Kif26a (kinesin family member 26A) - Rat Genome Database

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Gene: Kif26a (kinesin family member 26A) Rattus norvegicus
Analyze
Symbol: Kif26a
Name: kinesin family member 26A
RGD ID: 1307957
Description: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including nervous system development; regulation of cell growth by extracellular stimulus; and regulation of neuron migration. Predicted to be located in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688273; kinesin-like protein KIF26A; LOC314473
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,035,986 - 137,072,027 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,033,789 - 137,072,022 (+)EnsemblGRCr8
mRatBN7.26131,214,839 - 131,250,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6131,387,882 - 131,422,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,684,848 - 131,719,368 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,044,396 - 131,078,929 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,720,254 - 136,755,515 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,720,266 - 136,754,926 (+)Ensemblrn6Rnor6.0
Rnor_5.06145,729,938 - 145,764,803 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46136,947,394 - 137,007,168 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6128,767,372 - 128,829,093 (+)NCBICelera
RGSC_v3.16136,951,582 - 137,013,355 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19914172  


Genomics

Comparative Map Data
Kif26a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,035,986 - 137,072,027 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,033,789 - 137,072,022 (+)EnsemblGRCr8
mRatBN7.26131,214,839 - 131,250,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6131,387,882 - 131,422,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,684,848 - 131,719,368 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,044,396 - 131,078,929 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,720,254 - 136,755,515 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,720,266 - 136,754,926 (+)Ensemblrn6Rnor6.0
Rnor_5.06145,729,938 - 145,764,803 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46136,947,394 - 137,007,168 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6128,767,372 - 128,829,093 (+)NCBICelera
RGSC_v3.16136,951,582 - 137,013,355 (+)NCBI
Cytogenetic Map6q32NCBI
KIF26A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,138,587 - 104,180,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,136,454 - 104,180,894 (+)Ensemblhg38GRCh38
GRCh3714104,604,924 - 104,647,231 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,674,813 - 103,716,988 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3414103,675,216 - 103,716,984NCBI
Celera1484,659,257 - 84,701,440 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1484,784,732 - 84,827,340 (+)NCBIHuRef
CHM1_114104,543,544 - 104,585,776 (+)NCBICHM1_1
T2T-CHM13v2.01498,375,914 - 98,418,495 (+)NCBIT2T-CHM13v2.0
Kif26a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,109,378 - 112,148,181 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,112,642 - 112,148,181 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,143,974 - 112,181,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,146,208 - 112,181,747 (+)Ensemblmm10GRCm38
MGSCv3712113,384,419 - 113,419,958 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612112,594,016 - 112,629,557 (+)NCBIMGSCv36mm8
Celera12113,348,968 - 113,387,126 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.14NCBI
Kif26a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,800,385 - 2,832,936 (+)Ensembl
ChiLan1.0NW_0049555382,801,706 - 2,832,888 (+)NCBIChiLan1.0ChiLan1.0
KIF26A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,295,997 - 105,340,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114104,514,424 - 104,557,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,762,903 - 84,807,440 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114104,569,947 - 104,612,348 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14104,570,327 - 104,611,245 (+)EnsemblpanPan2panpan1.1
KIF26A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,789,024 - 71,827,794 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,788,821 - 71,827,804 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha871,298,277 - 71,336,515 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,064,940 - 72,103,193 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,062,687 - 72,103,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,753,370 - 71,791,509 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,794,017 - 71,831,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,192,632 - 72,230,872 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kif26a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,256,000 - 2,290,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,085,964 - 1,119,369 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,084,957 - 1,119,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF26A
(Sus scrofa - pig)		 No map positions available.
KIF26A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,072,506 - 82,115,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,074,837 - 82,114,589 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605369,401,444 - 69,442,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif26a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734885,863 - 915,403 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624734884,922 - 917,393 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kif26a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17129,747,185 - 129,782,832 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kif26a
149 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000018278
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 34 59 6 297 134 11 135 80 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000018278   ⟹   ENSRNOP00000018278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,033,789 - 137,072,022 (+)Ensembl
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)Ensembl
Rnor_6.0 Ensembl6136,720,266 - 136,754,802 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086868   ⟹   ENSRNOP00000069901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,036,010 - 137,072,022 (+)Ensembl
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)Ensembl
Rnor_6.0 Ensembl6136,720,582 - 136,754,926 (+)Ensembl
RefSeq Acc Id: NM_001170348   ⟹   NP_001163819
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,036,010 - 137,072,022 (+)NCBI
mRatBN7.26131,214,861 - 131,250,874 (+)NCBI
Rnor_6.06136,720,266 - 136,754,802 (+)NCBI
Rnor_5.06145,729,938 - 145,764,803 (+)NCBI
RGSC_v3.46136,947,394 - 137,007,168 (+)RGD
Celera6128,767,372 - 128,829,093 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001414931   ⟹   NP_001401860
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,036,010 - 137,072,022 (+)NCBI
mRatBN7.26131,214,861 - 131,250,874 (+)NCBI
RefSeq Acc Id: XM_006240635   ⟹   XP_006240697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,035,986 - 137,072,027 (+)NCBI
mRatBN7.26131,214,839 - 131,250,874 (+)NCBI
Rnor_6.06136,720,254 - 136,755,515 (+)NCBI
Rnor_5.06145,729,938 - 145,764,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112423   ⟹   XP_038968351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,051,221 - 137,072,027 (+)NCBI
mRatBN7.26131,230,065 - 131,250,874 (+)NCBI
RefSeq Acc Id: NP_001163819   ⟸   NM_001170348
- Peptide Label: isoform 2
- UniProtKB: D3ZUT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240697   ⟸   XM_006240635
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018278   ⟸   ENSRNOT00000018278
Ensembl Acc Id: ENSRNOP00000069901   ⟸   ENSRNOT00000086868
RefSeq Acc Id: XP_038968351   ⟸   XM_039112423
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001401860   ⟸   NM_001414931
- Peptide Label: isoform 1
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUT0-F1-model_v2 AlphaFold D3ZUT0 1-1873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694849
Promoter ID:EPDNEW_R5373
Type:initiation region
Name:Kif26a_1
Description:kinesin family member 26A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06136,720,266 - 136,720,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307957 AgrOrtholog
BioCyc Gene G2FUF-35800 BioCyc
Ensembl Genes ENSRNOG00000013661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018278 ENTREZGENE
  ENSRNOT00000018278.9 UniProtKB/TrEMBL
  ENSRNOT00000086868 ENTREZGENE
  ENSRNOT00000086868.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/TrEMBL
InterPro HTH_KIF26A_B_1st UniProtKB/TrEMBL
  Kinesin-like_fam UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:314473 UniProtKB/TrEMBL
NCBI Gene 314473 ENTREZGENE
PANTHER KINESIN-LIKE PROTEIN KIF26A UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam HTH_KIF26A_B_1st UniProtKB/TrEMBL
  Kinesin UniProtKB/TrEMBL
PhenoGen Kif26a PhenoGen
PRINTS KINESINHEAVY UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_DOMAIN2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013661 RatGTEx
SMART KISc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JWJ1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Kif26a  kinesin family member 26A  LOC688273  hypothetical protein LOC688273  Data merged from RGD:1591153 1643240 APPROVED
2013-05-24 Kif26a  kinesin family member 26A  LOC684940  similar to CG14535-PA  Data merged from RGD:1584416 1643240 APPROVED
2008-04-30 Kif26a  kinesin family member 26A   Kif26a_predicted  kinesin family member 26A (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC688273  hypothetical protein LOC688273      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684940  similar to CG14535-PA      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Kif26a_predicted  kinesin family member 26A (predicted)      Symbol and Name status set to approved 70820 APPROVED