Ercc3 (ERCC excision repair 3, TFIIH core complex helicase subunit) - Rat Genome Database

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Gene: Ercc3 (ERCC excision repair 3, TFIIH core complex helicase subunit) Rattus norvegicus
Analyze
Symbol: Ercc3
Name: ERCC excision repair 3, TFIIH core complex helicase subunit
RGD ID: 1307139
Description: Predicted to enable 3'-5' DNA helicase activity; ATP hydrolysis activity; and promoter-specific chromatin binding activity. Involved in embryonic organ development and response to hypoxia. Part of transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; general transcription and DNA repair factor IIH helicase subunit XPB; general transcription and DNA repair factor IIH helicase/translocase subunit XPB; LOC291703; MGC112916; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,157,831 - 24,188,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,148,084 - 24,190,898 (+)EnsemblGRCr8
mRatBN7.21823,883,613 - 23,914,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,883,580 - 23,914,329 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1824,011,704 - 24,042,414 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,769,645 - 24,800,699 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,106,694 - 24,137,406 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01825,037,668 - 25,068,380 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,037,625 - 25,068,389 (+)Ensemblrn6Rnor6.0
Rnor_5.01824,752,960 - 24,783,861 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41824,684,912 - 24,716,143 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1823,636,100 - 23,666,812 (+)NCBICelera
RGSC_v3.11824,711,564 - 24,742,649 (+)NCBI
Cytogenetic Map18p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Andressoo JO, etal., Mol Cell Biol. 2009 Mar;29(5):1276-90. doi: 10.1128/MCB.01229-08. Epub 2008 Dec 29.
2. mRNA levels of the hypoxia inducible factor (HIF-1) and DNA repair genes in perinatal asphyxia of the rat. Chiappe-Gutierrez M, etal., Life Sci. 1998;63(13):1157-67.
3. TFIIH: when transcription met DNA repair. Compe E and Egly JM, Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54. doi: 10.1038/nrm3350.
4. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
5. Increased steady state mRNA levels of DNA-repair genes XRCC1, ERCC2 and ERCC3 in brain of patients with Down syndrome. Fang-Kircher SG, etal., Life Sci. 1999;64(18):1689-99.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease. Hermon M, etal., Neurosci Lett. 1998 Jul 17;251(1):45-8.
9. Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. Hu Z, etal., Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1336-40.
10. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Jin K, etal., Ann Neurol. 2001 Jul;50(1):93-103.
11. Nucleotide excision repair: new tricks with old bricks. Kamileri I, etal., Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22.
12. BCR binds to the xeroderma pigmentosum group B protein. Maru Y, etal., Biochem Biophys Res Commun. 1999 Jul 5;260(2):309-12.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. Oh KS, etal., Hum Mutat. 2006 Nov;27(11):1092-103.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH. Qadri I, etal., Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10578-83.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Multifunctional RNA polymerase II initiation factor delta from rat liver. Relationship between carboxyl-terminal domain kinase, ATPase, and DNA helicase activities. Serizawa H, etal., J Biol Chem. 1993 Aug 15;268(23):17300-8.
23. Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Sullivan I, etal., Cancer Lett. 2014 Oct 28;353(2):160-6. doi: 10.1016/j.canlet.2014.07.023. Epub 2014 Jul 25.
24. Nucleotide excision repair gene expression in the rat conceptus during organogenesis. Vinson RK and Hales BF, Mutat Res. 2001 Jul 12;486(2):113-23.
25. A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. Weeda G, etal., Am J Hum Genet. 1997 Feb;60(2):320-9.
26. Immunohistochemical analysis of nucleotide excision repair factors XPA and XPB in adult rat brain. Yang SZ, etal., Anat Rec (Hoboken). 2008 Jul;291(7):775-80. doi: 10.1002/ar.20713.
27. DNA repair pathway profiling and microsatellite instability in colorectal cancer. Yu J, etal., Clin Cancer Res. 2006 Sep 1;12(17):5104-11. doi: 10.1158/1078-0432.CCR-06-0547.
Additional References at PubMed
PMID:1747940   PMID:2167179   PMID:8652557   PMID:8663148   PMID:8675009   PMID:8692841   PMID:8692842   PMID:9173976   PMID:9852112   PMID:10801852   PMID:11335038   PMID:12477932  
PMID:16914395   PMID:17088560   PMID:17466626   PMID:17509950   PMID:17614221   PMID:22323595   PMID:23562818   PMID:27193682  


Genomics

Comparative Map Data
Ercc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,157,831 - 24,188,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,148,084 - 24,190,898 (+)EnsemblGRCr8
mRatBN7.21823,883,613 - 23,914,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,883,580 - 23,914,329 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1824,011,704 - 24,042,414 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,769,645 - 24,800,699 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01824,106,694 - 24,137,406 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01825,037,668 - 25,068,380 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,037,625 - 25,068,389 (+)Ensemblrn6Rnor6.0
Rnor_5.01824,752,960 - 24,783,861 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41824,684,912 - 24,716,143 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1823,636,100 - 23,666,812 (+)NCBICelera
RGSC_v3.11824,711,564 - 24,742,649 (+)NCBI
Cytogenetic Map18p12NCBI
ERCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,257,290 - 127,294,144 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,257,285 - 127,294,188 (-)Ensemblhg38GRCh38
GRCh372128,014,866 - 128,051,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,731,336 - 127,768,222 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342127,731,095 - 127,767,982NCBI
Celera2121,326,339 - 121,363,248 (-)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,322,147 - 120,359,036 (-)NCBIHuRef
CHM1_12128,019,440 - 128,056,319 (-)NCBICHM1_1
T2T-CHM13v2.02127,692,506 - 127,729,368 (-)NCBIT2T-CHM13v2.0
Ercc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,373,357 - 32,403,206 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,373,353 - 32,403,204 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381832,240,304 - 32,270,151 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,240,300 - 32,270,151 (+)Ensemblmm10GRCm38
MGSCv371832,399,985 - 32,429,801 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361832,383,341 - 32,413,157 (+)NCBIMGSCv36mm8
Celera1832,722,096 - 32,752,097 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.97NCBI
Ercc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,210,479 - 3,242,576 (+)Ensembl
ChiLan1.0NW_0049554593,210,936 - 3,238,401 (+)NCBIChiLan1.0ChiLan1.0
ERCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,351,721 - 48,388,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,366,698 - 48,403,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,983,492 - 33,020,492 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B127,922,483 - 127,959,372 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B127,922,483 - 127,959,372 (-)EnsemblpanPan2panpan1.1
ERCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,310,911 - 23,344,083 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,310,986 - 23,337,683 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1923,558,376 - 23,591,562 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01924,637,517 - 24,670,735 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,637,573 - 24,670,653 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,341,076 - 23,374,276 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,536,737 - 23,569,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,667,951 - 24,701,129 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ercc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,619,300 - 97,647,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,969,740 - 43,998,448 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,970,002 - 43,998,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,189,663 - 25,228,066 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11525,189,644 - 25,224,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,869,717 - 28,904,073 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,926,410 - 2,963,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,926,350 - 2,963,823 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606119,789,937 - 19,827,350 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,729,947 - 13,776,870 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473213,730,648 - 13,776,886 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ercc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11511,958,961 - 11,989,623 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ercc3
237 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:140
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000018422
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181221923726822399Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181221923726822399Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181221923726822399Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181221923726822399Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181221923726822399Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181221923726822399Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181221923726822399Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Got23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21823,882,565 - 23,882,783 (+)MAPPERmRatBN7.2
Rnor_6.01825,036,621 - 25,036,838NCBIRnor6.0
Rnor_5.01824,751,913 - 24,752,130UniSTSRnor5.0
RGSC_v3.41824,683,864 - 24,684,082RGDRGSC3.4
RGSC_v3.41824,683,865 - 24,684,082UniSTSRGSC3.4
Celera1823,635,053 - 23,635,270UniSTS
RGSC_v3.11824,710,511 - 24,710,728RGD
RH 3.4 Map18292.1UniSTS
RH 3.4 Map18292.1RGD
RH 2.0 Map18607.7999RGD
Cytogenetic Map18p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018422   ⟹   ENSRNOP00000018422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,157,783 - 24,190,898 (+)Ensembl
mRatBN7.2 Ensembl1823,883,580 - 23,914,329 (+)Ensembl
Rnor_6.0 Ensembl1825,037,625 - 25,068,389 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094123   ⟹   ENSRNOP00000088038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,157,783 - 24,190,898 (+)Ensembl
mRatBN7.2 Ensembl1823,883,580 - 23,914,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104867   ⟹   ENSRNOP00000111151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,148,084 - 24,190,898 (+)Ensembl
RefSeq Acc Id: NM_001031644   ⟹   NP_001026814
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,157,831 - 24,188,543 (+)NCBI
mRatBN7.21823,883,613 - 23,914,326 (+)NCBI
Rnor_6.01825,037,668 - 25,068,380 (+)NCBI
Rnor_5.01824,752,960 - 24,783,861 (+)NCBI
RGSC_v3.41824,684,912 - 24,716,143 (+)RGD
Celera1823,636,100 - 23,666,812 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001026814 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98856 (Get FASTA)   NCBI Sequence Viewer  
  EDL76187 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018422
  ENSRNOP00000018422.5
GenBank Protein Q4G005 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026814   ⟸   NM_001031644
- UniProtKB: Q4G005 (UniProtKB/Swiss-Prot),   A6J2Q5 (UniProtKB/TrEMBL),   A0A8I6A5P4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018422   ⟸   ENSRNOT00000018422
Ensembl Acc Id: ENSRNOP00000088038   ⟸   ENSRNOT00000094123
Ensembl Acc Id: ENSRNOP00000111151   ⟸   ENSRNOT00000104867
Protein Domains
Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G005-F1-model_v2 AlphaFold Q4G005 1-782 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700684
Promoter ID:EPDNEW_R11208
Type:initiation region
Name:Ercc3_1
Description:ERCC excision repair 3, TFIIH core complex helicase subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01825,037,659 - 25,037,719EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307139 AgrOrtholog
BioCyc Gene G2FUF-8038 BioCyc
Ensembl Genes ENSRNOG00000013180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018422 ENTREZGENE
  ENSRNOT00000018422.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7379944 IMAGE-MGC_LOAD
InterPro ATP-dep_DNA_Helicase UniProtKB/Swiss-Prot
  ERCC3_RAD25_C UniProtKB/Swiss-Prot
  Helicase/UvrB_N UniProtKB/Swiss-Prot
  Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  XPB/Ssl2 UniProtKB/Swiss-Prot
  XPB/Ssl2_N UniProtKB/Swiss-Prot
KEGG Report rno:291703 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112916 IMAGE-MGC_LOAD
NCBI Gene 291703 ENTREZGENE
PANTHER GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB UniProtKB/Swiss-Prot
  RAD25/XP-B DNA REPAIR HELICASE UniProtKB/Swiss-Prot
Pfam ERCC3_RAD25_C UniProtKB/Swiss-Prot
  Helicase_C_3 UniProtKB/Swiss-Prot
  ResIII UniProtKB/Swiss-Prot
PhenoGen Ercc3 PhenoGen
PRINTS XRODRMPGMNTB UniProtKB/Swiss-Prot
PROSITE HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013180 RatGTEx
SMART DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6A5P4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M8V9_RAT UniProtKB/TrEMBL
  A6J2Q5 ENTREZGENE, UniProtKB/TrEMBL
  ERCC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Ercc3  ERCC excision repair 3, TFIIH core complex helicase subunit  Ercc3  excision repair cross-complementation group 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-12 Ercc3  excision repair cross-complementation group 3  Ercc3  excision repair cross-complementing rodent repair deficiency, complementation group 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ercc3  excision repair cross-complementing rodent repair deficiency, complementation group 3  Ercc3_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ercc3_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED