Foxred2 (FAD-dependent oxidoreductase domain containing 2) - Rat Genome Database

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Gene: Foxred2 (FAD-dependent oxidoreductase domain containing 2) Rattus norvegicus
Analyze
Symbol: Foxred2
Name: FAD-dependent oxidoreductase domain containing 2
RGD ID: 1306763
Description: Predicted to enable flavin adenine dinucleotide binding activity and monooxygenase activity. Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum lumen. Orthologous to human FOXRED2 (FAD dependent oxidoreductase domain containing 2); INTERACTS WITH 4,4'-sulfonyldiphenol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FAD-dependent oxidoreductase domain-containing protein 2; LOC315112; RGD1306763; similar to hypothetical protein FLJ23322
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,402,322 - 111,419,056 (-)NCBIGRCr8
mRatBN7.27109,521,761 - 109,538,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,521,761 - 109,540,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,274,238 - 111,286,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,497,798 - 113,510,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,465,916 - 113,478,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,172,189 - 119,186,670 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,170,181 - 119,185,238 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,166,948 - 119,181,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,861,724 - 115,874,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,895,953 - 115,908,439 (-)NCBI
Celera7105,865,520 - 105,877,679 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ERAD pathway  (IBA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19706418   PMID:20972601  


Genomics

Comparative Map Data
Foxred2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,402,322 - 111,419,056 (-)NCBIGRCr8
mRatBN7.27109,521,761 - 109,538,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,521,761 - 109,540,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,274,238 - 111,286,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,497,798 - 113,510,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,465,916 - 113,478,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,172,189 - 119,186,670 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,170,181 - 119,185,238 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,166,948 - 119,181,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,861,724 - 115,874,209 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,895,953 - 115,908,439 (-)NCBI
Celera7105,865,520 - 105,877,679 (-)NCBICelera
Cytogenetic Map7q34NCBI
FOXRED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,487,190 - 36,507,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,487,190 - 36,507,221 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,883,237 - 36,903,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,213,179 - 35,233,094 (-)NCBINCBI36Build 36hg18NCBI36
Celera2220,685,379 - 20,705,285 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,851,067 - 19,870,975 (-)NCBIHuRef
CHM1_12236,842,211 - 36,862,119 (-)NCBICHM1_1
T2T-CHM13v2.02236,947,364 - 36,967,214 (-)NCBIT2T-CHM13v2.0
Foxred2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,824,722 - 77,842,701 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,824,722 - 77,840,922 (-)EnsemblGRCm39 Ensembl
GRCm381577,940,522 - 77,958,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,940,522 - 77,956,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,770,952 - 77,787,152 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361577,767,780 - 77,783,890 (-)NCBIMGSCv36mm8
Celera1579,399,766 - 79,415,966 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Foxred2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,068,642 - 23,091,396 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,070,715 - 23,091,402 (-)NCBIChiLan1.0ChiLan1.0
FOXRED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,341,647 - 46,361,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,034,743 - 49,052,807 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,402,084 - 17,421,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,239,070 - 35,258,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,239,076 - 35,258,745 (-)Ensemblpanpan1.1panPan2
FOXRED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,908,090 - 27,923,602 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,908,629 - 27,923,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,862,253 - 27,877,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,693,853 - 28,708,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,693,339 - 28,708,859 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11028,422,353 - 28,437,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,730,086 - 28,745,089 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,908,907 - 28,924,100 (+)NCBIUU_Cfam_GSD_1.0
Foxred2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,262,531 - 11,281,948 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,273,431 - 4,289,344 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,272,965 - 4,292,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXRED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,233,902 - 11,254,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1511,233,835 - 11,254,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,916,259 - 8,934,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOXRED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,198,526 - 19,219,402 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,199,499 - 19,218,641 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,654,095 - 106,676,813 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxred2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475211,216,856 - 11,234,729 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475211,216,852 - 11,238,031 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxred2
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:67
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000007598
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 3
Low 3 43 57 41 19 41 8 11 59 35 38 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007598   ⟹   ENSRNOP00000007598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,521,761 - 109,540,874 (-)Ensembl
Rnor_6.0 Ensembl7119,170,181 - 119,185,238 (-)Ensembl
RefSeq Acc Id: NM_001191787   ⟹   NP_001178716
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,402,322 - 111,417,988 (-)NCBI
mRatBN7.27109,521,761 - 109,537,429 (-)NCBI
Rnor_6.07119,172,808 - 119,185,237 (-)NCBI
Rnor_5.07119,166,948 - 119,181,438 (-)NCBI
Celera7105,865,520 - 105,877,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765712   ⟹   XP_008763934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,402,322 - 111,419,056 (-)NCBI
mRatBN7.27109,521,761 - 109,538,300 (-)NCBI
Rnor_6.07119,172,189 - 119,186,670 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178716 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007598
  ENSRNOP00000007598.4
Reference Protein Sequences
RefSeq Acc Id: NP_001178716   ⟸   NM_001191787
- Peptide Label: precursor
- UniProtKB: D4A1A1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763934   ⟸   XM_008765712
- Peptide Label: isoform X1
- UniProtKB: D4A1A1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007598   ⟸   ENSRNOT00000007598

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1A1-F1-model_v2 AlphaFold D4A1A1 1-665 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306763 AgrOrtholog
BioCyc Gene G2FUF-32850 BioCyc
Ensembl Genes ENSRNOG00000005749 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007598 ENTREZGENE
  ENSRNOT00000007598.6 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
KEGG Report rno:315112 UniProtKB/TrEMBL
NCBI Gene 315112 ENTREZGENE
PANTHER FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220) UniProtKB/TrEMBL
Pfam Pyr_redox_3 UniProtKB/TrEMBL
PhenoGen Foxred2 PhenoGen
RatGTEx ENSRNOG00000005749 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt D4A1A1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Foxred2  FAD-dependent oxidoreductase domain containing 2  RGD1306763_predicted  similar to hypothetical protein FLJ23322 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306763_predicted  similar to hypothetical protein FLJ23322 (predicted)  LOC315112_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315112_predicted  similar to hypothetical protein FLJ23322 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL