Bmi1 (BMI1 proto-oncogene, polycomb ring finger) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bmi1 (BMI1 proto-oncogene, polycomb ring finger) Rattus norvegicus
Analyze
Symbol: Bmi1
Name: BMI1 proto-oncogene, polycomb ring finger
RGD ID: 1307403
Description: Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus; cellular response to interleukin-1; and regulation of kidney development. Predicted to be located in heterochromatin and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger); PARTICIPATES IN histone modification pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B lymphoma Mo-MLV insertion region 1; Bmi1 polycomb ring finger oncogene; LOC307151; Pcgf4; polycomb complex protein BMI-1; polycomb group ring finger 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,240,683 - 86,250,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1786,243,491 - 86,250,024 (+)EnsemblGRCr8
mRatBN7.21781,332,175 - 81,341,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1784,809,066 - 84,812,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01788,644,466 - 88,648,140 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01782,661,208 - 82,664,882 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,360,439 - 85,370,283 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)Ensemblrn6Rnor6.0
Rnor_5.01787,087,687 - 87,091,418 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41792,784,216 - 92,787,947 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1780,616,376 - 80,620,118 (+)NCBICelera
RGSC_v3.11792,795,131 - 92,798,710 (+)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
glucaric acid  (ISO)
glutathione  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
ibrutinib  (ISO)
indometacin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP,ISO)
malathion  (ISO)
melatonin  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
ozone  (EXP)
p-anisidine  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
heterochromatin  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleus  (IEA,ISO)
PcG protein complex  (IEA,ISO)
PRC1 complex  (IEA,ISO)
ubiquitin ligase complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations. Bose R, etal., Cell Death Dis. 2010 Nov 4;1:e92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PRC1 complex diversity: where is it taking us? Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
4. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Kim JH, etal., Cancer Lett. 2004 Jan 20;203(2):217-24.
5. The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. Martinez-Romero C, etal., J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.
6. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. Sawa M, etal., Int J Hematol. 2005 Jul;82(1):42-7.
12. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
13. Pro-inflammatory cytokine interleukin-1beta promotes the development of intestinal stem cells. Wang L, etal., Inflamm Res. 2012 Oct;61(10):1085-92. doi: 10.1007/s00011-012-0501-3. Epub 2012 Jun 16.
14. Methylation-associated silencing of miR-200b facilitates human hepatocellular carcinoma progression by directly targeting BMI1. Wu WR, etal., Oncotarget. 2016 Apr 5;7(14):18684-93. doi: 10.18632/oncotarget.7629.
15. Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus. Yamada A, etal., Int J Oncol. 2011 Feb;38(2):345-53. doi: 10.3892/ijo.2010.868. Epub 2010 Dec 9.
Additional References at PubMed
PMID:7926765   PMID:8887324   PMID:9312051   PMID:9367786   PMID:10445843   PMID:11290297   PMID:12167701   PMID:12183370   PMID:12477932   PMID:12714971   PMID:15334543   PMID:15964995  
PMID:16359901   PMID:16624538   PMID:16687444   PMID:16714294   PMID:17107999   PMID:17420273   PMID:18311137   PMID:19636380   PMID:20956546   PMID:21282530   PMID:21544870   PMID:22770845  
PMID:24105743   PMID:24352954   PMID:24623306   PMID:26151332   PMID:27716060   PMID:29479858   PMID:34101367  


Genomics

Comparative Map Data
Bmi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81786,240,683 - 86,250,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1786,243,491 - 86,250,024 (+)EnsemblGRCr8
mRatBN7.21781,332,175 - 81,341,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1784,809,066 - 84,812,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01788,644,466 - 88,648,140 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01782,661,208 - 82,664,882 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01785,360,439 - 85,370,283 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)Ensemblrn6Rnor6.0
Rnor_5.01787,087,687 - 87,091,418 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41792,784,216 - 92,787,947 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1780,616,376 - 80,620,118 (+)NCBICelera
RGSC_v3.11792,795,131 - 92,798,710 (+)NCBI
Cytogenetic Map17q12.3NCBI
BMI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381022,321,099 - 22,331,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1022,321,078 - 22,331,485 (+)Ensemblhg38GRCh38
GRCh371022,610,028 - 22,620,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361022,650,146 - 22,660,194 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341022,650,145 - 22,660,190NCBI
Celera1022,297,715 - 22,308,139 (+)NCBICelera
Cytogenetic Map10p12.2NCBI
HuRef1022,276,563 - 22,281,617 (+)NCBIHuRef
CHM1_11022,610,777 - 22,620,864 (+)NCBICHM1_1
T2T-CHM13v2.01022,340,133 - 22,350,740 (+)NCBIT2T-CHM13v2.0
Bmi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39218,681,953 - 18,691,440 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl218,681,829 - 18,691,440 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38218,677,018 - 18,686,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl218,677,018 - 18,686,629 (+)Ensemblmm10GRCm38
MGSCv37218,598,645 - 18,608,256 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36218,594,772 - 18,604,383 (+)NCBIMGSCv36mm8
Celera218,564,450 - 18,578,495 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map212.9NCBI
Bmi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554296,547,731 - 6,558,105 (-)Ensembl
ChiLan1.0NW_0049554296,548,586 - 6,553,730 (-)NCBIChiLan1.0ChiLan1.0
BMI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2835,001,734 - 35,011,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11035,006,599 - 35,016,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01022,477,755 - 22,487,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11022,854,230 - 22,863,482 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1022,857,776 - 22,863,479 (+)EnsemblpanPan2panpan1.1
BMI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1210,818,232 - 10,828,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl210,818,232 - 10,833,613 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha29,511,530 - 9,521,768 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.029,018,100 - 9,028,340 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl29,018,100 - 9,033,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128,381,805 - 8,392,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028,465,970 - 8,476,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028,633,839 - 8,644,069 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bmi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934422,243,467 - 22,253,222 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365205,707,778 - 5,717,024 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365205,707,542 - 5,716,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1052,586,509 - 52,596,564 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11052,586,089 - 52,596,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21058,240,742 - 58,245,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1922,095,592 - 22,104,894 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605127,837,839 - 27,848,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247966,274,561 - 6,282,984 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247966,277,201 - 6,282,830 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bmi1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1145,349,014 - 5,363,043 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bmi1
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000064257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat

Markers in Region
M64279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,341,181 - 81,341,361 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,840 - 85,370,019NCBIRnor6.0
Rnor_5.01787,093,044 - 87,093,223UniSTSRnor5.0
RGSC_v3.41792,789,573 - 92,789,752UniSTSRGSC3.4
Celera1780,621,744 - 80,621,923UniSTS
Cytogenetic Map17q12.3UniSTS
RH136669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,340,905 - 81,341,065 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,564 - 85,369,723NCBIRnor6.0
Rnor_5.01787,092,768 - 87,092,927UniSTSRnor5.0
RGSC_v3.41792,789,297 - 92,789,456UniSTSRGSC3.4
Celera1780,621,468 - 80,621,627UniSTS
RH 3.4 Map17832.8UniSTS
Cytogenetic Map17q12.3UniSTS
AI172222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21781,341,193 - 81,341,290 (+)MAPPERmRatBN7.2
Rnor_6.01785,369,852 - 85,369,948NCBIRnor6.0
Rnor_5.01787,093,056 - 87,093,152UniSTSRnor5.0
RGSC_v3.41792,789,585 - 92,789,681UniSTSRGSC3.4
Celera1780,621,756 - 80,621,852UniSTS
RH 3.4 Map17833.7UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064257   ⟹   ENSRNOP00000059998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1786,243,491 - 86,250,024 (+)Ensembl
mRatBN7.2 Ensembl1781,332,214 - 81,388,690 (+)Ensembl
Rnor_6.0 Ensembl1785,364,483 - 85,368,208 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126368   ⟹   ENSRNOP00000103433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1786,245,020 - 86,247,989 (+)Ensembl
RefSeq Acc Id: NM_001107368   ⟹   NP_001100838
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,244 - 86,247,975 (+)NCBI
mRatBN7.21781,335,825 - 81,339,556 (+)NCBI
Rnor_6.01785,364,483 - 85,368,214 (+)NCBI
Rnor_5.01787,087,687 - 87,091,418 (+)NCBI
RGSC_v3.41792,784,216 - 92,787,947 (+)RGD
Celera1780,616,376 - 80,620,118 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095805   ⟹   XP_038951733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,683 - 86,250,044 (+)NCBI
mRatBN7.21781,332,175 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095806   ⟹   XP_038951734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,982 - 86,250,044 (+)NCBI
mRatBN7.21781,332,635 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095807   ⟹   XP_038951735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,241,276 - 86,250,044 (+)NCBI
mRatBN7.21781,336,006 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_039095808   ⟹   XP_038951736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,352 - 86,250,044 (+)NCBI
mRatBN7.21781,336,164 - 81,341,625 (+)NCBI
RefSeq Acc Id: XM_063276500   ⟹   XP_063132570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,240,972 - 86,250,044 (+)NCBI
RefSeq Acc Id: XM_063276501   ⟹   XP_063132571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81786,244,359 - 86,250,044 (+)NCBI
RefSeq Acc Id: NP_001100838   ⟸   NM_001107368
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059998   ⟸   ENSRNOT00000064257
RefSeq Acc Id: XP_038951733   ⟸   XM_039095805
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951734   ⟸   XM_039095806
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951735   ⟸   XM_039095807
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951736   ⟸   XM_039095808
- Peptide Label: isoform X1
- UniProtKB: B4F7B6 (UniProtKB/TrEMBL),   A6JM95 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132570   ⟸   XM_063276500
- Peptide Label: isoform X1
- UniProtKB: A6JM95 (UniProtKB/TrEMBL),   B4F7B6 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132571   ⟸   XM_063276501
- Peptide Label: isoform X1
- UniProtKB: A6JM95 (UniProtKB/TrEMBL),   B4F7B6 (UniProtKB/TrEMBL),   F7FA44 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103433   ⟸   ENSRNOT00000126368
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4F7B6-F1-model_v2 AlphaFold B4F7B6 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307403 AgrOrtholog
BioCyc Gene G2FUF-8558 BioCyc
Ensembl Genes ENSRNOG00000016585 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064257 ENTREZGENE
  ENSRNOT00000064257.4 UniProtKB/TrEMBL
  ENSRNOT00000126368 ENTREZGENE
  ENSRNOT00000126368.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro RAWUL UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:307151 UniProtKB/TrEMBL
NCBI Gene 307151 ENTREZGENE
PANTHER POLYCOMB COMPLEX PROTEIN BMI-1 UniProtKB/TrEMBL
  RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT UniProtKB/TrEMBL
Pfam RAWUL UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PharmGKB BMI1 RGD
PhenoGen Bmi1 PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016585 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0ABZ3NNP3_RAT UniProtKB/TrEMBL
  A6JM95 ENTREZGENE, UniProtKB/TrEMBL
  B4F7B6 ENTREZGENE
  F7FA44 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B4F7B6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Bmi1  BMI1 proto-oncogene, polycomb ring finger  Bmi1  Bmi1 polycomb ring finger oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Bmi1  Bmi1 polycomb ring finger oncogene  Pcgf4_predicted  polycomb group ring finger 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pcgf4_predicted  polycomb group ring finger 4 (predicted)  Bmi1_predicted  B lymphoma Mo-MLV insertion region 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Bmi1_predicted  B lymphoma Mo-MLV insertion region 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED