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Gene: Prickle2 (prickle planar cell polarity protein 2) Rattus norvegicus

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Symbol:

Prickle2

Name:

prickle planar cell polarity protein 2

RGD ID:

1306723

Description:

Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including embryonic brain development; maintenance of postsynaptic density structure; and regulation of postsynaptic density assembly. Predicted to act upstream of or within establishment or maintenance of epithelial cell apical/basal polarity and neuron projection development. Predicted to be located in several cellular components, including apicolateral plasma membrane; dendrite; and lateral plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; Wnt signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; acrolein.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC312563; prickle homolog 2; prickle homolog 2 (Drosophila); prickle-like 2; prickle-like 2 (Drosophila); prickle-like protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRICKLE2 (prickle planar cell polarity protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Prickle2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prickle2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRICKLE2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRICKLE2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prickle2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRICKLE2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRICKLE2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prickle2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Prickle2 (prickle planar cell polarity protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PRICKLE2 (prickle planar cell polarity protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PRICKLE2 (prickle planar cell polarity protein 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prickle2 (prickle planar cell polarity protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Prickle2 (prickle planar cell polarity protein 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prickle2a (prickle homolog 2a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	prickle2a (prickle homolog 2a)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	prickle2b (prickle homolog 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prickle2b (prickle homolog 2b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	prkl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	prkl-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	esn	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	pk	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	pk	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prickle2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	prickle2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	126,426,767 - 126,771,986 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	126,426,771 - 126,772,008 (-)	Ensembl				GRCr8
mRatBN7.2	4	124,869,655 - 125,214,862 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	124,869,552 - 125,214,824 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	130,337,414 - 130,682,587 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	126,111,840 - 126,457,005 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	124,736,392 - 125,081,567 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	124,238,167 - 124,584,176 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	124,238,167 - 124,338,176 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	188,680,318 - 189,025,114 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	126,571,461 - 126,920,730 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	113,786,958 - 114,131,482 (-)	NCBI		Celera
RGSC_v3.1	4	126,820,833 - 126,938,959 (-)	NCBI
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder (ISO)

benign epilepsy with centrotemporal spikes (ISO)

epilepsy (ISO)

Liver Neoplasms (ISO)

Myoclonic Epilepsies (ISO)

pre-malignant neoplasm (ISO)

progressive myoclonus epilepsy (ISO)

progressive myoclonus epilepsy 5 (ISO)

sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5-triiodo-L-thyronine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

alpha-Zearalanol (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cocaine (EXP)

crotonaldehyde (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

dimethylselenide (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

hydroxyl (ISO)

indometacin (ISO)

isoflurane (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-nitrosoglutathione (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst formation (ISO)

embryonic brain development (ISO)

establishment or maintenance of epithelial cell apical/basal polarity (ISO)

maintenance of postsynaptic density structure (ISO)

neuron projection development (ISO)

protein localization to axon (ISO)

regulation of postsynaptic density assembly (ISO)

response to electrical stimulus (ISO)

Cellular Component

apicolateral plasma membrane (ISO)

axon (ISO)

cytoplasm (ISO)

dendrite (ISO)

glutamatergic synapse (ISO)

lateral plasma membrane (ISO)

nucleus (ISO)

postsynaptic density (ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (IEA)

Wnt signaling, the planar cell polarity pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Planar cell polarity signaling in vertebrates.	Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17376975	PMID:19788910	PMID:22333836	PMID:26257100

Genomics

Comparative Map Data

Prickle2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	126,426,767 - 126,771,986 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	126,426,771 - 126,772,008 (-)	Ensembl				GRCr8
mRatBN7.2	4	124,869,655 - 125,214,862 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	124,869,552 - 125,214,824 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	130,337,414 - 130,682,587 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	126,111,840 - 126,457,005 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	124,736,392 - 125,081,567 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	124,238,167 - 124,584,176 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	124,238,167 - 124,338,176 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	188,680,318 - 189,025,114 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	126,571,461 - 126,920,730 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	113,786,958 - 114,131,482 (-)	NCBI		Celera
RGSC_v3.1	4	126,820,833 - 126,938,959 (-)	NCBI
Cytogenetic Map	4	q34	NCBI

PRICKLE2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	64,092,236 - 64,268,173 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	64,092,236 - 64,445,476 (-)	Ensembl			hg38	GRCh38
GRCh37	3	64,077,912 - 64,253,849 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	64,054,587 - 64,186,171 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	64,054,590 - 64,186,171	NCBI
Celera	3	64,096,295 - 64,227,889 (-)	NCBI		Celera
Cytogenetic Map	3	p14.1	NCBI
HuRef	3	64,176,650 - 64,308,225 (-)	NCBI		HuRef
CHM1_1	3	64,030,867 - 64,162,475 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	64,135,847 - 64,311,751 (-)	NCBI		T2T-CHM13v2.0

Prickle2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	92,347,876 - 92,683,233 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	92,347,889 - 92,683,136 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	92,370,891 - 92,706,334 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	92,370,908 - 92,706,155 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	92,320,886 - 92,656,178 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	92,341,450 - 92,671,688 (-)	NCBI		MGSCv36	mm8
Celera	6	94,262,178 - 94,597,798 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	41.05	NCBI

Prickle2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955517	1,501,706 - 1,802,169 (+)	Ensembl
ChiLan1.0	NW_004955517	1,501,322 - 1,806,996 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRICKLE2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	64,013,389 - 64,368,630 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	64,018,177 - 64,372,142 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	63,995,566 - 64,347,679 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	65,374,853 - 65,723,643 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	65,377,760 - 65,723,662 (-)	Ensembl			panPan2	panpan1.1

PRICKLE2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	26,810,167 - 27,131,864 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	26,809,958 - 27,220,057 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	26,734,821 - 27,056,251 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	26,851,053 - 27,167,684 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	26,850,761 - 27,339,903 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	26,544,737 - 26,865,949 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	26,896,407 - 27,215,887 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	26,956,497 - 27,278,807 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Prickle2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	163,613,553 - 163,945,169 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936637	2,003,209 - 2,333,278 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936637	2,225,400 - 2,299,307 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRICKLE2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	45,620,368 - 45,968,152 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	45,620,372 - 45,968,295 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	50,094,626 - 50,263,960 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRICKLE2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	25,128,160 - 25,481,385 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	25,133,352 - 25,303,131 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	141,333,892 - 141,686,115 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prickle2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624888	1,537,138 - 1,821,215 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624888	1,537,080 - 1,825,955 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Prickle2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	54,256,174 - 54,592,306 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Prickle2
1384 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	643
Count of miRNA genes:	290
Interacting mature miRNAs:	401
Transcripts:	ENSRNOT00000016628
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	96731383	141731383	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	86583980	149763391	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	92406430	137406430	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	117737142	152833657	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	88883695	133883695	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	103834277	148834277	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	88883695	133883695	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	86058928	131411333	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	84349032	129349032	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	82336765	127336765	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	113634167	149763391	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	86583980	131583980	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	121020385	148834277	Rat

Markers in Region

D4Rat185

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	125,064,558 - 125,064,778 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	124,432,940 - 124,433,159	NCBI	Rnor6.0
Rnor_5.0	4	188,830,973 - 188,831,192	UniSTS	Rnor5.0
RGSC_v3.4	4	126,768,193 - 126,768,412	UniSTS	RGSC3.4
Celera	4	113,981,892 - 113,982,111	UniSTS
RGSC_v3.1	4	127,013,034 - 127,013,253	RGD
SHRSP x BN Map	4	55.5	UniSTS
SHRSP x BN Map	4	55.5	RGD
Cytogenetic Map	4	q34	UniSTS

D4Rat186

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	126,678,535 - 126,678,750 (+)	Marker Load Pipeline
mRatBN7.2	4	125,121,436 - 125,121,651 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	124,489,995 - 124,490,209	NCBI	Rnor6.0
Rnor_5.0	4	188,773,923 - 188,774,137	UniSTS	Rnor5.0
RGSC_v3.4	4	126,825,674 - 126,826,089	RGD	RGSC3.4
RGSC_v3.4	4	126,825,771 - 126,825,985	UniSTS	RGSC3.4
Celera	4	114,038,761 - 114,038,975	UniSTS
RGSC_v3.1	4	127,070,612 - 127,070,826	RGD
RH 3.4 Map	4	736.63	UniSTS
RH 3.4 Map	4	736.63	RGD
RH 2.0 Map	4	803.5	RGD
SHRSP x BN Map	4	55.49	RGD
Cytogenetic Map	4	q34	UniSTS

D4Uia9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	124,915,758 - 124,915,928 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	124,284,598 - 124,284,767	NCBI	Rnor6.0
Rnor_5.0	4	188,979,365 - 188,979,534	UniSTS	Rnor5.0
RGSC_v3.4	4	126,619,585 - 126,619,759	RGD	RGSC3.4
RGSC_v3.4	4	126,619,586 - 126,619,759	UniSTS	RGSC3.4
Celera	4	113,833,403 - 113,833,572	UniSTS
RGSC_v3.1	4	126,864,426 - 126,864,600	RGD
Cytogenetic Map	4	q34	UniSTS

RH143962

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	125,021,317 - 125,021,431 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	124,390,308 - 124,390,421	NCBI	Rnor6.0
Rnor_5.0	4	188,873,711 - 188,873,824	UniSTS	Rnor5.0
RGSC_v3.4	4	126,725,142 - 126,725,255	UniSTS	RGSC3.4
Celera	4	113,938,615 - 113,938,728	UniSTS
RH 3.4 Map	4	736.83	UniSTS
Cytogenetic Map	4	q34	UniSTS

RH141294

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	124,869,754 - 124,869,936 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	124,238,370 - 124,238,551	NCBI	Rnor6.0
Rnor_5.0	4	189,024,730 - 189,024,911	UniSTS	Rnor5.0
RGSC_v3.4	4	126,571,664 - 126,571,845	UniSTS	RGSC3.4
Celera	4	113,787,161 - 113,787,342	UniSTS
Cytogenetic Map	4	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	41	59	6	305	141	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016628 ⟹ ENSRNOP00000016628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	126,426,771 - 126,772,008 (-)	Ensembl
mRatBN7.2 Ensembl	4	124,869,552 - 125,214,824 (-)	Ensembl
Rnor_6.0 Ensembl	4	124,238,167 - 124,338,176 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148675 ⟹ ENSRNOP00000104520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	126,426,771 - 126,771,767 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155149 ⟹ ENSRNOP00000104444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	126,426,771 - 126,547,398 (-)	Ensembl

RefSeq Acc Id:

NM_001107876 ⟹ NP_001101346

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,426,771 - 126,771,916 (-)	NCBI
mRatBN7.2	4	124,869,659 - 125,214,824 (-)	NCBI
Rnor_6.0	4	124,238,167 - 124,584,045 (-)	NCBI
Rnor_5.0	4	188,680,318 - 189,025,114 (+)	NCBI
RGSC_v3.4	4	126,571,461 - 126,920,730 (-)	RGD
Celera	4	113,786,958 - 114,131,482 (-)	RGD

Sequence:

show sequence

CACATTCAACCGACAGCGCTGCTGGCAGGAAGCGCCCGGCCATGTTCAGCCGGAGCTCGAGGAA
AAGACTGTCCCGCCGCTCGGAAGATCTGCCTGCACTGCAAGTGTCCCCAGGAGGAGCACATGGT
GACAGTGATGCCGCTGGAGATGGAGAAGACCATTAGCAAGCTCATGTTTGACTTCCAGAGGAAT
TCAACCTCAGATGACGACTCGGGCTGTGCTTTGGAAGAATATGCCTGGGTCCCCCCGGGGCTGA
AGCCTGAGCAGGTGCACCAGTATTATAGCTGCCTCCCAGAAGAGAAAGTTCCCTATGTCAACAG
CCCTGGAGAGAAATTGCGAATCAAGCAGCTACTGCACCAGCTGCCACCCCACGACAATGAGGTT
CGGTATTGCAACTCCCTGGACGAGGAGGAGAAGCGGGAGCTGAAGCTGTTCAGCAACCAGAGGA
AACGTGAGAACCTGGGCCGAGGCAATGTCAGGCCCTTCCCCGTCACCATGACAGGGGCTATTTG
CGAACAGTGTGGAGGTCAGATTAAGGGCGGCGACATCGCTGTGTTTGCATCACGTGCTGGCCAT
GGCATCTGCTGGCATCCACCATGCTTTATATGCACAGTCTGCAATGAGCTTCTGGTTGACCTGA
TCTACTTTTACCAAGATGGGAAGATCTACTGTGGCAGGCACCATGCTGAGTGCCTGAAGCCGCG
CTGTGCAGCCTGTGATGAGATCATCTTTGCAGATGAGTGCACAGAGGCTGAAGGACGACATTGG
CACATGAGACACTTCTGCTGCTTCGAGTGTGAGACGGTGCTGGGGGGCCAGCGCTACATCATGA
AGGAGGGAAGACCCTACTGCTGTCACTGCTTTGAGTCCCTGTATGCAGAATATTGTGACACCTG
TGCCCAACATATAGGAATTGACCAAGGTCAAATGACCTATGACGGCCAACACTGGCATGCTACG
GAGAACTGTTTCTGCTGTGCTCATTGTAAGAAGTCTCTCCTGGGGCGGCCATTCCTCCCGAAGC
AAGGCCAGATATTCTGCTCACGGGCCTGTAGTGCTGGGGAGGACCCCAATGGCTCTGACTCATC
TGATTCAGCCTTCCAGAATGCCAGAGCCAAGGAGTCTCGCCGCAGTGCCAAAATTGGCAAGAAC
AAGGGCAAAACAGAGGAAACCATGCTGAACCAGCACAGCCAGCTGCAGGTGAGTTCTAACCGGC
TCTCAGCTGATGTGGACCCCCTGTCAGTGCAGATGGATCTCCTCAGCCTGTCCAGCCAGACGCC
CAGCCTCAACCGGGACCCCATTTGGAGGAGCCGGGATGAGCCCTTCCATTACGGGAACAAGATG
GAGCAGAACCAATCCCAGAGTCCTTTGCAGCTCCTCAGCCAGTGCAACATCAGAACGTCCTACA
GTCCAGGAGGGCAGGCAGCAGGAGCCCAGCCTGACATGTGGGCCAAGCACTTCAGCAACCCCAA
GAGAAGCTCATCAATGGCCCTGAAGGGGCACGGTGGCAGTTTTATCCAGGAATGTCGTGAGGAC
TATTACCCAGGGAGGCTGATGTCCCAGGAGAGCTACAGCGATATGTCTAGCCAAAGCTTTAGTG
AAACCCGAGGCAGCATCCCGGTTCCCAAGTATGAGGAGGAGGAGGAGGAGGAGGAGGAAGAAGG
TGGCATATCTACCCAGCAGTGCCGGCCCCGGCGTCCACTCAGCTCCCTGAAATACACAGAGGAC
ATGACACCCACAGAACAGACTCCTCGTGGCTCTATGGAATCACTGGCCCTGTCAAATGCAACAG
GCCTGTCTGCTGAAGGTGGTGCCAAGCGCCAGGAGCACCTATCCCGGTTTTCCATGCCTGACCT
CAGCAAAGACTCTGGAATGAATGTCTCGGAAAAGCTGAGCAACATGGGCACTCTCAACTCCTCA
ATGCAATTCAGGAGCGCAGAGTCTGTCCGCAGCCTACTGTCTGCGCAACAGTACCAGGAGATGG
AGGGAAACCTTCACCAGCTCAGCAACCCCCTGGGGTACAGGGACCTACAGTCCCATGGAAGGAT
GCACCAGAGCTTTGATTTTGATGGCGGCATAGCGAGCAGCAAGCTACCAGGGCAGGAAGGTGTT
CACATCCAGCCCATGAGTGAGCGCACCCGGAGGAGAACTACTTCCAGGGATGACAACCGCCGCT
TCCGCCCTCACCGGTCCAGGAGGTCCCGACGCTCACGTTCAGACAACGCCCTGCACCTAGCCAG
CGAGCGGGAAGTCATCGCTCGGTTGAAGGATAGGCCCCCTCTGAGAGCCAGGGAGGACTATGAC
CAGTTCGTGCGCCAACGCAGTTTTCAGGAGAGCATGGGGCAGGGTTCCCGGCGGGATCTGTACA
GCCAGTGTCCCAGGACTGTGTCAGACCTGGCTTTGCAGAATGCCTTTGGGGAACGATGGGGACC
CTACTTCACGGAGTATGATTGGTGCTCCACCTGCTCCTCCTCTTCAGAGTCCGACAATGAGGGC
TACTTCCTAGGAGAACCCATCCCCCAGCCAGCCCGCCTACGATATGTCACAAGTGATGAGCTCC
TGCACAAGTACAGCTCTTACGGTGTCCCCAAATCCTCCACCTTAGGTGGCAGAGGACAGTTGCA
CAGCAGGAAAAGACAGAAGAGCAAAAACTGTATCATTTCGTAATGTGATGGTGGTTGGGGAATC
GGGGAGATGGGAGCTAAGAATGTAAACTCAGAAACGTGCACTGTTGTGAATTCTCAAGTGCTCT
TGGGGATGGTTCATGGAGGAGAGATGGAGAATGCTCTCAGTTGAGGGAGGCAAGGCTGCAGGTT
GACTTGGTAGATACACTTGGTGTCACAGTTTGGGACGTGTTAAATATGATTTGCACATTTCACT
TTGGAAACACAGGCTGTGGAGGCCAGGGTAGGTCATGTCCTTTCCAAGGTGGAGTGGCCATTAA
CCAGATGACACACTGTAACCTGCTCACTTATATTCTTTCTGGTTCTCTTCCTTTTAGGATCCCT
TTTCCAGTAAATACTTTATTAGCCAGGACCCCAGACTAAGTTATTTACATGTTCATTGTAAATG
CAATGTAAATGAGAGTTCTGATAAAATATTTTTGTATTTTGTAATAACAACAGAATTTCTATAT
CGTAGGATTCAGTGGGGACTTGCATGCCTGTCCACCAGTACCTTCGAGTGATAGTAAACGGTGG
CCCAGGACCACCTGGTGTTTGTTGTTTGTTTTGATTTGGTTTGGTTTTCTTTCTATACAAATCT
GTTACATGTCAGTGAGACTGTTTTCAAAGGAGTATATTCAATTTGGCTTTTTGTGGCTGAAAAA
GAAAATTTTAACTATCCTACCCAAGGCATTCTATGCTCTAGTTCATCTAAAGGTCCGTCTTTAA
GTTCACTCCCACCCTCAGTAGAATTTATTCTCTACAAAGTAAGTAGGGTTTTTTTTTCTTTTAA
ATTTTTTTTTTATTGCAAATGTCGCTTTTGCTGATTAGATGACAACCAGTGTCAGTCCAGTTCT
GTGAGAAATGCCATCCTTGTTTGGAACCTTGAAGTTGCTTAATGTCGATCTGTCCCTCAGGGGT
AGTCGCAGTGACTGTGAGCGGTGCCGGTGTATGTGTCAGCATGGCCTTGTTTTGAGTGTGGAAC
TGTTTGGTGCTCATGTTTCCTGGATTGTATTTTCTGCTTTCTTCTTCCAAGGCAGACGGAGCTG
CTGCCTTAGCCTGACAACTGTTTGTCCTCATAGCAAATGAGCGTCAACGTTTAGCACTGAGGGA
CAAGAAGATGCTGGGGTGGGGAGGGGCTCTGGGTGCACTGGGTTGGTGCACATTATACAAGGGG
ATTTGAAAACTAAAAGCAGGTAGATGCTGAAAGGGGGAATATGAAGGAAAGTCAGGGAGAAAGA
ACTTTTAGGAAGAAATAGAGGTGACAGTCACCTTGACTAGTCCCCAGTGCTTTAGAGAGAATCC
AATCTGACAAGCTTAGTCACCACAGGGGCCGGCTTCTTACCCTGGAGGGTCAAGCTGCTGAGAT
GATAGGTAACAACATGGAAAAACAGACCTTGTGGCAAGAGAGATTTCCATTTTGAACTTTGAGG
ACTGTTGGTCAGACAGAAAGGCTCAAGAGTAAGTTTGCTTAAAGAAGACATTTCATTGCAGGTG
AGATAAATATATAGTGAAAAAAAAAAACCTTCTTGCCTCGCTTCAGTTTTTAAAAAAAAAAAAA
AATGAAGCCCTTGCTCTTGGTCCATTTTCTCCCTCTCCTCAGTGGATTGTGGCAAAAATCCATC
GGAGGACCCACCTTTTGTGAGATGTGCTGTCCCCTTATGCACAGTGTGTCTCAGTGGCCATTTG
CCGTGATGGCGAGCATGGTCTCTTTTCAGTATAGTACTTAACATTTTCTAGGGTTTTTTTTTTA
ATGGAGAGAATGGGAAGAGTGGCTTTTCAGACACCATGCTAAATGGGTCTGGGGTCGAGGGAGG
CTGTAAAGGATATGGTGATGATACCCCATCCAGGATGTATTAAAATGATTTGCTTTATAGGTAT
TAATACCACATTTGTCATTGTCACTGACTTTTTTTTTAAAGAAGCAATGCAAATGTTGGTTGTG
GCTGTTTTCCGCATGCTATCTTCATATCTAAGTGTTTCATTAATTATCCAAGCCTCTGGAGAAT
TAACTCTATTACGTTTGTACAGTAAGTTAATAAAGCTGCTTGACAAACTGTTTAAGAGATAAAT
ATGCAGCACCGTGCCACTCGGGTGGCAGGTTTCTGGTAGACATTGGGTGAGTCCAATTTGGAGC
ATTGAGTCTGTTGATTGGTGAGAATTAGAAAGGCGCTATTGGGAAAAGAAAAGAGGGGAGCGTA
GATCACTTAGCAAATGGTTGAAACCATGTATCCTCTCTGGCCCCAAATCCAACGAACAAAATTT
CCCCACTGGAAGTCGTTTTCTCACTCTGTCCTTGGCAGAGTACCTCTTACGTTTCCCAGATATG
TTTTTGACCAGCCCTCAGCCCAAAGAAGAAAGCAATATAGAAACTGCTTAAGTTACATCGAGTC
TAGCTGTCCAGAGAACATTCAAGCTCTTTCTAACCAAAACTTAAAATATAATGAGATACAGGCT
TCAGGGTCAAACGGTCCACCAGCAAGATCATCCCCTTCTGTCGAACCACTGAAGATTGCTTCCC
ATTCTAAAAGCAGCCAGGTGCCCTACAGAGAATGTCACCTGAGGAAGGCCAGGTCCTCACAATG
GTAGTAGGTCCTTAAAGCTACTGCCCATGTTGTGACAGTAAACTAGAATTTCTCTACCTTGAAG
TAACAACTTAAGAGATTTAACACCCGGAATCTCATTCCCAAAATTCAAGTGCATTCTTTTCTGA
GGTGAGAATTTAGGGTCCTCCCTGATTCTTCTAGTATATCCCTTACCTGCTACCAGCCAAGTTT
CCCTGAGGAGTCAGGCCTGTACTCAGTTCCCCTAGGTCGTTGTTTTATCTTCTGCAGACTGGCT
TTCAGAAGAGCCATCTTTCTCCCCTTTCTCGTCTCTGATGATTTGGCTATTTTTTCCCATCTCT
CCTCTTATTGGGCTGACTTCTATTTAGAACTACAGCTCTAGAGTTCAGTTCGTGTCACACTGCT
GCCAGATCCAGCACCAGCTAAGCCAGCCCCCTTCTCCGGGCCAAGGAGCGTGTACATCATTGAA
AGTTTCTGAGTGCACATCCCACCTTTGGTCCTGCAAAAAGGGTTCATGCTGAAGTGCGGTAGCT
TCCAGCATCCATCGTGGCCTTCAGAGACCCGCCCTTCTGTCCTGTGTAGTTCTAGATTCTCTAC
CATGAGTGTGAAGGTCAATGGGGTGAGGAAAATCGGACCTCATTTCCTGGTTTTTAACATACCT
AAAGGAGAATTGCTGGTGTTGGTTGTTTGAAACCCTCATTTACCGTCTAAGCAGCTGTCTGAAC
AGATTGGAGTTTTCTAATAGGAAAAGTCACAGTCTTTTCCTACAGAAGGCTCCCCCTACAGAGC
TGTAGGAAGATGGCGTTCTGTGCGCCCCTTCTAGGAGTTCCTACTTCCTATGACCTAGTTGGCC
ATCTTTCATCAGGTGGAGCCATGGTGGCATGAATGTAGCACTTTCTATGTGTGCTCTACCTGCC
ACCTTAGTGGATGACAAGCAGTGGATTACTGCACTTTCCAAGGAGAGCAGACTCTCATCCCAGG
TATCTTCACAAAACTCCAACAAGCCAGGGCTGATTGACTAGAGCCGGTCTCCTCTGTCTTATGA
CAGATCTTATTCATAAGCTGACTCTTTCCTGATTCCCTGGGAAAGGAGTACACCAGACATATAG
GAAGCATCCAAAACCAAGAATTGGGAGACCCCCCCATTCCTTCCCACACTGTGGAAGCTACAGG
AAGCTGACCTCTTAGGCCAAACAAGGCTCCCTTTGGCCTACTTCTTCGTGCTCAGGGTCTTTGC
CAGTTATGTGAGCAGCTCCTGCTCACTTTGCAGAAGTCAGCTAAGAGTCTGTTTTCTCATCCCA
GTCCATATTAGAGGGACACAGGACACTTAAATTCCAAAGCAGAGTGTTCTCTGCATTCGCCTAA
CAGAGACCAGACGCTGTGCCTCACAAAGATCCACCTATGACCAAGGGAAATAGAAAACTGAGCC
AGTGGCCTGAATGTCGCATGCAAACAGAGTTGTTCCTGGCCCCTGCCTGGCACCTTCAGGCAGA
TCCTGTTCCACAGGCTTCTATTACTGATCTAGAAGGCAGTTGCACATTATCACCTTTTGGAAAG
TACATTTCTTTGAGCATACAGGAAATAGGAATGAGACCTTTGCCTTCTTGTCAGTGGTTCACCC
CAGAGTATGTGTGTACGACCATCCAGACGCCAAGAAGGTCAGGATGGAGGAAGAATTGATTTAT
TTTTCTGTTTTCTCATATTAGAAGCCCAGTCAACACAACACCCCTATAGAGCACGACTATCGGA
AGCTATTACTCTGATATAAATTTATTTCCTGCTTCCAAAACCAGCCTCCCTCAGAGGAATAAAA
AGGAGGTTGGAAGGTCATGTGCTATTAACAGACATCTCTGTGGTTCAGATGTGATAAACTCACA
AGATAGATGTCTAGTTCTATCTCGAGCAATTTCTAAGAAAACCTTCATGGTCTAGGCATTTGGC
CATGGGGGTTCAATAGGTCACCAACCAAATGTTTCTAAATTTTGGGAGGTTACTTGCCAATATG
ACCGCTTCTTGTGTTTATCTAGTTGGTTCCCATAGTTTTCAATAAAGTATTCTGGTTTAATCCT
GACCCTGAGCTAACAACATAAGACCAGTGACTCTCCTGTAGTCTTCAGCAAAGTAGGCCAGCAT
TTATTCTCCCTAAACTCGTTTGTTCCTGCAGAGTTGCTTTGCTCAGATCCTATTTAATTCCACA
TGCATAAACAAAACCTCAGAGGGCCCAAGAAGGCGAAGCAGGCTGGAGTCTGTGTTATCTGTCA
AGTGTCAAGCTGTTTGTTAAGAAGGCCTGTCACGGGCTTTTGGCGTGGGATCTGCCAGAGACTG
TTCTGAACTCTTTGCTTGAGATCCGTGCCCTGTAAAGTGGATATGATGTTTTACTGATTCTGGA
ATACATTTGTAAACTTCCAATAAAATTTGAATAAAAGGAATGTTGTCATCCTTCTCAATCCTCA
CTCACGGTCCAGATTTGAGGAGTGGACTTGGCCTTAGGGAAAAGGCCAAGAAAAAGCATGTGTG
TCAGAGGCAGATATT

hide sequence

RefSeq Acc Id:

NM_001415880 ⟹ NP_001402809

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,426,771 - 126,601,531 (-)	NCBI
mRatBN7.2	4	124,869,659 - 125,044,427 (-)	NCBI

RefSeq Acc Id:

NM_001415881 ⟹ NP_001402810

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,426,771 - 126,547,398 (-)	NCBI
mRatBN7.2	4	124,869,659 - 124,990,294 (-)	NCBI

RefSeq Acc Id:

XM_039107620 ⟹ XP_038963548

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,426,767 - 126,771,952 (-)	NCBI
mRatBN7.2	4	124,869,655 - 125,214,860 (-)	NCBI

RefSeq Acc Id:

XM_039107621 ⟹ XP_038963549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,426,767 - 126,771,986 (-)	NCBI
mRatBN7.2	4	124,869,655 - 125,214,859 (-)	NCBI

RefSeq Acc Id:

XM_039107624 ⟹ XP_038963552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	126,442,824 - 126,771,955 (-)	NCBI
mRatBN7.2	4	124,894,975 - 125,214,862 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101346	(Get FASTA)	NCBI Sequence Viewer
	NP_001402809	(Get FASTA)	NCBI Sequence Viewer
	NP_001402810	(Get FASTA)	NCBI Sequence Viewer
	XP_038963548	(Get FASTA)	NCBI Sequence Viewer
	XP_038963549	(Get FASTA)	NCBI Sequence Viewer
	XP_038963552	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL91393	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016628
	ENSRNOP00000016628.7
	ENSRNOP00000104444
	ENSRNOP00000104444.1
	ENSRNOP00000104520.1

RefSeq Acc Id:

NP_001101346 ⟸ NM_001107876

- UniProtKB:

A6IBC5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYV
NSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGA
ICEQCGGQIKGGDIAVFASRAGHGICWHPPCFICTVCNELLVDLIYFYQDGKIYCGRHHAECLK
PRCAACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCD
TCAQHIGIDQGQMTYDGQHWHATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSD
SSDSAFQNARAKESRRSAKIGKNKGKTEETMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQ
TPSLNRDPIWRSRDEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQAAGAQPDMWAKHFSN
PKRSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFSETRGSIPVPKYEEEEEEEEE
EGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMP
DLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHG
RMHQSFDFDGGIASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHL
ASEREVIARLKDRPPLRAREDYDQFVRQRSFQESMGQGSRRDLYSQCPRTVSDLALQNAFGERW
GPYFTEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQ
LHSRKRQKSKNCIIS

hide sequence

Ensembl Acc Id:

ENSRNOP00000016628 ⟸ ENSRNOT00000016628

RefSeq Acc Id:	XP_038963548 ⟸ XM_039107620
- Peptide Label:	isoform X1
- UniProtKB:	F1M0J7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963549 ⟸ XM_039107621
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038963552 ⟸ XM_039107624
- Peptide Label:	isoform X3

RefSeq Acc Id:	NP_001402809 ⟸ NM_001415880
- UniProtKB:	A6IBC5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001402810 ⟸ NM_001415881
- UniProtKB:	A6IBC5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000104520 ⟸ ENSRNOT00000148675

Ensembl Acc Id:

ENSRNOP00000104444 ⟸ ENSRNOT00000155149

Protein Domains

LIM zinc-binding PET

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M0J7-F1-model_v2	AlphaFold	F1M0J7	1-847	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306723	AgrOrtholog
BioCyc Gene	G2FUF-43692	BioCyc
Ensembl Genes	ENSRNOG00000012364	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016628	ENTREZGENE
	ENSRNOT00000016628.8	UniProtKB/TrEMBL
	ENSRNOT00000148675.1	UniProtKB/TrEMBL
	ENSRNOT00000155149	ENTREZGENE
	ENSRNOT00000155149.1	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/TrEMBL
InterPro	LIM1_prickle	UniProtKB/TrEMBL
	LIM2_prickle	UniProtKB/TrEMBL
	LIM3_prickle	UniProtKB/TrEMBL
	PET_domain	UniProtKB/TrEMBL
	PET_prickle	UniProtKB/TrEMBL
	Pk/Esn/Tes	UniProtKB/TrEMBL
	Znf_LIM	UniProtKB/TrEMBL
KEGG Report	rno:312563	UniProtKB/TrEMBL
NCBI Gene	312563	ENTREZGENE
PANTHER	LIM DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	PRICKLE-LIKE PROTEIN 2	UniProtKB/TrEMBL
Pfam	LIM	UniProtKB/TrEMBL
	PET	UniProtKB/TrEMBL
PhenoGen	Prickle2	PhenoGen
PROSITE	LIM_DOMAIN_1	UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/TrEMBL
	PET	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012364	RatGTEx
SMART	LIM	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
UniProt	A0ABK0LLG8_RAT	UniProtKB/TrEMBL
	A0ABK0LLM3_RAT	UniProtKB/TrEMBL
	A6IBC5	ENTREZGENE, UniProtKB/TrEMBL
	F1M0J7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-21	Prickle2	prickle planar cell polarity protein 2	Prickle2	prickle homolog 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-30	Prickle2	prickle homolog 2	Prickle2	prickle homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Prickle2	prickle homolog 2 (Drosophila)	Prickle2	prickle-like 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Prickle2	prickle-like 2 (Drosophila)	Prickle2_predicted	prickle-like 2 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Prickle2_predicted	prickle-like 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)