Gene: Spink8 (serine peptidase inhibitor, Kazal type 8) Rattus norvegicus
Analyze
Symbol:
Spink8
Name:
serine peptidase inhibitor, Kazal type 8
RGD ID:
1307150
Description:
Orthologous to human SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC301016; RGD1307150; serine protease inhibitor Kazal-type 8; similar to Esophagus cancer-related gene-2 protein precursor (ECRG-2)
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Spink8 (serine peptidase inhibitor, Kazal type 8) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Spink8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LOC100739218 (double-headed protease inhibitor, submandibular gland-like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Spink8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Spink8 (serine peptidase inhibitor Kazal type 8 (putative)) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Spink8 (serine peptidase inhibitor, Kazal type 8)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
SPINK8 (serine peptidase inhibitor Kazal type 8 (putative))
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 118,686,362 - 118,707,449 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 8 118,686,366 - 118,707,544 (+) Ensembl GRCr8 mRatBN7.2 8 109,814,062 - 109,828,994 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 109,817,365 - 109,828,994 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 8 115,432,824 - 115,444,454 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 113,632,004 - 113,643,634 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 111,474,809 - 111,486,437 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 117,903,088 - 117,917,821 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 117,906,014 - 117,917,842 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 8 117,255,606 - 117,270,334 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 8 114,190,549 - 114,202,178 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 8 109,107,161 - 109,118,789 (+) NCBI Celera RGSC_v3.1 8 114,210,003 - 114,221,633 (+) NCBI Cytogenetic Map 8 q32 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Spink8 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPINK8 mRNA CTD PMID:34747641 Spink8 Rat 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SPINK8 mRNA CTD PMID:32119087 Spink8 Rat 4-hydroxyphenyl retinamide increases expression ISO Spink8 (Mus musculus) 6480464 Fenretinide results in increased expression of SPINK8 mRNA CTD PMID:28973697 Spink8 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SPINK8 mRNA CTD PMID:24780913 Spink8 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SPINK8 mRNA CTD PMID:30047161 Spink8 Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SPINK8 mRNA CTD PMID:35163327 Spink8 Rat amitrole increases expression EXP 6480464 Amitrole results in increased expression of SPINK8 mRNA CTD PMID:30047161 Spink8 Rat benzo[a]pyrene increases methylation ISO SPINK8 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SPINK8 3' UTR CTD PMID:27901495 Spink8 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPINK8 mRNA CTD PMID:25181051 Spink8 Rat bisphenol A decreases expression ISO Spink8 (Mus musculus) 6480464 bisphenol A results in decreased expression of SPINK8 mRNA CTD PMID:35598803 Spink8 Rat bisphenol A increases expression ISO Spink8 (Mus musculus) 6480464 bisphenol A results in increased expression of SPINK8 mRNA CTD PMID:32156529|PMID:38074096 Spink8 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SPINK8 gene CTD PMID:28505145 Spink8 Rat diethylstilbestrol affects expression EXP 6480464 Diethylstilbestrol affects the expression of SPINK8 mRNA CTD PMID:21658437 Spink8 Rat diuron increases expression EXP 6480464 Diuron results in increased expression of SPINK8 mRNA CTD PMID:21551480 Spink8 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of SPINK8 mRNA CTD PMID:30307764 Spink8 Rat furan increases expression EXP 6480464 furan results in increased expression of SPINK8 mRNA CTD PMID:27387713 Spink8 Rat glyphosate decreases expression ISO Spink8 (Mus musculus) 6480464 Glyphosate results in decreased expression of SPINK8 mRNA CTD PMID:33713393 Spink8 Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SPINK8 mRNA CTD PMID:35163327 Spink8 Rat phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of SPINK8 mRNA CTD PMID:30047161 Spink8 Rat progesterone decreases expression ISO Spink8 (Mus musculus) 6480464 Progesterone results in decreased expression of SPINK8 mRNA CTD PMID:22238285 Spink8 Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SPINK8 mRNA CTD PMID:28374803 Spink8 Rat silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of SPINK8 mRNA CTD PMID:22431001 Spink8 Rat sodium arsenite decreases expression ISO Spink8 (Mus musculus) 6480464 sodium arsenite results in decreased expression of SPINK8 mRNA CTD PMID:37682722 Spink8 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of SPINK8 mRNA CTD PMID:33387578 Spink8 Rat valproic acid decreases methylation ISO SPINK8 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of SPINK8 gene CTD PMID:29154799 Spink8 Rat valproic acid affects expression ISO Spink8 (Mus musculus) 6480464 Valproic Acid affects the expression of SPINK8 mRNA CTD PMID:17292431 Spink8 Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SPINK8 mRNA CTD PMID:23034163
References
Additional References at PubMed
Genomics
Comparative Map Data
Spink8 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 118,686,362 - 118,707,449 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 8 118,686,366 - 118,707,544 (+) Ensembl GRCr8 mRatBN7.2 8 109,814,062 - 109,828,994 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 109,817,365 - 109,828,994 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 8 115,432,824 - 115,444,454 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 113,632,004 - 113,643,634 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 111,474,809 - 111,486,437 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 117,903,088 - 117,917,821 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 117,906,014 - 117,917,842 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 8 117,255,606 - 117,270,334 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 8 114,190,549 - 114,202,178 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 8 109,107,161 - 109,118,789 (+) NCBI Celera RGSC_v3.1 8 114,210,003 - 114,221,633 (+) NCBI Cytogenetic Map 8 q32 NCBI
SPINK8 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 48,306,842 - 48,333,661 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 3 48,306,842 - 48,333,661 (-) Ensembl hg38 GRCh38 GRCh37 3 48,348,332 - 48,375,151 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 48,323,340 - 48,344,835 (-) NCBI Build 36 Build 36 hg18 NCBI36 Celera 3 48,298,735 - 48,320,292 (-) NCBI Celera Cytogenetic Map 3 p21.31 NCBI HuRef 3 48,402,368 - 48,423,818 (-) NCBI HuRef CHM1_1 3 48,300,661 - 48,322,136 (-) NCBI CHM1_1 T2T-CHM13v2.0 3 48,334,609 - 48,361,763 (-) NCBI T2T-CHM13v2.0
Spink8 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 9 109,641,271 - 109,655,696 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 9 109,641,348 - 109,655,701 (+) Ensembl GRCm39 Ensembl GRCm39 GRCm38 9 109,812,203 - 109,826,628 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 9 109,812,280 - 109,826,633 (+) Ensembl mm10 GRCm38 MGSCv37 9 109,719,141 - 109,729,142 (+) NCBI MGSCv37 MGSCv37 mm9 NCBIm37 MGSCv36 9 109,674,051 - 109,684,029 (+) NCBI MGSCv36 mm8 Celera 9 109,536,212 - 109,546,212 (+) NCBI Celera Cytogenetic Map 9 F2 NCBI cM Map 9 59.77 NCBI
Spink8 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955420 24,283,223 - 24,298,948 (+) NCBI ChiLan1.0 ChiLan1.0
SPINK8 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 2 48,272,287 - 48,297,772 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 3 48,277,055 - 48,302,540 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 3 48,219,663 - 48,249,064 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 3 49,304,505 - 49,327,605 (-) NCBI PanPan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 3 49,304,505 - 49,327,704 (-) Ensembl panPan2 panpan1.1
SPINK8 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 40,737,192 - 40,753,887 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 40,737,264 - 40,753,712 (+) Ensembl canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 40,654,746 - 40,671,418 (+) NCBI Dog10K_Boxer_Tasha Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 41,222,661 - 41,239,505 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 41,222,792 - 41,239,330 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 40,463,432 - 40,480,091 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 40,864,628 - 40,881,280 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 41,145,393 - 41,162,069 (+) NCBI UU_Cfam_GSD_1.0 UU_Cfam_GSD_1.0
LOC100739218
SPINK8 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 22 9,702,931 - 9,734,555 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 22 9,703,065 - 9,726,287 (-) Ensembl ChlSab1.1 Ensembl chlSab2 Vervet-AGM Vero_WHO_p1.0 NW_023666041 157,367,410 - 157,397,214 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Spink8
Spink8
miRNA Target Status (No longer updated)
Predicted Target Of
Count of predictions: 166 Count of miRNA genes: 131 Interacting mature miRNAs: 143 Transcripts: ENSRNOT00000056180 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction 
