Tbcc (tubulin folding cofactor C) - Rat Genome Database

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Gene: Tbcc (tubulin folding cofactor C) Rattus norvegicus
Analyze
Symbol: Tbcc
Name: tubulin folding cofactor C
RGD ID: 1306756
Description: Predicted to enable GTPase activity. Predicted to be involved in post-chaperonin tubulin folding pathway and tubulin complex assembly. Predicted to be located in photoreceptor connecting cilium. Predicted to be active in cytoplasm. Orthologous to human TBCC (tubulin folding cofactor C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC316221; tubulin-specific chaperone C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,596,472 - 21,597,660 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,595,615 - 21,597,842 (-)EnsemblGRCr8
mRatBN7.2914,098,855 - 14,100,043 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,098,868 - 14,100,042 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,681,090 - 22,682,278 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,744,644 - 27,745,832 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,044,455 - 26,045,643 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,405,187 - 16,406,338 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,405,185 - 16,406,338 (-)Ensemblrn6Rnor6.0
Rnor_5.0915,314,054 - 15,315,205 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.499,294,924 - 9,296,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,847,513 - 11,848,664 (-)NCBICelera
RGSC_v3.199,292,369 - 9,293,392 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
photoreceptor connecting cilium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11847227   PMID:12417528   PMID:12477932   PMID:22871113  


Genomics

Comparative Map Data
Tbcc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,596,472 - 21,597,660 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,595,615 - 21,597,842 (-)EnsemblGRCr8
mRatBN7.2914,098,855 - 14,100,043 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,098,868 - 14,100,042 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx922,681,090 - 22,682,278 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,744,644 - 27,745,832 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,044,455 - 26,045,643 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,405,187 - 16,406,338 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,405,185 - 16,406,338 (-)Ensemblrn6Rnor6.0
Rnor_5.0915,314,054 - 15,315,205 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.499,294,924 - 9,296,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,847,513 - 11,848,664 (-)NCBICelera
RGSC_v3.199,292,369 - 9,293,392 (-)NCBI
Cytogenetic Map9q12NCBI
TBCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,744,498 - 42,746,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,744,498 - 42,746,103 (-)Ensemblhg38GRCh38
GRCh37642,712,236 - 42,713,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36642,820,212 - 42,821,862 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34642,820,237 - 42,821,812NCBI
Celera644,264,486 - 44,266,136 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,430,373 - 42,432,023 (-)NCBIHuRef
CHM1_1642,714,735 - 42,716,385 (-)NCBICHM1_1
T2T-CHM13v2.0642,573,235 - 42,574,840 (-)NCBIT2T-CHM13v2.0
Tbcc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,201,547 - 47,203,389 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,201,610 - 47,202,773 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,890,621 - 46,892,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,890,684 - 46,891,847 (+)Ensemblmm10GRCm38
MGSCv371747,027,570 - 47,029,412 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361746,353,812 - 46,355,654 (+)NCBIMGSCv36mm8
Celera1750,326,534 - 50,328,376 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Tbcc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554378,808,021 - 8,809,598 (-)NCBIChiLan1.0ChiLan1.0
TBCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,242,809 - 57,244,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,112,795 - 53,114,484 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,334,902 - 42,336,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,630,273 - 43,631,992 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,630,810 - 43,631,943 (-)EnsemblpanPan2panpan1.1
TBCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,332,736 - 11,334,799 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,333,676 - 11,334,842 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1211,359,961 - 11,362,012 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01211,814,282 - 11,816,335 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,815,224 - 11,816,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,342,240 - 11,344,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,426,925 - 11,428,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,520,795 - 11,522,848 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tbcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,812,898 - 46,814,253 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,146,017 - 17,147,054 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,145,956 - 17,147,299 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,822,767 - 37,824,953 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1737,822,764 - 37,823,994 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,248,570 - 43,249,800 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBCC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,404,102 - 29,405,505 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604442,779,555 - 42,781,055 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbcc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475416,675,439 - 16,677,047 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tbcc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1482,981,604 - 82,982,803 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tbcc
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:34
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000073079
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH130690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,098,962 - 14,099,157 (+)MAPPERmRatBN7.2
Rnor_6.0916,405,275 - 16,405,469NCBIRnor6.0
Rnor_5.0915,314,142 - 15,314,336UniSTSRnor5.0
RGSC_v3.499,295,012 - 9,295,206UniSTSRGSC3.4
Celera911,847,601 - 11,847,795UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000073079   ⟹   ENSRNOP00000065504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl921,595,615 - 21,597,842 (-)Ensembl
mRatBN7.2 Ensembl914,098,868 - 14,100,042 (-)Ensembl
Rnor_6.0 Ensembl916,405,185 - 16,406,338 (-)Ensembl
RefSeq Acc Id: NM_001108200   ⟹   NP_001101670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8921,596,472 - 21,597,660 (-)NCBI
mRatBN7.2914,098,855 - 14,100,043 (-)NCBI
Rnor_6.0916,405,187 - 16,406,338 (-)NCBI
Rnor_5.0915,314,054 - 15,315,205 (-)NCBI
RGSC_v3.499,294,924 - 9,296,075 (-)RGD
Celera911,847,513 - 11,848,664 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101670 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66467 (Get FASTA)   NCBI Sequence Viewer  
  EDM18866 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065504.2
RefSeq Acc Id: NP_001101670   ⟸   NM_001108200
- UniProtKB: B2GUZ7 (UniProtKB/TrEMBL),   M0R7S2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065504   ⟸   ENSRNOT00000073079
Protein Domains
C-CAP/cofactor C-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUZ7-F1-model_v2 AlphaFold B2GUZ7 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696501
Promoter ID:EPDNEW_R7026
Type:multiple initiation site
Name:Tbcc_1
Description:tubulin folding cofactor C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,406,342 - 16,406,402EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306756 AgrOrtholog
BioCyc Gene G2FUF-28250 BioCyc
Ensembl Genes ENSRNOG00000048291 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073079.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1250 UniProtKB/TrEMBL
  2.160.20.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9035211 IMAGE-MGC_LOAD
InterPro C-CAP_CF_C-like UniProtKB/TrEMBL
  CAP/MinC_C UniProtKB/TrEMBL
  CARP_motif UniProtKB/TrEMBL
  TBCC UniProtKB/TrEMBL
  TBCC_N UniProtKB/TrEMBL
  TBCC_N_sf UniProtKB/TrEMBL
  Tubulin-bd_cofactor_C UniProtKB/TrEMBL
KEGG Report rno:316221 UniProtKB/TrEMBL
MGC_CLONE MGC:187838 IMAGE-MGC_LOAD
NCBI Gene 316221 ENTREZGENE
PANTHER PTHR15139 UniProtKB/TrEMBL
  TUBULIN-SPECIFIC CHAPERONE C UniProtKB/TrEMBL
Pfam TBCC UniProtKB/TrEMBL
  TBCC_N UniProtKB/TrEMBL
PhenoGen Tbcc PhenoGen
PROSITE C_CAP_COFACTOR_C UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048291 RatGTEx
SMART CARP UniProtKB/TrEMBL
UniProt B2GUZ7 ENTREZGENE, UniProtKB/TrEMBL
  M0R7S2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tbcc  tubulin folding cofactor C  Tbcc  tubulin-specific chaperone c   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tbcc  tubulin-specific chaperone c   Tbcc_predicted  tubulin-specific chaperone c (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tbcc_predicted  tubulin-specific chaperone c (predicted)      Symbol and Name status set to approved 70820 APPROVED