Cldn4 (claudin 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cldn4 (claudin 4) Rattus norvegicus
Analyze
Symbol: Cldn4
Name: claudin 4
RGD ID: 1307932
Description: Predicted to enable chloride channel activity and structural molecule activity. Involved in circadian rhythm; female pregnancy; and response to progesterone. Located in several cellular components, including apicolateral plasma membrane; basal plasma membrane; and lateral plasma membrane. Biomarker of peptic esophagitis. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: claudin-4; LOC304407
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,388,160 - 27,389,958 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,387,981 - 27,389,958 (+)EnsemblGRCr8
mRatBN7.21221,751,638 - 21,753,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,892,308 - 22,894,101 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,504,632 - 23,506,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,572,828 - 22,574,626 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,761,210 - 24,763,008 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,761,480 - 26,763,278 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,816,134 - 22,817,932 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,512,667 - 23,514,465 (+)NCBICelera
RGSC_v3.11222,686,996 - 22,688,792 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
Altertoxin II  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicyclanil  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
etomidate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP)
hexadecanoic acid  (ISO)
inulin  (ISO)
L-methionine  (ISO)
leuprolide  (ISO)
manganese(II) chloride  (EXP)
megestrol acetate  (ISO)
melanins  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalene  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
patulin  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rottlerin  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Acharya P, etal., Am J Physiol Renal Physiol. 2004 Aug;287(2):F305-18. Epub 2004 Apr 6.
2. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. Asaoka D, etal., J Gastroenterol. 2005 Aug;40(8):781-90.
3. [Claudin expression in different pancreatic cancers and its significance in differential diagnostics]. Borka K, Magy Onkol. 2009 Sep;53(3):273-8. doi: 10.1556/MOnkol.53.2009.3.7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Different changes in the expression of multiple kinds of tight-junction proteins during ischemia-reperfusion injury of the rat ileum. Inoue K, etal., Acta Histochem Cytochem. 2006 Apr 22;39(2):35-45. Epub 2006 Mar 17.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Nicholson MD, etal., Acta Histochem. 2010;112(1):42-52. Epub 2009 Jun 24.
9. Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Peppi M and Ghabriel MN, J Anat. 2004 Oct;205(4):257-66.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Therapeutic antitumor efficacy of monoclonal antibody against Claudin-4 for pancreatic and ovarian cancers. Suzuki M, etal., Cancer Sci. 2009 Sep;100(9):1623-30. Epub 2009 Jun 1.
15. Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas. Tsukahara M, etal., Pathol Int. 2005 Feb;55(2):63-9.
16. E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney. Yamato M, et al., J Nephrol. 2010 Jan-Feb;23(1):102-10.
Additional References at PubMed
PMID:9892664   PMID:12477932   PMID:15602007   PMID:15775979   PMID:16103090   PMID:16520537   PMID:16670314   PMID:17964719   PMID:18036336   PMID:18774778   PMID:18855016   PMID:19447895  
PMID:20375010   PMID:20921420   PMID:21388515   PMID:21515662   PMID:22696678   PMID:23407391   PMID:23610556   PMID:23816505   PMID:23963446   PMID:25503106   PMID:28493961   PMID:29179201  
PMID:30734065   PMID:33343804   PMID:37866316   PMID:38477100  


Genomics

Comparative Map Data
Cldn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,388,160 - 27,389,958 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,387,981 - 27,389,958 (+)EnsemblGRCr8
mRatBN7.21221,751,638 - 21,753,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,892,308 - 22,894,101 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,504,632 - 23,506,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,572,828 - 22,574,626 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,761,210 - 24,763,008 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,761,480 - 26,763,278 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,816,134 - 22,817,932 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,512,667 - 23,514,465 (+)NCBICelera
RGSC_v3.11222,686,996 - 22,688,792 (+)NCBI
Cytogenetic Map12q12NCBI
CLDN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,830,996 - 73,832,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,799,542 - 73,832,690 (+)Ensemblhg38GRCh38
GRCh37773,245,326 - 73,247,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,883,129 - 72,884,951 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34772,689,843 - 72,691,665NCBI
Celera768,723,847 - 68,725,669 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,128,478 - 69,130,300 (+)NCBIHuRef
CHM1_1773,390,573 - 73,392,395 (+)NCBICHM1_1
T2T-CHM13v2.0775,031,891 - 75,033,585 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,578,265 - 72,580,087 (+)NCBI
Cldn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,973,977 - 134,975,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,973,973 - 134,975,788 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385134,945,123 - 134,946,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,945,119 - 134,946,934 (-)Ensemblmm10GRCm38
MGSCv375135,420,993 - 135,422,804 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365135,229,754 - 135,231,542 (-)NCBIMGSCv36mm8
Celera5131,955,947 - 131,957,758 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.9NCBI
Cldn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,962,497 - 13,963,126 (-)Ensembl
ChiLan1.0NW_00495545613,961,743 - 13,965,498 (-)NCBIChiLan1.0ChiLan1.0
CLDN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,069,664 - 91,070,822 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,333,445 - 139,338,058 (-)NCBINHGRI_mPanPan1
PanPan1.1780,981,237 - 80,985,320 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,983,832 - 80,984,461 (+)EnsemblpanPan2panpan1.1
CLDN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,492,706 - 6,506,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,493,513 - 6,494,145 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha68,190,345 - 8,192,020 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.066,307,743 - 6,309,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.166,297,469 - 6,299,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,245,334 - 6,247,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,409,111 - 6,410,786 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cldn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,050,004 - 131,051,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,984,996 - 2,985,625 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,984,797 - 2,986,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,039,706 - 11,053,925 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1311,039,711 - 11,053,930 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,776,896 - 10,788,804 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,242,054 - 9,244,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,242,909 - 9,243,538 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660707,261,229 - 7,265,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474014,033,848 - 14,035,854 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cldn4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11619,099,054 - 19,101,031 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cldn4
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000002003
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH136879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,753,074 - 21,753,231 (+)MAPPERmRatBN7.2
Rnor_6.01224,762,647 - 24,762,803NCBIRnor6.0
Rnor_5.01226,762,917 - 26,763,073UniSTSRnor5.0
RGSC_v3.41222,817,571 - 22,817,727UniSTSRGSC3.4
Celera1223,514,104 - 23,514,260UniSTS
RH 3.4 Map12310.01UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 38 129 89 88 57 77 57 6 303 142 9 104 81 90 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000002003   ⟹   ENSRNOP00000002003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,387,981 - 27,389,958 (+)Ensembl
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)Ensembl
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)Ensembl
RefSeq Acc Id: NM_001012022   ⟹   NP_001012022
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,388,160 - 27,389,958 (+)NCBI
mRatBN7.21221,751,638 - 21,753,436 (+)NCBI
Rnor_6.01224,761,210 - 24,763,008 (+)NCBI
Rnor_5.01226,761,480 - 26,763,278 (+)NCBI
RGSC_v3.41222,816,134 - 22,817,932 (+)RGD
Celera1223,512,667 - 23,514,465 (+)RGD
Sequence:
RefSeq Acc Id: NP_001012022   ⟸   NM_001012022
- UniProtKB: Q5XIT8 (UniProtKB/TrEMBL),   A6J0G5 (UniProtKB/TrEMBL),   F7FBN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002003   ⟸   ENSRNOT00000002003

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIT8-F1-model_v2 AlphaFold Q5XIT8 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698564
Promoter ID:EPDNEW_R9089
Type:single initiation site
Name:Cldn4_1
Description:claudin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,761,218 - 24,761,278EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307932 AgrOrtholog
BioCyc Gene G2FUF-19595 BioCyc
Ensembl Genes ENSRNOG00000001476 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002003 ENTREZGENE
  ENSRNOT00000002003.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130270 IMAGE-MGC_LOAD
InterPro Claudin UniProtKB/TrEMBL
  Claudin4 UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report rno:304407 UniProtKB/TrEMBL
MGC_CLONE MGC:94208 IMAGE-MGC_LOAD
NCBI Gene 304407 ENTREZGENE
PANTHER Claudin UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PhenoGen Cldn4 PhenoGen
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN4 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001476 RatGTEx
UniProt A6J0G5 ENTREZGENE
  F7FBN1 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIT8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6J0G5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cldn4  claudin 4  Cldn4_predicted  claudin 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cldn4_predicted  claudin 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED