Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Mthfd1l (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like) Rattus norvegicus
Analyze
Symbol: Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
RGD ID: 1307311
Description: Predicted to enable ATP binding activity; formate-tetrahydrofolate ligase activity; and protein homodimerization activity. Predicted to be involved in chordate embryonic development; formate biosynthetic process; and tetrahydrofolate metabolic process. Predicted to be active in cytosol and mitochondrial matrix. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: formyltetrahydrofolate synthetase domain containing 1; Fthfsdc1; LOC361472; monofunctional C1-tetrahydrofolate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,849,424 - 43,038,313 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,849,374 - 43,038,309 (+)EnsemblGRCr8
mRatBN7.2140,443,926 - 40,632,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,444,008 - 40,632,905 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx140,971,049 - 41,159,905 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,958,247 - 47,147,101 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,046,668 - 41,235,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,529,092 - 40,719,232 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)Ensemblrn6Rnor6.0
Rnor_5.0141,876,363 - 42,065,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4134,759,445 - 34,800,865 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera136,135,294 - 36,323,637 (+)NCBICelera
RGSC_v3.1134,690,706 - 34,876,868 (+)NCBI
Cytogenetic Map1p11-q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycine betaine  (EXP)
glyphosate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Momb J, etal., Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):549-54. doi: 10.1073/pnas.1211199110. Epub 2012 Dec 24.
4. A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Parle-McDermott A, etal., Hum Mutat. 2009 Dec;30(12):1650-6. doi: 10.1002/humu.21109.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:12477932   PMID:12937168   PMID:16171773   PMID:18614015   PMID:19946888   PMID:19948730   PMID:30361391  


Genomics

Comparative Map Data
Mthfd1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,849,424 - 43,038,313 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,849,374 - 43,038,309 (+)EnsemblGRCr8
mRatBN7.2140,443,926 - 40,632,911 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,444,008 - 40,632,905 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx140,971,049 - 41,159,905 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,958,247 - 47,147,101 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,046,668 - 41,235,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,529,092 - 40,719,232 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)Ensemblrn6Rnor6.0
Rnor_5.0141,876,363 - 42,065,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4134,759,445 - 34,800,865 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera136,135,294 - 36,323,637 (+)NCBICelera
RGSC_v3.1134,690,706 - 34,876,868 (+)NCBI
Cytogenetic Map1p11-q11NCBI
MTHFD1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386150,865,702 - 151,101,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6150,865,679 - 151,101,887 (+)Ensemblhg38GRCh38
GRCh376151,186,838 - 151,423,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,228,384 - 151,464,716 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346151,278,804 - 151,515,135NCBI
Celera6151,920,551 - 152,156,863 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6148,750,394 - 148,986,848 (+)NCBIHuRef
CHM1_16151,450,554 - 151,687,113 (+)NCBICHM1_1
T2T-CHM13v2.06152,066,259 - 152,302,476 (+)NCBIT2T-CHM13v2.0
Mthfd1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,918,282 - 4,117,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl103,923,118 - 4,117,081 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38103,972,892 - 4,167,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,973,118 - 4,167,081 (+)Ensemblmm10GRCm38
MGSCv37106,179,460 - 6,373,466 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36106,190,430 - 6,373,423 (-)NCBIMGSCv36mm8
Celera103,900,899 - 4,096,959 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Mthfd1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,438,883 - 10,621,768 (-)Ensembl
ChiLan1.0NW_00495543910,432,732 - 10,621,991 (-)NCBIChiLan1.0ChiLan1.0
MTHFD1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25170,883,747 - 171,125,490 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16168,777,226 - 169,016,733 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06148,679,587 - 148,919,002 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,384,532 - 153,619,884 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,390,498 - 153,619,884 (+)EnsemblpanPan2panpan1.1
MTHFD1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,316,247 - 41,495,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,309,419 - 41,495,216 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha142,149,900 - 42,336,703 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0141,493,594 - 41,680,491 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,492,925 - 41,680,486 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,368,435 - 41,555,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,212,380 - 41,399,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0141,717,070 - 41,904,119 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mthfd1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,625,481 - 136,807,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364893,876,680 - 4,051,933 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364893,877,423 - 4,060,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,140,899 - 15,329,986 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1115,140,929 - 15,330,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,550,520 - 17,655,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,306,770 - 78,539,884 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,306,821 - 78,477,200 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604050,602,217 - 50,869,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247857,129,859 - 7,328,153 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247857,129,969 - 7,328,331 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mthfd1l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12198,763,662 - 198,953,155 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mthfd1l
1149 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:117
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000026564
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat

Markers in Region
RH128481  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,632,556 - 40,632,747 (+)MAPPERmRatBN7.2
Rnor_6.0140,718,878 - 40,719,068NCBIRnor6.0
Rnor_5.0142,065,040 - 42,065,230UniSTSRnor5.0
RGSC_v3.4134,880,782 - 34,880,972UniSTSRGSC3.4
Celera136,323,283 - 36,323,473UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 354 192 11 141 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026564   ⟹   ENSRNOP00000026564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,849,374 - 43,038,309 (+)Ensembl
mRatBN7.2 Ensembl140,444,008 - 40,632,905 (+)Ensembl
Rnor_6.0 Ensembl140,529,045 - 40,719,391 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156370   ⟹   ENSRNOP00000106257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,849,374 - 43,031,130 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173127   ⟹   ENSRNOP00000108928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,849,374 - 42,981,464 (+)Ensembl
RefSeq Acc Id: NM_001108462   ⟹   NP_001101932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,849,424 - 43,038,313 (+)NCBI
mRatBN7.2140,444,008 - 40,632,911 (+)NCBI
Rnor_6.0140,529,092 - 40,719,232 (+)NCBI
Rnor_5.0141,876,363 - 42,065,394 (+)NCBI
RGSC_v3.4134,759,445 - 34,800,865 (+)RGD
Celera136,135,294 - 36,323,637 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66462 (Get FASTA)   NCBI Sequence Viewer  
  EDL92872 (Get FASTA)   NCBI Sequence Viewer  
  EDL92873 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026564
  ENSRNOP00000026564.5
  ENSRNOP00000106257.1
  ENSRNOP00000108928.1
RefSeq Acc Id: NP_001101932   ⟸   NM_001108462
- UniProtKB: B2GUZ3 (UniProtKB/TrEMBL),   A6KIK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026564   ⟸   ENSRNOT00000026564
Ensembl Acc Id: ENSRNOP00000106257   ⟸   ENSRNOT00000156370
Ensembl Acc Id: ENSRNOP00000108928   ⟸   ENSRNOT00000173127
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUZ3-F1-model_v2 AlphaFold B2GUZ3 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689583
Promoter ID:EPDNEW_R108
Type:initiation region
Name:Mthfd1l_1
Description:methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,529,037 - 40,529,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307311 AgrOrtholog
BioCyc Gene G2FUF-61724 BioCyc
Ensembl Genes ENSRNOG00000019582 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026564 ENTREZGENE
  ENSRNOT00000026564.8 UniProtKB/TrEMBL
  ENSRNOT00000156370.1 UniProtKB/TrEMBL
  ENSRNOT00000173127.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.770 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Formyltetrahydrofolate synthetase, domain 3 UniProtKB/TrEMBL
  Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9030223 IMAGE-MGC_LOAD
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  Formate_THF_ligase UniProtKB/TrEMBL
  Formate_THF_ligase_CS UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
KEGG Report rno:361472 UniProtKB/TrEMBL
MGC_CLONE MGC:187798 IMAGE-MGC_LOAD
NCBI Gene 361472 ENTREZGENE
PANTHER C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/TrEMBL
  MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam FTHFS UniProtKB/TrEMBL
  THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PhenoGen Mthfd1l PhenoGen
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE FTHFS_1 UniProtKB/TrEMBL
  FTHFS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019582 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0ABK0LMY7_RAT UniProtKB/TrEMBL
  A0ABK0M2I1_RAT UniProtKB/TrEMBL
  A6KIK6 ENTREZGENE, UniProtKB/TrEMBL
  B2GUZ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mthfd1l  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like   Mthfd1l_predicted  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Mthfd1l_predicted  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (predicted)  Fthfsdc1_predicted  formyltetrahydrofolate synthetase domain containing 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Fthfsdc1_predicted  formyltetrahydrofolate synthetase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED