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Gene: Grap2 (GRB2-related adaptor protein 2) Rattus norvegicus

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Symbol:

Grap2

Name:

GRB2-related adaptor protein 2

RGD ID:

1307605

Description:

Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in cytosol; endosome; and nucleus. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2); PARTICIPATES IN T cell receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GRB2-related adapter protein 2; LOC366962; MGC125066

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRAP2 (GRB2 related adaptor protein 2)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Grap2 (GRB2-related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grap2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRAP2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRAP2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grap2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRAP2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRAP2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grap2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Grap2 (GRB2 related adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CEACAM21 (CEA cell adhesion molecule 21)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GRAP2 (GRB2 related adaptor protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grap2 (GRB2-related adaptor protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grap2b (GRB2 related adaptor protein 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grap2b (GRB2 related adaptor protein 2b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	grap2a (GRB2 related adaptor protein 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grap2a (GRB2 related adaptor protein 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	grap2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grap2	Alliance	DIOPT (OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	113,997,356 - 114,071,073 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	113,997,307 - 114,075,367 (+)	Ensembl				GRCr8
mRatBN7.2	7	112,117,142 - 112,190,880 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	112,117,142 - 112,190,877 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	113,872,662 - 113,946,895 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	116,096,186 - 116,170,437 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	116,065,563 - 116,139,810 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	121,791,330 - 121,864,835 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	121,841,855 - 121,864,679 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	121,781,461 - 121,854,021 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	118,856,130 - 118,931,148 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	108,442,874 - 108,515,048 (+)	NCBI		Celera
RGSC_v3.1	7	118,882,484 - 118,965,381 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anaphylaxis (ISO)

hepatitis C (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

alpha-Zearalanol (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

CGP 52608 (ISO)

clofibrate (ISO)

crocidolite asbestos (ISO)

D-glucose (ISO)

DDE (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

diuron (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

formaldehyde (ISO)

fructose (ISO)

furan (EXP)

glucose (ISO)

glyphosate (ISO)

Lasiocarpine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

Moniliformin (ISO)

nitrates (ISO)

ozone (ISO)

PCB138 (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

toluene 2,4-diisocyanate (ISO)

Tributyltin oxide (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of MAPK cascade (IBA)

signal transduction (IBA)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA,ISO)

endosome (IEA,ISO)

nucleoplasm (IBA,IEA,ISO)

nucleus (IEA,ISO)

plasma membrane (IBA)

Molecular Function

phosphotyrosine residue binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Genetic variations in humans associated with differences in the course of hepatitis C.	Saito T, etal., Biochem Biophys Res Commun. 2004 Apr 30;317(2):335-41. doi: 10.1016/j.bbrc.2004.03.056.
9.	Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.	Yamasaki S, etal., Int Immunol. 2008 Oct;20(10):1289-97. doi: 10.1093/intimm/dxn085. Epub 2008 Jul 29.

Additional References at PubMed

PMID:12477932	PMID:21179510

Genomics

Comparative Map Data

Grap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	113,997,356 - 114,071,073 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	113,997,307 - 114,075,367 (+)	Ensembl				GRCr8
mRatBN7.2	7	112,117,142 - 112,190,880 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	112,117,142 - 112,190,877 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	113,872,662 - 113,946,895 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	116,096,186 - 116,170,437 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	116,065,563 - 116,139,810 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	121,791,330 - 121,864,835 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	121,841,855 - 121,864,679 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	121,781,461 - 121,854,021 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	118,856,130 - 118,931,148 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	108,442,874 - 108,515,048 (+)	NCBI		Celera
RGSC_v3.1	7	118,882,484 - 118,965,381 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

GRAP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	39,893,820 - 39,973,721 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	39,901,084 - 39,973,721 (+)	Ensembl			hg38	GRCh38
GRCh37	22	40,297,088 - 40,369,725 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	38,627,032 - 38,697,330 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	38,621,585 - 38,691,884	NCBI
Celera	22	24,099,151 - 24,169,444 (+)	NCBI		Celera
Cytogenetic Map	22	q13.1	NCBI
HuRef	22	23,260,094 - 23,330,327 (+)	NCBI		HuRef
CHM1_1	22	40,256,126 - 40,326,591 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	40,364,806 - 40,444,710 (+)	NCBI		T2T-CHM13v2.0

Grap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	80,456,798 - 80,537,055 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	80,456,795 - 80,537,055 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	80,572,597 - 80,652,854 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	80,572,594 - 80,652,854 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	80,453,913 - 80,480,728 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	80,450,738 - 80,477,553 (+)	NCBI		MGSCv36	mm8
Celera	15	82,743,068 - 82,770,161 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.88	NCBI

Grap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	25,691,439 - 25,758,813 (+)	Ensembl
ChiLan1.0	NW_004955413	25,691,824 - 25,758,461 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRAP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	49,740,213 - 49,826,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	52,431,531 - 52,517,497 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	20,831,191 - 20,878,867 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	38,651,719 - 38,696,566 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	38,651,719 - 38,696,566 (+)	Ensembl			panPan2	panpan1.1

GRAP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	25,156,233 - 25,220,106 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	25,157,841 - 25,220,222 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	25,092,401 - 25,156,329 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	25,908,310 - 25,972,290 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	25,909,919 - 25,972,202 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	25,619,908 - 25,683,843 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	25,942,524 - 26,006,115 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	26,117,033 - 26,181,059 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	8,745,057 - 8,816,596 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	1,759,298 - 1,796,049 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	1,759,182 - 1,796,049 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRAP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	8,375,762 - 8,445,068 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	8,372,920 - 8,445,128 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	5,668,663 - 5,744,087 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRAP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	22,478,744 - 22,548,829 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	22,524,851 - 22,552,977 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	103,050,792 - 103,121,149 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	8,458,292 - 8,476,256 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	8,453,946 - 8,476,256 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Grap2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	250,337,435 - 250,412,820 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Grap2
206 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	30
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000024673
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	71621154	114982716	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

BI277894

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	112,173,694 - 112,173,799 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	121,847,849 - 121,847,953	NCBI	Rnor6.0
Rnor_5.0	7	121,837,628 - 121,837,732	UniSTS	Rnor5.0
RGSC_v3.4	7	118,912,401 - 118,912,505	UniSTS	RGSC3.4
Celera	7	108,498,465 - 108,498,569	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	11	66	150	91	90	59	92	59	6	349	190	11	125	77	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC105895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024673 ⟹ ENSRNOP00000024673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	113,997,307 - 114,075,367 (+)	Ensembl
mRatBN7.2 Ensembl	7	112,117,142 - 112,190,877 (+)	Ensembl
Rnor_6.0 Ensembl	7	121,841,855 - 121,864,679 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095205 ⟹ ENSRNOP00000094684

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	113,997,307 - 114,075,367 (+)	Ensembl
mRatBN7.2 Ensembl	7	112,117,142 - 112,190,877 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099654 ⟹ ENSRNOP00000079385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	112,117,142 - 112,189,629 (+)	Ensembl

RefSeq Acc Id:

NM_001034944 ⟹ NP_001030116

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	113,997,356 - 114,071,073 (+)	NCBI
mRatBN7.2	7	112,117,142 - 112,190,880 (+)	NCBI
Rnor_6.0	7	121,791,330 - 121,864,835 (+)	NCBI
Rnor_5.0	7	121,781,461 - 121,854,021 (+)	NCBI
RGSC_v3.4	7	118,856,130 - 118,931,148 (+)	RGD
Celera	7	108,442,874 - 108,515,048 (+)	RGD

Sequence:

show sequence

CGGCGCGGTAAACTTGACATTTGAGTGCATCTTCCCACCGGCAAAAGACGAACCTAATAACTCG
TTGTCAAAGCCGAGATACACACTCAACTCAGGCTCTTCGCTTCCCAAAGCTTCTCGTCAAGACA
TGGAAGCTATTGCCAAGTTCGATTTCATGGCCTCGGGTGAGGACGAATTGAGCTTTCACACTGG
AGATATTCTGAAGATCCTAAGCAACCAGGAGGAGTGGCTCAAGGCGGAGCTTGGAAGCCAAGAA
GGATATGTGCCTAAGAATTTTATAGATATCAAGTTTCCTGAGTGGTTCCATGAAGGCCTCTCTC
GACATCAGGCAGAAAACTTACTCATGGGCAAGGAAATTGGATTCTTCGTCATCAGGGCCAGTCA
GAGTTCACCAGGAGACTTCTCCATCTCTGTCAGGCATGAGGACGATGTTCAGCACTTCAAAGTC
ATGCGAGACACCAAGGGCAATTACTTCCTGTGGACTGAGAAGTTCCCATCCCTAAATAAGCTGG
TGGACTACTACCGGACAACTTCCATCTCCAAACAGAAGCAGATCTTCCTTCGGGATGGAACCCA
AGATCAGCAGGGTCACCGGGGCAACAGCCTGGACAGGAGAACCCAGGGAGGCCCTCCCAGGGAG
GTTCCAAGTGGGACCGCAGGAGAAGAAATCCGACCCTTGATGAACCGGAAGCTGTCAGACCACC
TTCCTCTGGGTACCCAGCAGTTCCACCCGCACCAGCAACTGCCCCCCCAGTTCCCACCAGGGCC
CCAGCCCCCTCCACAGCAGCGCTATCTGCAGCATTTTCACCAGGACCGTCGTGGAGGCAGCCTG
GACATAAACGATGGACACCTCGGCATTGGCAGTGAGATGAATGCCACCCTGATGCACCGGAGAC
ATACAGACCCCGTACAACTCCAGGCGGCAGGGCGAGTGCGCTGGGCCAGGGCACTCTATGACTT
TGAGGCCCTGGAGGAAGATGAGCTGGGGCTCAGAAGTGGAGAGGTGGTCGAAGTCCTGGACAGC
TCCAACCCGTCTTGGTGGACCGGCCGCCTGCACAACAAACTGGGTCTCTTCCCTGCCAACTATG
TGGCCCCCATGATGCGATGAGTCATGCTGGGAGGCTTAGGGGCTTTTCGTCTGAAGCCTCCTGC
AAGATGGAGGCAAGGGGGAAAAGCTGAACTCAATAACTACACATACATGCATACATGTGCATGT
GTGCGCCTGTGTACACACAACATGTATATGTACGCCTATGTCTACACAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001030116	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05896	(Get FASTA)	NCBI Sequence Viewer
	EDM15748	(Get FASTA)	NCBI Sequence Viewer
	EDM15749	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024673.8
	ENSRNOP00000094684
	ENSRNOP00000094684.1

RefSeq Acc Id:

NP_001030116 ⟸ NM_001034944

- UniProtKB:

Q3KR57 (UniProtKB/TrEMBL), D3ZG10 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAIAKFDFMASGEDELSFHTGDILKILSNQEEWLKAELGSQEGYVPKNFIDIKFPEWFHEGLS
RHQAENLLMGKEIGFFVIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTEKFPSLNKL
VDYYRTTSISKQKQIFLRDGTQDQQGHRGNSLDRRTQGGPPREVPSGTAGEEIRPLMNRKLSDH
LPLGTQQFHPHQQLPPQFPPGPQPPPQQRYLQHFHQDRRGGSLDINDGHLGIGSEMNATLMHRR
HTDPVQLQAAGRVRWARALYDFEALEEDELGLRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANY
VAPMMR

hide sequence

Ensembl Acc Id:

ENSRNOP00000024673 ⟸ ENSRNOT00000024673

Ensembl Acc Id:

ENSRNOP00000079385 ⟸ ENSRNOT00000099654

Ensembl Acc Id:

ENSRNOP00000094684 ⟸ ENSRNOT00000095205

Protein Domains

SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZG10-F1-model_v2	AlphaFold	D3ZG10	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307605	AgrOrtholog
BioCyc Gene	G2FUF-32697	BioCyc
Ensembl Genes	ENSRNOG00000018316	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024673.9	UniProtKB/TrEMBL
	ENSRNOT00000095205	ENTREZGENE
	ENSRNOT00000095205.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7380480	IMAGE-MGC_LOAD
InterPro	GRAP2_C_SH3	UniProtKB/TrEMBL
	Grb2-like	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	STAM	UniProtKB/TrEMBL
KEGG Report	rno:366962	UniProtKB/TrEMBL
MGC_CLONE	MGC:125066	IMAGE-MGC_LOAD
NCBI Gene	366962	ENTREZGENE
PANTHER	JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE	UniProtKB/TrEMBL
	JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE	UniProtKB/TrEMBL
	PTHR46037	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Grap2	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018316	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A6HSX3_RAT	UniProtKB/TrEMBL
	D3ZG10	ENTREZGENE, UniProtKB/TrEMBL
	Q3KR57	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Grap2	GRB2-related adaptor protein 2	Grap2_predicted	GRB2-related adaptor protein 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Grap2_predicted	GRB2-related adaptor protein 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)