Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Slc66a3 | Rat | 1,1-dichloroethene | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of SLC66A3 mRNA | CTD | PMID:26682919 | Slc66a3 | Rat | 1,2-dichloroethane | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of SLC66A3 mRNA | CTD | PMID:28189721|PMID:28960355 | Slc66a3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of SLC66A3 mRNA | CTD | PMID:22206623 | Slc66a3 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SLC66A3 mRNA | CTD | PMID:22206623 | Slc66a3 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SLC66A3 mRNA | CTD | PMID:25380136|PMID:30723492 | Slc66a3 | Rat | 17beta-estradiol | affects expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Estradiol affects the expression of SLC66A3 mRNA | CTD | PMID:22574217 | Slc66a3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SLC66A3 mRNA | CTD | PMID:20106945|PMID:21632981 | Slc66a3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SLC66A3 mRNA | CTD | PMID:20159946 | Slc66a3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC66A3 mRNA | CTD | PMID:21570461 | Slc66a3 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of SLC66A3 mRNA | CTD | PMID:25172293 | Slc66a3 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Slc66a3 | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of SLC66A3 mRNA | CTD | PMID:25380136 | Slc66a3 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of SLC66A3 gene; [INS protein co-treated more ... | CTD | PMID:28628672|PMID:31601247 | Slc66a3 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of SLC66A3 mRNA | CTD | PMID:28973697 | Slc66a3 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SLC66A3 mRNA | CTD | PMID:24780913|PMID:25825206 | Slc66a3 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SLC66A3 mRNA | CTD | PMID:31881176 | Slc66a3 | Rat | aflatoxin B1 | affects expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of SLC66A3 protein | CTD | PMID:20106945 | Slc66a3 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of SLC66A3 mRNA | CTD | PMID:23630614|PMID:25378103 | Slc66a3 | Rat | all-trans-retinoic acid | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SLC66A3 mRNA | CTD | PMID:21934132 | Slc66a3 | Rat | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of SLC66A3 mRNA | CTD | PMID:20488242 | Slc66a3 | Rat | aristolochic acid A | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SLC66A3 mRNA | CTD | PMID:33212167 | Slc66a3 | Rat | atrazine | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Atrazine results in increased expression of SLC66A3 mRNA | CTD | PMID:22378314 | Slc66a3 | Rat | benzo[a]pyrene | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SLC66A3 mRNA | CTD | PMID:20106945|PMID:21632981 | Slc66a3 | Rat | benzo[a]pyrene | increases methylation | ISO | SLC66A3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SLC66A3 promoter | CTD | PMID:27901495 | Slc66a3 | Rat | benzo[a]pyrene | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SLC66A3 mRNA | CTD | PMID:22228805|PMID:22610609|PMID:25908611|PMID:27195522 | Slc66a3 | Rat | benzo[a]pyrene | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Slc66a3 | Rat | benzo[b]fluoranthene | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of SLC66A3 mRNA | CTD | PMID:26377693 | Slc66a3 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Slc66a3 | Rat | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC66A3 mRNA | CTD | PMID:18164116 | Slc66a3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SLC66A3 mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Slc66a3 | Rat | bisphenol A | decreases methylation | ISO | SLC66A3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SLC66A3 gene | CTD | PMID:31601247 | Slc66a3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SLC66A3 mRNA | CTD | PMID:25181051 | Slc66a3 | Rat | cadmium atom | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC66A3 more ... | CTD | PMID:35301059 | Slc66a3 | Rat | cadmium atom | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PQLC3 more ... | CTD | PMID:37325564 | Slc66a3 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of SLC66A3 mRNA | CTD | PMID:25993096 | Slc66a3 | Rat | cadmium dichloride | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PQLC3 more ... | CTD | PMID:37325564 | Slc66a3 | Rat | cadmium dichloride | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC66A3 more ... | CTD | PMID:35301059 | Slc66a3 | Rat | carbon nanotube | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of SLC66A3 mRNA | CTD | PMID:25554681 | Slc66a3 | Rat | chrysene | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Slc66a3 | Rat | cisplatin | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SLC66A3 mRNA | CTD | PMID:27594783 | Slc66a3 | Rat | copper(II) sulfate | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SLC66A3 mRNA | CTD | PMID:19549813 | Slc66a3 | Rat | cyclosporin A | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SLC66A3 mRNA | CTD | PMID:20106945|PMID:25562108 | Slc66a3 | Rat | dexamethasone | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Slc66a3 | Rat | Dibutyl phosphate | affects expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PQLC3 mRNA | CTD | PMID:37042841 | Slc66a3 | Rat | dicrotophos | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SLC66A3 mRNA | CTD | PMID:28302478 | Slc66a3 | Rat | dioxygen | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of SLC66A3 mRNA | CTD | PMID:24205000 | Slc66a3 | Rat | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SLC66A3 mRNA | CTD | PMID:21551480 | Slc66a3 | Rat | dorsomorphin | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Slc66a3 | Rat | entinostat | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | entinostat results in increased expression of SLC66A3 mRNA | CTD | PMID:27188386 | Slc66a3 | Rat | fenamidone | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | fenamidone results in increased expression of SLC66A3 mRNA | CTD | PMID:27029645 | Slc66a3 | Rat | fenvalerate | decreases expression | EXP | | 6480464 | fenvalerate results in decreased expression of SLC66A3 mRNA | CTD | PMID:30307764 | Slc66a3 | Rat | folic acid | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SLC66A3 mRNA | CTD | PMID:22206623 | Slc66a3 | Rat | fulvestrant | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of SLC66A3 gene | CTD | PMID:31601247 | Slc66a3 | Rat | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of SLC66A3 gene | CTD | PMID:27387713 | Slc66a3 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of SLC66A3 mRNA | CTD | PMID:25539665|PMID:26194646|PMID:27387713 | Slc66a3 | Rat | indometacin | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... | CTD | PMID:28628672 | Slc66a3 | Rat | methylmercury chloride | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SLC66A3 mRNA | CTD | PMID:23179753|PMID:27188386 | Slc66a3 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC66A3 mRNA | CTD | PMID:18164116 | Slc66a3 | Rat | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SLC66A3 mRNA | CTD | PMID:19638242 | Slc66a3 | Rat | N-nitrosodiethylamine | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of SLC66A3 mRNA | CTD | PMID:24535843 | Slc66a3 | Rat | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of SLC66A3 mRNA | CTD | PMID:25380136 | Slc66a3 | Rat | nickel sulfate | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of SLC66A3 mRNA | CTD | PMID:22714537 | Slc66a3 | Rat | p-toluidine | increases expression | EXP | | 6480464 | 4-toluidine results in increased expression of SLC66A3 mRNA | CTD | PMID:27638505 | Slc66a3 | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of PQLC3 mRNA | CTD | PMID:37995155 | Slc66a3 | Rat | phenobarbital | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SLC66A3 mRNA | CTD | PMID:19482888 | Slc66a3 | Rat | phenobarbital | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC66A3 mRNA] | CTD | PMID:19482888 | Slc66a3 | Rat | quercetin | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Quercetin results in increased expression of SLC66A3 mRNA | CTD | PMID:21632981 | Slc66a3 | Rat | resveratrol | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of SLC66A3 mRNA | CTD | PMID:23557933 | Slc66a3 | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SLC66A3 mRNA | CTD | PMID:19013527 | Slc66a3 | Rat | SB 431542 | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Slc66a3 | Rat | silicon dioxide | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SLC66A3 mRNA | CTD | PMID:25895662 | Slc66a3 | Rat | sodium arsenite | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SLC66A3 mRNA | CTD | PMID:22714537 | Slc66a3 | Rat | sodium arsenite | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SLC66A3 mRNA | CTD | PMID:39719251 | Slc66a3 | Rat | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of SLC66A3 mRNA | CTD | PMID:25993096 | Slc66a3 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of SLC66A3 mRNA | CTD | PMID:19281266 | Slc66a3 | Rat | sunitinib | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SLC66A3 mRNA | CTD | PMID:31533062 | Slc66a3 | Rat | temozolomide | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SLC66A3 mRNA | CTD | PMID:31758290 | Slc66a3 | Rat | tetrachloromethane | increases expression | ISO | Slc66a3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SLC66A3 mRNA | CTD | PMID:27339419 | Slc66a3 | Rat | tetraphene | multiple interactions | ISO | Slc66a3 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of more ... | CTD | PMID:27858113 | Slc66a3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SLC66A3 mRNA | CTD | PMID:23411599|PMID:34492290 | Slc66a3 | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of SLC66A3 gene | CTD | PMID:27618143 | Slc66a3 | Rat | triclosan | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Triclosan results in increased expression of SLC66A3 mRNA | CTD | PMID:30510588 | Slc66a3 | Rat | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of SLC66A3 mRNA | CTD | PMID:30589522 | Slc66a3 | Rat | valproic acid | affects expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SLC66A3 mRNA | CTD | PMID:25979313 | Slc66a3 | Rat | valproic acid | multiple interactions | ISO | SLC66A3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Slc66a3 | Rat | valproic acid | increases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SLC66A3 mRNA | CTD | PMID:23179753|PMID:26272509|PMID:27188386|PMID:28001369 | Slc66a3 | Rat | valproic acid | increases methylation | ISO | SLC66A3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SLC66A3 gene | CTD | PMID:29154799 | Slc66a3 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of SLC66A3 mRNA | CTD | PMID:19015723 | Slc66a3 | Rat | zinc atom | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of SLC66A3 mRNA | CTD | PMID:22171008 | Slc66a3 | Rat | zinc(0) | decreases expression | ISO | SLC66A3 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of SLC66A3 mRNA | CTD | PMID:22171008 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















