RGD Reference Report - Genetic variations in humans associated with differences in the course of hepatitis C. - Rat Genome Database

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Genetic variations in humans associated with differences in the course of hepatitis C.

Authors: Saito, Takafumi  Ji, Guijin  Shinzawa, Haruhide  Okumoto, Kazuo  Hattori, Etsuko  Adachi, Tohru  Takeda, Tadashi  Sugahara, Kazuhiko  Ito, Jun-itsu  Watanabe, Hisayoshi  Saito, Koji  Togashi, Hitoshi  Ishii, Keisuke  Matsuura, Tadashi  Inageda, Kiyoshi  Muramatsu, Masaaki  Kawata, Sumio 
Citation: Saito T, etal., Biochem Biophys Res Commun. 2004 Apr 30;317(2):335-41. doi: 10.1016/j.bbrc.2004.03.056.
RGD ID: 126790487
Pubmed: PMID:15063762   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.03.056   (Journal Full-text)

The outcome of hepatitis C virus (HCV) infection varies among individuals, but the genetic factors involved remain unknown. We conducted a population-based association study in which 238 Japanese individuals positive for anti-HCV antibody were genotyped for 269 single nucleotide polymorphisms (SNPs) in 103 candidate genes that might influence the course of infection. Altogether, 50 SNPs in 32 genes were listed. Genetic polymorphisms in IL4, IL8RB, IL10RA, PRL, ADA, NFKB1, GRAP2, CABIN1, IFNAR2, IFI27, IFI41, TNFRSF1A, ALDOB, AP1B1, SULT2B1, EGF, EGFR, TGFB1, LTBP2, and CD4 were associated with persistent viremia (P < 0.05), whereas those in IL1B, IL1RL1, IL2RB, IL12RB1, IL18R1, STAT5A, GRAP2, CABIN1, IFNAR1, Mx1, BMP8, FGL1, LTBP2, CD34, and CD80 were associated with different serum alanine aminotransferase levels in HCV carriers (P < 0.05). The sorted genes allow us to draw novel hypotheses for future studies of HCV infection to ultimately identify bona fide genes and their variations.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRAP2Humanhepatitis C severityIAGP DNA:SNP:intron: (human)RGD 
Grap2Rathepatitis C severityISOGRAP2 (Homo sapiens)DNA:SNP:intron: (human)RGD 
Grap2Mousehepatitis C severityISOGRAP2 (Homo sapiens)DNA:SNP:intron: (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grap2  (GRB2-related adaptor protein 2)

Genes (Mus musculus)
Grap2  (GRB2-related adaptor protein 2)

Genes (Homo sapiens)
GRAP2  (GRB2 related adaptor protein 2)


Additional Information