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Gene: Hipk4 (homeodomain interacting protein kinase 4) Rattus norvegicus

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Symbol:

Hipk4

Name:

homeodomain interacting protein kinase 4

RGD ID:

1307541

Description:

Predicted to enable histone kinase activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within regulation of signal transduction by p53 class mediator. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIPK4 (homeodomain interacting protein kinase 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

homeodomain-interacting protein kinase 4; LOC308449

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	91,938,308 - 91,948,680 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	91,938,278 - 91,948,683 (+)	Ensembl				GRCr8
mRatBN7.2	1	82,810,708 - 82,821,080 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	82,810,708 - 82,821,077 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	88,213,590 - 88,223,723 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	96,700,799 - 96,711,024 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	89,969,453 - 89,979,586 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	84,328,114 - 84,338,486 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	84,328,114 - 84,338,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	85,544,935 - 85,555,307 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	82,601,693 - 82,612,048 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	77,225,371 - 77,233,912 (+)	NCBI		Celera
RGSC_v3.1	1	82,679,800 - 82,690,156 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

aldehydo-D-glucose (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

D-glucose (ISO)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

ethanol (ISO)

fructose (ISO)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

gentamycin (EXP)

glucose (ISO)

glycitein (ISO)

glycitin (ISO)

herbicide (ISO)

Licochalcone B (ISO)

methimazole (EXP)

paracetamol (EXP)

phenobarbital (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

peptidyl-serine phosphorylation (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

regulation of signal transduction by p53 class mediator (ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

histone kinase activity (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

protein tyrosine kinase activity (IBA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:18022393

Genomics

Comparative Map Data

Hipk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	91,938,308 - 91,948,680 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	91,938,278 - 91,948,683 (+)	Ensembl				GRCr8
mRatBN7.2	1	82,810,708 - 82,821,080 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	82,810,708 - 82,821,077 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	88,213,590 - 88,223,723 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	96,700,799 - 96,711,024 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	89,969,453 - 89,979,586 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	84,328,114 - 84,338,486 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	84,328,114 - 84,338,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	85,544,935 - 85,555,307 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	82,601,693 - 82,612,048 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	77,225,371 - 77,233,912 (+)	NCBI		Celera
RGSC_v3.1	1	82,679,800 - 82,690,156 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

HIPK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	40,379,271 - 40,390,181 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	40,379,271 - 40,390,181 (-)	Ensembl			hg38	GRCh38
GRCh37	19	40,885,178 - 40,896,088 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	45,577,018 - 45,587,934 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	45,577,018 - 45,587,934	NCBI
Celera	19	37,684,720 - 37,695,637 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	37,320,650 - 37,331,675 (-)	NCBI		HuRef
CHM1_1	19	40,884,875 - 40,895,766 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	43,199,897 - 43,210,807 (-)	NCBI		T2T-CHM13v2.0

Hipk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	27,222,686 - 27,230,605 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	27,222,692 - 27,230,600 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	27,523,261 - 27,531,180 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	27,523,267 - 27,531,175 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	28,308,280 - 28,316,194 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	27,235,819 - 27,239,932 (+)	NCBI		MGSCv36	mm8
Celera	7	22,105,713 - 22,113,627 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	15.92	NCBI

Hipk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955578	876,030 - 884,098 (+)	Ensembl
ChiLan1.0	NW_004955578	876,022 - 884,098 (+)	NCBI	ChiLan1.0	ChiLan1.0

HIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	46,641,141 - 46,653,818 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	48,512,745 - 48,524,468 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	37,427,496 - 37,439,259 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	45,940,130 - 45,950,032 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

HIPK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	113,297,079 - 113,304,399 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	113,297,258 - 113,304,101 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	112,699,056 - 112,706,341 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	113,895,477 - 113,902,762 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	113,895,619 - 113,902,464 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	113,454,740 - 113,462,021 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,087,236 - 113,094,521 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,081,231 - 114,088,517 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hipk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	14,336,589 - 14,342,039 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	2,764,661 - 2,770,110 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	2,764,661 - 2,770,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HIPK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	48,666,728 - 48,674,346 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	48,666,726 - 48,672,977 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	44,413,581 - 44,419,494 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HIPK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	34,834,526 - 34,848,751 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	34,835,059 - 34,848,138 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	12,930,020 - 12,944,332 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hipk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624925	383,124 - 389,900 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624925	382,368 - 391,039 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hipk4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	168,413,946 - 168,423,828 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hipk4
115 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	213
Count of miRNA genes:	142
Interacting mature miRNAs:	155
Transcripts:	ENSRNOT00000028266
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat

Markers in Region

D1Got262

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	82,816,189 - 82,816,347 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	84,333,596 - 84,333,753	NCBI	Rnor6.0
Rnor_5.0	1	85,550,417 - 85,550,574	UniSTS	Rnor5.0
RGSC_v3.4	1	82,607,157 - 82,607,315	RGD	RGSC3.4
RGSC_v3.4	1	82,607,158 - 82,607,315	UniSTS	RGSC3.4
Celera	1	77,229,020 - 77,229,179	UniSTS
RGSC_v3.1	1	82,685,269 - 82,685,426	RGD
RH 3.4 Map	1	840.5	UniSTS
RH 3.4 Map	1	840.5	RGD
RH 2.0 Map	1	516.0	RGD
Cytogenetic Map	1	q21	UniSTS

RH134206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	82,820,846 - 82,821,062 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	84,338,253 - 84,338,468	NCBI	Rnor6.0
Rnor_5.0	1	85,555,074 - 85,555,289	UniSTS	Rnor5.0
RGSC_v3.4	1	82,611,815 - 82,612,030	UniSTS	RGSC3.4
Celera	1	77,233,679 - 77,233,894	UniSTS
RH 3.4 Map	1	830.3	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	150	91	90	59	53	59	6	315	152	11	129	80	92	31	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ891398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028266 ⟹ ENSRNOP00000028266

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	91,938,278 - 91,948,683 (+)	Ensembl
mRatBN7.2 Ensembl	1	82,810,708 - 82,821,077 (+)	Ensembl
Rnor_6.0 Ensembl	1	84,328,114 - 84,338,483 (+)	Ensembl

RefSeq Acc Id:

NM_001024776 ⟹ NP_001019947

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	91,938,308 - 91,948,680 (+)	NCBI
mRatBN7.2	1	82,810,708 - 82,821,080 (+)	NCBI
Rnor_6.0	1	84,328,114 - 84,338,486 (+)	NCBI
Rnor_5.0	1	85,544,935 - 85,555,307 (+)	NCBI
RGSC_v3.4	1	82,601,693 - 82,612,048 (+)	RGD
Celera	1	77,225,371 - 77,233,912 (+)	RGD

Sequence:

show sequence

GCCTGAGCCCCCTCATCCCAAGCCAAGAGGGCTTTGGGGGAGGGGTGCAGCCCCTGGTAGACTC
ACCGTGTGGCCAAGGGGGTCAAGGGGCGTCAGAGAGACAGGGGCTGAACTCATAGAGAGAGAGA
GAAGTGTGGTTATCTTTCCCCCACTAGGAGGACTAGCTAGGGGCGATCATCAGGTTGGGAGGTC
TAGGCAACCAAGCCAGTCGTTCAGGAGTAAAGGCAGAGTAGTGACTGGCAGCCAGGGCACCATG
GCCACCATCCAGTCAGAGACTGACTGTTACGACATCATTGAAGTCCTGGGCAAGGGCACTTTTG
GAGAGGTGGCCAAGGGCTGGCGTCGGAGTACAGGAGAAATGGTGGCCATCAAGATCTTGAAGAA
CGACGCGTACCGAAGCCGTATCATCAAGAATGAGTTGAAGCTGCTGCGCTGTGTACGAGGCCTG
GACCCCGACGAGGCCCACGTCATCCGCTTCCTTGAATTCTTCCATGATGCCCTCAAGTTCTACC
TGGTCTTTGAGCTATTGGAGCAAAACCTCTTTGAGTTCCAGAAAGAGAACAACTTCGCACCCCT
CCCTGCCAGGCACATCCGAACTGTCACACTGCAGGTCCTAAGAGCGCTGGCCCGGCTCAAGGAG
TTGGCTATCATCCATGCTGACCTCAAGCCAGAAAACATTATGTTGGTAGATCAGACCCGCTGCC
CCTTCAGGGTAAAGGTGATCGACTTTGGCTCGGCCAGCATATTCAGTGAGGTGCGCTATGTGAA
GGAGCCTTACATCCAGTCCCGCTTCTACAGGGCCCCAGAGATCCTGTTGGGGTTGCCGTTCTGC
GAGAAGGTGGACGTGTGGTCTCTGGGCTGTGTCATGGCTGAGTTACACCTGGGCTGGCCTCTCT
ACCCAGGCAACAATGAGTATGACCAGGTGCGCTACATCTGTGAGACCCAGGGCTTACCCAAGCC
CCATCTGCTGCATGCGGCCCGCAAGGCTCACCACTTCTTCAAGCGTAACCCCCACCCCGATGCC
ACCAACCCCTGGCAGCTCAAGTCCTCTGCTGACTACCTAGCTGAGACCAAGGTACGCCCACTGG
AGCGCCGCAAGTACATGCTCAAATCCTTGGACCAAATTGAGACGGTGAATGGTGGCGGCGCTGT
GAATCGGTTGAGTTTTCCAGACCGGGAGGCACTGGCGGAACACGCGGACCTCAAGAGCATGGTG
GAGCTGATCAAACGCATGCTGACATGGGAGTCTCACGAGCGCATCAGTCCCAGCGCGGCCCTGC
GCCACCCCTTCGTGTCCATGCAGCAGCTGCGTAGTGCCCACGAGGCCACCCGCTACTACCAGCT
GTCCCTCCGAGGCTGTCGGCTGTCCCTGCAGGTGGACGGCAAGCCACCCCCACCTGTCATAGCC
AACGCAGAGGACGGGCCTCCCTACTACCGCCTGGCTGAGGAGGAGGAGACTGCAGGCCTGGGTG
GTGTGACCGGCAGTGGGTCCTTCTTCAGGGAGGACAAGGCTCCCGGAATGCAGAGAGCCATCGA
CCAGCTCGATGACCTGAGTCTGCAGGAGGCCCGCCGGGGGCTGTGGAGCGACACGCGGGCCGAC
ATGGTCTCTGACATGCTGGCTCCACTCAAAGTAGCCACTACCAGCCATCGAGTCCCCGACTCGG
GCCCGGAGCCTATCCTGGCCTTCTACGGCAGCCGCTTGACTGGCCGCCATAAGGCCCGCAAGGC
CCCAGCAGGCTCCAAATCCGACTCCAACTTCAGTAACCTCATCCGGCTGAGCCAGGCCTCACCT
GAGGATGCGGGGTCCTGTAGGGGCAGTGGTTGGGAAGAAGGAGAAGGCCACACGACTTCCACAG
AGCCGTCTGCCATCCCACAACGGGAAGGAGATGGACCCAGCATCAAAGACAGGCCCATGGATGC
TGAGAGGTCAGGCCCTGAGCTCTTTGATCCCAGCGGCTGTCCTGGAGAGTGGCTAAATGAACCA
GAATGGACCCTAGAGGGCATCCGGGGGTCTCGAGCTCAAGGGCTTCCAGCTCGCCATCCCCACC
CACACGGGCCGCCCAGGACCACCAGCTTTCTGCAGCATGTTGGAGGGCACCACTGATGGGGACT
CACCCTAACGTTTCTTGGGCTGGGCTGGCGTCCCCCCTTTTGATCTGAAATGGCACCTTAGAGC
CATCCTCTGAACCTACAGATTATTCTTACAGAAAAATAGAAATCCAGAATGTTCCTATTTCCCT
GCCCCTGGCACATGTCTGTATCCCACCCTAAATGTTGGAGGTCGTCAGGGTCTGGCCCGAGTCC
CTGAGGCCAGTGAGTCGGGAAGAGGCTGCACCCCATTGGCCATGCGTGTGCCCGGGCCTGCCTG
CCTCTGTGTATTTCAATAAATAACTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019947	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98070	(Get FASTA)	NCBI Sequence Viewer
	CAH68682	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028266
	ENSRNOP00000028266.3
GenBank Protein	Q4V793	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019947 ⟸ NM_001024776

- UniProtKB:

Q4V793 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MATIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCVRG
LDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLK
ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPF
CEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPD
ATNPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVNRLSFPDREALAEHADLKSM
VELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVI
ANAEDGPPYYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSLQEARRGLWSDTRA
DMVSDMLAPLKVATTSHRVPDSGPEPILAFYGSRLTGRHKARKAPAGSKSDSNFSNLIRLSQAS
PEDAGSCRGSGWEEGEGHTTSTEPSAIPQREGDGPSIKDRPMDAERSGPELFDPSGCPGEWLNE
PEWTLEGIRGSRAQGLPARHPHPHGPPRTTSFLQHVGGHH

hide sequence

Ensembl Acc Id:

ENSRNOP00000028266 ⟸ ENSRNOT00000028266

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V793-F1-model_v2	AlphaFold	Q4V793	1-616	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689854

Promoter ID:

EPDNEW_R379

Type:

multiple initiation site

Name:

Hipk4_1

Description:

homeodomain interacting protein kinase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	84,328,084 - 84,328,144	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307541	AgrOrtholog
BioCyc Gene	G2FUF-60305	BioCyc
Ensembl Genes	ENSRNOG00000020835	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000028266	ENTREZGENE
	ENSRNOT00000028266.6	UniProtKB/Swiss-Prot
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7455473	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	Ser_Thr_dual-spec_kinase	UniProtKB/Swiss-Prot
KEGG Report	rno:308449	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116268	IMAGE-MGC_LOAD
NCBI Gene	308449	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN KINASE	UniProtKB/Swiss-Prot
	HOMEODOMAIN-INTERACTING PROTEIN KINASE 4	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Hipk4	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020835	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	HIPK4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Hipk4	homeodomain interacting protein kinase 4	Hipk4_predicted	homeodomain interacting protein kinase 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Hipk4_predicted	homeodomain interacting protein kinase 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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