Cdkn3 (cyclin-dependent kinase inhibitor 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cdkn3 (cyclin-dependent kinase inhibitor 3) Rattus norvegicus
Analyze
Symbol: Cdkn3
Name: cyclin-dependent kinase inhibitor 3
RGD ID: 1307781
Description: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3); INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDK2-associated dual-specificity phosphatase; kinase-associated phosphatase; LOC289993
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,502,299 - 22,513,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1522,502,382 - 22,513,722 (+)EnsemblGRCr8
mRatBN7.21520,022,522 - 20,033,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1522,803,376 - 22,814,712 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,761,370 - 23,772,706 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,011,622 - 22,022,961 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,553,171 - 23,564,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)Ensemblrn6Rnor6.0
Rnor_5.01527,496,654 - 27,508,025 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41522,617,409 - 22,624,922 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1520,421,091 - 20,428,602 (+)NCBICelera
RGSC_v3.11522,633,120 - 22,644,448 (+)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenanthridine  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
brequinar  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
chlordecone  (ISO)
chlorendic acid  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cryptolepine  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glycidol  (EXP)
heptachlor  (EXP)
irinotecan  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleus  (IBA)
perinuclear region of cytoplasm  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. Dai W, etal., Mol Med Rep. 2016 Aug;14(2):1509-14. doi: 10.3892/mmr.2016.5410. Epub 2016 Jun 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. Lin WR, etal., Oncol Rep. 2013 Mar;29(3):903-10. doi: 10.3892/or.2012.2208. Epub 2012 Dec 24.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation. Xing C, etal., Biochem Biophys Res Commun. 2012 Mar 30;420(1):29-35. doi: 10.1016/j.bbrc.2012.02.107. Epub 2012 Feb 27.
Additional References at PubMed
PMID:8242750   PMID:10669749   PMID:12477932   PMID:12745075  


Genomics

Comparative Map Data
Cdkn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,502,299 - 22,513,725 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1522,502,382 - 22,513,722 (+)EnsemblGRCr8
mRatBN7.21520,022,522 - 20,033,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1522,803,376 - 22,814,712 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,761,370 - 23,772,706 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,011,622 - 22,022,961 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,553,171 - 23,564,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)Ensemblrn6Rnor6.0
Rnor_5.01527,496,654 - 27,508,025 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41522,617,409 - 22,624,922 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1520,421,091 - 20,428,602 (+)NCBICelera
RGSC_v3.11522,633,120 - 22,644,448 (+)NCBI
Cytogenetic Map15p14NCBI
CDKN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381454,397,007 - 54,420,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1454,396,849 - 54,420,218 (+)Ensemblhg38GRCh38
GRCh371454,863,725 - 54,886,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,933,476 - 53,956,682 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341453,933,475 - 53,956,682NCBI
Celera1434,913,202 - 34,936,466 (+)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1435,026,265 - 35,049,580 (+)NCBIHuRef
CHM1_11454,802,348 - 54,825,637 (+)NCBICHM1_1
T2T-CHM13v2.01448,602,154 - 48,625,376 (+)NCBIT2T-CHM13v2.0
Cdkn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,997,912 - 47,008,987 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,997,998 - 47,009,126 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381446,760,461 - 46,771,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,760,541 - 46,771,669 (+)Ensemblmm10GRCm38
MGSCv371447,380,216 - 47,391,200 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361445,682,418 - 45,693,546 (+)NCBIMGSCv36mm8
Celera1442,925,363 - 42,936,240 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.28NCBI
Cdkn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,015,353 - 9,031,050 (-)Ensembl
ChiLan1.0NW_0049554099,015,220 - 9,030,983 (-)NCBIChiLan1.0ChiLan1.0
CDKN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,518,975 - 55,545,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11454,735,482 - 54,759,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01434,984,819 - 35,008,807 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,263,518 - 53,287,119 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,263,584 - 53,287,113 (+)EnsemblpanPan2panpan1.1
CDKN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,344,991 - 30,374,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,345,082 - 30,360,563 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha830,113,573 - 30,142,985 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0830,602,027 - 30,632,721 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,602,109 - 30,617,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,206,074 - 30,235,518 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,282,425 - 30,311,885 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0830,648,188 - 30,678,870 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdkn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,896,356 - 74,909,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936697670,785 - 683,996 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936697669,154 - 684,077 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,792,688 - 183,809,174 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11183,792,606 - 183,809,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,290,145 - 204,304,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,554,461 - 31,578,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2431,554,510 - 31,579,664 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605319,789,412 - 19,812,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,838,561 - 14,852,554 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473114,838,555 - 14,853,588 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdkn3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11276,280,703 - 76,291,721 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdkn3
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:27
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000012985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat

Markers in Region
AA859789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21520,032,225 - 20,033,856 (+)MAPPERmRatBN7.2
Rnor_6.01523,562,816 - 23,564,446NCBIRnor6.0
Rnor_5.01527,506,303 - 27,507,933UniSTSRnor5.0
RGSC_v3.41522,627,026 - 22,628,656UniSTSRGSC3.4
Celera1520,430,706 - 20,432,336UniSTS
RH 3.4 Map15189.9UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 165 91 90 59 92 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012985   ⟹   ENSRNOP00000012985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1522,502,387 - 22,513,722 (+)Ensembl
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)Ensembl
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110557   ⟹   ENSRNOP00000096902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1522,502,382 - 22,513,136 (+)Ensembl
mRatBN7.2 Ensembl1520,024,498 - 20,033,945 (+)Ensembl
RefSeq Acc Id: NM_001106028   ⟹   NP_001099498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,386 - 22,509,899 (+)NCBI
mRatBN7.21520,022,609 - 20,030,122 (+)NCBI
Rnor_6.01523,553,199 - 23,560,712 (+)NCBI
Rnor_5.01527,496,654 - 27,508,025 (+)NCBI
RGSC_v3.41522,617,409 - 22,624,922 (+)RGD
Celera1520,421,091 - 20,428,602 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401040   ⟹   NP_001387969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,398 - 22,513,725 (+)NCBI
mRatBN7.21520,022,621 - 20,033,948 (+)NCBI
RefSeq Acc Id: XM_006251792   ⟹   XP_006251854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,299 - 22,513,725 (+)NCBI
mRatBN7.21520,022,522 - 20,033,948 (+)NCBI
Rnor_6.01523,553,171 - 23,564,538 (+)NCBI
Rnor_5.01527,496,654 - 27,508,025 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274093   ⟹   XP_063130163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81522,502,367 - 22,513,725 (+)NCBI
RefSeq Acc Id: NP_001099498   ⟸   NM_001106028
- Peptide Label: isoform 2
- UniProtKB: A6KE22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251854   ⟸   XM_006251792
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012985   ⟸   ENSRNOT00000012985
Ensembl Acc Id: ENSRNOP00000096902   ⟸   ENSRNOT00000110557
RefSeq Acc Id: NP_001387969   ⟸   NM_001401040
- Peptide Label: isoform 1
- UniProtKB: B2RZ50 (UniProtKB/Swiss-Prot),   A0A8I6ARV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130163   ⟸   XM_063274093
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ARV6 (UniProtKB/TrEMBL)
Protein Domains
CDKN3   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ50-F1-model_v2 AlphaFold B2RZ50 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699603
Promoter ID:EPDNEW_R10127
Type:initiation region
Name:Cdkn3_1
Description:cyclin-dependent kinase inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01523,553,233 - 23,553,293EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307781 AgrOrtholog
BioCyc Gene G2FUF-14173 BioCyc
Ensembl Genes ENSRNOG00000009785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012985 ENTREZGENE
  ENSRNOT00000012985.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8375927 IMAGE-MGC_LOAD
InterPro CDK_inhib_3 UniProtKB/Swiss-Prot
  CDKN3 UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTP UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:189250 IMAGE-MGC_LOAD
NCBI Gene 289993 ENTREZGENE
PANTHER TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam CDKN3 UniProtKB/Swiss-Prot
PhenoGen Cdkn3 PhenoGen
PIRSF CDKN3 UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009785 RatGTEx
SMART PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
UniProt A0A8I6ARV6 ENTREZGENE, UniProtKB/TrEMBL
  A6KE22 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ50 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cdkn3  cyclin-dependent kinase inhibitor 3   Cdkn3_predicted  cyclin-dependent kinase inhibitor 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cdkn3_predicted  cyclin-dependent kinase inhibitor 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED