Myh14 (myosin heavy chain 14) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Myh14 (myosin heavy chain 14) Rattus norvegicus
Analyze
Symbol: Myh14
Name: myosin heavy chain 14
RGD ID: 1306821
Description: Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Predicted to be involved in several processes, including neuronal action potential; sensory perception of sound; and vocalization behavior. Predicted to act upstream of or within actin filament-based movement. Predicted to be located in several cellular components, including brush border; myosin II filament; and stress fiber. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14); PARTICIPATES IN myocarditis pathway; INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308572; myosin, heavy chain 14; myosin, heavy chain 14, non-muscle; myosin, heavy polypeptide 14; myosin-14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,232,778 - 104,295,369 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,232,778 - 104,323,404 (-)EnsemblGRCr8
mRatBN7.2195,096,266 - 95,158,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,096,266 - 95,158,836 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,481,656 - 100,544,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,954,312 - 109,016,882 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,244,723 - 102,307,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,608,975 - 100,671,086 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,608,966 - 100,671,074 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,674,230 - 101,737,060 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,081,948 - 95,146,449 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,358,486 - 89,415,924 (-)NCBICelera
RGSC_v3.1195,160,058 - 95,224,566 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2-bromohexadecanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
ampicillin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
dexamethasone  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenpropidin  (ISO)
fipronil  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
metronidazole  (EXP)
neomycin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
prothioconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spiroxamine  (ISO)
succimer  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA)
actomyosin  (IEA,ISO)
apical part of cell  (IEA)
axon  (IEA,ISO)
brush border  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
growth cone  (IEA,ISO)
myosin complex  (IEA,ISO)
myosin filament  (IBA)
myosin II complex  (IBA,IEA,ISO)
myosin II filament  (IEA,ISO)
stress fiber  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4). Donaudy F, etal., Am J Hum Genet. 2004 Apr;74(4):770-6. Epub 2004 Mar 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14594953   PMID:15774463   PMID:15845534   PMID:15880105   PMID:17634366   PMID:19056867   PMID:19946888   PMID:21480433   PMID:21700703   PMID:22114352   PMID:23376485   PMID:24072716  
PMID:24625528   PMID:35352799  


Genomics

Comparative Map Data
Myh14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,232,778 - 104,295,369 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,232,778 - 104,323,404 (-)EnsemblGRCr8
mRatBN7.2195,096,266 - 95,158,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,096,266 - 95,158,836 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,481,656 - 100,544,224 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,954,312 - 109,016,882 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,244,723 - 102,307,289 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,608,975 - 100,671,086 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,608,966 - 100,671,074 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,674,230 - 101,737,060 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,081,948 - 95,146,449 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,358,486 - 89,415,924 (-)NCBICelera
RGSC_v3.1195,160,058 - 95,224,566 (-)NCBI
Cytogenetic Map1q22NCBI
MYH14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,203,622 - 50,310,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,188,186 - 50,310,545 (+)Ensemblhg38GRCh38
GRCh371950,706,879 - 50,813,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,398,697 - 55,505,613 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341955,398,696 - 55,505,610NCBI
Celera1947,757,054 - 47,864,132 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,045,574 - 47,152,034 (+)NCBIHuRef
CHM1_11950,708,735 - 50,815,614 (+)NCBICHM1_1
T2T-CHM13v2.01953,291,137 - 53,398,069 (+)NCBIT2T-CHM13v2.0
Myh14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,255,227 - 44,320,296 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,255,227 - 44,320,267 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,605,803 - 44,670,872 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,605,803 - 44,670,843 (-)Ensemblmm10GRCm38
MGSCv37751,861,189 - 51,920,873 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,473,861 - 44,533,545 (-)NCBIMGSCv36mm8
Celera740,055,770 - 40,115,661 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.85NCBI
Myh14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559797,107 - 853,053 (-)Ensembl
ChiLan1.0NW_004955559796,455 - 856,082 (-)NCBIChiLan1.0ChiLan1.0
MYH14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,271,738 - 56,375,910 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,192,707 - 58,297,218 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,169,303 - 47,273,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,076,709 - 56,178,650 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,081,644 - 56,177,902 (+)EnsemblpanPan2panpan1.1
MYH14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,371,952 - 106,460,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,371,939 - 106,458,901 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1105,955,580 - 106,057,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01106,893,609 - 106,995,633 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,893,609 - 106,977,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,565,643 - 106,667,627 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,207,137 - 106,309,519 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,047,874 - 107,149,770 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myh14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,245,734 - 22,308,625 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889122,853 - 183,928 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936889121,724 - 184,374 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,113,521 - 55,200,750 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1655,097,851 - 55,200,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,879,598 - 50,942,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYH14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,270,363 - 43,372,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,275,715 - 43,372,190 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607323,249,905 - 23,356,116 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myh14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,176,914 - 4,230,863 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,176,632 - 4,234,763 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Myh14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,869,986 - 154,929,262 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myh14
558 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:68
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000027132
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Got97  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81104,270,009 - 104,270,199 (+)Marker Load Pipeline
mRatBN7.2195,133,500 - 95,133,690 (+)MAPPERmRatBN7.2
Rnor_6.01100,645,522 - 100,645,711NCBIRnor6.0
Rnor_5.01101,711,501 - 101,711,690UniSTSRnor5.0
RGSC_v3.4195,120,716 - 95,120,903RGDRGSC3.4
RGSC_v3.4195,120,717 - 95,120,906UniSTSRGSC3.4
Celera189,395,834 - 89,396,023UniSTS
RGSC_v3.1195,198,827 - 95,199,014RGD
RH 3.4 Map1903.6RGD
RH 3.4 Map1903.6UniSTS
RH 2.0 Map1589.7RGD
Cytogenetic Map1q22UniSTS
AU048673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,099,704 - 95,099,802 (+)MAPPERmRatBN7.2
Rnor_6.01100,612,414 - 100,612,511NCBIRnor6.0
Rnor_5.01101,677,801 - 101,677,898UniSTSRnor5.0
RGSC_v3.4195,085,387 - 95,085,484UniSTSRGSC3.4
Celera189,361,925 - 89,362,022UniSTS
Cytogenetic Map1q22UniSTS
RH142730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,096,265 - 95,096,365 (+)MAPPERmRatBN7.2
Rnor_6.01100,608,975 - 100,609,074NCBIRnor6.0
Rnor_5.01101,674,362 - 101,674,461UniSTSRnor5.0
RGSC_v3.4195,081,948 - 95,082,047UniSTSRGSC3.4
Celera189,358,486 - 89,358,585UniSTS
RH 3.4 Map1904.9UniSTS
Cytogenetic Map1q22UniSTS
AW532989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,096,410 - 95,096,630 (+)MAPPERmRatBN7.2
Rnor_6.01100,609,120 - 100,609,339NCBIRnor6.0
Rnor_5.01101,674,507 - 101,674,726UniSTSRnor5.0
RGSC_v3.4195,082,093 - 95,082,312UniSTSRGSC3.4
Celera189,358,631 - 89,358,850UniSTS
RH 3.4 Map1903.9UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 77 59 6 341 177 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027132   ⟹   ENSRNOP00000027132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,232,778 - 104,323,404 (-)Ensembl
mRatBN7.2 Ensembl195,096,266 - 95,158,836 (-)Ensembl
Rnor_6.0 Ensembl1100,608,975 - 100,671,074 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091760   ⟹   ENSRNOP00000072636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,232,778 - 104,295,344 (-)Ensembl
mRatBN7.2 Ensembl195,096,266 - 95,158,836 (-)Ensembl
Rnor_6.0 Ensembl1100,608,966 - 100,669,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094017   ⟹   ENSRNOP00000089689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,232,778 - 104,295,344 (-)Ensembl
mRatBN7.2 Ensembl195,096,266 - 95,158,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139210   ⟹   ENSRNOP00000112760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,232,778 - 104,323,404 (-)Ensembl
RefSeq Acc Id: NM_001100690   ⟹   NP_001094160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,232,778 - 104,295,344 (-)NCBI
mRatBN7.2195,096,266 - 95,158,836 (-)NCBI
Rnor_6.01100,608,975 - 100,671,074 (-)NCBI
Rnor_5.01101,674,230 - 101,737,060 (-)NCBI
RGSC_v3.4195,081,948 - 95,146,449 (-)RGD
Celera189,358,486 - 89,415,924 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229056   ⟹   XP_006229118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,232,778 - 104,295,369 (-)NCBI
mRatBN7.2195,096,665 - 95,158,861 (-)NCBI
Rnor_6.01100,608,975 - 100,671,086 (-)NCBI
Rnor_5.01101,674,230 - 101,737,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229057   ⟹   XP_006229119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,232,778 - 104,295,369 (-)NCBI
mRatBN7.2195,096,665 - 95,158,861 (-)NCBI
Rnor_6.01100,608,975 - 100,671,086 (-)NCBI
Rnor_5.01101,674,230 - 101,737,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063261923   ⟹   XP_063117993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,232,778 - 104,295,365 (-)NCBI
RefSeq Acc Id: NP_001094160   ⟸   NM_001100690
- UniProtKB: A0A0G2K3H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229119   ⟸   XM_006229057
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006229118   ⟸   XM_006229056
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000072636   ⟸   ENSRNOT00000091760
Ensembl Acc Id: ENSRNOP00000027132   ⟸   ENSRNOT00000027132
Ensembl Acc Id: ENSRNOP00000089689   ⟸   ENSRNOT00000094017
RefSeq Acc Id: XP_063117993   ⟸   XM_063261923
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000112760   ⟸   ENSRNOT00000139210
Protein Domains
Myosin motor   Myosin N-terminal SH3-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNF0-F1-model_v2 AlphaFold F1LNF0 1-2000 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690004
Promoter ID:EPDNEW_R529
Type:initiation region
Name:Myh14_1
Description:myosin heavy chain 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,669,569 - 100,669,629EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306821 AgrOrtholog
BioCyc Gene G2FUF-59757 BioCyc
Ensembl Genes ENSRNOG00000020014 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027132.7 UniProtKB/TrEMBL
  ENSRNOT00000091760.3 UniProtKB/TrEMBL
  ENSRNOT00000094017 ENTREZGENE
  ENSRNOT00000094017.2 UniProtKB/TrEMBL
  ENSRNOT00000139210 ENTREZGENE
  ENSRNOT00000139210.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
  1.20.5.4820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.250.2420 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 308572 ENTREZGENE
PANTHER MYOSIN UniProtKB/TrEMBL
  MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/TrEMBL
  MYOSIN-11 UniProtKB/TrEMBL
  MYOSIN-14 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/TrEMBL
PhenoGen Myh14 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020014 RatGTEx
SMART MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K3H1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9A3_RAT UniProtKB/TrEMBL
  A0ABK0M939_RAT UniProtKB/TrEMBL
  A6JAR9_RAT UniProtKB/TrEMBL
  F1LNF0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Myh14  myosin heavy chain 14  Myh14  myosin, heavy chain 14, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Myh14  myosin, heavy chain 14, non-muscle  Myh14  myosin, heavy chain 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh14  myosin, heavy chain 14  Myh14  myosin, heavy polypeptide 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Myh14  myosin, heavy polypeptide 14  Myh14_predicted  myosin, heavy polypeptide 14 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Myh14_predicted  myosin, heavy polypeptide 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED