Notum (NOTUM, palmitoleoyl-protein carboxylesterase) - Rat Genome Database

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Gene: Notum (NOTUM, palmitoleoyl-protein carboxylesterase) Rattus norvegicus
Analyze
Symbol: Notum
Name: NOTUM, palmitoleoyl-protein carboxylesterase
RGD ID: 1307119
Description: Predicted to enable lipase activity and palmitoleyl hydrolase activity. Acts upstream of or within bone development. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC303743; LOC303743; MGC109547; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); palmitoleoyl-protein carboxylesterase NOTUM; RGD1307119
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,431,572 - 106,438,654 (-)NCBIGRCr8
mRatBN7.210105,933,245 - 105,940,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,933,249 - 105,940,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,036,811 - 111,043,850 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,499,852 - 110,506,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,853,700 - 105,860,766 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,832,977 - 109,840,661 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,832,981 - 109,840,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,425,669 - 109,432,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,047,040 - 110,054,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,061,546 - 110,064,337 (-)NCBI
Celera10104,476,752 - 104,483,846 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NOTUM inhibition increases endocortical bone formation and bone strength. Brommage R, etal., Bone Res. 2019 Jan 8;7:2. doi: 10.1038/s41413-018-0038-3. eCollection 2019.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:15326124   PMID:18429952   PMID:25731175   PMID:25771893  


Genomics

Comparative Map Data
Notum
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,431,572 - 106,438,654 (-)NCBIGRCr8
mRatBN7.210105,933,245 - 105,940,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,933,249 - 105,940,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,036,811 - 111,043,850 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,499,852 - 110,506,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,853,700 - 105,860,766 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,832,977 - 109,840,661 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,832,981 - 109,840,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,425,669 - 109,432,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,047,040 - 110,054,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,061,546 - 110,064,337 (-)NCBI
Celera10104,476,752 - 104,483,846 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
NOTUM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,952,507 - 81,961,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,952,507 - 81,961,840 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,910,383 - 79,919,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,503,678 - 77,512,353 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,514,308 - 76,540,092 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,311,107 - 75,319,589 (-)NCBIHuRef
CHM1_11779,996,557 - 80,005,040 (-)NCBICHM1_1
T2T-CHM13v2.01782,819,665 - 82,828,345 (-)NCBIT2T-CHM13v2.0
Notum
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,544,614 - 120,552,019 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,544,614 - 120,552,001 (-)EnsemblGRCm39 Ensembl
GRCm3811120,653,788 - 120,661,193 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,653,788 - 120,661,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,515,102 - 120,522,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,475,247 - 120,477,905 (+)NCBIMGSCv36mm8
Celera11132,389,181 - 132,396,231 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.38NCBI
Notum
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,203,309 - 1,212,966 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,203,309 - 1,212,938 (+)NCBIChiLan1.0ChiLan1.0
NOTUM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,486,375 - 98,496,502 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,387,419 - 103,395,942 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,353,528 - 76,364,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,057,344 - 82,074,874 (-)NCBIpanpan1.1PanPan1.1panPan2
NOTUM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19344,648 - 350,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9344,020 - 350,368 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9946,787 - 952,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09938,019 - 944,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9937,352 - 947,429 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19963,161 - 969,164 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,089,807 - 1,095,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,168,436 - 1,174,439 (+)NCBIUU_Cfam_GSD_1.0
Notum
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602945,618 - 953,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,457,687 - 5,465,162 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,458,825 - 5,465,135 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTUM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,036,488 - 1,044,397 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,033,814 - 1,044,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103243743
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,826,835 - 73,835,453 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607745,300,039 - 45,308,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notum
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,791,939 - 10,802,463 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,795,603 - 10,802,394 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Notum
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:170
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000054947
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 17 1 17 2 17
Low 5 25 10 8 10 2 2 74 22 21 11 2
Below cutoff 2 33 12 12 10 12 6 9 11 3 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ204914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB768482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO562343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV215880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EX493402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000054947   ⟹   ENSRNOP00000051830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,933,249 - 105,940,315 (-)Ensembl
Rnor_6.0 Ensembl10109,832,981 - 109,840,047 (-)Ensembl
RefSeq Acc Id: NM_001013975   ⟹   NP_001013997
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,431,572 - 106,438,654 (-)NCBI
mRatBN7.210105,933,245 - 105,940,327 (-)NCBI
Rnor_6.010109,832,981 - 109,840,047 (-)NCBI
Rnor_5.010109,425,669 - 109,432,739 (-)NCBI
RGSC_v3.410110,047,040 - 110,054,106 (-)RGD
Celera10104,476,752 - 104,483,846 (-)RGD
Sequence:
RefSeq Acc Id: NM_001415777   ⟹   NP_001402706
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,431,572 - 106,438,040 (-)NCBI
mRatBN7.210105,933,245 - 105,939,713 (-)NCBI
RefSeq Acc Id: XM_006247887   ⟹   XP_006247949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,431,572 - 106,438,486 (-)NCBI
mRatBN7.210105,933,245 - 105,940,055 (-)NCBI
Rnor_6.010109,832,977 - 109,839,945 (-)NCBI
Rnor_5.010109,425,669 - 109,432,739 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247888   ⟹   XP_006247950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,431,572 - 106,437,450 (-)NCBI
mRatBN7.210105,933,245 - 105,939,105 (-)NCBI
Rnor_6.010109,832,977 - 109,838,944 (-)NCBI
Rnor_5.010109,425,669 - 109,432,739 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086224   ⟹   XP_038942152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,433,201 - 106,438,511 (-)NCBI
mRatBN7.210105,934,879 - 105,940,055 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013997   ⟸   NM_001013975
- Peptide Label: precursor
- UniProtKB: D3ZXI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247949   ⟸   XM_006247887
- Peptide Label: isoform X1
- UniProtKB: A6HLH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247950   ⟸   XM_006247888
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000051830   ⟸   ENSRNOT00000054947
RefSeq Acc Id: XP_038942152   ⟸   XM_039086224
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001402706   ⟸   NM_001415777
- Peptide Label: precursor
- UniProtKB: D3ZXI3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXI3-F1-model_v2 AlphaFold D3ZXI3 1-503 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697973
Promoter ID:EPDNEW_R8497
Type:single initiation site
Name:Notum_1
Description:NOTUM, palmitoleoyl-protein carboxylesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,840,059 - 109,840,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307119 AgrOrtholog
BioCyc Gene G2FUF-22398 BioCyc
Ensembl Genes ENSRNOG00000036680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054947 ENTREZGENE
  ENSRNOT00000054947.3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321508 IMAGE-MGC_LOAD
  IMAGE:7325212 IMAGE-MGC_LOAD
InterPro Pec_acetylest UniProtKB/TrEMBL
KEGG Report rno:303743 UniProtKB/TrEMBL
MGC_CLONE MGC:109547 IMAGE-MGC_LOAD
  MGC:188212 IMAGE-MGC_LOAD
NCBI Gene 303743 ENTREZGENE
PANTHER PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM UniProtKB/TrEMBL
  PTHR21562 UniProtKB/TrEMBL
Pfam PAE UniProtKB/TrEMBL
PhenoGen Notum PhenoGen
RatGTEx ENSRNOG00000036680 RatGTEx
UniProt A6HLH5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Notum  NOTUM, palmitoleoyl-protein carboxylesterase  Notum  notum pectinacetylesterase homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Notum  notum pectinacetylesterase homolog (Drosophila)  RGD1307119  hypothetical LOC303743  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307119  hypothetical LOC303743  RGD1307119_predicted  hypothetical LOC303743 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307119_predicted  hypothetical LOC303743 (predicted)  LOC303743_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303743_predicted  hypothetical LOC303743 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL