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Gene: Pycr1 (pyrroline-5-carboxylate reductase 1) Rattus norvegicus

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Symbol:

Pycr1

Name:

pyrroline-5-carboxylate reductase 1

RGD ID:

1307863

Description:

Predicted to enable identical protein binding activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in several processes, including L-proline biosynthetic process; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC287877; pyrroline-5-carboxylate reductase 1, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PYCR1 (pyrroline-5-carboxylate reductase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PYCR1 (pyrroline-5-carboxylate reductase 1)	Alliance	DIOPT (HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pycr1 (pyrroline-5-carboxylate reductase 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pycr1a (pyrroline-5-carboxylate reductase 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pycr1a (pyrroline-5-carboxylate reductase 1a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pycr1b (pyrroline-5-carboxylate reductase 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pycr1b (pyrroline-5-carboxylate reductase 1b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRO3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRO3	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	M153.1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	M153.1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	P5cr-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	P5cr-2	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pycr1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pycr1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,416,056 - 106,420,982 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,412,576 - 106,423,393 (-)	Ensembl				GRCr8
mRatBN7.2	10	105,917,732 - 105,922,658 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,917,680 - 105,922,549 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	111,022,441 - 111,025,645 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,485,479 - 110,488,683 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,839,131 - 105,842,439 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,817,300 - 109,822,218 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,818,177 - 109,821,807 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,411,300 - 109,414,609 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	110,030,931 - 110,035,883 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,462,087 - 104,465,395 (-)	NCBI		Celera
RGSC_v3.1	10	110,046,548 - 110,050,508 (-)	NCBI
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Cutis Laxa (ISO)

autosomal recessive cutis laxa type IIB (ISO)

autosomal recessive cutis laxa type IIIB (ISO)

COVID-19 (ISO)

cutis laxa (ISO)

Desbuquois dysplasia (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

microcephaly (ISO)

progeria (ISO)

Wiedemann-Rautenstrauch syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzatropine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

choline (ISO)

cidofovir anhydrous (ISO)

cisplatin (EXP,ISO)

clodronic acid (ISO)

clozapine (ISO)

cobalt dichloride (EXP,ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP,ISO)

dexamethasone (ISO)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

diuron (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

glafenine (EXP)

haloperidol (ISO)

hydrogen peroxide (ISO)

ifosfamide (ISO)

ivermectin (ISO)

L-methionine (ISO)

manganese(II) chloride (EXP)

metformin (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

naled (ISO)

naphthalene (ISO)

nevirapine (EXP)

nobiletin (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

streptozocin (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trovafloxacin (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid biosynthetic process (IEA)

cellular response to oxidative stress (ISO)

L-proline biosynthetic process (IBA,IEA,ISO)

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (ISO)

regulation of mitochondrial membrane potential (ISO)

Cellular Component

mitochondrion (ISO)

pyrroline-5-carboxylate reductase complex (ISO)

Molecular Function

identical protein binding (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

pyrroline-5-carboxylate reductase activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

arginine and proline metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2722838	PMID:12477932	PMID:14651853	PMID:16730026	PMID:18614015	PMID:19648921	PMID:23024808	PMID:23106098	PMID:23743200

Genomics

Comparative Map Data

Pycr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,416,056 - 106,420,982 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,412,576 - 106,423,393 (-)	Ensembl				GRCr8
mRatBN7.2	10	105,917,732 - 105,922,658 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,917,680 - 105,922,549 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	111,022,441 - 111,025,645 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,485,479 - 110,488,683 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,839,131 - 105,842,439 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,817,300 - 109,822,218 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,818,177 - 109,821,807 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,411,300 - 109,414,609 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	110,030,931 - 110,035,883 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,462,087 - 104,465,395 (-)	NCBI		Celera
RGSC_v3.1	10	110,046,548 - 110,050,508 (-)	NCBI
Cytogenetic Map	10	q32.3	NCBI

PYCR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,932,391 - 81,937,300 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,932,378 - 81,942,412 (-)	Ensembl			hg38	GRCh38
GRCh37	17	79,890,267 - 79,895,176 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,483,558 - 77,488,259 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	17	76,494,307 - 76,499,008 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,291,232 - 75,295,933 (-)	NCBI		HuRef
CHM1_1	17	79,976,471 - 79,981,172 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,799,550 - 82,804,459 (-)	NCBI		T2T-CHM13v2.0

Pycr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,527,591 - 120,534,602 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,526,538 - 120,534,595 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	120,638,998 - 120,643,748 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,635,712 - 120,643,769 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	120,497,026 - 120,504,984 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,455,514 - 120,459,794 (-)	NCBI		MGSCv36	mm8
Celera	11	132,371,062 - 132,379,022 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.37	NCBI

Pycr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,231,863 - 1,236,550 (+)	Ensembl
ChiLan1.0	NW_004955506	1,231,874 - 1,236,550 (+)	NCBI	ChiLan1.0	ChiLan1.0

PYCR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,468,518 - 98,479,691 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,369,297 - 103,386,282 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,337,991 - 76,348,207 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,040,824 - 82,045,691 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,040,824 - 82,045,686 (-)	Ensembl			panPan2	panpan1.1

PYCR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	360,353 - 364,795 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	360,376 - 364,570 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	962,468 - 966,895 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	953,687 - 958,114 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	953,684 - 958,106 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	978,841 - 983,268 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,105,463 - 1,109,889 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,184,099 - 1,188,527 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pycr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	968,399 - 972,773 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,439,175 - 5,443,564 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,439,911 - 5,443,535 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PYCR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,060,570 - 1,064,805 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	1,060,028 - 1,064,808 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PYCR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,805,680 - 73,810,707 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,805,409 - 73,810,199 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	45,257,773 - 45,262,751 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pycr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,776,747 - 10,781,614 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624801	10,777,407 - 10,781,572 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pycr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	63,378,835 - 63,383,475 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pycr1
26 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	30
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000054949
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93723381	107556066	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
1576313	Pia25	Pristane induced arthritis QTL 25			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	97202388	107556066	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1576307	Cia28	Collagen induced arthritis QTL 28			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91727883	107713808	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	97202388	107556066	Rat

Markers in Region

RH137343

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	105,917,787 - 105,917,971 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	109,817,356 - 109,817,539	NCBI	Rnor6.0
Rnor_5.0	10	109,410,408 - 109,410,591	UniSTS	Rnor5.0
RGSC_v3.4	10	110,030,960 - 110,031,143	UniSTS	RGSC3.4
Celera	10	104,461,184 - 104,461,367	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	157	91	90	59	71	59	6	319	169	11	136	67	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000054949 ⟹ ENSRNOP00000051832

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,416,098 - 106,423,393 (-)	Ensembl
mRatBN7.2 Ensembl	10	105,917,778 - 105,922,549 (-)	Ensembl
Rnor_6.0 Ensembl	10	109,818,177 - 109,821,807 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109183 ⟹ ENSRNOP00000092681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,412,576 - 106,420,812 (-)	Ensembl
mRatBN7.2 Ensembl	10	105,917,680 - 105,922,453 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110897 ⟹ ENSRNOP00000093202

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,416,056 - 106,422,683 (-)	Ensembl
mRatBN7.2 Ensembl	10	105,917,680 - 105,922,467 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122777 ⟹ ENSRNOP00000106212

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,415,340 - 106,420,982 (-)	Ensembl

RefSeq Acc Id:

NM_001105857 ⟹ NP_001099327

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,416,056 - 106,420,812 (-)	NCBI
mRatBN7.2	10	105,917,732 - 105,922,488 (-)	NCBI
Rnor_6.0	10	109,818,248 - 109,821,556 (-)	NCBI
Rnor_5.0	10	109,411,300 - 109,414,609 (-)	NCBI
RGSC_v3.4	10	110,030,931 - 110,035,883 (-)	RGD
Celera	10	104,462,087 - 104,465,395 (-)	NCBI

Sequence:

show sequence

ATGAGCGTAGGCTTCATCGGGGCAGGGCAGCTAGCCTTTGCCCTAGCCAAGGGCTTCACAGCTG
CAGGTGTTCTGGCTGCTCACAAGATAATGGCCAGCTCCCCAGACATGGACCAAGCCACAGTCTC
TGCCCTCCGGAAGATAGGGGTGAACCTGACACCCCACAACAAGGAGACGGTGTGCCACAGCGAT
GTGCTCTTCCTGGCTGTGAAGCCCCACATCATCCCCTTCATCCTGGATGAAATTGGTGCTAACA
TTGAGGACAGGCACATTGTAGTGTCCTGTGCGGCAGGTGTCACCATCAACTCCATTGAAAAGAA
ACTGACAGCGTTCCAACCTGCTCCCAAAGTCATCCGATGCATGACTAACACCCCGGTCGTGGTA
CGGGAGGGGGTTACTGTGTACGCCACGGGTACTCACGCTCAGGTGGAAGATGGCAAGCTTGTGG
AGCAGCTCATGGGCAGCGTGGGCTTCTGCACAGAGGTGGAAGAAGATCTGATCGATGCCGTCAC
GGGGCTCAGTGGCAGCGGCCCTGCCTATGCTTTCACAGCCCTGGATGCTCTGGCTGATGGTGGT
GTGAAAATGGGGCTTCCAAGACGTCTGGCAGTCCGCCTTGGGGCCCAGGCCCTCCTGGGGGCAG
CCAAGATGCTACTAGATTCAGAACAACATCCGGGCCAGCTCAAGGACAATGTCTGCTCTCCTGG
TGGGGCCACCATCCATGCCTTGCATGTGCTGGAGAGTGGGGGCTTTCGTTCCCTGCTTATCAAT
GCTGTGGAAGCCTCCTGTATCCGCACACGGGAGCTGCAGACCATGGCTGATCAGGAAACCGTCT
CCCCTGCTGCCATAAAGAAGACTGTACTGGACAAGGTGAAGCTAGACTCCTCTGCTGGGGTCTC
TCTGTCTTCTGGCCATGTTAAGCCGATGTCCTGA

hide sequence

RefSeq Acc Id:

XM_008768472 ⟹ XP_008766694

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,416,056 - 106,420,982 (-)	NCBI
mRatBN7.2	10	105,917,732 - 105,922,658 (-)	NCBI
Rnor_6.0	10	109,817,300 - 109,822,182 (-)	NCBI

Sequence:

show sequence

CAATGTACAAGGCTCCAGCTGCAGCTCTGGATTGGCTAGCTCTCAAAGGCCGCACAGCTCATTG
GCTGAAGTGGAATGGGGGCGAGGCCGTTCTCTGCTGCCCTACAGAGCCGGACGTCAGCTGTGAA
GGTTGTGGGTCCTGGAACTCCAGACATGAGCGTAGGCTTCATCGGGGCAGGGCAGCTAGCCTTT
GCCCTAGCCAAGGGCTTCACAGCTGCAGGTGTTCTGGCTGCTCACAAGATAATGGCCAGCTCCC
CAGACATGGACCAAGCCACAGTCTCTGCCCTCCGGAAGATAGGGGTGAACCTGACACCCCACAA
CAAGGAGACGGTGTGCCACAGCGATGTGCTCTTCCTGGCTGTGAAGCCCCACATCATCCCCTTC
ATCCTGGATGAAATTGGTGCTAACATTGAGGACAGGCACATTGTAGTGTCCTGTGCGGCAGGTG
TCACCATCAACTCCATTGAAAAGAAACTGACAGCGTTCCAACCTGCTCCCAAAGTCATCCGATG
CATGACTAACACCCCGGTCGTGGTACGGGAGGGGGTTACTGTGTACGCCACGGGTACTCACGCT
CAGGTGGAAGATGGCAAGCTTGTGGAGCAGCTCATGGGCAGCGTGGGCTTCTGCACAGAGGTGG
AAGAAGATCTGATCGATGCCGTCACGGGGCTCAGTGGCAGCGGCCCTGCCTATGCTTTCACAGC
CCTGGATGCTCTGGCTGATGGTGGTGTGAAAATGGGGCTTCCAAGACGTCTGGCAGTCCGCCTT
GGGGCCCAGGCCCTCCTGGGGGCAGCCAAGATGCTACTAGATTCAGAACAACATCCGGGCCAGC
TCAAGGACAATGTCTGCTCTCCTGGTGGGGCCACCATCCATGCCTTGCATGTGCTGGAGAGTGG
GGGCTTTCGTTCCCTGCTTATCAATGCTGTGGAAGCCTCCTGTATCCGCACACGGGAGCTGCAG
ACCATGGCTGATCAGGAAACCGTCTCCCCTGCTGCCATAAAGAAGACTGTACTGGACAAGCTTC
TGTCCTGGTGCTCTCAGACAACACAGAATATCCCCACAGCAGGCCCTTGCCCACAGCCAGGTCA
GCTGGGAAGGGAACATCACTTACAACTAGGGACCTCCATTGATACTCAAGTGCCAGCTGGAAAC
AGGGTGGGTGCTCAGTCCGCCACCTCTTCAGCTTCCCCTGGAGCTCAGGCCTGTGGGGGTCTTT
ATCCTCCCTAGTTTTGGGGTCAGCTAGCTGGCTTAGCCACGGTCCCTTCCTGTGATCCACTCAC
AGGGTTCCTTTCTGTGACAGCCAGCTAGTCCCAGACAATCTGTACCTCCCTCCTTCTAGGGACT
TAATGCTTTACCAATAATCCCACTAGGCATTTGGGAAAAGAACTTCTCAGGTAGCCGACGAAAC
TCCTGCATGTTCCTCGACTCAACAAATGCTGTTACTTCTCTTCCTGTACTTTCAGTTGAATAAT
TAAAAAAAAAAAAAATCCCCCAAA

hide sequence

RefSeq Acc Id:

XM_008768473 ⟹ XP_008766695

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,416,056 - 106,420,936 (-)	NCBI
mRatBN7.2	10	105,917,732 - 105,922,582 (-)	NCBI
Rnor_6.0	10	109,817,300 - 109,822,218 (-)	NCBI

Sequence:

show sequence

CAGGGAGGAGCGTCTGTCCCGGTCCTGTGTATGATGCAATGTACAAGGCTCCAGCTGCAGCTCT
GGATTGGCTAGCTCTCAAAGGCCGCACAGCTCATTGGCTGAAGTGGAATGGGGGCGAGGCCGGT
AGGCACGGGTGCCGCGTGGCGAATGCAGAGGGCTGGACTGTCGTAGGTGTGCGCCAGAGTAGCC
ACGCTTTCTCTGCTGCCCTACAGAGCCGGACGTCAGCTGTGAAGGTTGTGGGTCCTGGAACTCC
AGACATGAGCGTAGGCTTCATCGGGGCAGGGCAGCTAGCCTTTGCCCTAGCCAAGGGCTTCACA
GCTGCAGGTGTTCTGGCTGCTCACAAGATAATGGCCAGCTCCCCAGACATGGACCAAGCCACAG
TCTCTGCCCTCCGGAAGATAGGGGTGAACCTGACACCCCACAACAAGGAGACGGTGTGCCACAG
CGATGTGCTCTTCCTGGCTGTGAAGCCCCACATCATCCCCTTCATCCTGGATGAAATTGGTGCT
AACATTGAGGACAGGCACATTGTAGTGTCCTGTGCGGCAGGTGTCACCATCAACTCCATTGAAA
AGAAACTGACAGCGTTCCAACCTGCTCCCAAAGTCATCCGATGCATGACTAACACCCCGGTCGT
GGTACGGGAGGGGGTTACTGTGTACGCCACGGGTACTCACGCTCAGGTGGAAGATGGCAAGCTT
GTGGAGCAGCTCATGGGCAGCGTGGGCTTCTGCACAGAGGTGGAAGAAGATCTGATCGATGCCG
TCACGGGGCTCAGTGGCAGCGGCCCTGCCTATGCTTTCACAGCCCTGGATGCTCTGGCTGATGG
TGGTGTGAAAATGGGGCTTCCAAGACGTCTGGCAGTCCGCCTTGGGGCCCAGGCCCTCCTGGGG
GCAGCCAAGATGCTACTAGATTCAGAACAACATCCGGGCCAGCTCAAGGACAATGTCTGCTCTC
CTGGTGGGGCCACCATCCATGCCTTGCATGTGCTGGAGAGTGGGGGCTTTCGTTCCCTGCTTAT
CAATGCTGTGGAAGCCTCCTGTATCCGCACACGGGAGCTGCAGACCATGGCTGATCAGGAAACC
GTCTCCCCTGCTGCCATAAAGAAGACTGTACTGGACAAGCTTCTGTCCTGGTGCTCTCAGACAA
CACAGAATATCCCCACAGCAGGCCCTTGCCCACAGCCAGGTCAGCTGGGAAGGGAACATCACTT
ACAACTAGGGACCTCCATTGATACTCAAGTGCCAGCTGGAAACAGGGTGGGTGCTCAGTCCGCC
ACCTCTTCAGCTTCCCCTGGAGCTCAGGCCTGTGGGGGTCTTTATCCTCCCTAGTTTTGGGGTC
AGCTAGCTGGCTTAGCCACGGTCCCTTCCTGTGATCCACTCACAGGGTTCCTTTCTGTGACAGC
CAGCTAGTCCCAGACAATCTGTACCTCCCTCCTTCTAGGGACTTAATGCTTTACCAATAATCCC
ACTAGGCATTTGGGAAAAGAACTTCTCAGGTAGCCGACGAAACTCCTGCATGTTCCTCGACTCA
ACAAATGCTGTTACTTCTCTTCCTGTACTTTCAGTTGAATAATTAAAAAAAAAAAAAATCCCCC
AAA

hide sequence

RefSeq Acc Id:

XM_008768474 ⟹ XP_008766696

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,416,056 - 106,420,883 (-)	NCBI
mRatBN7.2	10	105,917,732 - 105,922,559 (-)	NCBI
Rnor_6.0	10	109,817,300 - 109,822,102 (-)	NCBI

Sequence:

show sequence

GGCGAGGCCGGTAGGCACGGGTGCCGCGTGGCGAATGCAGAGGGCTGGACTGTCGTAGTTCTCT
GCTGCCCTACAGAGCCGGACGTCAGCTGTGAAGGTTGTGGGTCCTGGAACTCCAGACATGAGCG
TAGGCTTCATCGGGGCAGGGCAGCTAGCCTTTGCCCTAGCCAAGGGCTTCACAGCTGCAGGTGT
TCTGGCTGCTCACAAGATAATGGCCAGCTCCCCAGACATGGACCAAGCCACAGTCTCTGCCCTC
CGGAAGATAGGGGTGAACCTGACACCCCACAACAAGGAGACGGTGTGCCACAGCGATGTGCTCT
TCCTGGCTGTGAAGCCCCACATCATCCCCTTCATCCTGGATGAAATTGGTGCTAACATTGAGGA
CAGGCACATTGTAGTGTCCTGTGCGGCAGGTGTCACCATCAACTCCATTGAAAAGAAACTGACA
GCGTTCCAACCTGCTCCCAAAGTCATCCGATGCATGACTAACACCCCGGTCGTGGTACGGGAGG
GGGTTACTGTGTACGCCACGGGTACTCACGCTCAGGTGGAAGATGGCAAGCTTGTGGAGCAGCT
CATGGGCAGCGTGGGCTTCTGCACAGAGGTGGAAGAAGATCTGATCGATGCCGTCACGGGGCTC
AGTGGCAGCGGCCCTGCCTATGCTTTCACAGCCCTGGATGCTCTGGCTGATGGTGGTGTGAAAA
TGGGGCTTCCAAGACGTCTGGCAGTCCGCCTTGGGGCCCAGGCCCTCCTGGGGGCAGCCAAGAT
GCTACTAGATTCAGAACAACATCCGGGCCAGCTCAAGGACAATGTCTGCTCTCCTGGTGGGGCC
ACCATCCATGCCTTGCATGTGCTGGAGAGTGGGGGCTTTCGTTCCCTGCTTATCAATGCTGTGG
AAGCCTCCTGTATCCGCACACGGGAGCTGCAGACCATGGCTGATCAGGAAACCGTCTCCCCTGC
TGCCATAAAGAAGACTGTACTGGACAAGCTTCTGTCCTGGTGCTCTCAGACAACACAGAATATC
CCCACAGCAGGCCCTTGCCCACAGCCAGGTCAGCTGGGAAGGGAACATCACTTACAACTAGGGA
CCTCCATTGATACTCAAGTGCCAGCTGGAAACAGGGTGGGTGCTCAGTCCGCCACCTCTTCAGC
TTCCCCTGGAGCTCAGGCCTGTGGGGGTCTTTATCCTCCCTAGTTTTGGGGTCAGCTAGCTGGC
TTAGCCACGGTCCCTTCCTGTGATCCACTCACAGGGTTCCTTTCTGTGACAGCCAGCTAGTCCC
AGACAATCTGTACCTCCCTCCTTCTAGGGACTTAATGCTTTACCAATAATCCCACTAGGCATTT
GGGAAAAGAACTTCTCAGGTAGCCGACGAAACTCCTGCATGTTCCTCGACTCAACAAATGCTGT
TACTTCTCTTCCTGTACTTTCAGTTGAATAATTAAAAAAAAAAAAAATCCCCCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099327	(Get FASTA)	NCBI Sequence Viewer
	XP_008766694	(Get FASTA)	NCBI Sequence Viewer
	XP_008766695	(Get FASTA)	NCBI Sequence Viewer
	XP_008766696	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM06878	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000051832
	ENSRNOP00000051832.5
	ENSRNOP00000092681.2
	ENSRNOP00000093202
	ENSRNOP00000093202.2
	ENSRNOP00000106212
	ENSRNOP00000106212.1

RefSeq Acc Id:

NP_001099327 ⟸ NM_001105857

- UniProtKB:

A0A8I6AII4 (UniProtKB/TrEMBL), A6HLH3 (UniProtKB/TrEMBL), A0A8I6GJW9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDQATVSALRKIGVNLTPHNKETVCHSD
VLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTINSIEKKLTAFQPAPKVIRCMTNTPVVV
REGVTVYATGTHAQVEDGKLVEQLMGSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGG
VKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIHALHVLESGGFRSLLIN
AVEASCIRTRELQTMADQETVSPAAIKKTVLDKVKLDSSAGVSLSSGHVKPMS

hide sequence

RefSeq Acc Id:	XP_008766694 ⟸ XM_008768472
- Peptide Label:	isoform X2
- UniProtKB:	D3ZXI0 (UniProtKB/TrEMBL), A0A8I6GJW9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGARPFSAALQSRTSAVKVVGPGTPDMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMD QATVSALRKIGVNLTPHNKETVCHSDVLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTIN SIEKKLTAFQPAPKVIRCMTNTPVVVREGVTVYATGTHAQVEDGKLVEQLMGSVGFCTEVEEDL IDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDN VCSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQTMADQETVSPAAIKKTVLDKLLSWC SQTTQNIPTAGPCPQPGQLGREHHLQLGTSIDTQVPAGNRVGAQSATSSASPGAQACGGLYPP hide sequence

RefSeq Acc Id:	XP_008766696 ⟸ XM_008768474
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6GJW9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDQATVSALRKIGVNLTPHNKETVCHSD VLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTINSIEKKLTAFQPAPKVIRCMTNTPVVV REGVTVYATGTHAQVEDGKLVEQLMGSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGG VKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIHALHVLESGGFRSLLIN AVEASCIRTRELQTMADQETVSPAAIKKTVLDKLLSWCSQTTQNIPTAGPCPQPGQLGREHHLQ LGTSIDTQVPAGNRVGAQSATSSASPGAQACGGLYPP hide sequence

RefSeq Acc Id:

XP_008766695 ⟸ XM_008768473

- Peptide Label:

isoform X1

- Sequence:

show sequence

MYKAPAAALDWLALKGRTAHWLKWNGGEAGRHGCRVANAEGWTVVGVRQSSHAFSAALQSRTSA
VKVVGPGTPDMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDQATVSALRKIGVNLTP
HNKETVCHSDVLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTINSIEKKLTAFQPAPKVI
RCMTNTPVVVREGVTVYATGTHAQVEDGKLVEQLMGSVGFCTEVEEDLIDAVTGLSGSGPAYAF
TALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPGQLKDNVCSPGGATIHALHVLE
SGGFRSLLINAVEASCIRTRELQTMADQETVSPAAIKKTVLDKLLSWCSQTTQNIPTAGPCPQP
GQLGREHHLQLGTSIDTQVPAGNRVGAQSATSSASPGAQACGGLYPP

hide sequence

Ensembl Acc Id:

ENSRNOP00000051832 ⟸ ENSRNOT00000054949

Ensembl Acc Id:

ENSRNOP00000092681 ⟸ ENSRNOT00000109183

Ensembl Acc Id:

ENSRNOP00000093202 ⟸ ENSRNOT00000110897

Ensembl Acc Id:

ENSRNOP00000106212 ⟸ ENSRNOT00000122777

Protein Domains

Pyrroline-5-carboxylate reductase catalytic N- Pyrroline-5-carboxylate reductase dimerisation

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZXI0-F1-model_v2	AlphaFold	D3ZXI0	1-359	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307863	AgrOrtholog
BioCyc Gene	G2FUF-22400	BioCyc
BioCyc Pathway	ARG-PRO-PWY [L-arginine degradation VI (arginase 2 pathway)]	BioCyc
BioCyc Pathway Image	ARG-PRO-PWY	BioCyc
Ensembl Genes	ENSRNOG00000036682	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000054949	ENTREZGENE
	ENSRNOT00000054949.6	UniProtKB/TrEMBL
	ENSRNOT00000109183.2	UniProtKB/TrEMBL
	ENSRNOT00000110897	ENTREZGENE
	ENSRNOT00000110897.2	UniProtKB/TrEMBL
	ENSRNOT00000122777	ENTREZGENE
	ENSRNOT00000122777.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	ProC C-terminal domain-like	UniProtKB/TrEMBL
InterPro	6-PGluconate_DH_C-like	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P5CR	UniProtKB/TrEMBL
	P5CR-like	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
	ProC_N	UniProtKB/TrEMBL
KEGG Report	rno:287877	UniProtKB/TrEMBL
NCBI Gene	287877	ENTREZGENE
PANTHER	PTHR11645	UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
PhenoGen	Pycr1	PhenoGen
PIRSF	Pyrrol-5-carb_rd	UniProtKB/TrEMBL
PROSITE	P5CR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000036682	RatGTEx
Superfamily-SCOP	6DGDH_C_like	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8I6AII4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GJW9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LMJ1_RAT	UniProtKB/TrEMBL
	A6HLH3	ENTREZGENE, UniProtKB/TrEMBL
	B2RYR3_RAT	UniProtKB/TrEMBL
	D3ZXI0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Pycr1	pyrroline-5-carboxylate reductase 1	Pycr1_predicted	pyrroline-5-carboxylate reductase 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pycr1_predicted	pyrroline-5-carboxylate reductase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways