Gtf2ird2 (GTF2I repeat domain containing 2) - Rat Genome Database

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Gene: Gtf2ird2 (GTF2I repeat domain containing 2) Rattus norvegicus
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Symbol: Gtf2ird2
Name: GTF2I repeat domain containing 2
RGD ID: 1307435
Description: Predicted to enable DNA binding activity. Predicted to act upstream of or within transition between fast and slow fiber. Predicted to be active in nucleus. Orthologous to several human genes including GTF2IRD2 (GTF2I repeat domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: general transcription factor II I repeat domain-containing 2; general transcription factor II-I repeat domain-containing protein 2B; LOC288606; RGD1307435; RGD1566086; similar to gtf2ird2
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81228,134,199 - 28,179,089 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1228,133,792 - 28,172,876 (-)EnsemblGRCr8
mRatBN7.21222,497,767 - 22,536,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,498,091 - 22,536,263 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,640,806 - 23,677,363 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,251,903 - 24,288,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,317,370 - 23,354,011 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,509,059 - 25,555,554 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,509,653 - 25,546,200 (-)Ensemblrn6Rnor6.0
Rnor_5.01227,517,572 - 27,563,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,650,480 - 23,681,954 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,259,281 - 24,310,588 (-)NCBICelera
RGSC_v3.11223,527,583 - 23,545,170 (-)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22899722  


Genomics

Comparative Map Data
Gtf2ird2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81228,134,199 - 28,179,089 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1228,133,792 - 28,172,876 (-)EnsemblGRCr8
mRatBN7.21222,497,767 - 22,536,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,498,091 - 22,536,263 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,640,806 - 23,677,363 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,251,903 - 24,288,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,317,370 - 23,354,011 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,509,059 - 25,555,554 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,509,653 - 25,546,200 (-)Ensemblrn6Rnor6.0
Rnor_5.01227,517,572 - 27,563,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,650,480 - 23,681,954 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1224,259,281 - 24,310,588 (-)NCBICelera
RGSC_v3.11223,527,583 - 23,545,170 (-)NCBI
Cytogenetic Map12q12NCBI
GTF2IRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,796,151 - 74,851,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,796,144 - 74,851,611 (-)Ensemblhg38GRCh38
GRCh37774,210,490 - 74,267,901 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,848,420 - 73,905,777 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map7q11.23NCBI
CHM1_1774,355,560 - 74,410,992 (-)NCBICHM1_1
T2T-CHM13v2.0775,998,467 - 76,053,913 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2773,543,547 - 73,600,936NCBI
Gtf2ird2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,211,629 - 134,246,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,212,858 - 134,253,209 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385134,182,557 - 134,218,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,184,019 - 134,224,355 (+)Ensemblmm10GRCm38
MGSCv375134,659,908 - 134,694,013 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365134,468,665 - 134,502,770 (+)NCBIMGSCv36mm8
Celera5131,186,642 - 131,221,475 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.45NCBI
GTF2IRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,030,819 - 90,105,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,295,435 - 138,370,365 (+)NCBINHGRI_mPanPan1
PanPan1.1781,939,131 - 81,997,391 (-)NCBIPanPan1.1PanPan1.1panPan2

Variants

.
Variants in Gtf2ird2
777 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:84
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000002030
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH135134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,519,890 - 22,520,110 (+)MAPPERmRatBN7.2
Rnor_6.01225,531,250 - 25,531,469NCBIRnor6.0
Rnor_5.01227,539,228 - 27,539,447UniSTSRnor5.0
RGSC_v3.41223,672,306 - 23,672,525UniSTSRGSC3.4
Celera1224,279,794 - 24,280,013UniSTS
RH 3.4 Map12348.2UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,498,213 - 22,528,005 (-)Ensembl
Rnor_6.0 Ensembl1225,509,653 - 25,546,200 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1225,513,105 - 25,516,941 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1225,523,542 - 25,533,843 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113330   ⟹   ENSRNOP00000088990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1228,134,200 - 28,172,876 (-)Ensembl
mRatBN7.2 Ensembl1222,498,091 - 22,536,263 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115001   ⟹   ENSRNOP00000079418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1228,133,792 - 28,172,876 (-)Ensembl
mRatBN7.2 Ensembl1222,498,213 - 22,536,263 (-)Ensembl
RefSeq Acc Id: NM_001393697   ⟹   NP_001380626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81228,134,200 - 28,172,876 (-)NCBI
mRatBN7.21222,497,767 - 22,536,455 (-)NCBI
RefSeq Acc Id: XM_063271158   ⟹   XP_063127228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81228,134,199 - 28,179,089 (-)NCBI
RefSeq Acc Id: XM_063271159   ⟹   XP_063127229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81228,134,199 - 28,140,675 (-)NCBI
Ensembl Acc Id: ENSRNOP00000079418   ⟸   ENSRNOT00000115001
Ensembl Acc Id: ENSRNOP00000088990   ⟸   ENSRNOT00000113330
RefSeq Acc Id: NP_001380626   ⟸   NM_001393697
- UniProtKB: A0A8I5ZN25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127228   ⟸   XM_063271158
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A695 (UniProtKB/TrEMBL),   A0A8I5ZN25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127229   ⟸   XM_063271159
- Peptide Label: isoform X2
- UniProtKB: A6J0K6 (UniProtKB/TrEMBL)
Protein Domains
SPIN-DOC-like zinc-finger

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307435 AgrOrtholog
BioCyc Gene G2FUF-19568 BioCyc
Ensembl Genes ENSRNOG00000001482 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000113330 ENTREZGENE
  ENSRNOT00000113330.2 UniProtKB/TrEMBL
  ENSRNOT00000115001 ENTREZGENE
  ENSRNOT00000115001.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1460.10 UniProtKB/TrEMBL
InterPro GTF2I UniProtKB/TrEMBL
  GTF2I-like_rpt_sf UniProtKB/TrEMBL
  GTF2IRD2 UniProtKB/TrEMBL
  SPIN-DOC_Znf-C2H2 UniProtKB/TrEMBL
NCBI Gene 288606 ENTREZGENE
PANTHER GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-RELATED UniProtKB/TrEMBL
  PTHR47831 UniProtKB/TrEMBL
Pfam GTF2I UniProtKB/TrEMBL
  zf-C2H2_12 UniProtKB/TrEMBL
PhenoGen Gtf2ird2 PhenoGen
PROSITE GTF2I UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001482 RatGTEx
Superfamily-SCOP SSF117773 UniProtKB/TrEMBL
UniProt A0A8I5ZN25 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A695 ENTREZGENE, UniProtKB/TrEMBL
  A6J0K6 ENTREZGENE, UniProtKB/TrEMBL
  Q2V6E4_RAT UniProtKB/TrEMBL
  Q2V6E6_RAT UniProtKB/TrEMBL
  Q2V6E7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Gtf2ird2  GTF2I repeat domain containing 2  RGD1566086  similar to gtf2ird2  Data merged from RGD:1566086 1643240 APPROVED
2008-04-30 RGD1566086  similar to gtf2ird2   RGD1566086_predicted  similar to gtf2ird2 (predicted)  'predicted' is removed 2292626 APPROVED
2008-03-07 Gtf2ird2  GTF2I repeat domain containing 2  RGD1307435_predicted  similar to gtf2ird2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566086_predicted  similar to gtf2ird2 (predicted)  LOC360795  similar to gtf2ird2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360795  similar to gtf2ird2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1307435_predicted  similar to gtf2ird2 (predicted)  LOC288606_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288606_predicted  similar to gtf2ird2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL