Txlnb (taxilin beta) - Rat Genome Database

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Gene: Txlnb (taxilin beta) Rattus norvegicus
Analyze
Symbol: Txlnb
Name: taxilin beta
RGD ID: 1307979
Description: Predicted to enable syntaxin binding activity. Predicted to be located in cytoplasm. Orthologous to human TXLNB (taxilin beta); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-taxilin; LOC308622; RGD1307979; similar to muscle-derived protein MDP77 variant 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,224,647 - 14,269,837 (+)NCBIGRCr8
mRatBN7.2112,404,845 - 12,449,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,404,859 - 12,449,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,167,527 - 12,213,188 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0118,169,452 - 18,215,113 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,385,196 - 12,430,312 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,915,781 - 12,961,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,915,734 - 12,961,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,609,469 - 14,655,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,814,809 - 12,857,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,753,057 - 12,856,515 (+)NCBI
Celera110,862,671 - 10,907,830 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Txlnb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,224,647 - 14,269,837 (+)NCBIGRCr8
mRatBN7.2112,404,845 - 12,449,977 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,404,859 - 12,449,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,167,527 - 12,213,188 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0118,169,452 - 18,215,113 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,385,196 - 12,430,312 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,915,781 - 12,961,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,915,734 - 12,961,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,609,469 - 14,655,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,814,809 - 12,857,077 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,753,057 - 12,856,515 (+)NCBI
Celera110,862,671 - 10,907,830 (+)NCBICelera
Cytogenetic Map1p12NCBI
TXLNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,159,162 - 139,323,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6139,239,083 - 139,291,998 (-)EnsemblGRCh38hg38GRCh38
GRCh376139,561,198 - 139,613,135 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,602,891 - 139,654,849 (-)NCBINCBI36Build 36hg18NCBI36
Build 346139,602,893 - 139,654,849NCBI
Celera6140,301,267 - 140,353,271 (-)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,122,735 - 137,174,737 (-)NCBIHuRef
CHM1_16139,824,342 - 139,876,297 (-)NCBICHM1_1
T2T-CHM13v2.06140,347,705 - 140,507,844 (-)NCBIT2T-CHM13v2.0
Txlnb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,671,967 - 17,721,411 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,671,974 - 17,721,413 (+)EnsemblGRCm39 Ensembl
GRCm381017,796,219 - 17,845,663 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,796,226 - 17,845,665 (+)EnsemblGRCm38mm10GRCm38
MGSCv371017,516,025 - 17,565,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,485,696 - 17,535,079 (+)NCBIMGSCv36mm8
Celera1017,679,390 - 17,728,131 (+)NCBICelera
Cytogenetic Map10A2NCBI
cM Map107.24NCBI
Txlnb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,445,205 - 20,482,523 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543620,442,605 - 20,481,758 (+)NCBIChiLan1.0ChiLan1.0
TXLNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25159,208,553 - 159,293,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16157,102,881 - 157,186,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06137,002,343 - 137,086,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16141,083,798 - 141,133,794 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6141,084,075 - 141,130,691 (-)Ensemblpanpan1.1panPan2
TXLNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,417,182 - 31,464,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,417,538 - 31,464,624 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,288,265 - 32,338,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0131,575,856 - 31,625,741 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,575,904 - 31,625,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,451,654 - 31,501,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,334,143 - 31,384,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,645,609 - 31,695,514 (-)NCBIUU_Cfam_GSD_1.0
Txlnb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,472,022 - 126,513,407 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,251,213 - 6,292,598 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365606,253,195 - 6,292,556 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXLNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,228,615 - 25,285,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,228,602 - 25,285,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,367,688 - 28,425,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXLNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,099,200 - 34,151,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1334,099,435 - 34,151,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660406,241,641 - 6,291,264 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txlnb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475314,712,569 - 14,761,243 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475314,712,618 - 14,759,830 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txlnb
634 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:111
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000016553
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
D1Got15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,415,078 - 12,415,253 (+)MAPPERmRatBN7.2
Rnor_6.0112,926,320 - 12,926,494NCBIRnor6.0
Rnor_5.0114,619,900 - 14,620,074UniSTSRnor5.0
RGSC_v3.4112,821,397 - 12,821,572RGDRGSC3.4
RGSC_v3.4112,821,398 - 12,821,572UniSTSRGSC3.4
RGSC_v3.1112,821,459 - 12,821,634RGD
Celera110,873,620 - 10,873,794UniSTS
RH 2.0 Map165.0RGD
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 49 113 75 74 43 25 43 6 189 97 93 33 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000089066   ⟹   ENSRNOP00000072363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl112,404,859 - 12,449,975 (+)Ensembl
Rnor_6.0 Ensembl112,915,734 - 12,961,670 (+)Ensembl
RefSeq Acc Id: NM_001135859   ⟹   NP_001129331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,224,719 - 14,269,835 (+)NCBI
mRatBN7.2112,404,859 - 12,449,975 (+)NCBI
Rnor_6.0112,915,781 - 12,961,678 (+)NCBI
Rnor_5.0114,609,469 - 14,655,264 (+)NCBI
RGSC_v3.4112,814,809 - 12,857,077 (+)RGD
Celera110,862,671 - 10,907,830 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227657   ⟹   XP_006227719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,224,647 - 14,269,837 (+)NCBI
mRatBN7.2112,404,845 - 12,449,977 (+)NCBI
Rnor_6.0112,915,781 - 12,961,680 (+)NCBI
Rnor_5.0114,609,469 - 14,655,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112431   ⟹   XP_038968359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,225,850 - 14,269,837 (+)NCBI
mRatBN7.2112,405,989 - 12,449,977 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001129331 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227719 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072363.2
RefSeq Acc Id: NP_001129331   ⟸   NM_001135859
- UniProtKB: A0A0G2K2T1 (UniProtKB/TrEMBL),   A6JP90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227719   ⟸   XM_006227657
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2T1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072363   ⟸   ENSRNOT00000089066
RefSeq Acc Id: XP_038968359   ⟸   XM_039112431
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2T1-F1-model_v2 AlphaFold A0A0G2K2T1 1-685 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689503
Promoter ID:EPDNEW_R28
Type:multiple initiation site
Name:Txlnb_1
Description:taxilin beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0112,915,831 - 12,915,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307979 AgrOrtholog
BioCyc Gene G2FUF-62284 BioCyc
Ensembl Genes ENSRNOG00000060021 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089066.2 UniProtKB/TrEMBL
InterPro Taxilin_fam UniProtKB/TrEMBL
KEGG Report rno:308622 UniProtKB/TrEMBL
NCBI Gene 308622 ENTREZGENE
PANTHER BETA-TAXILIN UniProtKB/TrEMBL
  PTHR16127 UniProtKB/TrEMBL
Pfam Taxilin UniProtKB/TrEMBL
PhenoGen Txlnb PhenoGen
RatGTEx ENSRNOG00000060021 RatGTEx
UniProt A0A0G2K2T1 ENTREZGENE, UniProtKB/TrEMBL
  A6JP90 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Txlnb  taxilin beta   Txlnb_predicted  taxilin beta (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Txlnb_predicted  taxilin beta (predicted)  RGD1307979_predicted  similar to muscle-derived protein MDP77 variant 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307979_predicted  similar to muscle-derived protein MDP77 variant 1 (predicted)  LOC308622_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308622_predicted  similar to muscle-derived protein MDP77 variant 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL