Gene: TBCC (tubulin folding cofactor C)
Homo sapiens
Symbol:
TBCC
Name:
tubulin folding cofactor C
Description:
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
CFC; OTTHUMP00000016406; tubulin-folding cofactor C; tubulin-specific chaperone C
Orthologs:
Mus musculus : Tbcc
(tubulin-specific chaperone C)
MGI
Tbcc
(tubulin folding cofactor C)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 6 42,622,852 - 42,624,502 - NCBI Human Genome Assembly HuRef 6 42,430,373 - 42,432,023 - NCBI Human Genome Assembly GRCh37 6 42,712,234 - 42,713,884 - NCBI Human Celera Assembly 6 44,264,486 - 44,266,136 - NCBI Human Genome Assembly Build 36 6 42,820,212 - 42,821,862 - NCBI Human Cytogenetic Map 6 p21.1 NCBI Human Genome Assembly 6 42,820,237 - 42,821,812 NCBI
Model
Gene Ontology Annotations
Biological Process 'de novo' posttranslational protein folding TAS 2290271 Reactome:REACT_16952 Reactome Reactome:REACT_16952 cell morphogenesis IEA InterPro:IPR016098 2290271 GO_REF:0000002 InterPro GO_REF:0000002 cellular protein metabolic process TAS 2290271 Reactome:REACT_17015 Reactome Reactome:REACT_17015 GTP catabolic process IDA 2290271 PMID:11847227 GOC PMID:11847227 post-chaperonin tubulin folding pathway IDA 2290271 PMID:11847227 UniProtKB PMID:11847227 protein folding TAS 2290271 PMID:8706133 UniProtKB PMID:8706133
2289164 BW111_H Body weight QTL 111 (human) .002 Body fat amount percent fat 6 18540451 44540451 Human 2289194 BW353_H Body weight QTL 353 (human) .012 Body fat amount percent fat 6 18540451 44540451 Human 2289175 BW112_H Body weight QTL 112 (human) .048 Body fat amount percent fat 6 18683815 44683815 Human 1358839 MULTSCL5_H Multiple sclerosis susceptibility QTL 5 (human) Multiple sclerosis susceptibility 6 19552079 45552079 Human 1358857 MULTSCL19_H Multiple sclerosis susceptibility QTL 19 (human) Multiple sclerosis susceptibility 6 19552079 45552079 Human 1559135 LDLPS2_H Low density lipoprotein particle size QTL 2 (human) 4.1 LDL particle size 3 23001248 49001248 Human 1357292 AASTH34_H Allergic/atopic asthma related QTL 34 (human) 2.61 Atopy reversible airflow obstruction 6 23265619 49265619 Human 2289170 BW113_H Body weight QTL 113 (human) .018 Body fat amount percent fat 6 23265619 49265619 Human 2292786 PRSTS7_H Prostate tumor susceptibility QTL 7 (human) Prostate tumor susceptibility late onset 6 28677275 54677275 Human 1298490 OSTEAR22_H Osteoarthritis QTL 22 (human) 2.9 Joint/bone inflammation hip osteoarthritis 6 39259604 140014781 Human 1298473 RA12_H Rheumatoid arthritis QTL 12 (human) .0043 Joint/bone inflammation rheumatoid arthritis 6 39475357 65475357 Human 2289587 BW467_H Body weight QTL 467 (human) 2.4 Body fat amount percent fat 6 40642207 131730853 Human 1298438 BP4_H Blood pressure QTL 4 (human) 2.5 Blood pressure diastolic 6 41677196 104674060 Human
Gene Ontology Annotations
