Spc25 (SPC25 component of NDC80 kinetochore complex) - Rat Genome Database

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Gene: Spc25 (SPC25 component of NDC80 kinetochore complex) Rattus norvegicus
Analyze
Symbol: Spc25
Name: SPC25 component of NDC80 kinetochore complex
RGD ID: 1307811
Description: Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic spindle organization. Predicted to be located in kinetochore. Predicted to be part of Ndc80 complex. Orthologous to human SPC25 (SPC25 component of NDC80 kinetochore complex); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kinetochore protein Spc25; LOC295661; MGC108932; RGD1307811; similar to AD024 protein; Spbc25; SPC25, NDC80 kinetochore complex component; SPC25, NDC80 kinetochore complex component, homolog; SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); spindle pole body component 25; spindle pole body component 25 homolog; spindle pole body component 25 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,337,872 - 74,396,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl374,383,548 - 74,396,718 (-)EnsemblGRCr8
mRatBN7.2353,930,013 - 53,988,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,975,704 - 53,988,959 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx357,376,126 - 57,389,267 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,959,682 - 65,972,823 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,721,842 - 63,735,020 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,438,534 - 55,451,961 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,438,536 - 55,451,798 (-)Ensemblrn6Rnor6.0
Rnor_5.0362,050,000 - 62,063,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4351,361,185 - 51,374,357 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera353,537,785 - 53,550,955 (-)NCBICelera
RGSC_v3.1351,257,558 - 51,270,729 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
kinetochore  (IEA,ISO,ISS)
Ndc80 complex  (IBA,IEA,ISO,ISS)
nucleus  (IEA)
outer kinetochore  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14699129   PMID:15489334  


Genomics

Comparative Map Data
Spc25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,337,872 - 74,396,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl374,383,548 - 74,396,718 (-)EnsemblGRCr8
mRatBN7.2353,930,013 - 53,988,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl353,975,704 - 53,988,959 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx357,376,126 - 57,389,267 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0365,959,682 - 65,972,823 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,721,842 - 63,735,020 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,438,534 - 55,451,961 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,438,536 - 55,451,798 (-)Ensemblrn6Rnor6.0
Rnor_5.0362,050,000 - 62,063,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4351,361,185 - 51,374,357 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera353,537,785 - 53,550,955 (-)NCBICelera
RGSC_v3.1351,257,558 - 51,270,729 (-)NCBI
Cytogenetic Map3q21NCBI
SPC25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,861,521 - 168,890,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,834,132 - 168,913,371 (-)Ensemblhg38GRCh38
GRCh372169,727,401 - 169,746,940 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,435,647 - 169,455,190 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2163,352,703 - 163,372,246 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2161,623,412 - 161,643,117 (-)NCBIHuRef
CHM1_12169,733,212 - 169,752,754 (-)NCBICHM1_1
T2T-CHM13v2.02169,319,011 - 169,364,874 (-)NCBIT2T-CHM13v2.0
Spc25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,009,753 - 69,036,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,024,239 - 69,036,538 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38269,193,895 - 69,206,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,193,895 - 69,206,194 (-)Ensemblmm10GRCm38
MGSCv37269,031,953 - 69,044,214 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36268,994,735 - 69,006,996 (-)NCBIMGSCv36mm8
Celera270,859,628 - 70,872,362 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.64NCBI
Spc25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,533,450 - 5,557,835 (+)Ensembl
ChiLan1.0NW_0049554495,533,464 - 5,556,341 (+)NCBIChiLan1.0ChiLan1.0
SPC25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,532,236 - 71,574,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,547,209 - 71,589,160 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,148,325 - 56,190,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,613,457 - 173,632,947 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,613,457 - 173,655,791 (-)EnsemblpanPan2panpan1.1
SPC25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,697,389 - 13,710,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,697,456 - 13,710,635 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3613,708,404 - 13,721,357 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03613,813,505 - 13,826,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,813,585 - 13,826,318 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,898,536 - 13,911,444 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,885,686 - 13,899,255 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,999,234 - 14,012,225 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spc25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,965,506 - 130,989,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,628,230 - 10,652,232 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,628,235 - 10,652,168 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPC25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,336,514 - 75,371,277 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11575,339,171 - 75,371,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,441,925 - 84,474,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPC25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,390,300 - 54,423,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,403,157 - 54,423,245 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040145,110,045 - 145,152,265 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spc25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,608,039 - 6,624,597 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247876,608,403 - 6,624,533 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Spc25
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1546,515,253 - 46,528,559 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spc25
928 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:62
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000008837
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 165 91 90 59 86 59 6 349 185 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008837   ⟹   ENSRNOP00000008837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl374,383,548 - 74,396,718 (-)Ensembl
mRatBN7.2 Ensembl353,975,704 - 53,988,959 (-)Ensembl
Rnor_6.0 Ensembl355,438,536 - 55,451,798 (-)Ensembl
RefSeq Acc Id: NM_001009654   ⟹   NP_001009654
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,383,546 - 74,396,718 (-)NCBI
mRatBN7.2353,975,689 - 53,988,861 (-)NCBI
Rnor_6.0355,438,534 - 55,451,798 (-)NCBI
Rnor_5.0362,050,000 - 62,063,404 (-)NCBI
RGSC_v3.4351,361,185 - 51,374,357 (-)RGD
Celera353,537,785 - 53,550,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104489   ⟹   XP_038960417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,383,556 - 74,396,803 (-)NCBI
mRatBN7.2353,975,689 - 53,988,921 (-)NCBI
RefSeq Acc Id: XM_039104490   ⟹   XP_038960418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,337,872 - 74,396,797 (-)NCBI
mRatBN7.2353,930,013 - 53,988,940 (-)NCBI
RefSeq Acc Id: XM_039104491   ⟹   XP_038960419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,387,343 - 74,396,797 (-)NCBI
mRatBN7.2353,979,681 - 53,988,940 (-)NCBI
RefSeq Acc Id: XM_063283274   ⟹   XP_063139344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,383,556 - 74,396,825 (-)NCBI
RefSeq Acc Id: NP_001009654   ⟸   NM_001009654
- UniProtKB: Q5M856 (UniProtKB/Swiss-Prot),   A6HLZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008837   ⟸   ENSRNOT00000008837
RefSeq Acc Id: XP_038960418   ⟸   XM_039104490
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960417   ⟸   XM_039104489
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960419   ⟸   XM_039104491
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063139344   ⟸   XM_063283274
- Peptide Label: isoform X1
Protein Domains
Chromosome segregation protein Spc25 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M856-F1-model_v2 AlphaFold Q5M856 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692111
Promoter ID:EPDNEW_R2636
Type:multiple initiation site
Name:Spc25_1
Description:SPC25, NDC80 kinetochore complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,451,846 - 55,451,906EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307811 AgrOrtholog
BioCyc Gene G2FUF-49515 BioCyc
Ensembl Genes ENSRNOG00000006731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008837 ENTREZGENE
  ENSRNOT00000008837.6 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1950 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7383479 IMAGE-MGC_LOAD
InterPro Spc25 UniProtKB/Swiss-Prot
  Spc25 UniProtKB/Swiss-Prot
KEGG Report rno:295661 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108932 IMAGE-MGC_LOAD
NCBI Gene 295661 ENTREZGENE
PANTHER KINETOCHORE PROTEIN SPC25 UniProtKB/Swiss-Prot
  PTHR14281 UniProtKB/Swiss-Prot
Pfam Spindle_Spc25 UniProtKB/Swiss-Prot
PhenoGen Spc25 PhenoGen
RatGTEx ENSRNOG00000006731 RatGTEx
UniProt A6HLZ8 ENTREZGENE, UniProtKB/TrEMBL
  Q5M856 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Spc25  SPC25 component of NDC80 kinetochore complex  Spc25  SPC25, NDC80 kinetochore complex component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-14 Spc25  SPC25, NDC80 kinetochore complex component  Spc25  SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Spc25  SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)  Spbc25  spindle pole body component 25 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Spbc25  spindle pole body component 25 homolog (S. cerevisiae)  RGD1307811  similar to AD024 protein  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307811  similar to AD024 protein  RGD1307811_predicted  similar to AD024 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307811_predicted  similar to AD024 protein (predicted)  LOC295661_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC295661_predicted  similar to AD024 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL