HIPK4 (homeodomain interacting protein kinase 4) - Rat Genome Database

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Gene: HIPK4 (homeodomain interacting protein kinase 4) Chlorocebus sabaeus
Analyze
Symbol: HIPK4
Name: homeodomain interacting protein kinase 4
RGD ID: 18505812
Description: ENCODES a protein that exhibits ATP binding (inferred); histone kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN regulation of signal transduction by p53 class mediator (ortholog); ASSOCIATED WITH Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); craniosynostosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeodomain-interacting protein kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,834,526 - 34,848,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,835,059 - 34,848,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,930,020 - 12,944,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HIPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,834,526 - 34,848,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,835,059 - 34,848,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,930,020 - 12,944,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HIPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,379,271 - 40,390,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,379,271 - 40,390,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,885,178 - 40,896,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,577,018 - 45,587,934 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,577,018 - 45,587,934NCBI
Celera1937,684,720 - 37,695,637 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,320,650 - 37,331,675 (-)NCBIHuRef
CHM1_11940,884,875 - 40,895,766 (-)NCBICHM1_1
T2T-CHM13v2.01943,199,897 - 43,210,807 (-)NCBIT2T-CHM13v2.0
Hipk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,222,686 - 27,230,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,222,692 - 27,230,600 (+)EnsemblGRCm39 Ensembl
GRCm38727,523,261 - 27,531,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,523,267 - 27,531,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,308,280 - 28,316,194 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,235,819 - 27,239,932 (+)NCBIMGSCv36mm8
Celera722,105,713 - 22,113,627 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.92NCBI
Hipk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,938,308 - 91,948,680 (+)NCBIGRCr8
mRatBN7.2182,810,708 - 82,821,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,810,708 - 82,821,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,213,590 - 88,223,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,700,799 - 96,711,024 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,969,453 - 89,979,586 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,328,114 - 84,338,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,328,114 - 84,338,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,544,935 - 85,555,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,601,693 - 82,612,048 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,679,800 - 82,690,156 (+)NCBI
Celera177,225,371 - 77,233,912 (+)NCBICelera
Cytogenetic Map1q21NCBI
Hipk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578876,030 - 884,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578876,022 - 884,098 (+)NCBIChiLan1.0ChiLan1.0
HIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,641,141 - 46,653,818 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,512,745 - 48,524,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,427,496 - 37,439,259 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,940,130 - 45,950,032 (-)NCBIpanpan1.1PanPan1.1panPan2
HIPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,297,079 - 113,304,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,297,258 - 113,304,101 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,699,056 - 112,706,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,895,477 - 113,902,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,895,619 - 113,902,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,454,740 - 113,462,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,087,236 - 113,094,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,081,231 - 114,088,517 (+)NCBIUU_Cfam_GSD_1.0
Hipk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,336,589 - 14,342,039 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,764,661 - 2,770,110 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,764,661 - 2,770,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,666,728 - 48,674,346 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,666,726 - 48,672,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,413,581 - 44,419,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Hipk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925383,124 - 389,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925382,368 - 391,039 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1
Low 10 39
Below cutoff 3 7 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007996835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000001757   ⟹   ENSCSAP00000000099
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl634,835,059 - 34,848,138 (-)Ensembl
RefSeq Acc Id: XM_007996835   ⟹   XP_007995026
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,834,526 - 34,848,751 (-)NCBI
Vero_WHO_p1.0NW_02366607312,930,020 - 12,944,332 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007995026 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000099.1
Reference Protein Sequences
RefSeq Acc Id: XP_007995026   ⟸   XM_007996835
- UniProtKB: A0A0D9QUR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000099   ⟸   ENSCSAT00000001757


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003733 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001757.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103234703 UniProtKB/TrEMBL
NCBI Gene HIPK4 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  HOMEODOMAIN-INTERACTING PROTEIN KINASE 4 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QUR0 ENTREZGENE, UniProtKB/TrEMBL