of PPP2R5A mRNA | CTD | PMID:39298647 | Ppp2r5a | Rat | 17beta-estradiol | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Estradiol results in increased expression of PPP2R5A mRNA | CTD | PMID:31614463 | Ppp2r5a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression more ... | CTD | PMID:25975270 | Ppp2r5a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PPP2R5A mRNA | CTD | PMID:33387578 | Ppp2r5a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPP2R5A mRNA | CTD | PMID:34747641 | Ppp2r5a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PPP2R5A mRNA | CTD | PMID:26290441 | Ppp2r5a | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PPP2R5A mRNA | CTD | PMID:20188158 | Ppp2r5a | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPP2R5A mRNA | CTD | PMID:24848799 | Ppp2r5a | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PPP2R5A mRNA | CTD | PMID:18648102 | Ppp2r5a | Rat | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of PPP2R5A mRNA | CTD | PMID:33565098 | Ppp2r5a | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | bisphenol S results in increased expression of PPP2R5A mRNA | CTD | PMID:39298647 | Ppp2r5a | Rat | 4-vinylcyclohexene dioxide | affects expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of PPP2R5A mRNA | CTD | PMID:20829426 | Ppp2r5a | Rat | aflatoxin B1 | decreases methylation | ISO | PPP2R5A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PPP2R5A gene | CTD | PMID:27153756 | Ppp2r5a | Rat | all-trans-retinoic acid | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PPP2R5A mRNA | CTD | PMID:23724009|PMID:33167477 | Ppp2r5a | Rat | Aroclor 1254 | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP2R5A mRNA | CTD | PMID:23650126 | Ppp2r5a | Rat | arsenite(3-) | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PPP2R5A mRNA] | CTD | PMID:32406909 | Ppp2r5a | Rat | arsenous acid | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PPP2R5A mRNA | CTD | PMID:20458559 | Ppp2r5a | Rat | atrazine | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Atrazine results in increased expression of PPP2R5A mRNA | CTD | PMID:22378314 | Ppp2r5a | Rat | benzo[a]pyrene | affects methylation | ISO | PPP2R5A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PPP2R5A intron; Benzo(a)pyrene affects the methylation of PPP2R5A promoter | CTD | PMID:27901495|PMID:30157460 | Ppp2r5a | Rat | benzo[a]pyrene | decreases methylation | ISO | Ppp2r5a (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of PPP2R5A intron | CTD | PMID:27901495 | Ppp2r5a | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PPP2R5A mRNA | CTD | PMID:33754040 | Ppp2r5a | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PPP2R5A mRNA | CTD | PMID:25181051 | Ppp2r5a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PPP2R5A mRNA | CTD | PMID:30816183|PMID:32528016 | Ppp2r5a | Rat | bisphenol AF | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of PPP2R5A protein | CTD | PMID:34186270 | Ppp2r5a | Rat | Bisphenol B | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | bisphenol B results in increased expression of PPP2R5A protein | CTD | PMID:34186270 | Ppp2r5a | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PPP2R5A mRNA | CTD | PMID:19167457 | Ppp2r5a | Rat | cadmium dichloride | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Cadmium Chloride results in decreased expression of PPP2R5A protein | CTD | PMID:35183672 | Ppp2r5a | Rat | calcitriol | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PPP2R5A mRNA | CTD | PMID:16002434 | Ppp2r5a | Rat | carbamazepine | affects expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Carbamazepine affects the expression of PPP2R5A mRNA | CTD | PMID:24752500 | Ppp2r5a | Rat | carbon nanotube | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PPP2R5A mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Ppp2r5a | Rat | chlorpyrifos | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PPP2R5A mRNA | CTD | PMID:37019170 | Ppp2r5a | Rat | choline | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992 | Ppp2r5a | Rat | copper atom | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PPP2R5A mRNA | CTD | PMID:30911355 | Ppp2r5a | Rat | copper(0) | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of PPP2R5A mRNA | CTD | PMID:30911355 | Ppp2r5a | Rat | dexamethasone | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of PPP2R5A mRNA | CTD | PMID:17998272 | Ppp2r5a | Rat | dexamethasone | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPP2R5A mRNA | CTD | PMID:24848799 | Ppp2r5a | Rat | diarsenic trioxide | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PPP2R5A mRNA | CTD | PMID:20458559 | Ppp2r5a | Rat | dibutyl phthalate | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PPP2R5A mRNA | CTD | PMID:21266533 | Ppp2r5a | Rat | diclofenac | affects expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Diclofenac affects the expression of PPP2R5A mRNA | CTD | PMID:24752500 | Ppp2r5a | Rat | dicrotophos | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PPP2R5A mRNA | CTD | PMID:28302478 | Ppp2r5a | Rat | dorsomorphin | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Ppp2r5a | Rat | doxorubicin | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PPP2R5A mRNA | CTD | PMID:29803840 | Ppp2r5a | Rat | ethanol | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | PPP2R5A protein affects the reaction [Ethanol affects the localization of CTNNB1 protein]; PPP2R5A protein affects more ... | CTD | PMID:30567741 | Ppp2r5a | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PPP2R5A mRNA | CTD | PMID:24136188 | Ppp2r5a | Rat | folic acid | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992|PMID:22206623 | Ppp2r5a | Rat | FR900359 | increases phosphorylation | ISO | PPP2R5A (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PPP2R5A protein | CTD | PMID:37730182 | Ppp2r5a | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PPP2R5A mRNA | CTD | PMID:22061828 | Ppp2r5a | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PPP2R5A mRNA | CTD | PMID:33387578 | Ppp2r5a | Rat | hydroquinone | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | PPP2R5A protein affects the reaction [hydroquinone affects the localization of CTNNB1 protein]; PPP2R5A protein affects more ... | CTD | PMID:30567741 | Ppp2r5a | Rat | L-methionine | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992 | Ppp2r5a | Rat | lead(0) | affects expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Lead affects the expression of PPP2R5A mRNA | CTD | PMID:28903495 | Ppp2r5a | Rat | melphalan | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Melphalan results in decreased expression of PPP2R5A mRNA | CTD | PMID:22363485 | Ppp2r5a | Rat | methidathion | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | methidathion results in decreased expression of PPP2R5A mRNA | CTD | PMID:34813904 | Ppp2r5a | Rat | methylmercury chloride | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PPP2R5A mRNA | CTD | PMID:23179753 | Ppp2r5a | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of PPP2R5A mRNA | CTD | PMID:24136188 | Ppp2r5a | Rat | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of PPP2R5A mRNA | CTD | PMID:24136188 | Ppp2r5a | Rat | paracetamol | affects expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Acetaminophen affects the expression of PPP2R5A mRNA | CTD | PMID:17562736 | Ppp2r5a | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PPP2R5A mRNA | CTD | PMID:33387578 | Ppp2r5a | Rat | paracetamol | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | Acetaminophen promotes the reaction [CTNNB1 protein binds to PPP2R5A protein]; PPP2R5A protein affects the reaction more ... | CTD | PMID:30567741 | Ppp2r5a | Rat | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PPP2R5A mRNA | CTD | PMID:19162173 | Ppp2r5a | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ppp2r5a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPP2R5A mRNA | CTD | PMID:36331819 | Ppp2r5a | Rat | perfluorooctane-1-sulfonic acid | affects expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | perfluorooctane sulfonic acid affects the expression of PPP2R5A mRNA | CTD | PMID:19429403 | Ppp2r5a | Rat | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of PPP2R5A mRNA | CTD | PMID:19162173 | Ppp2r5a | Rat | perfluorooctanoic acid | affects expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | perfluorooctanoic acid affects the expression of PPP2R5A mRNA | CTD | PMID:19429403 | Ppp2r5a | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of PPP2R5A mRNA | CTD | PMID:28903501 | Ppp2r5a | Rat | resveratrol | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | resveratrol results in decreased expression of PPP2R5A protein | CTD | PMID:18089832 | Ppp2r5a | Rat | rotenone | decreases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Rotenone results in decreased expression of PPP2R5A mRNA | CTD | PMID:33512557 | Ppp2r5a | Rat | SB 431542 | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Ppp2r5a | Rat | silicon dioxide | decreases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of PPP2R5A mRNA | CTD | PMID:38811393 | Ppp2r5a | Rat | sodium arsenite | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PPP2R5A mRNA | CTD | PMID:38568856|PMID:39719251 | Ppp2r5a | Rat | sunitinib | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PPP2R5A mRNA | CTD | PMID:31533062 | Ppp2r5a | Rat | tetrachloroethene | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of PPP2R5A mRNA | CTD | PMID:28973375 | Ppp2r5a | Rat | tetrachloromethane | affects expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PPP2R5A mRNA | CTD | PMID:17484886 | Ppp2r5a | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PPP2R5A mRNA | CTD | PMID:31150632 | Ppp2r5a | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPP2R5A mRNA] | CTD | PMID:31150632 | Ppp2r5a | Rat | thiram | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Thiram results in increased expression of PPP2R5A mRNA | CTD | PMID:38568856 | Ppp2r5a | Rat | titanium dioxide | decreases methylation | ISO | Ppp2r5a (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PPP2R5A promoter | CTD | PMID:35295148 | Ppp2r5a | Rat | tributylstannane | increases expression | ISO | Ppp2r5a (Mus musculus) | 6480464 | tributyltin results in increased expression of PPP2R5A mRNA | CTD | PMID:24848799 | Ppp2r5a | Rat | triphenyl phosphate | affects expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PPP2R5A mRNA | CTD | PMID:37042841 | Ppp2r5a | Rat | urethane | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Urethane results in increased expression of PPP2R5A mRNA | CTD | PMID:28818685 | Ppp2r5a | Rat | valproic acid | decreases methylation | ISO | PPP2R5A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PPP2R5A gene | CTD | PMID:29154799 | Ppp2r5a | Rat | valproic acid | increases expression | ISO | PPP2R5A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PPP2R5A mRNA | CTD | PMID:19101580|PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509 | Ppp2r5a | Rat | valproic acid | multiple interactions | ISO | PPP2R5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















