Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) - Rat Genome Database

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Gene: Lrrc8c (leucine rich repeat containing 8 VRAC subunit C) Rattus norvegicus
Analyze
Symbol: Lrrc8c
Name: leucine rich repeat containing 8 VRAC subunit C
RGD ID: 1306585
Description: Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transmembrane transport. Part of monoatomic ion channel complex. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine rich repeat containing 8 family, member C; leucine-rich repeat-containing protein 8C; LOC289443; MGC112653; RGD1306585; similar to hypothetical protein AD158; volume-regulated anion channel subunit LRRC8C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,528,721 - 4,621,259 (-)NCBIGRCr8
mRatBN7.2144,223,901 - 4,315,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,224,741 - 4,312,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,524,900 - 5,612,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,230,446 - 4,317,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrethrins  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes. Schober AL, etal., J Physiol. 2017 Nov 15;595(22):6939-6951. doi: 10.1113/JP275053. Epub 2017 Sep 12.
Additional References at PubMed
PMID:12477932   PMID:15184384   PMID:15489334   PMID:19946888   PMID:24790029   PMID:26824658   PMID:29769723  


Genomics

Comparative Map Data
Lrrc8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,528,721 - 4,621,259 (-)NCBIGRCr8
mRatBN7.2144,223,901 - 4,315,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,224,741 - 4,312,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,524,900 - 5,612,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,230,446 - 4,317,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
LRRC8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,615,824 - 89,719,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,633,072 - 89,769,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,098,679 - 90,185,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,871,350 - 89,953,169 (+)NCBINCBI36Build 36hg18NCBI36
Celera188,344,351 - 88,430,780 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,215,951 - 88,302,419 (+)NCBIHuRef
CHM1_1190,213,622 - 90,300,056 (+)NCBICHM1_1
T2T-CHM13v2.0189,459,056 - 89,562,765 (+)NCBIT2T-CHM13v2.0
Lrrc8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,666,850 - 105,760,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,667,254 - 105,760,884 (+)EnsemblGRCm39 Ensembl
GRCm385105,519,345 - 105,613,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,519,388 - 105,613,018 (+)EnsemblGRCm38mm10GRCm38
MGSCv375105,948,490 - 106,037,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365105,759,773 - 105,849,256 (+)NCBIMGSCv36mm8
Celera5102,631,726 - 102,729,227 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Lrrc8c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,460,212 - 4,494,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,460,212 - 4,494,317 (-)NCBIChiLan1.0ChiLan1.0
LRRC8C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,298,993 - 137,386,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,454,826 - 136,542,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,299,691 - 92,384,733 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,001,695 - 91,134,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,105,551 - 91,138,447 (+)Ensemblpanpan1.1panPan2
LRRC8C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,895,769 - 58,932,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,899,996 - 58,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,605,421 - 61,690,225 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0659,407,523 - 59,492,055 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl659,409,555 - 59,493,796 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,981,235 - 59,065,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0658,934,585 - 59,019,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0659,414,770 - 59,499,275 (-)NCBIUU_Cfam_GSD_1.0
Lrrc8c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,823,337 - 99,897,484 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365379,049,944 - 9,124,619 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365379,050,495 - 9,124,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,957,105 - 127,037,216 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,996,955 - 139,119,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,752,341 - 43,842,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,752,370 - 43,842,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603374,090,984 - 74,181,626 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247428,009,901 - 8,096,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc8c
458 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:70
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000002896
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat

Markers in Region
AI326115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,228,029 - 4,228,206 (+)MAPPERmRatBN7.2
Rnor_6.0145,287,784 - 5,287,960NCBIRnor6.0
Rnor_5.0145,278,501 - 5,278,677UniSTSRnor5.0
RGSC_v3.4145,306,420 - 5,306,596UniSTSRGSC3.4
Celera144,390,868 - 4,391,044UniSTS
Cytogenetic Map14p22UniSTS
RH135313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,266,065 - 4,266,285 (+)MAPPERmRatBN7.2
Rnor_6.0145,325,890 - 5,326,109NCBIRnor6.0
Rnor_5.0145,316,607 - 5,316,826UniSTSRnor5.0
RGSC_v3.4145,344,454 - 5,344,673UniSTSRGSC3.4
Celera144,428,886 - 4,429,105UniSTS
RH 3.4 Map1480.7UniSTS
Cytogenetic Map14p22UniSTS
RH137556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,255,709 - 4,255,833 (+)MAPPERmRatBN7.2
Rnor_6.0145,315,461 - 5,315,584NCBIRnor6.0
Rnor_5.0145,306,178 - 5,306,301UniSTSRnor5.0
RGSC_v3.4145,334,097 - 5,334,220UniSTSRGSC3.4
Celera144,418,530 - 4,418,653UniSTS
Cytogenetic Map14p22UniSTS
BE096967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,268,264 - 4,268,429 (+)MAPPERmRatBN7.2
Rnor_6.0145,328,088 - 5,328,252NCBIRnor6.0
Rnor_5.0145,318,805 - 5,318,969UniSTSRnor5.0
RGSC_v3.4145,346,652 - 5,346,816UniSTSRGSC3.4
Celera144,431,084 - 4,431,248UniSTS
RH 3.4 Map1484.7UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002896   ⟹   ENSRNOP00000002896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104559   ⟹   ENSRNOP00000082962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,227,832 - 4,315,249 (-)Ensembl
RefSeq Acc Id: NM_001037179   ⟹   NP_001032256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,532,657 - 4,620,014 (-)NCBI
mRatBN7.2144,227,837 - 4,315,205 (-)NCBI
Rnor_6.0145,287,591 - 5,378,698 (-)NCBI
Rnor_5.0145,274,372 - 5,369,435 (-)NCBI
RGSC_v3.4145,306,227 - 5,393,820 (-)RGD
Celera144,390,675 - 4,477,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250542   ⟹   XP_006250604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,528,721 - 4,621,259 (-)NCBI
mRatBN7.2144,223,901 - 4,315,588 (-)NCBI
Rnor_6.0145,283,655 - 5,378,738 (-)NCBI
Rnor_5.0145,274,372 - 5,369,435 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032256 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250604 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00077 (Get FASTA)   NCBI Sequence Viewer  
  EDL99473 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082962.1
  ENSRNOP00055035321
  ENSRNOP00060013763
  ENSRNOP00065015691
GenBank Protein Q498T9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032256   ⟸   NM_001037179
- UniProtKB: Q498T9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250604   ⟸   XM_006250542
- Peptide Label: isoform X1
- UniProtKB: Q498T9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002896   ⟸   ENSRNOT00000002896
Ensembl Acc Id: ENSRNOP00000082962   ⟸   ENSRNOT00000104559

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498T9-F1-model_v2 AlphaFold Q498T9 1-803 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699166
Promoter ID:EPDNEW_R9691
Type:initiation region
Name:Lrrc8c_1
Description:leucine rich repeat containing 8 VRAC subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0145,378,670 - 5,378,730EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306585 AgrOrtholog
BioCyc Gene G2FUF-16553 BioCyc
Ensembl Genes ENSRNOG00000002122 Ensembl
  ENSRNOG00000065000 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055025124 UniProtKB/Swiss-Prot
  ENSRNOG00060010474 UniProtKB/Swiss-Prot
  ENSRNOG00065012562 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104559.1 UniProtKB/Swiss-Prot
  ENSRNOT00055043307 UniProtKB/Swiss-Prot
  ENSRNOT00060017707 UniProtKB/Swiss-Prot
  ENSRNOT00065020421 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7386007 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRR_domain-containing UniProtKB/Swiss-Prot
  LRRC8_Pannexin-like UniProtKB/Swiss-Prot
KEGG Report rno:289443 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112653 IMAGE-MGC_LOAD
NCBI Gene 289443 ENTREZGENE
PANTHER PTHR48051 UniProtKB/Swiss-Prot
  VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE UniProtKB/Swiss-Prot
Pfam LRR_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pannexin_like UniProtKB/Swiss-Prot
PhenoGen Lrrc8c PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002122 RatGTEx
  ENSRNOG00000065000 RatGTEx
  ENSRNOG00055025124 RatGTEx
  ENSRNOG00060010474 RatGTEx
  ENSRNOG00065012562 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt A6K5Q3_RAT UniProtKB/TrEMBL
  LRC8C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Lrrc8c  leucine rich repeat containing 8 VRAC subunit C  Lrrc8c  leucine rich repeat containing 8 family, member C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrrc8c  leucine rich repeat containing 8 family, member C  RGD1306585  similar to hypothetical protein AD158  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1306585  similar to hypothetical protein AD158  RGD1306585_predicted  similar to hypothetical protein AD158 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306585_predicted  similar to hypothetical protein AD158 (predicted)  LOC289443_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289443_predicted  similar to hypothetical protein AD158 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL