Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Nek3 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEK3 mRNA | CTD | PMID:22079256 | Nek3 | Rat | 1,1-dichloroethene | increases expression | ISO | Nek3 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of NEK3 mRNA | CTD | PMID:26682919 | Nek3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NEK3 mRNA | CTD | PMID:20106945 and PMID:21632981 | Nek3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NEK3 mRNA | CTD | PMID:33387578 | Nek3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nek3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEK3 mRNA | CTD | PMID:21570461 | Nek3 | Rat | 4-hydroxynon-2-enal | increases expression | ISO | Nek3 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of NEK3 mRNA | CTD | PMID:19191707 | Nek3 | Rat | acrolein | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased expression of NEK3 mRNA | CTD | PMID:32845096 | Nek3 | Rat | aflatoxin B1 | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of NEK3 mRNA | CTD | PMID:19770486 | Nek3 | Rat | aflatoxin B1 | decreases methylation | ISO | NEK3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of NEK3 gene | CTD | PMID:27153756 | Nek3 | Rat | aristolochic acid A | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of NEK3 mRNA | CTD | PMID:33212167 | Nek3 | Rat | atrazine | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of NEK3 mRNA | CTD | PMID:18585445 | Nek3 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of NEK3 mRNA | CTD | PMID:26496021 | Nek3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NEK3 mRNA | CTD | PMID:30816183 more ... | Nek3 | Rat | cadmium atom | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NEK3 mRNA | CTD | PMID:31738976 | Nek3 | Rat | cadmium dichloride | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NEK3 mRNA | CTD | PMID:31738976 | Nek3 | Rat | cadmium dichloride | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of NEK3 mRNA | CTD | PMID:38568856 | Nek3 | Rat | cadmium sulfate | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | cadmium sulfate results in decreased expression of NEK3 mRNA | CTD | PMID:12064557 | Nek3 | Rat | caffeine | affects phosphorylation | ISO | NEK3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of NEK3 protein | CTD | PMID:35688186 | Nek3 | Rat | chlordecone | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of NEK3 mRNA | CTD | PMID:29980752 | Nek3 | Rat | chromium(6+) | affects expression | ISO | Nek3 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of NEK3 mRNA | CTD | PMID:28472532 | Nek3 | Rat | chromium(6+) | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of NEK3 mRNA | CTD | PMID:38479592 | Nek3 | Rat | chromium(6+) | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | chromium hexavalent ion results in decreased expression of NEK3 mRNA | CTD | PMID:30690063 | Nek3 | Rat | copper(II) sulfate | affects expression | ISO | NEK3 (Homo sapiens) | 6480464 | Copper Sulfate affects the expression of NEK3 mRNA | CTD | PMID:19549813 | Nek3 | Rat | cyclosporin A | increases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of NEK3 mRNA | CTD | PMID:20106945 and PMID:27989131 | Nek3 | Rat | DDE | increases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of NEK3 mRNA | CTD | PMID:38568856 | Nek3 | Rat | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of NEK3 mRNA | CTD | PMID:22546817 | Nek3 | Rat | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of NEK3 mRNA | CTD | PMID:22546817 | Nek3 | Rat | doxorubicin | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NEK3 mRNA | CTD | PMID:29803840 | Nek3 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of NEK3 mRNA | CTD | PMID:24136188 | Nek3 | Rat | formaldehyde | increases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of NEK3 mRNA | CTD | PMID:27664576 | Nek3 | Rat | FR900359 | affects phosphorylation | ISO | NEK3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of NEK3 protein | CTD | PMID:37730182 | Nek3 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of NEK3 mRNA | CTD | PMID:33387578 | Nek3 | Rat | hydroxyurea | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | Hydroxyurea results in decreased expression of NEK3 mRNA | CTD | PMID:12929121 | Nek3 | Rat | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of NEK3 mRNA | CTD | PMID:20864626 | Nek3 | Rat | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of NEK3 mRNA | CTD | PMID:22546817 | Nek3 | Rat | ozone | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased expression of NEK3 mRNA | CTD | PMID:32845096 | Nek3 | Rat | p-anisidine | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | 4-anisidine results in decreased expression of NEK3 mRNA | CTD | PMID:12929121 | Nek3 | Rat | paracetamol | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of NEK3 mRNA | CTD | PMID:21420995 and PMID:22230336 | Nek3 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of NEK3 mRNA | CTD | PMID:33387578 | Nek3 | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Nek3 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of NEK3 mRNA | CTD | PMID:37995155 | Nek3 | Rat | pirinixic acid | increases expression | ISO | Nek3 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of NEK3 mRNA | CTD | PMID:17426115 | Nek3 | Rat | pirinixic acid | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of NEK3 mRNA | CTD | PMID:23811191 | Nek3 | Rat | potassium chromate | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEK3 mRNA | CTD | PMID:22079256 | Nek3 | Rat | potassium chromate | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of NEK3 mRNA | CTD | PMID:22079256 and PMID:22714537 | Nek3 | Rat | silver atom | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | Silver results in decreased expression of NEK3 mRNA | CTD | PMID:27131904 | Nek3 | Rat | silver(0) | decreases expression | ISO | Nek3 (Mus musculus) | 6480464 | Silver results in decreased expression of NEK3 mRNA | CTD | PMID:27131904 | Nek3 | Rat | succimer | multiple interactions | ISO | NEK3 (Homo sapiens) | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NEK3 mRNA | CTD | PMID:26378955 | Nek3 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of NEK3 mRNA | CTD | PMID:26496021 | Nek3 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of NEK3 mRNA | CTD | PMID:31150632 | Nek3 | Rat | valproic acid | affects expression | ISO | Nek3 (Mus musculus) | 6480464 | Valproic Acid affects the expression of NEK3 mRNA | CTD | PMID:17292431 | Nek3 | Rat | valproic acid | decreases expression | ISO | NEK3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of NEK3 mRNA | CTD | PMID:23179753 | Nek3 | Rat | valproic acid | affects expression | ISO | NEK3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NEK3 mRNA | CTD | PMID:25979313 | |