Adipor2 (adiponectin receptor 2) - Rat Genome Database

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Gene: Adipor2 (adiponectin receptor 2) Rattus norvegicus
Analyze
Symbol: Adipor2
Name: adiponectin receptor 2
RGD ID: 1307891
Description: Predicted to enable adipokinetic hormone receptor activity; adiponectin binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of hepatic stellate cell migration; positive regulation of D-glucose import; and response to fructose. Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of end stage renal disease; glucose metabolism disease (multiple); obesity; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2); PARTICIPATES IN adiponectin signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adiponectin receptor protein 2; LOC312670
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,195,440 - 154,261,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4154,172,567 - 154,231,666 (-)EnsemblGRCr8
mRatBN7.24152,524,604 - 152,588,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,524,623 - 152,559,355 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4158,792,285 - 158,806,087 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,575,983 - 154,589,788 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,199,317 - 153,213,123 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04151,412,135 - 151,480,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4151,414,684 - 151,428,894 (-)Ensemblrn6Rnor6.0
Rnor_5.04217,327,044 - 217,392,865 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44155,664,035 - 155,677,627 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4141,389,717 - 141,403,635 (-)NCBICelera
RGSC_v3.14155,907,605 - 155,942,117 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-aminobenzamide  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cysteamine  (EXP)
D-glucose  (EXP)
Deoxyschizandrin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
finasteride  (EXP)
folic acid  (ISO)
fosinopril  (EXP)
fructose  (ISO)
genistein  (ISO)
glafenine  (EXP)
glucose  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (EXP,ISO)
isoflavones  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
metformin  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
oleic acid  (EXP)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rosiglitazone  (EXP)
rotenone  (EXP)
scopoletin  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sodium oleate  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Resveratrol alleviates alcoholic fatty liver in mice. Ajmo JM, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G833-42. doi: 10.1152/ajpgi.90358.2008. Epub 2008 Aug 28.
2. The role of AdipoR1 and AdipoR2 in liver fibrosis. Alzahrani B, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):700-708. doi: 10.1016/j.bbadis.2017.12.012. Epub 2017 Dec 10.
3. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. Bagley HN, etal., J Obes. 2013;2013:312153. doi: 10.1155/2013/312153. Epub 2013 Mar 6.
4. Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. Beylot M, etal., Metabolism. 2006 Mar;55(3):396-401.
5. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Bonnard C, etal., Diabetes Metab. 2008 Feb;34(1):52-61. Epub 2008 Jan 25.
6. Expression and regulation of adiponectin and receptor in human and rat placenta. Caminos JE, etal., J Clin Endocrinol Metab. 2005 Jul;90(7):4276-86. Epub 2005 Apr 26.
7. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. Cha A, etal., J Biomed Biotechnol. 2012;2012:141395. doi: 10.1155/2012/141395. Epub 2011 Oct 12.
8. Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet. de Sousa AR, etal., Food Res Int. 2018 Oct;112:48-55. doi: 10.1016/j.foodres.2018.06.004. Epub 2018 Jun 4.
9. Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts. Fang X, etal., J Mol Endocrinol. 2005 Dec;35(3):465-76.
10. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Fujioka D, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2409-16. Epub 2006 Jan 13.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Guo Z, etal., Metabolism. 2007 Oct;56(10):1363-71.
13. Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone. Jang C, etal., Clin Endocrinol (Oxf). 2008 Nov;69(5):745-50. Epub 2008 Mar 15.
14. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Kadowaki T, etal., J Clin Invest. 2006 Jul;116(7):1784-92.
15. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Lee HI and Lee MK, Toxicol Lett. 2015 Sep 17;237(3):210-8. doi: 10.1016/j.toxlet.2015.06.016. Epub 2015 Jun 23.
16. Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease. Lei L, etal., Clin Exp Pharmacol Physiol. 2018 Aug;45(8):819-831. doi: 10.1111/1440-1681.12940. Epub 2018 Apr 30.
17. Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease. Lemoine M, etal., Liver Int. 2009 Oct;29(9):1431-8. doi: 10.1111/j.1478-3231.2009.02022.x. Epub 2009 Apr 24.
18. Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats. Li J, etal., J Diabetes Res. 2018 Aug 27;2018:4627842. doi: 10.1155/2018/4627842. eCollection 2018.
19. Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway. Li Z, etal., Int J Clin Exp Med. 2015 Oct 15;8(10):17295-307. eCollection 2015.
20. Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Liang X, etal., Antioxid Redox Signal. 2011 Jul 15;15(2):425-35. doi: 10.1089/ars.2010.3780. Epub 2011 May 4.
21. Association of the +33371 A/G polymorphism in adiponectin receptor 2 gene with Type 2 diabetes in the Chinese population. Liao YF, etal., J Endocrinol Invest. 2007 Nov;30(10):860-4.
22. The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats. Liu S, etal., Eur J Pharmacol. 2011 Jan 10;650(1):384-9. doi: 10.1016/j.ejphar.2010.09.082. Epub 2010 Oct 20.
23. Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD. Ma H, etal., Ann Hepatol. 2015 Jan-Feb;14(1):108-17.
24. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. Neumeier M, etal., World J Gastroenterol. 2006 Sep 14;12(34):5490-4.
27. Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice. Peng Y, etal., J Gastrointest Surg. 2009 Nov;13(11):2043-9. doi: 10.1007/s11605-009-1032-2. Epub 2009 Sep 18.
28. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Potapov VA, etal., Rev Diabet Stud. 2008 Spring;5(1):28-37. Epub 2008 May 10.
29. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Qiao L, etal., Diabetologia. 2014 May;57(5):1027-36. doi: 10.1007/s00125-014-3180-5. Epub 2014 Feb 16.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats. Sakai S, etal., J Surg Res. 2013 Nov;185(1):353-63. doi: 10.1016/j.jss.2013.06.002. Epub 2013 Jun 25.
33. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Steinmetz M, etal., Basic Res Cardiol. 2005 May;100(3):263-9. Epub 2005 Mar 9.
34. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Teras LR, etal., Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2553-7. doi: 10.1158/1055-9965.EPI-09-0542. Epub 2009 Sep 1.
35. Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Tomita K, etal., Hepatology. 2008 Aug;48(2):458-73. doi: 10.1002/hep.22365.
36. Coculture with primary visceral rat adipocytes from control but not streptozotocin-induced diabetic animals increases glucose uptake in rat skeletal muscle cells: role of adiponectin. Vu V, etal., Endocrinology. 2007 Sep;148(9):4411-9. Epub 2007 Jun 14.
37. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Wang M, etal., Sci Rep. 2016 May 25;6:26826. doi: 10.1038/srep26826.
38. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. Wang Y, etal., J Genet Genomics. 2009 Jul;36(7):417-23.
39. Tissue-specific effect of dietary cysteamine on expression of adiponectin receptors in rats. Xu J, etal., J Agric Food Chem. 2007 Sep 19;55(19):7968-73. doi: 10.1021/jf0718695. Epub 2007 Aug 16.
40. Changes of adiponectin and its receptors in rats following chronic renal failure. Yu Y, etal., Ren Fail. 2014 Feb;36(1):92-7. doi: 10.3109/0886022X.2013.830975. Epub 2013 Sep 13.
41. [Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease]. Zhang C and Guo L, Nan Fang Yi Ke Da Xue Xue Bao. 2014 Oct;34(10):1481-7.
42. ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES. Zhang X, etal., Clin Exp Pharmacol Physiol. 2008 Nov 28.
43. Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats. Zhang X, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1058-63. Epub 2009 Feb 9.
44. Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Zhang Y, etal., Eur J Nutr. 2014 Feb;53(1):221-32. doi: 10.1007/s00394-013-0519-5.
45. Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. Zhu Z, etal., Alcohol Clin Exp Res. 2014 Jun;38(6):1510-9. doi: 10.1111/acer.12418. Epub 2014 May 5.
Additional References at PubMed
PMID:12802337   PMID:16988040   PMID:18353182   PMID:18971219   PMID:19500219   PMID:19887079   PMID:19958641   PMID:20206611   PMID:20380822   PMID:20600433   PMID:20846698   PMID:21852089  
PMID:22873349   PMID:23043361   PMID:23378066   PMID:23667684   PMID:24742672   PMID:34973951   PMID:35271883  


Genomics

Comparative Map Data
Adipor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84154,195,440 - 154,261,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4154,172,567 - 154,231,666 (-)EnsemblGRCr8
mRatBN7.24152,524,604 - 152,588,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,524,623 - 152,559,355 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4158,792,285 - 158,806,087 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04154,575,983 - 154,589,788 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04153,199,317 - 153,213,123 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04151,412,135 - 151,480,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4151,414,684 - 151,428,894 (-)Ensemblrn6Rnor6.0
Rnor_5.04217,327,044 - 217,392,865 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44155,664,035 - 155,677,627 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4141,389,717 - 141,403,635 (-)NCBICelera
RGSC_v3.14155,907,605 - 155,942,117 (-)NCBI
Cytogenetic Map4q42NCBI
ADIPOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,691,070 - 1,788,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,688,574 - 1,788,680 (+)Ensemblhg38GRCh38
GRCh37121,800,236 - 1,897,840 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,670,508 - 1,768,106 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34121,670,507 - 1,768,105NCBI
Celera123,408,168 - 3,505,568 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef121,655,190 - 1,752,562 (+)NCBIHuRef
CHM1_1121,799,110 - 1,896,969 (+)NCBICHM1_1
T2T-CHM13v2.0121,687,685 - 1,784,807 (+)NCBIT2T-CHM13v2.0
Adipor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,330,111 - 119,394,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,330,111 - 119,394,665 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386119,353,150 - 119,417,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,353,150 - 119,417,704 (-)Ensemblmm10GRCm38
MGSCv376119,303,168 - 119,367,501 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366119,318,769 - 119,383,102 (-)NCBIMGSCv36mm8
Celera6121,185,998 - 121,250,677 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.78NCBI
Adipor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554544,243,898 - 4,327,308 (+)Ensembl
ChiLan1.0NW_0049554544,243,898 - 4,327,255 (+)NCBIChiLan1.0ChiLan1.0
ADIPOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2107,200,284 - 7,329,962 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1127,197,038 - 7,326,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,772,426 - 1,902,070 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,750,756 - 1,852,251 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,817,620 - 1,852,251 (+)EnsemblpanPan2panpan1.1
ADIPOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12743,739,269 - 43,840,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2743,741,679 - 43,878,467 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha272,844,989 - 2,990,473 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02744,061,828 - 44,210,393 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2744,061,877 - 44,207,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,993,124 - 44,138,443 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,965,465 - 44,111,111 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,202,709 - 2,348,377 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adipor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945107,176,992 - 107,255,585 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,948,743 - 2,007,163 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366061,911,104 - 2,007,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADIPOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,755,811 - 68,807,235 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1568,755,789 - 68,807,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,997,251 - 71,062,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADIPOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,802,694 - 1,836,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,738,026 - 1,837,060 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660636,490,807 - 6,589,764 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adipor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473511,103,076 - 11,174,337 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473511,103,082 - 11,174,277 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adipor2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1627,385,331 - 27,400,336 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adipor2
308 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:218
Interacting mature miRNAs:267
Transcripts:ENSRNOT00000010556
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH138934  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84154,197,003 - 154,197,147 (+)Marker Load Pipeline
mRatBN7.24152,524,703 - 152,524,847 (+)MAPPERmRatBN7.2
Rnor_6.04151,413,699 - 151,413,842NCBIRnor6.0
Rnor_5.04217,328,608 - 217,328,751UniSTSRnor5.0
RGSC_v3.44155,662,865 - 155,663,008UniSTSRGSC3.4
Celera4141,388,547 - 141,388,690UniSTS
RH 3.4 Map4975.1UniSTS
Cytogenetic Map4q42UniSTS
BM386739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,525,507 - 152,525,676 (+)MAPPERmRatBN7.2
Rnor_6.04151,414,503 - 151,414,671NCBIRnor6.0
Rnor_5.04217,329,412 - 217,329,580UniSTSRnor5.0
RGSC_v3.44155,663,669 - 155,663,837UniSTSRGSC3.4
Celera4141,389,351 - 141,389,519UniSTS
RH 3.4 Map4974.1UniSTS
Cytogenetic Map4q42UniSTS
Adipor2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24152,529,079 - 152,529,735 (+)MAPPERmRatBN7.2
Rnor_6.04151,418,075 - 151,418,728NCBIRnor6.0
Rnor_5.04217,332,984 - 217,333,637UniSTSRnor5.0
RGSC_v3.44155,667,241 - 155,667,894UniSTSRGSC3.4
Celera4141,392,923 - 141,393,576UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010556   ⟹   ENSRNOP00000010556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4154,196,923 - 154,231,650 (-)Ensembl
mRatBN7.2 Ensembl4152,524,623 - 152,559,355 (-)Ensembl
Rnor_6.0 Ensembl4151,414,684 - 151,428,894 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142199   ⟹   ENSRNOP00000106556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4154,172,567 - 154,231,666 (-)Ensembl
RefSeq Acc Id: NM_001037979   ⟹   NP_001033068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,198,174 - 154,211,979 (-)NCBI
mRatBN7.24152,525,874 - 152,539,683 (-)NCBI
Rnor_6.04151,414,869 - 151,428,819 (-)NCBI
Rnor_5.04217,327,044 - 217,392,865 (-)NCBI
RGSC_v3.44155,664,035 - 155,677,627 (-)RGD
Celera4141,389,717 - 141,403,635 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237183   ⟹   XP_006237245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,232,353 (-)NCBI
mRatBN7.24152,524,604 - 152,559,411 (-)NCBI
Rnor_6.04151,412,135 - 151,448,754 (-)NCBI
Rnor_5.04217,327,044 - 217,392,865 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237184   ⟹   XP_006237246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,261,141 (-)NCBI
mRatBN7.24152,525,730 - 152,588,848 (-)NCBI
Rnor_6.04151,414,725 - 151,480,108 (-)NCBI
Rnor_5.04217,327,044 - 217,392,865 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107651   ⟹   XP_038963579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,261,107 (-)NCBI
mRatBN7.24152,525,730 - 152,588,781 (-)NCBI
RefSeq Acc Id: XM_063286112   ⟹   XP_063142182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,261,121 (-)NCBI
RefSeq Acc Id: XM_063286113   ⟹   XP_063142183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,261,137 (-)NCBI
RefSeq Acc Id: XM_063286114   ⟹   XP_063142184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84154,195,440 - 154,261,094 (-)NCBI
RefSeq Acc Id: NP_001033068   ⟸   NM_001037979
- Sequence:
RefSeq Acc Id: XP_006237246   ⟸   XM_006237184
- Peptide Label: isoform X1
- UniProtKB: G3V707 (UniProtKB/TrEMBL),   A6IL82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237245   ⟸   XM_006237183
- Peptide Label: isoform X1
- UniProtKB: G3V707 (UniProtKB/TrEMBL),   A6IL82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010556   ⟸   ENSRNOT00000010556
RefSeq Acc Id: XP_038963579   ⟸   XM_039107651
- Peptide Label: isoform X1
- UniProtKB: G3V707 (UniProtKB/TrEMBL),   A6IL82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142183   ⟸   XM_063286113
- Peptide Label: isoform X1
- UniProtKB: A6IL82 (UniProtKB/TrEMBL),   G3V707 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142182   ⟸   XM_063286112
- Peptide Label: isoform X1
- UniProtKB: A6IL82 (UniProtKB/TrEMBL),   G3V707 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142184   ⟸   XM_063286114
- Peptide Label: isoform X1
- UniProtKB: A6IL82 (UniProtKB/TrEMBL),   G3V707 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106556   ⟸   ENSRNOT00000142199

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V707-F1-model_v2 AlphaFold G3V707 1-386 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307891 AgrOrtholog
BioCyc Gene G2FUF-43221 BioCyc
Ensembl Genes ENSRNOG00000007990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010556 ENTREZGENE
  ENSRNOT00000010556.7 UniProtKB/TrEMBL
  ENSRNOT00000142199 ENTREZGENE
  ENSRNOT00000142199.1 UniProtKB/TrEMBL
InterPro HlyIII-related UniProtKB/TrEMBL
KEGG Report rno:312670 UniProtKB/TrEMBL
NCBI Gene 312670 ENTREZGENE
PANTHER ADIPONECTIN RECEPTOR PROTEIN 2 UniProtKB/TrEMBL
  HlyIII_related UniProtKB/TrEMBL
Pfam HlyIII UniProtKB/TrEMBL
PhenoGen Adipor2 PhenoGen
RatGTEx ENSRNOG00000007990 RatGTEx
UniProt A0ABK0LNX4_RAT UniProtKB/TrEMBL
  A6IL82 ENTREZGENE, UniProtKB/TrEMBL
  G3V707 ENTREZGENE, UniProtKB/TrEMBL
  Q3YAF7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Adipor2  adiponectin receptor 2  Adipor2_predicted  adiponectin receptor 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Adipor2_predicted  adiponectin receptor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED