Lztfl1 (leucine zipper transcription factor-like 1) - Rat Genome Database

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Gene: Lztfl1 (leucine zipper transcription factor-like 1) Rattus norvegicus
Analyze
Symbol: Lztfl1
Name: leucine zipper transcription factor-like 1
RGD ID: 1306628
Description: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of protein localization to ciliary membrane. Predicted to act upstream of or within flagellated sperm motility and spermatogenesis. Predicted to be located in cilium and manchette. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine zipper transcription factor-like protein 1; LOC316102; MGC108960
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,222,339 - 132,237,757 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8132,222,342 - 132,237,684 (-)EnsemblGRCr8
mRatBN7.28123,344,085 - 123,360,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,344,925 - 123,360,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,934,872 - 128,950,188 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,133,848 - 127,149,164 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,963,362 - 124,978,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,774,393 - 132,790,922 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,775,587 - 132,790,839 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,927,093 - 131,943,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,474,651 - 128,489,845 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,453,145 - 122,468,456 (-)NCBICelera
RGSC_v3.18128,494,387 - 128,509,582 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
manchette  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22072986   PMID:24550735   PMID:25416956   PMID:27107012  


Genomics

Comparative Map Data
Lztfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,222,339 - 132,237,757 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8132,222,342 - 132,237,684 (-)EnsemblGRCr8
mRatBN7.28123,344,085 - 123,360,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,344,925 - 123,360,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8128,934,872 - 128,950,188 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,133,848 - 127,149,164 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,963,362 - 124,978,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,774,393 - 132,790,922 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,775,587 - 132,790,839 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,927,093 - 131,943,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,474,651 - 128,489,845 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,453,145 - 122,468,456 (-)NCBICelera
RGSC_v3.18128,494,387 - 128,509,582 (-)NCBI
Cytogenetic Map8q32NCBI
LZTFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,823,316 - 45,915,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,823,316 - 45,916,042 (-)Ensemblhg38GRCh38
GRCh37345,864,808 - 45,957,216 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,840,450 - 45,858,625 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34345,840,449 - 45,858,625NCBI
Celera345,803,051 - 45,821,229 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,908,751 - 46,001,249 (-)NCBIHuRef
CHM1_1345,814,798 - 45,907,189 (-)NCBICHM1_1
T2T-CHM13v2.0345,838,956 - 45,931,607 (-)NCBIT2T-CHM13v2.0
Lztfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,523,469 - 123,546,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,523,481 - 123,546,762 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389123,694,404 - 123,717,625 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,694,416 - 123,717,697 (-)Ensemblmm10GRCm38
MGSCv379123,606,711 - 123,626,675 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369123,546,291 - 123,566,255 (-)NCBIMGSCv36mm8
Celera9124,153,826 - 124,173,814 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map974.36NCBI
Lztfl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,130,434 - 26,146,955 (+)Ensembl
ChiLan1.0NW_00495542026,130,432 - 26,145,516 (+)NCBIChiLan1.0ChiLan1.0
LZTFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,788,706 - 45,809,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,793,473 - 45,814,487 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,733,361 - 45,823,810 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1346,840,340 - 46,930,286 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,840,037 - 46,929,864 (-)EnsemblpanPan2panpan1.1
LZTFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,651,762 - 42,666,426 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,651,802 - 42,666,417 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2042,567,532 - 42,582,201 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02043,135,402 - 43,150,109 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,135,374 - 43,150,106 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,375,638 - 42,390,332 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,783,280 - 42,797,949 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02043,058,184 - 43,072,886 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lztfl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118197,753,885 - 197,767,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936695106,175 - 121,606 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936695106,216 - 118,408 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LZTFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,977,503 - 29,005,445 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11328,975,202 - 29,005,245 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,073,764 - 32,093,033 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LZTFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,292,390 - 7,310,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,294,733 - 7,307,687 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041159,855,888 - 159,874,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lztfl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,041,790 - 75,071,728 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473075,041,943 - 75,069,972 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lztfl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18114,815,990 - 114,839,574 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:159
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000008255
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat

Markers in Region
RH131915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,345,107 - 123,345,293 (+)MAPPERmRatBN7.2
Rnor_6.08132,775,787 - 132,775,972NCBIRnor6.0
Rnor_5.08131,928,487 - 131,928,672UniSTSRnor5.0
RGSC_v3.48128,474,854 - 128,475,039UniSTSRGSC3.4
Celera8122,453,348 - 122,453,533UniSTS
RH 3.4 Map81259.6UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008255   ⟹   ENSRNOP00000008254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8132,775,587 - 132,790,778 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091431   ⟹   ENSRNOP00000071325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8132,222,342 - 132,237,684 (-)Ensembl
mRatBN7.2 Ensembl8123,344,925 - 123,360,192 (-)Ensembl
Rnor_6.0 Ensembl8132,775,613 - 132,790,839 (-)Ensembl
RefSeq Acc Id: NM_001024266   ⟹   NP_001019437
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,222,339 - 132,237,533 (-)NCBI
mRatBN7.28123,344,905 - 123,360,101 (-)NCBI
Rnor_6.08132,775,584 - 132,790,778 (-)NCBI
Rnor_5.08131,927,093 - 131,943,622 (-)NCBI
RGSC_v3.48128,474,651 - 128,489,845 (-)RGD
Celera8122,453,145 - 122,468,456 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244191   ⟹   XP_006244253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,222,339 - 132,237,677 (-)NCBI
mRatBN7.28123,344,085 - 123,360,245 (-)NCBI
Rnor_6.08132,774,393 - 132,790,922 (-)NCBI
Rnor_5.08131,927,093 - 131,943,622 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005487858
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,222,339 - 132,237,757 (-)NCBI
mRatBN7.28123,344,085 - 123,360,245 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019437 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244253 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH92585 (Get FASTA)   NCBI Sequence Viewer  
  EDL76754 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071325
  ENSRNOP00000071325.1
GenBank Protein Q562C6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019437   ⟸   NM_001024266
- UniProtKB: Q562C6 (UniProtKB/Swiss-Prot),   A6I4C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244253   ⟸   XM_006244191
- Peptide Label: isoform X1
- UniProtKB: Q562C6 (UniProtKB/Swiss-Prot),   A6I4C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008254   ⟸   ENSRNOT00000008255
Ensembl Acc Id: ENSRNOP00000071325   ⟸   ENSRNOT00000091431

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q562C6-F1-model_v2 AlphaFold Q562C6 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696411
Promoter ID:EPDNEW_R6936
Type:initiation region
Name:Lztfl1_1
Description:leucine zipper transcription factor-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,790,763 - 132,790,823EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306628 AgrOrtholog
BioCyc Gene G2FUF-28609 BioCyc
Ensembl Genes ENSRNOG00000006244 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091431 ENTREZGENE
  ENSRNOT00000091431.2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121316 IMAGE-MGC_LOAD
  IMAGE:7127181 IMAGE-MGC_LOAD
InterPro LZTFL1 UniProtKB/Swiss-Prot
KEGG Report rno:316102 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108960 IMAGE-MGC_LOAD
  MGC:93679 IMAGE-MGC_LOAD
NCBI Gene 316102 ENTREZGENE
PANTHER LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR21635 UniProtKB/Swiss-Prot
Pfam Leu_zip UniProtKB/Swiss-Prot
PhenoGen Lztfl1 PhenoGen
RatGTEx ENSRNOG00000006244 RatGTEx
UniProt A6I4C3 ENTREZGENE, UniProtKB/TrEMBL
  LZTL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lztfl1  leucine zipper transcription factor-like 1  Lztfl1_predicted  leucine zipper transcription factor-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lztfl1_predicted  leucine zipper transcription factor-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED