Medag (mesenteric estrogen-dependent adipogenesis) - Rat Genome Database

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Gene: Medag (mesenteric estrogen-dependent adipogenesis) Rattus norvegicus
Analyze
Symbol: Medag
Name: mesenteric estrogen-dependent adipogenesis
RGD ID: 1307396
Description: Predicted to be involved in positive regulation of fat cell differentiation. Predicted to be active in cytoplasm. Orthologous to human MEDAG (mesenteric estrogen dependent adipogenesis); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360757; RGD1307396; similar to RIKEN cDNA 6330406I15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,649,526 - 10,670,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,649,526 - 10,692,756 (-)EnsemblGRCr8
mRatBN7.2125,613,191 - 5,634,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,613,208 - 5,634,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,279,708 - 6,300,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,903,180 - 6,924,463 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,930,909 - 5,952,145 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,711,745 - 6,730,959 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,711,747 - 6,740,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,808,629 - 8,828,437 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4126,104,957 - 6,126,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,371,986 - 7,393,743 (-)NCBICelera
RGSC_v3.1126,104,981 - 6,126,628 (-)NCBI
Cytogenetic Map12p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22510272  


Genomics

Comparative Map Data
Medag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,649,526 - 10,670,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,649,526 - 10,692,756 (-)EnsemblGRCr8
mRatBN7.2125,613,191 - 5,634,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,613,208 - 5,634,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx126,279,708 - 6,300,994 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,903,180 - 6,924,463 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0125,930,909 - 5,952,145 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,711,745 - 6,730,959 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,711,747 - 6,740,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0128,808,629 - 8,828,437 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4126,104,957 - 6,126,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,371,986 - 7,393,743 (-)NCBICelera
RGSC_v3.1126,104,981 - 6,126,628 (-)NCBI
Cytogenetic Map12p11NCBI
MEDAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,906,271 - 30,925,572 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,906,271 - 30,925,572 (+)Ensemblhg38GRCh38
GRCh371331,480,408 - 31,499,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,378,328 - 30,397,678 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1312,546,863 - 12,566,248 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,291,191 - 12,310,577 (+)NCBIHuRef
CHM1_11331,447,426 - 31,466,813 (+)NCBICHM1_1
T2T-CHM13v2.01330,128,196 - 30,147,488 (+)NCBIT2T-CHM13v2.0
Medag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,335,214 - 149,355,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,335,214 - 149,355,188 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385149,367,641 - 149,431,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,411,749 - 149,431,723 (+)Ensemblmm10GRCm38
MGSCv375150,214,381 - 150,234,278 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365149,680,185 - 149,700,082 (+)NCBIMGSCv36mm8
Celera5147,412,123 - 147,432,091 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Medag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543114,916,369 - 14,937,385 (-)Ensembl
ChiLan1.0NW_00495543114,918,560 - 14,937,385 (-)NCBIChiLan1.0ChiLan1.0
MEDAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,487,042 - 30,506,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,593,822 - 21,613,941 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,180,622 - 12,200,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,614,989 - 30,634,048 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,614,989 - 30,632,912 (+)EnsemblpanPan2panpan1.1
MEDAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,182,441 - 9,201,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,183,443 - 9,200,051 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha259,224,982 - 9,242,610 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,287,047 - 9,305,980 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,287,076 - 9,304,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,185,976 - 9,203,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,194,040 - 9,211,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,236,109 - 9,253,732 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Medag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,298,447 - 170,317,740 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,634,349 - 25,653,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,634,444 - 25,653,708 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEDAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,545,494 - 7,562,737 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1117,545,400 - 7,562,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,396,838 - 7,414,378 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEDAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,779,644 - 9,799,113 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605734,569,194 - 34,588,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Medag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,278,545 - 7,300,602 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247767,280,321 - 7,300,505 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Medag
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1164,439,596 - 4,460,417 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Medag
171 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000001205
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat

Markers in Region
AA892578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,613,365 - 5,613,486 (+)MAPPERmRatBN7.2
Rnor_6.0126,711,920 - 6,712,040NCBIRnor6.0
Rnor_5.0128,808,804 - 8,808,924UniSTSRnor5.0
RGSC_v3.4126,104,557 - 6,104,677UniSTSRGSC3.4
Celera127,372,161 - 7,372,281UniSTS
RH 3.4 Map1241.4UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 141 91 90 59 31 59 6 295 131 11 120 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000001205   ⟹   ENSRNOP00000001205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,649,526 - 10,670,913 (-)Ensembl
mRatBN7.2 Ensembl125,613,208 - 5,634,767 (-)Ensembl
Rnor_6.0 Ensembl126,711,747 - 6,740,714 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156087   ⟹   ENSRNOP00000103199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1210,649,526 - 10,692,756 (-)Ensembl
RefSeq Acc Id: NM_001398808   ⟹   NP_001385737
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,649,526 - 10,670,913 (-)NCBI
mRatBN7.2125,613,191 - 5,634,583 (-)NCBI
RefSeq Acc Id: NM_001398809   ⟹   NP_001385738
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,649,526 - 10,670,913 (-)NCBI
mRatBN7.2125,613,191 - 5,634,583 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385737 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385738 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89523 (Get FASTA)   NCBI Sequence Viewer  
  EDL89524 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001205
  ENSRNOP00000001205.6
  ENSRNOP00000103199
  ENSRNOP00000103199.1
Ensembl Acc Id: ENSRNOP00000001205   ⟸   ENSRNOT00000001205
RefSeq Acc Id: NP_001385738   ⟸   NM_001398809
- Peptide Label: isoform 2
- UniProtKB: A6K165 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385737   ⟸   NM_001398808
- Peptide Label: isoform 1
- UniProtKB: D3ZTT1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103199   ⟸   ENSRNOT00000156087

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTT1-F1-model_v2 AlphaFold D3ZTT1 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698396
Promoter ID:EPDNEW_R8914
Type:multiple initiation site
Name:Medag_1
Description:mesenteric estrogen-dependent adipogenesis
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0126,740,721 - 6,740,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307396 AgrOrtholog
BioCyc Gene G2FUF-20194 BioCyc
Ensembl Genes ENSRNOG00000000906 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001205 ENTREZGENE
  ENSRNOT00000001205.9 UniProtKB/TrEMBL
  ENSRNOT00000156087 ENTREZGENE
  ENSRNOT00000156087.1 UniProtKB/TrEMBL
InterPro MEDAG/TEX26 UniProtKB/TrEMBL
NCBI Gene 360757 ENTREZGENE
PANTHER PTHR33769 UniProtKB/TrEMBL
  PTHR33769:SF3 UniProtKB/TrEMBL
PhenoGen Medag PhenoGen
RatGTEx ENSRNOG00000000906 RatGTEx
UniProt A0ABK0LN92_RAT UniProtKB/TrEMBL
  A6K165 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Medag  mesenteric estrogen-dependent adipogenesis  RGD1307396  similar to RIKEN cDNA 6330406I15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307396  similar to RIKEN cDNA 6330406I15   RGD1307396_predicted  similar to RIKEN cDNA 6330406I15 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307396_predicted  similar to RIKEN cDNA 6330406I15 (predicted)  LOC360757_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360757_predicted  similar to RIKEN cDNA 6330406I15 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL