Frem1 (Fras1 related extracellular matrix 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Frem1 (Fras1 related extracellular matrix 1) Rattus norvegicus
Analyze
Symbol: Frem1
Name: Fras1 related extracellular matrix 1
RGD ID: 1306981
Description: Predicted to enable carbohydrate binding activity and metal ion binding activity. Predicted to be involved in craniofacial suture morphogenesis. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in basement membrane. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: FRAS1-related extracellular matrix protein 1; LOC298185; RGD1306981; similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85102,367,201 - 102,515,464 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5102,367,201 - 102,515,404 (-)EnsemblGRCr8
mRatBN7.2597,321,266 - 97,469,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx599,702,040 - 99,826,307 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05101,500,424 - 101,619,223 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05101,512,896 - 101,637,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05101,018,009 - 101,166,794 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,020,448 - 101,166,651 (-)Ensemblrn6Rnor6.0
Rnor_5.05105,039,872 - 105,188,547 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45101,773,603 - 101,891,178 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera595,876,081 - 95,993,467 (-)NCBICelera
RGSC_v3.15101,778,828 - 102,082,081 (-)NCBI
Cytogenetic Map5q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. Beck TF, etal., Hum Mol Genet. 2013 Mar 1;22(5):1026-38. doi: 10.1093/hmg/dds507. Epub 2012 Dec 5.
2. Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3. Beck TF, etal., PLoS One. 2013;8(3):e58830. doi: 10.1371/journal.pone.0058830. Epub 2013 Mar 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. Slavotinek AM, etal., J Med Genet. 2011 Jun;48(6):375-82. doi: 10.1136/jmg.2011.089631. Epub 2011 Apr 20.
10. Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia. Takahashi T, etal., Eur J Pediatr Surg. 2016 Feb;26(1):81-5. doi: 10.1055/s-0035-1559884. Epub 2015 Sep 18.
11. Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice. Vissers LE, etal., PLoS Genet. 2011 Sep;7(9):e1002278. doi: 10.1371/journal.pgen.1002278. Epub 2011 Sep 8.
Additional References at PubMed
PMID:15345741   PMID:16880404   PMID:17251066   PMID:17596926   PMID:18757743  


Genomics

Comparative Map Data
Frem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85102,367,201 - 102,515,464 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5102,367,201 - 102,515,404 (-)EnsemblGRCr8
mRatBN7.2597,321,266 - 97,469,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx599,702,040 - 99,826,307 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05101,500,424 - 101,619,223 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05101,512,896 - 101,637,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05101,018,009 - 101,166,794 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5101,020,448 - 101,166,651 (-)Ensemblrn6Rnor6.0
Rnor_5.05105,039,872 - 105,188,547 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45101,773,603 - 101,891,178 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera595,876,081 - 95,993,467 (-)NCBICelera
RGSC_v3.15101,778,828 - 102,082,081 (-)NCBI
Cytogenetic Map5q31NCBI
FREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38914,737,152 - 14,910,995 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl914,734,671 - 14,910,995 (-)Ensemblhg38GRCh38
GRCh37914,737,150 - 14,910,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36914,727,150 - 14,900,234 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34914,727,154 - 14,900,993NCBI
Celera914,668,102 - 14,844,502 (-)NCBICelera
Cytogenetic Map9p22.3NCBI
HuRef914,697,961 - 14,874,294 (-)NCBIHuRef
CHM1_1914,734,708 - 14,910,773 (-)NCBICHM1_1
T2T-CHM13v2.0914,746,865 - 14,921,449 (-)NCBIT2T-CHM13v2.0
Frem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39482,816,157 - 82,970,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl482,816,164 - 82,970,576 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38482,897,920 - 83,052,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl482,897,920 - 83,052,339 (-)Ensemblmm10GRCm38
MGSCv37482,543,831 - 82,667,006 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36482,369,158 - 82,492,333 (-)NCBIMGSCv36mm8
Celera481,433,285 - 81,556,740 (-)NCBICelera
Cytogenetic Map4C3NCBI
cM Map439.4NCBI
Frem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543417,753,925 - 17,901,407 (-)Ensembl
ChiLan1.0NW_00495543417,754,002 - 17,901,416 (-)NCBIChiLan1.0ChiLan1.0
FREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211109,625,035 - 109,801,076 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19109,630,982 - 109,807,023 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0914,567,781 - 14,748,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1915,081,208 - 15,254,581 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl915,081,208 - 15,253,399 (-)EnsemblpanPan2panpan1.1
FREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11135,174,390 - 35,338,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1135,176,934 - 35,310,335 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1133,817,394 - 33,982,281 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01136,078,485 - 36,243,845 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1136,079,144 - 36,351,936 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11134,782,597 - 34,947,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01134,574,867 - 34,739,782 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01135,231,916 - 35,396,660 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Frem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947149,898,217 - 150,055,395 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365398,351,159 - 8,508,069 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365398,338,624 - 8,508,031 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1207,641,011 - 207,801,952 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11207,535,811 - 207,804,525 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21231,366,665 - 231,496,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11264,681,181 - 64,849,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603852,885,675 - 53,067,141 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473618,989,320 - 19,132,416 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473618,975,104 - 19,346,159 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Frem1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1170,710,759 - 70,829,496 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Frem1
812 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:119
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000058615
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat

Markers in Region
D5Got291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2597,331,351 - 97,331,445 (+)MAPPERmRatBN7.2
Rnor_6.05101,028,082 - 101,028,175NCBIRnor6.0
Rnor_5.05105,049,945 - 105,050,038UniSTSRnor5.0
RGSC_v3.45101,781,241 - 101,781,334UniSTSRGSC3.4
Celera595,883,719 - 95,883,812UniSTS
Cytogenetic Map5q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 67 157 91 90 59 58 59 6 315 158 11 136 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000058615   ⟹   ENSRNOP00000055412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5101,020,448 - 101,138,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078862   ⟹   ENSRNOP00000075592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5102,367,201 - 102,515,404 (-)Ensembl
mRatBN7.2 Ensembl597,322,538 - 97,469,543 (-)Ensembl
Rnor_6.0 Ensembl5101,023,247 - 101,166,651 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158737   ⟹   ENSRNOP00000105253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5102,371,289 - 102,515,404 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171692   ⟹   ENSRNOP00000103991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5102,367,201 - 102,515,404 (-)Ensembl
RefSeq Acc Id: NM_001411535   ⟹   NP_001398464
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85102,367,201 - 102,515,404 (-)NCBI
mRatBN7.2597,321,266 - 97,469,469 (-)NCBI
RefSeq Acc Id: XM_039109508   ⟹   XP_038965436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85102,424,244 - 102,515,464 (-)NCBI
mRatBN7.2597,378,319 - 97,469,523 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001398464 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965436 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075592
  ENSRNOP00000075592.3
  ENSRNOP00000103991.1
  ENSRNOP00000105253.1
Ensembl Acc Id: ENSRNOP00000055412   ⟸   ENSRNOT00000058615
Ensembl Acc Id: ENSRNOP00000075592   ⟸   ENSRNOT00000078862
RefSeq Acc Id: XP_038965436   ⟸   XM_039109508
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001398464   ⟸   NM_001411535
- Peptide Label: precursor
- UniProtKB: A0A0G2KB00 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105253   ⟸   ENSRNOT00000158737
Ensembl Acc Id: ENSRNOP00000103991   ⟸   ENSRNOT00000171692

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC92-F1-model_v2 AlphaFold D3ZC92 1-2209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306981 AgrOrtholog
BioCyc Gene G2FUF-40888 BioCyc
Ensembl Genes ENSRNOG00000022309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078862 ENTREZGENE
  ENSRNOT00000078862.3 UniProtKB/TrEMBL
  ENSRNOT00000158737.1 UniProtKB/TrEMBL
  ENSRNOT00000171692.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2030 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CalX-like_sf UniProtKB/TrEMBL
  Calx_beta UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/TrEMBL
  FRAS1-rel_N UniProtKB/TrEMBL
  FRAS1_ECM UniProtKB/TrEMBL
NCBI Gene 298185 ENTREZGENE
PANTHER MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
  PTHR45739:SF7 UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/TrEMBL
  Calx-beta UniProtKB/TrEMBL
  Frem_N UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
PhenoGen Frem1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  CSPG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022309 RatGTEx
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
  SSF141072 UniProtKB/TrEMBL
UniProt A0A0G2KB00 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQE0_RAT UniProtKB/TrEMBL
  A0ABK0LWS4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Frem1  Fras1 related extracellular matrix 1  RGD1306981_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306981_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)  LOC298185_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298185_predicted  similar to bM410K19.2.2 (novel protein similar to extra-cellular matrix proteins and chondroitin sulfate proteoglycans, variant 2) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL